CY1110964T1 - Μεθοδος παραγωγης εμβολιων μεγαλης κλιμακας - Google Patents
Μεθοδος παραγωγης εμβολιων μεγαλης κλιμακαςInfo
- Publication number
- CY1110964T1 CY1110964T1 CY20101101097T CY101101097T CY1110964T1 CY 1110964 T1 CY1110964 T1 CY 1110964T1 CY 20101101097 T CY20101101097 T CY 20101101097T CY 101101097 T CY101101097 T CY 101101097T CY 1110964 T1 CY1110964 T1 CY 1110964T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pharmaceutical
- active ingredient
- mdck cells
- producing large
- culture
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229960005486 vaccine Drugs 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000002671 adjuvant Substances 0.000 abstract 1
- -1 auxiliary Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000004114 suspension culture Methods 0.000 abstract 1
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2710/16011—Herpesviridae
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- C12N2720/12011—Reoviridae
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- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
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- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
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- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μεθόδους για την παραγωγή ενεργού συστατικού για φαρμακευτικό ή διαγνωστικό μέσο, στις οποίες (α) MDCK-κύτταρα μολύνονται με ιό• και (β) τα MDCK-κύτταρα καλλιεργούνται εντός καλλιέργειας αιωρήματος σε τεχνική κλίμακα υπό συνθήκες οι οποίες καθιστούν δυνατό τον πολλαπλασιασμό των ιών• όπου η καλλιέργεια πραγματοποιείται εντός όγκου τουλάχιστον 30 L. Η εφεύρεση αναφέρεται περαιτέρω σε μέθοδο για την παραγωγή φαρμακευτικού ή διαγνωστικού μέσου, στην οποία παράγεται ενεργό συστατικό σύμφωνα με κάποια από τις παραπάνω μεθόδους και αναμειγνύεται με κατάλληλο ανοσοενισχυτικό, βοηθητική ουσία, ρυθμιστικό διάλυμα, αραιωτικό μέσο ή φαρμακευτικό φορέα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10144906A DE10144906B4 (de) | 2001-09-12 | 2001-09-12 | Verfahren zur großtechnischen Herstellung von Impfstoffen |
EP02777069A EP1427815B1 (de) | 2001-09-12 | 2002-09-11 | Verfahren zur grosstechnischen herstellung von impfstoffen |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110964T1 true CY1110964T1 (el) | 2015-06-11 |
Family
ID=7698764
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101101097T CY1110964T1 (el) | 2001-09-12 | 2010-11-30 | Μεθοδος παραγωγης εμβολιων μεγαλης κλιμακας |
CY20111100819T CY1113241T1 (el) | 2001-09-12 | 2011-08-26 | Μεθοδος για την παραγωγη ενεργου συστατικου ενος φαρμακευτικου ή διαγνωστικου μεσου εντος καλλιεργειας αιωρηματος κυτταρων mdck |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100819T CY1113241T1 (el) | 2001-09-12 | 2011-08-26 | Μεθοδος για την παραγωγη ενεργου συστατικου ενος φαρμακευτικου ή διαγνωστικου μεσου εντος καλλιεργειας αιωρηματος κυτταρων mdck |
Country Status (17)
Country | Link |
---|---|
US (1) | US10329536B2 (el) |
EP (3) | EP2011862B1 (el) |
JP (4) | JP2005532779A (el) |
KR (1) | KR100999345B1 (el) |
AT (2) | ATE512213T1 (el) |
AU (2) | AU2002338667B2 (el) |
BR (1) | BR0212470A (el) |
CA (1) | CA2455189C (el) |
CY (2) | CY1110964T1 (el) |
DE (3) | DE10144906B4 (el) |
DK (2) | DK2011862T3 (el) |
ES (2) | ES2351300T3 (el) |
HK (1) | HK1062030A1 (el) |
NZ (1) | NZ532202A (el) |
PT (2) | PT2011862E (el) |
SI (1) | SI1427815T1 (el) |
WO (1) | WO2003023021A2 (el) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101094915A (zh) * | 2004-05-20 | 2007-12-26 | 益得生物医学公司 | 生产流感疫苗的方法 |
EP2578229B1 (en) | 2004-09-09 | 2013-07-10 | Novartis Vaccines and Diagnostics GmbH | Decreasing potential iatrogenic risks associated with vaccine antigens |
FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
PL2301572T3 (pl) | 2005-11-01 | 2015-02-27 | Novartis Influenza Vaccines Marburg Gmbh | Szczepionki wirusowe otrzymane z komórek o niskim poziomie pozostałości DNA komórkowego |
EP1951298A1 (en) | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted influenza vaccines including cytokine-inducing agents |
NZ567978A (en) | 2005-11-04 | 2011-09-30 | Novartis Vaccines & Diagnostic | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
WO2007052061A2 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
EP2368572B1 (en) | 2005-11-04 | 2020-03-04 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
EP2382987A1 (en) | 2006-03-24 | 2011-11-02 | Novartis Vaccines and Diagnostics GmbH | Storage of influenza vaccines without refrigeration |
CA2647985C (en) | 2006-03-31 | 2014-12-30 | Warf-Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
EP3456348A1 (en) | 2006-09-11 | 2019-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
EP2069480B1 (en) | 2006-09-15 | 2014-03-19 | MedImmune, LLC | Mdck cell lines supporting viral growth to high titers and bioreactor process using the same |
WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
EP2484377A1 (en) | 2007-06-27 | 2012-08-08 | Novartis AG | Low-additive influenza vaccines |
US9439960B2 (en) * | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
KR20110074563A (ko) | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
KR20120027276A (ko) | 2009-04-27 | 2012-03-21 | 노파르티스 아게 | 인플루엔자를 예방하기 위한 면역증강된 백신 |
WO2011011660A2 (en) | 2009-07-23 | 2011-01-27 | Xcellerex, Inc. | Drain down and re-feed of microcarrier bioreactor |
JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
US20110142863A1 (en) | 2009-12-16 | 2011-06-16 | Millipore Corporation | Flow through purification processes for large biomolecules |
US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
US20130039943A1 (en) * | 2010-05-03 | 2013-02-14 | Bruno Rene Andre | Novel method |
US9426989B2 (en) | 2010-05-06 | 2016-08-30 | Novartis Ag | Organic peroxide compounds for microorganism inactivation |
WO2011145081A1 (en) | 2010-05-21 | 2011-11-24 | Novartis Ag | Influenza virus reassortment method |
AU2011262312B2 (en) | 2010-06-01 | 2015-05-28 | Novartis Ag | Concentration and lyophilization of influenza vaccine antigens |
WO2011151723A2 (en) | 2010-06-01 | 2011-12-08 | Novartis Ag | Concentration of vaccine antigens without lyophilization |
ES2531577T3 (es) | 2010-08-20 | 2015-03-17 | Novartis Ag | Conjuntos de agujas para la administración de vacuna soluble contra la gripe |
WO2012033236A1 (ko) * | 2010-09-06 | 2012-03-15 | 에스케이케미칼 주식회사 | 무혈청 배양 및 부유 배양에 적응된 mdck 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법 |
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