JP2005532779A5 - - Google Patents
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- Publication number
- JP2005532779A5 JP2005532779A5 JP2003527086A JP2003527086A JP2005532779A5 JP 2005532779 A5 JP2005532779 A5 JP 2005532779A5 JP 2003527086 A JP2003527086 A JP 2003527086A JP 2003527086 A JP2003527086 A JP 2003527086A JP 2005532779 A5 JP2005532779 A5 JP 2005532779A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- mdck cells
- medium
- culture
- propagation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144906A DE10144906B4 (de) | 2001-09-12 | 2001-09-12 | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| PCT/EP2002/010208 WO2003023021A2 (de) | 2001-09-12 | 2002-09-11 | Verfahren zur herstellung eines aktiven bestandteils eines arznei- oder diagnosemittels in mdck-zell-suspensionskultur |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204890A Division JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005532779A JP2005532779A (ja) | 2005-11-04 |
| JP2005532779A5 true JP2005532779A5 (enExample) | 2008-10-02 |
Family
ID=7698764
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527086A Pending JP2005532779A (ja) | 2001-09-12 | 2002-09-11 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2010058365A Expired - Fee Related JP5264812B2 (ja) | 2001-09-12 | 2010-03-15 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2010058365A Expired - Fee Related JP5264812B2 (ja) | 2001-09-12 | 2010-03-15 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10329536B2 (enExample) |
| EP (3) | EP1427815B1 (enExample) |
| JP (4) | JP2005532779A (enExample) |
| KR (1) | KR100999345B1 (enExample) |
| AT (2) | ATE512213T1 (enExample) |
| AU (2) | AU2002338667B2 (enExample) |
| BR (1) | BR0212470A (enExample) |
| CA (1) | CA2455189C (enExample) |
| CY (2) | CY1110964T1 (enExample) |
| DE (3) | DE10144906B4 (enExample) |
| DK (2) | DK1427815T3 (enExample) |
| ES (2) | ES2351300T3 (enExample) |
| NZ (1) | NZ532202A (enExample) |
| PT (2) | PT2011862E (enExample) |
| SI (1) | SI1427815T1 (enExample) |
| WO (1) | WO2003023021A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ551640A (en) * | 2004-05-20 | 2010-05-28 | Id Biomedical Corp | Process for the production of an influenza vaccine |
| EP2578229B1 (en) | 2004-09-09 | 2013-07-10 | Novartis Vaccines and Diagnostics GmbH | Decreasing potential iatrogenic risks associated with vaccine antigens |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| CN101365480B (zh) | 2005-11-01 | 2014-11-05 | 诺华疫苗和诊断有限两合公司 | 经由β-丙内酯处理的残留细胞DNA水平降低的细胞衍生病毒疫苗 |
| NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
| HUE051122T2 (hu) | 2005-11-04 | 2021-03-01 | Seqirus Uk Ltd | Sejttenyészetben növesztett influenzavírusból elõállított nemvirion anti-géneket tartalmazó adjuvált vakcinák |
| WO2007052058A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| AU2006310163B2 (en) | 2005-11-04 | 2011-09-15 | Seqirus UK Limited | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| EA014028B1 (ru) | 2005-11-04 | 2010-08-30 | Новартис Вэксинс Энд Диагностикс Срл | Эмульсии, содержащие свободное поверхностно-активное вещество в водной фазе в качестве адъюванта сплит вакцин против гриппа |
| CN101448523A (zh) | 2006-03-24 | 2009-06-03 | 诺华疫苗和诊断有限两合公司 | 无需冷藏储存流感疫苗 |
| WO2007126810A2 (en) | 2006-03-31 | 2007-11-08 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP4585610A3 (en) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| EP2069480B1 (en) | 2006-09-15 | 2014-03-19 | MedImmune, LLC | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| US9439960B2 (en) * | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| JP5548207B2 (ja) | 2008-09-24 | 2014-07-16 | メディミューン，エルエルシー | ウイルスの精製方法 |
| CN102548577A (zh) | 2009-04-27 | 2012-07-04 | 诺华有限公司 | 用于抵抗流感的佐剂疫苗 |
| WO2011011660A2 (en) | 2009-07-23 | 2011-01-27 | Xcellerex, Inc. | Drain down and re-feed of microcarrier bioreactor |
| WO2011056591A1 (en) | 2009-10-26 | 2011-05-12 | Warf - Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US20110142863A1 (en) * | 2009-12-16 | 2011-06-16 | Millipore Corporation | Flow through purification processes for large biomolecules |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| ES2562818T3 (es) * | 2010-05-03 | 2016-03-08 | Glaxosmithkline Biologicals S.A. | Procedimiento de inactivación del virus de la gripe |
