JP2012526531A5 - - Google Patents
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- JP2012526531A5 JP2012526531A5 JP2012510276A JP2012510276A JP2012526531A5 JP 2012526531 A5 JP2012526531 A5 JP 2012526531A5 JP 2012510276 A JP2012510276 A JP 2012510276A JP 2012510276 A JP2012510276 A JP 2012510276A JP 2012526531 A5 JP2012526531 A5 JP 2012526531A5
- Authority
- JP
- Japan
- Prior art keywords
- orthopoxvirus
- anion exchange
- cell
- exchange adsorbent
- packaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 30
- 241000700629 Orthopoxvirus Species 0.000 claims description 22
- 239000003463 adsorbent Substances 0.000 claims description 19
- 238000005349 anion exchange Methods 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000004806 packaging method and process Methods 0.000 claims description 15
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 14
- 101710163270 Nuclease Proteins 0.000 claims description 11
- 239000011780 sodium chloride Substances 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims description 5
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims description 4
- YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 claims description 3
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 239000012228 culture supernatant Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 20
- 241000271566 Aves Species 0.000 claims 8
- 239000011148 porous material Substances 0.000 claims 5
- 108010017842 Telomerase Proteins 0.000 claims 4
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 claims 4
- 238000011026 diafiltration Methods 0.000 claims 4
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 claims 2
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 210000000170 cell membrane Anatomy 0.000 claims 2
- 238000005352 clarification Methods 0.000 claims 2
- 238000011118 depth filtration Methods 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108010034546 Serratia marcescens nuclease Proteins 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 230000000593 degrading effect Effects 0.000 claims 1
- -1 dimethylaminoethyl Chemical group 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000002523 gelfiltration Methods 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 238000001471 micro-filtration Methods 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 238000000527 sonication Methods 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 description 10
- 239000000872 buffer Substances 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 2
- 235000013923 monosodium glutamate Nutrition 0.000 description 2
- 229940073490 sodium glutamate Drugs 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09305422.9 | 2009-05-12 | ||
| EP09305422 | 2009-05-12 | ||
| US21348409P | 2009-06-12 | 2009-06-12 | |
| US61/213,484 | 2009-06-12 | ||
| PCT/EP2010/056491 WO2010130753A1 (en) | 2009-05-12 | 2010-05-11 | Method for orthopoxvirus production and purification |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526531A JP2012526531A (ja) | 2012-11-01 |
| JP2012526531A5 true JP2012526531A5 (enExample) | 2015-11-19 |
| JP5855564B2 JP5855564B2 (ja) | 2016-02-09 |
Family
ID=43084645
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510278A Ceased JP2012526532A (ja) | 2009-05-12 | 2010-05-11 | 不死化鳥類細胞系およびその用途 |
| JP2012510276A Expired - Fee Related JP5855564B2 (ja) | 2009-05-12 | 2010-05-11 | オルソポックスウイルスの製造および精製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510278A Ceased JP2012526532A (ja) | 2009-05-12 | 2010-05-11 | 不死化鳥類細胞系およびその用途 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8609392B2 (enExample) |
| EP (2) | EP2429579A1 (enExample) |
| JP (2) | JP2012526532A (enExample) |
| KR (1) | KR20120026526A (enExample) |
| CN (2) | CN102740881A (enExample) |
| AU (2) | AU2010247374A1 (enExample) |
| BR (2) | BRPI1007743A2 (enExample) |
| CA (2) | CA2760465A1 (enExample) |
| CR (1) | CR20110641A (enExample) |
| IL (2) | IL216310A0 (enExample) |
| NZ (1) | NZ596595A (enExample) |
| RU (2) | RU2011148791A (enExample) |
| SG (1) | SG176554A1 (enExample) |
