JP2008538286A5 - - Google Patents

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Publication number

JP2008538286A5

JP2008538286A5 JP2008505635A JP2008505635A JP2008538286A5 JP 2008538286 A5 JP2008538286 A5 JP 2008538286A5 JP 2008505635 A JP2008505635 A JP 2008505635A JP 2008505635 A JP2008505635 A JP 2008505635A JP 2008538286 A5 JP2008538286 A5 JP 2008538286A5

Authority

JP

Japan

Prior art keywords

amino acid

seq

nature

modified

aav

Prior art date

2006-04-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 125000003275 alpha amino acid group Chemical group 0.000 claims 40
• 125000000539 amino acid group Chemical group 0.000 claims 37
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 22
• 235000013922 glutamic acid Nutrition 0.000 claims 22
• 239000004220 glutamic acid Substances 0.000 claims 22
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 20
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 18
• 239000004472 Lysine Substances 0.000 claims 18
• 238000000034 method Methods 0.000 claims 18
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 12
• 235000001014 amino acid Nutrition 0.000 claims 12
• 210000000234 capsid Anatomy 0.000 claims 12
• 239000004471 Glycine Substances 0.000 claims 10
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 8
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 7
• 229940024606 amino acid Drugs 0.000 claims 7
• 150000001413 amino acids Chemical class 0.000 claims 7
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 6
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 6
• 229960001230 asparagine Drugs 0.000 claims 6
• 235000009582 asparagine Nutrition 0.000 claims 6
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 4
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
• 239000002245 particle Substances 0.000 claims 4
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 4
• 238000004806 packaging method and process Methods 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 239000013603 viral vector Substances 0.000 claims 3
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 2
• 229940009098 aspartate Drugs 0.000 claims 2
• 235000003704 aspartic acid Nutrition 0.000 claims 2
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 238000002741 site-directed mutagenesis Methods 0.000 claims 2
• 230000026683 transduction Effects 0.000 claims 2
• 238000010361 transduction Methods 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 108020004705 Codon Proteins 0.000 claims 1
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 229930182817 methionine Natural products 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 239000013612 plasmid Substances 0.000 claims 1
• 239000004474 valine Substances 0.000 claims 1