| EP2566323A2 (en) | 2010-05-06 | 2013-03-13 | Novartis AG | Organic peroxide compounds for microorganism inactivation |
| EP2571520B1 (en) | 2010-05-21 | 2018-04-04 | Seqirus UK Limited | Influenza virus reassortment method |
| AU2011262309B2 (en) | 2010-06-01 | 2015-08-13 | Seqirus UK Limited | Concentration of influenza vaccine antigens without lyophilization |
| AU2011262312B2 (en) | 2010-06-01 | 2015-05-28 | Novartis Ag | Concentration and lyophilization of influenza vaccine antigens |
| US9517205B2 (en) | 2010-08-20 | 2016-12-13 | Seqirus UK Limited | Soluble needle arrays for delivery of influenza vaccines |
| WO2012033236A1 (ko) | 2010-09-06 | 2012-03-15 | 에스케이케미칼 주식회사 | 무혈청 배양 및 부유 배양에 적응된 ｍｄｃｋ 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| WO2012082723A2 (en) | 2010-12-15 | 2012-06-21 | Emd Millipore Corporation | Purification of immunogens using a non-polysaccharide matrix |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| CA2866465A1 (en) | 2012-03-06 | 2013-09-12 | Crucell Holland B.V. | Improved vaccination against influenza |
| KR101370512B1 (ko) * | 2013-06-07 | 2014-03-06 | 재단법인 목암생명공학연구소 | 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법 |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| BR112017028011A2 (pt) | 2015-06-26 | 2018-08-28 | Seqirus Uk Ltd | vacinas de gripe correspondentes antigenicamente |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| CN108027371B (zh) | 2015-07-07 | 2020-08-18 | 思齐乐 | 流感效力试验 |
| WO2017072744A1 (en) | 2015-10-30 | 2017-05-04 | National Institute Of Infectious Diseases And Vaccinology, National Health Research Institutes | Mdck suspension cell lines in serum-free, chemically-defined media for vaccine production |
| CN105561317B (zh) * | 2015-12-22 | 2018-03-20 | 肇庆大华农生物药品有限公司 | 重组伪狂犬病病毒疫苗耐热冻干保护剂及其制备方法 |
| WO2017143236A1 (en) | 2016-02-19 | 2017-08-24 | Yoshihiro Kawaoka | Improved influenza b virus replication for vaccine development |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| JP2022527235A (ja) | 2019-01-23 | 2022-06-01 | 義裕 河岡 | インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異 |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| CN110237246B (zh) * | 2019-07-25 | 2022-11-15 | 北京鼎持生物技术有限公司 | 一种全悬浮细胞培养禽流感（h9）灭活疫苗的方法 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| MX2022006005A (es) | 2019-11-18 | 2022-10-27 | Seqirus Pty Ltd | Metodo para producir virus de la influenza reagrupados. |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CA3183701A1 (en) * | 2020-06-22 | 2021-12-30 | Sung Jin Kim | Method for large scale-production of vaccinia virus using suspension cells |
| WO2022125793A1 (en) * | 2020-12-10 | 2022-06-16 | Sarepta Therapeutics, Inc. | Suspension mode seed train development for adherent cells |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278075B (de) | 1964-06-22 | 1968-09-19 | Norden Lab Inc | Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen |
| US4064232A (en) | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
| CA1122527A (en) * | 1979-05-15 | 1982-04-27 | Karen K. Brown | Influenza vaccine production in liquid cell culture |
| USRE33164E (en) | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| US4500513A (en) | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
| US4525349A (en) | 1981-12-29 | 1985-06-25 | Societe Anonyme Dite: Institut Merueux | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine |
| US5013663A (en) | 1983-06-15 | 1991-05-07 | American Home Products Corporation | Canine corona virus vaccine |
| US4783411A (en) | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| EP0389925B1 (en) | 1989-03-29 | 1995-12-27 | The Research Foundation Of State University Of New York | A method for purifying an outer membrane protein of Haemophilus influenzae |
| AT393277B (de) | 1990-01-04 | 1991-09-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen |
| MY107664A (en) * | 1991-01-17 | 1996-05-30 | Kao Corp | Novel alkaline proteinase and process for producing the same |
| GB9110808D0 (en) * | 1991-05-17 | 1991-07-10 | Retroscreen Ltd | Aids vaccine and method for its production |
