DE19612966B4 - MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren - Google Patents

MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren Download PDF

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Publication number
DE19612966B4
DE19612966B4 DE19612966A DE19612966A DE19612966B4 DE 19612966 B4 DE19612966 B4 DE 19612966B4 DE 19612966 A DE19612966 A DE 19612966A DE 19612966 A DE19612966 A DE 19612966A DE 19612966 B4 DE19612966 B4 DE 19612966B4
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DE
Germany
Prior art keywords
cells
infection
influenza viruses
cell
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19612966A
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German (de)
English (en)
Other versions
DE19612966A1 (de
Inventor
Albrecht Dr. Gröner
Jürgen Dr. Vorlop
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines GmbH
Original Assignee
Novartis Vaccines and Diagnostics GmbH
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19612966A priority Critical patent/DE19612966B4/de
Application filed by Novartis Vaccines and Diagnostics GmbH, Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics GmbH
Priority to HK99104226.0A priority patent/HK1019233B/en
Priority to US09/155,581 priority patent/US6455298B1/en
Priority to EP97915627A priority patent/EP0904351B1/en
Priority to EP10075278A priority patent/EP2275535A1/en
Priority to PT97915627T priority patent/PT904351E/pt
Priority to PCT/IB1997/000403 priority patent/WO1997037000A1/en
Priority to AT97915627T priority patent/ATE482267T1/de
Priority to JP53508997A priority patent/JP4243349B2/ja
Priority to DK97915627.0T priority patent/DK0904351T3/da
Priority to CA002250714A priority patent/CA2250714C/en
Priority to ES97915627T priority patent/ES2352638T3/es
Priority to DE69740002T priority patent/DE69740002D1/de
Publication of DE19612966A1 publication Critical patent/DE19612966A1/de
Priority to US10/194,784 priority patent/US6656720B2/en
Priority to JP2004233905A priority patent/JP2004331673A/ja
Priority to US11/057,370 priority patent/US20050202553A1/en
Priority to JP2005108075A priority patent/JP2005211080A/ja
Priority to JP2006147486A priority patent/JP2006230415A/ja
Priority to US12/146,689 priority patent/US20080274141A1/en
Priority to JP2008287206A priority patent/JP2009034115A/ja
Application granted granted Critical
Publication of DE19612966B4 publication Critical patent/DE19612966B4/de
Priority to JP2011192118A priority patent/JP2012005502A/ja
Priority to JP2011224914A priority patent/JP2012016358A/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5252Virus inactivated (killed)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE19612966A 1996-04-01 1996-04-01 MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren Expired - Fee Related DE19612966B4 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE19612966A DE19612966B4 (de) 1996-04-01 1996-04-01 MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US09/155,581 US6455298B1 (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
EP97915627A EP0904351B1 (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
EP10075278A EP2275535A1 (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
PT97915627T PT904351E (pt) 1996-04-01 1997-04-01 Células animais e processos para a replicação de vírus influenza
PCT/IB1997/000403 WO1997037000A1 (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
AT97915627T ATE482267T1 (de) 1996-04-01 1997-04-01 Tierzellen und verfahren für die replikation von influenza viren
JP53508997A JP4243349B2 (ja) 1996-04-01 1997-04-01 インフルエンザウイルスの複製のための動物細胞および方法
DK97915627.0T DK0904351T3 (da) 1996-04-01 1997-04-01 Dyreceller og fremgangsmåder til replikationen af influenzavirus
CA002250714A CA2250714C (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
ES97915627T ES2352638T3 (es) 1996-04-01 1997-04-01 Células animales y procedimientos de replicación del virus de la gripe.
DE69740002T DE69740002D1 (de) 1996-04-01 1997-04-01 Tierzellen und verfahren für die replikation von influenza viren
HK99104226.0A HK1019233B (en) 1996-04-01 1997-04-01 Animal cells and processes for the replication of influenza viruses
US10/194,784 US6656720B2 (en) 1996-04-01 2002-07-12 Animal cells and processes for the replication of influenza viruses
JP2004233905A JP2004331673A (ja) 1996-04-01 2004-08-10 インフルエンザウイルスの複製のための動物細胞および方法
US11/057,370 US20050202553A1 (en) 1996-04-01 2005-02-15 Animal cells and processes for the replication of influenza viruses
JP2005108075A JP2005211080A (ja) 1996-04-01 2005-04-04 インフルエンザウイルスの複製のための動物細胞および方法
JP2006147486A JP2006230415A (ja) 1996-04-01 2006-05-26 インフルエンザウイルスの複製のための動物細胞および方法
US12/146,689 US20080274141A1 (en) 1996-04-01 2008-06-26 Animal cells and processes for the replication of influenza viruses
JP2008287206A JP2009034115A (ja) 1996-04-01 2008-11-07 インフルエンザウイルスの複製のための動物細胞および方法
JP2011192118A JP2012005502A (ja) 1996-04-01 2011-09-02 インフルエンザウイルスの複製のための動物細胞および方法
JP2011224914A JP2012016358A (ja) 1996-04-01 2011-10-12 インフルエンザウイルスの複製のための動物細胞および方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19655438 1996-04-01
DE19612966A DE19612966B4 (de) 1996-04-01 1996-04-01 MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren

Publications (2)

Publication Number Publication Date
DE19612966A1 DE19612966A1 (de) 1997-10-02
DE19612966B4 true DE19612966B4 (de) 2009-12-10

Family

ID=7790126

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19612966A Expired - Fee Related DE19612966B4 (de) 1996-04-01 1996-04-01 MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
DE69740002T Expired - Lifetime DE69740002D1 (de) 1996-04-01 1997-04-01 Tierzellen und verfahren für die replikation von influenza viren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69740002T Expired - Lifetime DE69740002D1 (de) 1996-04-01 1997-04-01 Tierzellen und verfahren für die replikation von influenza viren

Country Status (9)

Country Link
US (4) US6455298B1 (enExample)
EP (2) EP0904351B1 (enExample)
JP (7) JP4243349B2 (enExample)
AT (1) ATE482267T1 (enExample)
DE (2) DE19612966B4 (enExample)
DK (1) DK0904351T3 (enExample)
ES (1) ES2352638T3 (enExample)
PT (1) PT904351E (enExample)
WO (1) WO1997037000A1 (enExample)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
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