TR201905021T4 - Skualen içeren bir suda yağ emülsiyonunun üretimi. - Google Patents

Skualen içeren bir suda yağ emülsiyonunun üretimi. Download PDF

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Publication number
TR201905021T4
TR201905021T4 TR2019/05021T TR201905021T TR201905021T4 TR 201905021 T4 TR201905021 T4 TR 201905021T4 TR 2019/05021 T TR2019/05021 T TR 2019/05021T TR 201905021 T TR201905021 T TR 201905021T TR 201905021 T4 TR201905021 T4 TR 201905021T4
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TR
Turkey
Prior art keywords
oil
production
water emulsion
squalene
emulsion containing
Prior art date
Application number
TR2019/05021T
Other languages
English (en)
Inventor
Hora Maninder
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44358794&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201905021(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TR201905021T4 publication Critical patent/TR201905021T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/21—Alkatrienes; Alkatetraenes; Other alkapolyenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/10—Vacuum distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/14—Fractional distillation or use of a fractionation or rectification column
    • B01D3/143—Fractional distillation or use of a fractionation or rectification column by two or more of a fractionation, separation or rectification step
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/10—Wash bottles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/04—Purification; Separation; Use of additives by distillation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

Skualen içeren bir bileşimden skualen hazırlamak için geliştirilmiş bir yöntem olup, burada bahsedilen yöntem (a) T1 sıcaklığında gerçekleştirilen bir saflaştırma damıtma adımını; (b) T2 sıcaklığında gerçekleştirilen bir denatüre edici damıtma adımlarını içerir; buradaki (a) ve (b) adımları, her iki sırada da gerçekleştirilebilir; T2>T1; ve T2>200°C durumunda T1 ve T2 sıcaklıkları skualenin kaynamasına neden olmak için yeterlidir.
TR2019/05021T 2010-05-12 2011-05-12 Skualen içeren bir suda yağ emülsiyonunun üretimi. TR201905021T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39544810P 2010-05-12 2010-05-12

Publications (1)

Publication Number Publication Date
TR201905021T4 true TR201905021T4 (tr) 2019-05-21

Family

ID=44358794

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/05021T TR201905021T4 (tr) 2010-05-12 2011-05-12 Skualen içeren bir suda yağ emülsiyonunun üretimi.

Country Status (20)

Country Link
US (5) US9199897B2 (tr)
EP (4) EP3103784B1 (tr)
JP (2) JP5946188B2 (tr)
KR (1) KR101875894B1 (tr)
CN (2) CN105125488A (tr)
AU (1) AU2011251706B2 (tr)
BR (1) BR112012028711B1 (tr)
CA (1) CA2798924C (tr)
EA (1) EA027142B1 (tr)
ES (4) ES2597158T5 (tr)
IL (1) IL222855A (tr)
MX (1) MX352758B (tr)
NZ (1) NZ603918A (tr)
PL (4) PL3103784T3 (tr)
PT (3) PT2620423T (tr)
SG (2) SG10201503689TA (tr)
SI (1) SI2569267T1 (tr)
TR (1) TR201905021T4 (tr)
WO (1) WO2011141819A1 (tr)
ZA (1) ZA201208381B (tr)

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Also Published As

Publication number Publication date
SG10201503689TA (en) 2015-06-29
SG185419A1 (en) 2012-12-28
CA2798924A1 (en) 2011-11-17
EP2569267A1 (en) 2013-03-20
EA201291225A1 (ru) 2013-06-28
ES2817446T3 (es) 2021-04-07
PT3489211T (pt) 2020-09-22
PL2569267T3 (pl) 2014-05-30
AU2011251706B2 (en) 2015-10-22
EP2569267B1 (en) 2013-12-25
EP3489211B1 (en) 2020-07-15
CN102892734B (zh) 2015-07-22
EP2620423A1 (en) 2013-07-31
SI2569267T1 (sl) 2014-03-31
BR112012028711B1 (pt) 2020-12-01
JP2015157858A (ja) 2015-09-03
AU2011251706A1 (en) 2012-12-20
US10517947B2 (en) 2019-12-31
PL3103784T3 (pl) 2019-07-31
EP2620423B1 (en) 2016-07-20
ES2597158T3 (es) 2017-01-16
ZA201208381B (en) 2014-04-30
US20130209510A1 (en) 2013-08-15
EP2569267B2 (en) 2017-03-22
EA027142B1 (ru) 2017-06-30
JP2013530941A (ja) 2013-08-01
KR20130103668A (ko) 2013-09-24
PL2620423T3 (pl) 2017-09-29
PL2569267T5 (pl) 2017-10-31
US20170072053A1 (en) 2017-03-16
IL222855A (en) 2015-11-30
CA2798924C (en) 2014-05-06
CN102892734A (zh) 2013-01-23
EP3489211A1 (en) 2019-05-29
MX352758B (es) 2017-12-07
ES2453316T5 (es) 2017-07-18
NZ603918A (en) 2015-04-24
IL222855A0 (en) 2012-12-31
US9199897B2 (en) 2015-12-01
EP3103784B1 (en) 2019-02-06
BR112012028711A2 (pt) 2017-03-21
US20180169225A1 (en) 2018-06-21
PT2620423T (pt) 2016-09-23
JP5946188B2 (ja) 2016-07-05
PL2620423T5 (pl) 2019-12-31
CN105125488A (zh) 2015-12-09
ES2453316T3 (es) 2014-04-07
WO2011141819A1 (en) 2011-11-17
US11077186B2 (en) 2021-08-03
US20160051670A1 (en) 2016-02-25
ES2597158T5 (es) 2020-03-26
KR101875894B1 (ko) 2018-08-02
US20200061187A1 (en) 2020-02-27
MX2012013027A (es) 2012-12-17
US9545440B2 (en) 2017-01-17
ES2717266T3 (es) 2019-06-20
EP3103784A1 (en) 2016-12-14
EP2620423B2 (en) 2019-07-31
PL3489211T3 (pl) 2020-12-14
US9867877B2 (en) 2018-01-16
PT3103784T (pt) 2019-05-20

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