| EP0592692B1 (en) * | 1992-05-01 | 1997-07-02 | Teijin Limited | Fed batch process for protein secreting cells |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| ES2323490T3 (es) * | 1994-11-10 | 2009-07-17 | Baxter Healthcare Sa | Procedimiento de produccion de agentes biologicos en un medio de cultivo sin proteinas. |
| US5756341A (en) | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| AU694592B2 (en) | 1994-11-16 | 1998-07-23 | St. Jude Children's Research Hospital | Novel replication process |
| US5646033A (en) | 1994-11-30 | 1997-07-08 | Dyncorp | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines |
| JPH11513372A (ja) | 1995-09-22 | 1999-11-16 | コノート ラボラトリーズ リミテッド | パラインフルエンザウイルスの糖タンパクおよびワクチン |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| CN1618464A (zh) * | 1998-10-05 | 2005-05-25 | 财团法人阪大微生物病研究会 | 用于抗日本脑炎病毒感染的灭活疫苗的增强免疫原及其生产方法 |
| US6514502B1 (en) | 1999-01-26 | 2003-02-04 | Schering-Plough Veterinary Corporation | Propagation of bovine cononavirus in chinese hamster ovary cells |
| WO2001029246A1 (fr) * | 1999-10-19 | 2001-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un polypeptide |
| US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| DE60142506D1 (de) | 2000-03-03 | 2010-08-19 | Chemo Sero Therapeut Res Inst | In serumfreier kultur verwendbare zelle, kultursuspension und verfahren zur virusproduktion als impfstoff unter verwendung der zelle |
| US20060147477A1 (en) | 2002-06-11 | 2006-07-06 | Glaxo Group Limited | Immunogenic compositions |
| MXPA05009580A (es) | 2003-03-07 | 2005-10-19 | Merck & Co Inc | Vacuna contra el virus de la influenza. |
| DE602004029657D1 (de) | 2003-03-24 | 2010-12-02 | Intercell Ag | Verbesserte impfstoffe |
| EP1863529A1 (en) | 2005-03-23 | 2007-12-12 | GlaxoSmithKline Biologicals S.A. | Novel composition |
| EP4585610A3 (en) | 2006-09-11 | 2025-09-24 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| CN101522218B (zh) | 2006-10-12 | 2012-09-26 | 葛兰素史密丝克莱恩生物有限公司 | 包含水包油乳液佐剂的疫苗 |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| PE20090146A1 (es) | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| AU2011225748A1 (en) | 2010-03-08 | 2012-09-13 | Novartis Ag | Methods of testing for intracellular pathogens |
-
2001
- 2001-09-12 DE DE10144906A patent/DE10144906B4/de not_active Expired - Lifetime
-
2002
- 2002-09-11 JP JP2003527086A patent/JP2005532779A/ja active Pending
- 2002-09-11 PT PT08018057T patent/PT2011862E/pt unknown
- 2002-09-11 ES ES02777069T patent/ES2351300T3/es not_active Expired - Lifetime
- 2002-09-11 AU AU2002338667A patent/AU2002338667B2/en not_active Expired
- 2002-09-11 DE DE50214630T patent/DE50214630D1/de not_active Expired - Lifetime
- 2002-09-11 DK DK02777069.2T patent/DK1427815T3/da active
- 2002-09-11 ES ES08018057T patent/ES2367833T3/es not_active Expired - Lifetime
- 2002-09-11 NZ NZ532202A patent/NZ532202A/en not_active IP Right Cessation
- 2002-09-11 US US10/487,707 patent/US10329536B2/en not_active Expired - Fee Related
- 2002-09-11 KR KR1020047003712A patent/KR100999345B1/ko not_active Expired - Lifetime
- 2002-09-11 EP EP02777069A patent/EP1427815B1/de not_active Expired - Lifetime
- 2002-09-11 PT PT02777069T patent/PT1427815E/pt unknown
- 2002-09-11 WO PCT/EP2002/010208 patent/WO2003023021A2/de not_active Ceased
- 2002-09-11 AT AT08018057T patent/ATE512213T1/de active
- 2002-09-11 DK DK08018057.3T patent/DK2011862T3/da active
- 2002-09-11 CA CA2455189A patent/CA2455189C/en not_active Expired - Lifetime
- 2002-09-11 BR BR0212470-0A patent/BR0212470A/pt active Search and Examination
- 2002-09-11 AT AT02777069T patent/ATE479742T1/de active
- 2002-09-11 DE DE122011000005C patent/DE122011000005I1/de active Pending
- 2002-09-11 EP EP08018057A patent/EP2011862B1/de not_active Expired - Lifetime
- 2002-09-11 SI SI200230924T patent/SI1427815T1/sl unknown
- 2002-09-11 EP EP10004227A patent/EP2216400A1/de not_active Withdrawn
-
2008
- 2008-08-07 JP JP2008204890A patent/JP2008289499A/ja active Pending
- 2008-08-28 AU AU2008207588A patent/AU2008207588B2/en not_active Expired
-
2010
- 2010-03-15 JP JP2010058365A patent/JP5264812B2/ja not_active Expired - Fee Related
- 2010-11-30 CY CY20101101097T patent/CY1110964T1/el unknown
-
2011
- 2011-07-19 JP JP2011158481A patent/JP2011212021A/ja not_active Withdrawn
- 2011-08-26 CY CY20111100819T patent/CY1113241T1/el unknown
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