JP2010138205A5 - - Google Patents
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- JP2010138205A5 JP2010138205A5 JP2010058365A JP2010058365A JP2010138205A5 JP 2010138205 A5 JP2010138205 A5 JP 2010138205A5 JP 2010058365 A JP2010058365 A JP 2010058365A JP 2010058365 A JP2010058365 A JP 2010058365A JP 2010138205 A5 JP2010138205 A5 JP 2010138205A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- adenovirus
- protein
- culture
- mdck
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10144906.2 | 2001-09-12 | ||
| DE10144906A DE10144906B4 (de) | 2001-09-12 | 2001-09-12 | Verfahren zur großtechnischen Herstellung von Impfstoffen |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008204890A Division JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010138205A JP2010138205A (ja) | 2010-06-24 |
| JP2010138205A5 true JP2010138205A5 (enExample) | 2011-09-08 |
| JP5264812B2 JP5264812B2 (ja) | 2013-08-14 |
Family
ID=7698764
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527086A Pending JP2005532779A (ja) | 2001-09-12 | 2002-09-11 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2010058365A Expired - Fee Related JP5264812B2 (ja) | 2001-09-12 | 2010-03-15 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003527086A Pending JP2005532779A (ja) | 2001-09-12 | 2002-09-11 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
| JP2008204890A Pending JP2008289499A (ja) | 2001-09-12 | 2008-08-07 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011158481A Withdrawn JP2011212021A (ja) | 2001-09-12 | 2011-07-19 | Ｍｄｃｋ細胞懸濁培養物において薬物または診断剤の活性成分を生成する方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10329536B2 (enExample) |
| EP (3) | EP2011862B1 (enExample) |
| JP (4) | JP2005532779A (enExample) |
| KR (1) | KR100999345B1 (enExample) |
| AT (2) | ATE512213T1 (enExample) |
| AU (2) | AU2002338667B2 (enExample) |
| BR (1) | BR0212470A (enExample) |
| CA (1) | CA2455189C (enExample) |
| CY (2) | CY1110964T1 (enExample) |
| DE (3) | DE10144906B4 (enExample) |
| DK (2) | DK1427815T3 (enExample) |
| ES (2) | ES2351300T3 (enExample) |
| NZ (1) | NZ532202A (enExample) |
| PT (2) | PT2011862E (enExample) |
| SI (1) | SI1427815T1 (enExample) |
| WO (1) | WO2003023021A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ551640A (en) * | 2004-05-20 | 2010-05-28 | Id Biomedical Corp | Process for the production of an influenza vaccine |
| PT1789084E (pt) | 2004-09-09 | 2011-02-22 | Novartis Vaccines & Diagnostic | Redução de riscos iatrogénicos pontenciais associados às vacinas contra a gripe |
| FR2884255B1 (fr) * | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| WO2007052163A2 (en) | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| PL2368572T3 (pl) | 2005-11-04 | 2020-11-16 | Seqirus UK Limited | Szczepionki z adjuwantem z niewirionowymi antygenami otrzymane z wirusów grypy hodowanych w hodowli komórkowej |
| ES2377884T3 (es) | 2005-11-04 | 2012-04-02 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
| NZ567979A (en) | 2005-11-04 | 2012-02-24 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents which is an agonist of Toll-Like Receptor 7 |
| WO2007052155A2 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| US20090220541A1 (en) | 2005-11-04 | 2009-09-03 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines |
| JP2009534303A (ja) | 2006-03-24 | 2009-09-24 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス ゲーエムベーハー アンド カンパニー カーゲー | 冷蔵しないインフルエンザワクチンの保存 |