| WO (2) | WO2010130753A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009132195A1 (en) * | 2008-04-23 | 2009-10-29 | Michigan State University | Immortal avian cell line and methods of use |
| KR20120026526A (ko) * | 2009-05-12 | 2012-03-19 | 트랜스진 에스.에이. | 불멸화 조류 세포주 및 그의 용도 |
| CN102807969B (zh) * | 2011-06-03 | 2013-09-25 | 中国科学院动物研究所 | 高产杆状病毒的转基因卵巢细胞系及其制备方法和应用 |
| TWI623618B (zh) | 2011-07-12 | 2018-05-11 | 傳斯堅公司 | Ｈｂｖ聚合酶突變體 |
| WO2013045658A1 (en) | 2011-09-29 | 2013-04-04 | Transgene Sa | Immunotherapy composition and regimen for treating hepatitis c virus infection |
| WO2013045668A2 (en) | 2011-09-29 | 2013-04-04 | Transgene Sa | Immunotherapy composition and regimen for treating hepatitis c virus infection |
| WO2013181575A2 (en) | 2012-06-01 | 2013-12-05 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
| US20150141620A1 (en) * | 2012-06-01 | 2015-05-21 | Momenta Pharmaceuticals, Inc. | Methods related to rituximab |
| WO2014009433A1 (en) | 2012-07-10 | 2014-01-16 | Transgene Sa | Mycobacterium resuscitation promoting factor for use as adjuvant |
| US10357555B2 (en) | 2012-07-10 | 2019-07-23 | Transgene Sa | Mycobacterial antigen vaccine |
| TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
| SMT202400297T1 (it) | 2013-03-13 | 2024-09-16 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Proteine f del rsv pre-fusione e loro uso |
| WO2014149067A1 (en) | 2013-03-15 | 2014-09-25 | Momenta Pharmaceuticals, Inc. | Methods related to ctla4-fc fusion proteins |
| US10464996B2 (en) | 2013-05-13 | 2019-11-05 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
| GB201310031D0 (en) * | 2013-06-05 | 2013-07-17 | Pirbright Inst The | Cell |
| CA2922996C (en) * | 2013-10-07 | 2023-03-21 | Novartis Ag | Treated filter |
| US20160257754A1 (en) | 2013-10-16 | 2016-09-08 | Momenta Pharmaceuticals Inc. | Sialylated glycoproteins |
| RU2695462C2 (ru) | 2014-01-09 | 2019-07-23 | Трансген Са | Гибридизация гетероолигомерных микобактериальных антигенов |
| JP6895374B2 (ja) | 2014-07-16 | 2021-06-30 | トランジェーヌＴｒａｎｓｇｅｎｅ | 免疫チェックポイントモジュレーターの発現用腫瘍溶解性ウイルス |
| AU2015357225B2 (en) | 2014-12-01 | 2020-04-09 | Transgene Sa | Stable liquid vaccinia virus formulations |
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| WO2016128542A1 (en) | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| WO2016131945A1 (en) | 2015-02-20 | 2016-08-25 | Transgene Sa | Combination product with autophagy modulator |
| CN109069611B (zh) | 2016-03-29 | 2022-11-04 | 美国政府(由卫生和人类服务部的部长所代表) | 取代修饰的融合前rsv f蛋白及其用途 |
| EP3452081A1 (en) | 2016-05-04 | 2019-03-13 | Transgene SA | Combination therapy with cpg tlr9 ligand |
| GB201616365D0 (en) * | 2016-09-27 | 2016-11-09 | Helsingin Yliopisto | Non-genetic modification of enveloped viruses |
| US20190328869A1 (en) | 2016-10-10 | 2019-10-31 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018091680A1 (en) | 2016-11-18 | 2018-05-24 | Transgene Sa | Cowpox-based oncolytic vectors |
| CA3043790A1 (en) | 2016-12-16 | 2018-06-21 | Institute For Research In Biomedicine | Novel recombinant prefusion rsv f proteins and uses thereof |
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| US11306292B2 (en) | 2017-05-15 | 2022-04-19 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| JP7406377B2 (ja) | 2017-05-15 | 2023-12-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定なウイルス含有組成物 |
| KR102684237B1 (ko) | 2017-06-21 | 2024-07-11 | 트랜스진 | 개인 맞춤형 백신 |
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| CA3080656A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
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| KR20210043580A (ko) | 2018-08-10 | 2021-04-21 | 리젠엑스바이오 인크. | 재조합 aav 생산을 위한 규모 조정 가능한 방법 |
| EP3617230A1 (en) | 2018-09-03 | 2020-03-04 | BioInvent International AB | Novel antibodies and nucleotide sequences, and uses thereof |
| CA3111273C (en) | 2018-09-06 | 2024-03-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| EP3867412A1 (en) | 2018-10-15 | 2021-08-25 | REGENXBIO Inc. | Method for measuring the infectivity of replication defective viral vectors and viruses |
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| CN111763661B (zh) * | 2019-04-02 | 2022-07-29 | 普莱柯生物工程股份有限公司 | 一种病毒纯化的方法、制备的疫苗组合物及其应用 |
