|
GB9206016D0
(en)
|
1992-03-19 |
1992-04-29 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
|
US6306829B1
(en)
|
1995-12-08 |
2001-10-23 |
Hybridon, Inc. |
Modified VEGF oligonucleotides for treatment of skin disorders
|
|
US5639872A
(en)
|
1993-07-27 |
1997-06-17 |
Hybridon, Inc. |
Human VEGF-specific oligonucleotides
|
|
US6440425B1
(en)
|
1995-05-01 |
2002-08-27 |
Aventis Pasteur Limited |
High molecular weight major outer membrane protein of moraxella
|
|
US6001650A
(en)
|
1995-08-03 |
1999-12-14 |
Avigen, Inc. |
High-efficiency wild-type-free AAV helper functions
|
|
US6096548A
(en)
|
1996-03-25 |
2000-08-01 |
Maxygen, Inc. |
Method for directing evolution of a virus
|
|
WO1997038723A1
(en)
|
1996-04-16 |
1997-10-23 |
Immusol Incorporated |
Targeted viral vectors
|
|
US6710036B2
(en)
|
1997-07-25 |
2004-03-23 |
Avigen, Inc. |
Induction of immune response to antigens expressed by recombinant adeno-associated virus
|
|
WO1999014354A1
(en)
|
1997-09-19 |
1999-03-25 |
The Trustees Of The University Of The Pennsylvania |
Methods and vector constructs useful for production of recombinant aav
|
|
AU1449499A
(en)
|
1997-10-31 |
1999-05-24 |
Maxygen, Incorporated |
Modification of virus tropism and host range by viral genome shuffling
|
|
US6410300B1
(en)
|
1998-01-12 |
2002-06-25 |
The University Of North Carolina At Chapel Hill |
Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
DE19827457C1
(de)
|
1998-06-19 |
2000-03-02 |
Medigene Ag |
Strukturprotein von AAV, seine Herstellung und Verwendung
|
|
ATE294874T1
(de)
|
1998-09-11 |
2005-05-15 |
Univ California |
Rekombinante adenovirus für gewebespezifische genexpression ins herz
|
|
DE69941905D1
(de)
|
1998-11-10 |
2010-02-25 |
Univ North Carolina |
Virusvektoren und verfahren für ihre herstellung und verabreichung.
|
|
US6943153B1
(en)
|
1999-03-15 |
2005-09-13 |
The Regents Of The University Of California |
Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7314912B1
(en)
|
1999-06-21 |
2008-01-01 |
Medigene Aktiengesellschaft |
AAv scleroprotein, production and use thereof
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
DE19933719A1
(de)
|
1999-07-19 |
2001-01-25 |
Medigene Ag |
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
|
|
US8232081B2
(en)
|
1999-09-21 |
2012-07-31 |
Basf Se |
Methods and microorganisms for production of panto-compounds
|
|
DE19961180C2
(de)
|
1999-12-18 |
2002-02-28 |
Daimler Chrysler Ag |
Dünnschichtwiderstand mit hohem Temperaturkoeffizienten als passives Halbleiterbauelement für integrierte Schaltungen und Herstellungsverfahren
|
|
US6855314B1
(en)
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US20030149235A1
(en)
|
2000-11-17 |
2003-08-07 |
Baker Andrew Howard |
Targeting peptides
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
AU2002248297A1
(en)
|
2001-01-05 |
2002-07-16 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
EP1386004A4
(en)
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
|
US20030144221A1
(en)
|
2001-07-17 |
2003-07-31 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL2-associated X protein expression
|
|
US7647184B2
(en)
|
2001-08-27 |
2010-01-12 |
Hanall Pharmaceuticals, Co. Ltd |
High throughput directed evolution by rational mutagenesis
|
|
US20030129203A1
(en)
|
2001-08-27 |
2003-07-10 |
Nautilus Biotech S.A. |
Mutant recombinant adeno-associated viruses
|
|
EP1572893B1
(en)
|
2001-11-09 |
2009-01-07 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Production of adeno-associated virus in insect cells
|
|
NZ618298A
(en)
|
2001-11-13 |
2015-04-24 |
Univ Pennsylvania |
A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