| CN101472941B (zh) | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP3456348B1 (en) * | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| KR101464783B1 (ko) | 2006-09-15 | 2014-11-26 | 메디뮨 엘엘씨 | 높은 역가로 바이러스 증식을 지원하는 ｍｄｃｋ 세포주 및 이를 이용한 생물반응기 공정 |
| WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| CN101784283A (zh) | 2007-06-27 | 2010-07-21 | 诺华有限公司 | 低添加流感疫苗 |
| US9439960B2 (en) * | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
| FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
| CA2769003C (en) * | 2009-07-23 | 2018-10-16 | Xcellerex, Inc. | Drain down and re-feed of microcarrier bioreactor |
| JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
| US20110142863A1 (en) * | 2009-12-16 | 2011-06-16 | Millipore Corporation | Flow through purification processes for large biomolecules |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| CN102858961A (zh) * | 2010-05-03 | 2013-01-02 | 葛兰素史密丝克莱恩生物有限公司 | 新方法 |
| CA2796213A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
| US8945904B2 (en) | 2010-05-21 | 2015-02-03 | Novartis Ag | Influenza virus reassortment |
| CN102939104A (zh) | 2010-06-01 | 2013-02-20 | 诺华有限公司 | 用冻干浓缩疫苗抗原 |
| KR102113512B1 (ko) | 2010-06-01 | 2020-05-22 | 노파르티스 아게 | 동결건조하지 않는 인플루엔자 백신 항원의 농축 |
| ES2531577T3 (es) | 2010-08-20 | 2015-03-17 | Novartis Ag | Conjuntos de agujas para la administración de vacuna soluble contra la gripe |
| WO2012033236A1 (ko) | 2010-09-06 | 2012-03-15 | 에스케이케미칼 주식회사 | 무혈청 배양 및 부유 배양에 적응된 ｍｄｃｋ 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
| WO2012082723A2 (en) | 2010-12-15 | 2012-06-21 | Emd Millipore Corporation | Purification of immunogens using a non-polysaccharide matrix |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| GB201216121D0 (en) | 2012-09-10 | 2012-10-24 | Novartis Ag | Sample quantification by disc centrifugation |
| JP5918870B2 (ja) | 2012-03-06 | 2016-05-18 | クルセル ホランド ベー ヴェー | インフルエンザに対する改善されたワクチン接種 |
| KR101370512B1 (ko) | 2013-06-07 | 2014-03-06 | 재단법인 목암생명공학연구소 | 무단백 배지에서 부유 배양되는 mdck 유래 세포주 및 상기 세포주를 이용하여 바이러스를 증식시키는 방법 |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| KR20180035807A (ko) | 2015-06-26 | 2018-04-06 | 세퀴러스 유케이 리미티드 | 항원적으로 매치된 인플루엔자 백신 |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2017005880A1 (en) | 2015-07-07 | 2017-01-12 | Seqirus UK Limited | Influenza potency assays |
| WO2017072744A1 (en) * | 2015-10-30 | 2017-05-04 | National Institute Of Infectious Diseases And Vaccinology, National Health Research Institutes | Mdck suspension cell lines in serum-free, chemically-defined media for vaccine production |
| CN105561317B (zh) * | 2015-12-22 | 2018-03-20 | 肇庆大华农生物药品有限公司 | 重组伪狂犬病病毒疫苗耐热冻干保护剂及其制备方法 |
| CN109477074B (zh) | 2016-02-19 | 2023-01-24 | 威斯康星旧生研究基金会 | 用于疫苗开发的改进的乙型流感病毒复制 |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (en) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein |
| WO2020167432A2 (en) | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| CN110237246B (zh) * | 2019-07-25 | 2022-11-15 | 北京鼎持生物技术有限公司 | 一种全悬浮细胞培养禽流感（h9）灭活疫苗的方法 |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| IL293031A (en) | 2019-11-18 | 2022-07-01 | Seqirus Pty Ltd | A method for producing reassortant influenza viruses |
| EP4093415A1 (en) | 2020-01-24 | 2022-11-30 | Wisconsin Alumni Research Foundation (WARF) | Recombinant influenza viruses with stabilized na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| BR112022026319A2 (pt) * | 2020-06-22 | 2023-01-17 | Kolon Life Science Inc | Método para produção em massa de vírus vaccinia por meio do uso de células em suspensão |
