MX344381B - Circulacion de componentes durante la homogenizacion de emulsiones. - Google Patents

Circulacion de componentes durante la homogenizacion de emulsiones.

Info

Publication number
MX344381B
MX344381B MX2014014449A MX2014014449A MX344381B MX 344381 B MX344381 B MX 344381B MX 2014014449 A MX2014014449 A MX 2014014449A MX 2014014449 A MX2014014449 A MX 2014014449A MX 344381 B MX344381 B MX 344381B
Authority
MX
Mexico
Prior art keywords
circulation
emulsions
components during
during homogenization
container
Prior art date
Application number
MX2014014449A
Other languages
English (en)
Inventor
Rueckl Harald
Scheffczik Hanno
Santry Barbara
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43923723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344381(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX344381B publication Critical patent/MX344381B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Edible Oils And Fats (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Liquid Carbonaceous Fuels (AREA)

Abstract

La presente invención se refiere a un método para la fabricación de una emulsión de aceite en agua que contiene escualeno, el método se caracteriza porque comprende las etapas de: (b) microfluidizar una primera emulsión formada usando un homogeneizador mecánico, en donde la primera emulsión tiene un primer tamaño medio de gotita de aceite, (c) hacer circular la primera emulsión mediante la transferencia de un primer recipiente de emulsión a través de un primer dispositivo de microfluidización a un segundo recipiente de emulsión, y luego de nuevo a través del mismo dispositivo de microfluidización, a fin de forma runa segunda emulsión que tenga un segundo tamaño medio de gotita de aceite que sea menor que el primer tamaño medio de gotita de aceite; y (d) filtrar la segunda emulsión.
MX2014014449A 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones. MX344381B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28351809P 2009-12-03 2009-12-03
PCT/IB2010/003394 WO2011067673A2 (en) 2009-12-03 2010-12-03 Circulation of components during homogenization of emulsions

Publications (1)

Publication Number Publication Date
MX344381B true MX344381B (es) 2016-12-14

Family

ID=43923723

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2012006216A MX2012006216A (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014450A MX360299B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014449A MX344381B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2012006216A MX2012006216A (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.
MX2014014450A MX360299B (es) 2009-12-03 2010-12-03 Circulacion de componentes durante la homogenizacion de emulsiones.

Country Status (25)

Country Link
US (6) US8895629B2 (es)
EP (4) EP4410306A3 (es)
JP (2) JP5820390B2 (es)
KR (1) KR101523215B1 (es)
CN (2) CN102753149B (es)
AU (1) AU2010325752B2 (es)
BR (1) BR112012013427B8 (es)
CA (1) CA2782511C (es)
DK (2) DK2638895T3 (es)
EA (1) EA024770B1 (es)
ES (3) ES2975170T3 (es)
FI (1) FI2638895T3 (es)
HK (2) HK1160396A1 (es)
HR (1) HRP20130398T1 (es)
HU (1) HUE066873T2 (es)
IL (1) IL219984B (es)
MX (3) MX2012006216A (es)
NZ (1) NZ600323A (es)
PL (1) PL2356983T3 (es)
PT (1) PT2356983E (es)
RS (1) RS52748B (es)
SG (2) SG10201501611QA (es)
SI (2) SI2356983T1 (es)
SM (1) SMT201300044B (es)
WO (1) WO2011067673A2 (es)

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