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| JP7630443B2 (ja) | 2019-04-19 | 2025-02-17 | レジェンクスバイオ インコーポレーテッド | アデノ随伴ウイルスベクター製剤及び方法 |
| CN112143693B (zh) * | 2019-06-28 | 2024-12-27 | 杭州康万达医药科技有限公司 | 一种生产病毒的方法及收获液组合物 |
| CN110468107A (zh) * | 2019-08-09 | 2019-11-19 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 一种对jev易感的猪扁桃体细胞系 |
| CN110396502A (zh) * | 2019-08-09 | 2019-11-01 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | 对jev易感的猪扁桃体细胞系的构建方法 |
| EP3842065A1 (en) | 2019-12-23 | 2021-06-30 | Transgene | Process for designing a recombinant poxvirus for a therapeutic vaccine |
| EP3871690A1 (en) * | 2020-02-27 | 2021-09-01 | Technische Hochschule Mittelhessen | Method for virus production |
| JP7712284B2 (ja) | 2020-03-12 | 2025-07-23 | バヴァリアン・ノルディック・アクティーゼルスカブ | ポックスウイルスの安定性を改善する組成物 |
| TW202217002A (zh) | 2020-07-13 | 2022-05-01 | 法商傳斯堅公司 | 免疫抑制之治療 |
| CN116590346B (zh) * | 2020-09-15 | 2024-05-14 | 上海药明巨诺生物医药研发有限公司 | 一种慢病毒载体纯化方法 |
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| CN101365789A (zh) * | 2006-01-05 | 2009-02-11 | 特兰斯吉恩股份有限公司 | 鸟类端粒酶反转录酶 |
| EP2013229A2 (en) | 2006-04-21 | 2009-01-14 | Transgene S.A. | Hpv-18-based papillomavirus vaccine |
| KR101082296B1 (ko) * | 2006-06-20 | 2011-11-09 | 트랜스진 에스.에이. | 폭스바이러스 및 폭스바이러스 조성물 제조 방법 |
| EP1982727A1 (en) * | 2007-04-17 | 2008-10-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for purification of viral proteins |
| EP1985305A1 (en) * | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
| NZ578960A (en) | 2007-05-14 | 2012-11-30 | Bavarian Nordic As | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
| US8003363B2 (en) * | 2007-05-14 | 2011-08-23 | Bavarian Nordic A/S | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines |
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| KR101445433B1 (ko) * | 2008-02-25 | 2014-09-26 | 백스터 인터내셔널 인코포레이티드 | 연속 세포주 제조 방법 |
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| KR20120026526A (ko) * | 2009-05-12 | 2012-03-19 | 트랜스진 에스.에이. | 불멸화 조류 세포주 및 그의 용도 |
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2010
- 2010-05-11 KR KR20117029009A patent/KR20120026526A/ko not_active Withdrawn
- 2010-05-11 RU RU2011148791/02A patent/RU2011148791A/ru not_active Application Discontinuation
- 2010-05-11 CN CN2010800316470A patent/CN102740881A/zh active Pending
- 2010-05-11 RU RU2011148790/10A patent/RU2560976C2/ru not_active IP Right Cessation
- 2010-05-11 CA CA2760465A patent/CA2760465A1/en not_active Abandoned
- 2010-05-11 NZ NZ59659510A patent/NZ596595A/xx not_active IP Right Cessation
- 2010-05-11 CA CA 2761457 patent/CA2761457A1/en not_active Abandoned
- 2010-05-11 US US13/319,874 patent/US8609392B2/en not_active Expired - Fee Related
- 2010-05-11 AU AU2010247374A patent/AU2010247374A1/en not_active Abandoned
- 2010-05-11 BR BRPI1007743A patent/BRPI1007743A2/pt not_active IP Right Cessation
- 2010-05-11 JP JP2012510278A patent/JP2012526532A/ja not_active Ceased
- 2010-05-11 EP EP10718219A patent/EP2429579A1/en not_active Withdrawn
- 2010-05-11 JP JP2012510276A patent/JP5855564B2/ja not_active Expired - Fee Related
- 2010-05-11 WO PCT/EP2010/056491 patent/WO2010130753A1/en not_active Ceased
- 2010-05-11 CN CN201080021253.7A patent/CN103547285A/zh active Pending
- 2010-05-11 EP EP10721439A patent/EP2429580A1/en not_active Withdrawn
- 2010-05-11 AU AU2010247371A patent/AU2010247371B2/en not_active Ceased
- 2010-05-11 US US12/777,731 patent/US8445270B2/en not_active Expired - Fee Related
- 2010-05-11 WO PCT/EP2010/056497 patent/WO2010130756A1/en not_active Ceased
- 2010-05-11 BR BRPI1007744A patent/BRPI1007744A2/pt not_active IP Right Cessation
- 2010-05-11 SG SG2011082518A patent/SG176554A1/en unknown
-
2011
- 2011-11-10 IL IL216310A patent/IL216310A0/en unknown
- 2011-11-10 IL IL216312A patent/IL216312A0/en unknown
- 2011-11-29 CR CR20110641A patent/CR20110641A/es unknown
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2013
- 2013-02-25 US US13/775,314 patent/US8778675B2/en not_active Expired - Fee Related
- 2013-11-12 US US14/077,621 patent/US9012198B2/en not_active Expired - Fee Related
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