| WO2022125793A1 (en) | 2020-12-10 | 2022-06-16 | Sarepta Therapeutics, Inc. | Suspension mode seed train development for adherent cells |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1278075B (de) | 1964-06-22 | 1968-09-19 | Norden Lab Inc | Verwendung von Gewebekulturen zur Zuechtung von Viren fuer die Gewinnung von Impfstoffen |
| US4064232A (en) | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
| USRE33164E (en) | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
| CA1122527A (en) * | 1979-05-15 | 1982-04-27 | Karen K. Brown | Influenza vaccine production in liquid cell culture |
| US4500513A (en) | 1979-05-15 | 1985-02-19 | Miles Laboratories, Inc. | Influenza vaccine production in liquid cell culture |
| US4525349A (en) | 1981-12-29 | 1985-06-25 | Societe Anonyme Dite: Institut Merueux | Process for the large-scale production of a vaccine against poliomyelitis and the resulting vaccine |
| US5013663A (en) | 1983-06-15 | 1991-05-07 | American Home Products Corporation | Canine corona virus vaccine |
| US4783411A (en) | 1984-10-22 | 1988-11-08 | Janis Gabliks | Influenza-A virus vaccine from fish cell cultures |
| EP0389925B1 (en) | 1989-03-29 | 1995-12-27 | The Research Foundation Of State University Of New York | A method for purifying an outer membrane protein of Haemophilus influenzae |
| AT393277B (de) | 1990-01-04 | 1991-09-25 | Immuno Ag | Verfahren zur herstellung von fruehsommer- meningoenzephalitis-virus (fsme-virus)-antigen |
| MY107664A (en) * | 1991-01-17 | 1996-05-30 | Kao Corp | Novel alkaline proteinase and process for producing the same |
| GB9110808D0 (en) * | 1991-05-17 | 1991-07-10 | Retroscreen Ltd | Aids vaccine and method for its production |
| WO1993022448A1 (en) * | 1992-05-01 | 1993-11-11 | Teijin Limited | Fed batch culture method for protein secreting cells |
| US5762939A (en) | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
| US5824536A (en) | 1994-08-23 | 1998-10-20 | St. Jude Children's Research Hospital | Influenza virus replicated in mammalian cell culture and vaccine production |
| ATE542891T1 (de) | 1994-11-10 | 2012-02-15 | Baxter Healthcare Sa | Verfahren zur herstellung von biologischen produkten in protein-freier kultur |
| US5756341A (en) | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| AU694592B2 (en) | 1994-11-16 | 1998-07-23 | St. Jude Children's Research Hospital | Novel replication process |
| US5646033A (en) | 1994-11-30 | 1997-07-08 | Dyncorp | African green monkey kidney cell lines useful for maintaining viruses and for preparation of viral vaccines |
| CN1285608C (zh) | 1995-09-22 | 2006-11-22 | 康诺特实验室有限公司 | 副流感病毒糖蛋白和疫苗 |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| DE19612966B4 (de) * | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| KR20010032699A (ko) * | 1998-10-05 | 2001-04-25 | 무따이 마사히꼬 | 일본 뇌염 바이러스 감염에 대한 불활성 백신을 위한증강된 면역원 및 그 제조방법 |
| US6514502B1 (en) | 1999-01-26 | 2003-02-04 | Schering-Plough Veterinary Corporation | Propagation of bovine cononavirus in chinese hamster ovary cells |
| CA2388245C (en) * | 1999-10-19 | 2012-01-10 | Kyowa Kirin Co., Ltd. | The use of serum-free adapted rat cells for producing heterologous polypeptides |
| US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
| EP1260581B1 (en) | 2000-03-03 | 2010-07-07 | Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute | Cell usable in serum-free culture and suspension culture and process for producing virus for vaccine by using the cell |
