MX360299B - Circulacion de componentes durante la homogenizacion de emulsiones. - Google Patents

Circulacion de componentes durante la homogenizacion de emulsiones.

Info

Publication number
MX360299B
MX360299B MX2014014450A MX2014014450A MX360299B MX 360299 B MX360299 B MX 360299B MX 2014014450 A MX2014014450 A MX 2014014450A MX 2014014450 A MX2014014450 A MX 2014014450A MX 360299 B MX360299 B MX 360299B
Authority
MX
Mexico
Prior art keywords
circulation
emulsions
components during
during homogenization
container
Prior art date
Application number
MX2014014450A
Other languages
English (en)
Inventor
Rueckl Harald
Scheffczik Hanno
Santry Barbara
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43923723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360299(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX360299B publication Critical patent/MX360299B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Edible Oils And Fats (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Liquid Carbonaceous Fuels (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La presente invención se refiere a un método para una fabricación a gran escala de una emulsión de aceite de agua uniforme, el método que comprende las etapas de: proporcionar una primera emulsión pasar la primera emulsión a través de un dispositivo al menos dos veces, en donde el dispositivo funciona a alta presión y alta velocidad suficiente para reducir el tamaño promedio de las gotitas de aceite en la primera emulsión con el fin de formar una segunda emulsión; y, filtrar la segunda emulsión con una membrana hidrófila asimétrica a fin de formar una emulsión de aceite en agua uniforme, caracterizado porque el tamaño promedio de gotita de aceite es de 220 nm o menos y el número de gotitas de aceite que tienen un tamaño > 1.2 µm es 5 x 108/ml o menos, y en donde la emulsión de aceite en agua uniforme tiene un volumen mayor que o igual a 50 litros.
MX2014014450A 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones. MX360299B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28351809P 2009-12-03 2009-12-03
PCT/IB2010/003394 WO2011067673A2 (en) 2009-12-03 2010-12-03 Circulation of components during homogenization of emulsions

Publications (1)

Publication Number Publication Date
MX360299B true MX360299B (es) 2018-10-29

Family

ID=43923723

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014014449A MX344381B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014450A MX360299B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2012006216A MX2012006216A (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2014014449A MX344381B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012006216A MX2012006216A (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Country Status (24)

Country Link
US (6) USRE46441E1 (es)
EP (4) EP2506834B1 (es)
JP (2) JP5820390B2 (es)
KR (1) KR101523215B1 (es)
CN (2) CN102753149B (es)
AU (1) AU2010325752B2 (es)
BR (1) BR112012013427B8 (es)
CA (1) CA2782511C (es)
DK (2) DK2638895T3 (es)
EA (1) EA024770B1 (es)
ES (3) ES2402569T3 (es)
FI (1) FI2638895T3 (es)
HR (1) HRP20130398T1 (es)
HU (1) HUE066873T2 (es)
IL (1) IL219984B (es)
MX (3) MX344381B (es)
NZ (1) NZ600323A (es)
PL (1) PL2356983T3 (es)
PT (1) PT2356983E (es)
RS (1) RS52748B (es)
SG (2) SG181096A1 (es)
SI (2) SI2506834T1 (es)
SM (1) SMT201300044B (es)
WO (1) WO2011067673A2 (es)

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