|
|
US20050106558A1
(en)
|
2001-12-21 |
2005-05-19 |
Luca Perabo |
Library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism
|
|
US6846666B2
(en)
|
2002-03-21 |
2005-01-25 |
Council Of Scientific And Industrial Research |
Bacterial strain MTCC 5098 and a method of reducing total dissolved solids (TDS) from pulp and paper wastewater effluents using the said strain
|
|
US20060292117A1
(en)
|
2002-04-17 |
2006-12-28 |
Loiler Scott A |
Improved rAAv vectors
|
|
WO2003093295A2
(en)
|
2002-04-30 |
2003-11-13 |
University Of North Carolina At Chapel Hill |
Secretion signal vectors
|
|
WO2003092594A2
(en)
|
2002-04-30 |
2003-11-13 |
Duke University |
Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
|
|
AU2003237159A1
(en)
|
2002-04-30 |
2003-11-17 |
University Of Florida |
Treatment for phenylketonuria
|
|
AU2003231230A1
(en)
|
2002-05-01 |
2003-11-17 |
University Of Florida Research Foundation, Inc. |
Improved raav expression systems and methods for enhancing transduction of mammalian neural cells
|
|
US7254489B2
(en)
|
2002-05-31 |
2007-08-07 |
Microsoft Corporation |
Systems, methods and apparatus for reconstructing phylogentic trees
|
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
AU2003265855A1
(en)
|
2002-08-28 |
2004-03-19 |
University Of Florida |
Modified aav
|
|
WO2004083441A2
(en)
*
|
2003-03-19 |
2004-09-30 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Random peptide library displayed on aav vectors
|
|
WO2004108922A2
(en)
|
2003-04-25 |
2004-12-16 |
The Trustees Of The University Of Pennsylvania |
Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver
|
|
EP1486567A1
(en)
|
2003-06-11 |
2004-12-15 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Improved adeno-associated virus (AAV) vector for gene therapy
|
|
PT2657248T
(pt)
|
2003-06-19 |
2017-06-26 |
Genzyme Corp |
Viriões aav com imunorreatividade diminuída e seus usos
|
|
WO2005000240A2
(en)
|
2003-06-23 |
2005-01-06 |
A & G Pharmaceutical, Inc. |
Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US20050019927A1
(en)
|
2003-07-13 |
2005-01-27 |
Markus Hildinger |
DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
|
|
US8106180B2
(en)
|
2003-08-07 |
2012-01-31 |
Whitehead Institute For Biomedical Research |
Methods and products for expression of micro RNAs
|
|
US20050142581A1
(en)
|
2003-09-04 |
2005-06-30 |
Griffey Richard H. |
Microrna as ligands and target molecules
|
|
WO2005030932A2
(en)
|
2003-09-24 |
2005-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Igf-1 instructs multipotent adult cns neural stem cells to an oligodendroglial lineage
|
|
EP2292780B1
(en)
|
2003-09-30 |
2017-08-23 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
US20050266552A1
(en)
|
2003-12-05 |
2005-12-01 |
Doench John G |
Reagents and methods for identification of RNAi pathway genes and chemical modulators of RNAi
|
|
EP2365077B1
(en)
|
2004-03-12 |
2013-05-08 |
Alnylam Pharmaceuticals, Inc. |
iRNA agents targeting VEGF
|
|
KR100614827B1
(ko)
|
2004-05-06 |
2006-08-25 |
재단법인서울대학교산학협력재단 |
양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
EP1828390B1
(en)
|
2004-12-15 |
2012-06-13 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
WO2006101634A1
(en)
|
2005-02-17 |
2006-09-28 |
The Regents Of The University Of California |
Müller cell specific gene therapy
|
|
EP2359865B1
(en)
|
2005-04-07 |
2013-10-02 |
The Trustees of The University of Pennsylvania |
Method of increasing the function of an AAV vector
|
|
US8906360B2
(en)
|
2005-07-22 |
2014-12-09 |
The Board Of Trustees Of The Leland Stanford Junior University |