| DK1511768T3 (da) | 2002-06-11 | 2007-08-20 | Glaxosmithkline Biolog Sa | Immunogene sammensætninger |
| BRPI0407877A (pt) | 2003-03-07 | 2006-03-01 | Merck & Co Inc | conjugado de peptìdeo-proteìna, vacina para a prevenção ou melhora da infecção pelo vìrus influenza, e, método para induzir um resposta imune em um paciente |
| ES2562456T3 (es) | 2003-03-24 | 2016-03-04 | Valneva Austria Gmbh | Uso de un adyuvante que induce una respuesta inmune Th1 para mejorar las respuestas inmunes |
| PE20061428A1 (es) | 2005-03-23 | 2007-01-16 | Glaxosmithkline Biolog Sa | Formulacion de vacuna que comprende un adyuvante de emulsion aceite en agua y 3d-mpl |
| EP3456348B1 (en) | 2006-09-11 | 2025-03-26 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| ES2397714T3 (es) | 2006-10-12 | 2013-03-08 | Glaxosmithkline Biologicals S.A. | Vacuna que comprende un adyuvante de emulsión de aceite en agua |
| PL2121011T3 (pl) | 2006-12-06 | 2014-10-31 | Novartis Ag | Szczepionki zawierające antygeny czterech szczepów wirusa grypy |
| PE20090146A1 (es) | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| JP2013521771A (ja) | 2010-03-08 | 2013-06-13 | ノバルティス アーゲー | 細胞内病原体について試験する方法 |
-
2001
- 2001-09-12 DE DE10144906A patent/DE10144906B4/de not_active Expired - Lifetime
-
2002
- 2002-09-11 ES ES02777069T patent/ES2351300T3/es not_active Expired - Lifetime
- 2002-09-11 DK DK02777069.2T patent/DK1427815T3/da active
- 2002-09-11 AT AT08018057T patent/ATE512213T1/de active
- 2002-09-11 NZ NZ532202A patent/NZ532202A/en not_active IP Right Cessation
- 2002-09-11 PT PT08018057T patent/PT2011862E/pt unknown
- 2002-09-11 KR KR1020047003712A patent/KR100999345B1/ko not_active Expired - Lifetime
- 2002-09-11 US US10/487,707 patent/US10329536B2/en not_active Expired - Fee Related
- 2002-09-11 JP JP2003527086A patent/JP2005532779A/ja active Pending
- 2002-09-11 SI SI200230924T patent/SI1427815T1/sl unknown
- 2002-09-11 AU AU2002338667A patent/AU2002338667B2/en not_active Expired
- 2002-09-11 ES ES08018057T patent/ES2367833T3/es not_active Expired - Lifetime
- 2002-09-11 DE DE50214630T patent/DE50214630D1/de not_active Expired - Lifetime
- 2002-09-11 EP EP08018057A patent/EP2011862B1/de not_active Expired - Lifetime
- 2002-09-11 CA CA2455189A patent/CA2455189C/en not_active Expired - Lifetime
- 2002-09-11 WO PCT/EP2002/010208 patent/WO2003023021A2/de not_active Ceased
- 2002-09-11 BR BR0212470-0A patent/BR0212470A/pt active Search and Examination
- 2002-09-11 DE DE122011000005C patent/DE122011000005I1/de active Pending
- 2002-09-11 DK DK08018057.3T patent/DK2011862T3/da active
- 2002-09-11 PT PT02777069T patent/PT1427815E/pt unknown
- 2002-09-11 EP EP02777069A patent/EP1427815B1/de not_active Expired - Lifetime
- 2002-09-11 EP EP10004227A patent/EP2216400A1/de not_active Withdrawn
- 2002-09-11 AT AT02777069T patent/ATE479742T1/de active
-
2008
- 2008-08-07 JP JP2008204890A patent/JP2008289499A/ja active Pending
- 2008-08-28 AU AU2008207588A patent/AU2008207588B2/en not_active Expired
-
2010
- 2010-03-15 JP JP2010058365A patent/JP5264812B2/ja not_active Expired - Fee Related
- 2010-11-30 CY CY20101101097T patent/CY1110964T1/el unknown
-
2011
- 2011-07-19 JP JP2011158481A patent/JP2011212021A/ja not_active Withdrawn
- 2011-08-26 CY CY20111100819T patent/CY1113241T1/el unknown
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