Light-activated cation channel and uses thereof
|
|
WO2007089632A2
(en)
|
2006-01-27 |
2007-08-09 |
The University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
EP2007795B1
(en)
|
2006-03-30 |
2016-11-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Aav capsid proteins
|
|
EP2019588A4
(en)
|
2006-05-04 |
2010-11-24 |
Univ Wayne State |
RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
|
|
US7872118B2
(en)
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
CN1966082B
(zh)
|
2006-11-03 |
2010-06-30 |
许瑞安 |
一种防治结直肠癌的基因药物及其制备方法和用途
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
NZ579985A
(en)
|
2007-04-13 |
2012-02-24 |
Catalyst Biosciences Inc |
Modified factor vii polypetides and uses thereof
|
|
EP1985708B1
(en)
|
2007-04-27 |
2015-04-15 |
Universität Rostock |
Selective targeting of viruses to neural precursor cells
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US20120093772A1
(en)
|
2008-05-20 |
2012-04-19 |
Alan Horsager |
Vectors for delivery of light sensitive proteins and methods of use
|
|
EP2297185A1
(en)
|
2008-06-17 |
2011-03-23 |
Amsterdam Molecular Therapeutics (AMT) B.V. |
Parvoviral capsid with incorporated gly-ala repeat region
|
|
EP2396343B1
(en)
*
|
2009-02-11 |
2017-05-17 |
The University of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
CN101532024A
(zh)
|
2009-04-30 |
2009-09-16 |
许瑞安 |
一种用于基因治疗的新型细胞特异性内含microRNA结合序列的基因HAAVmir
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
MY175954A
(en)
|
2010-03-17 |
2020-07-16 |
The Board Of Trustees Of Leland Stanford Junior Univ |
Light-sensitive ion-passing molecules
|
|
WO2011117258A2
(en)
|
2010-03-22 |
2011-09-29 |
Association Institut De Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
US8263396B2
(en)
|
2010-04-01 |
2012-09-11 |
Weidong Xiao |
Methods and compositions for the production of recombinant virus vectors
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス, インコーポレイテッド |
新規のdna結合タンパク質及びその使用
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
JP5704361B2
(ja)
|
2010-10-27 |
2015-04-22 |
学校法人自治医科大学 |
神経系細胞への遺伝子導入のためのアデノ随伴ウイルスビリオン
|
|
CA2816971A1
(en)
|
2010-11-05 |
2012-05-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Light-activated chimeric opsins and methods of using the same
|
|
WO2012061744A2
(en)
|
2010-11-05 |
2012-05-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Stabilized step function opsin proteins and methods of using the same
|
|
DK2699270T3
(en)
|
2011-04-22 |
2017-10-02 |
Univ California |
ADENO-ASSOCIATED VIRUS VIRUSES WITH VARIANT CAPSID AND METHODS FOR USING IT
|
|
WO2013029030A1
(en)
|
2011-08-24 |
2013-02-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
New aav capsid proteins for nucleic acid transfer
|
|
ES2862912T3
(es)
|
2012-04-18 |
2021-10-08 |
Childrens Hospital Philadelphia |
Composición y procedimientos para la transferencia genética de alta eficiencia utilizando variantes de cápside de VAA
|
|
JP6385920B2
(ja)
|
2012-05-09 |
2018-09-05 |
オレゴン ヘルス アンド サイエンス ユニバーシティー |
アデノ随伴ウイルスプラスミド及びベクター
|
|
TWI702955B
(zh)
|
2012-05-15 |
2020-09-01 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
JP6363958B2
(ja)
*
|
2012-12-25 |
2018-07-25 |
タカラバイオ株式会社 |
Aav変異体
|
|
EP2954051B1
(en)
|
2013-02-08 |
2019-03-27 |
The Trustees Of The University Of Pennsylvania |
Modified aav8 capsid for gene transfer for retinal therapies
|
|
US11685935B2
(en)
|
2013-05-29 |
2023-06-27 |
Cellectis |
Compact scaffold of Cas9 in the type II CRISPR system
|
|
ES2897508T3
(es)
|
2013-05-31 |
2022-03-01 |
Univ California |
Variantes de virus adenoasociados y métodos de uso de las mismas
|
|
WO2014200910A2
(en)
|
2013-06-10 |
2014-12-18 |
Iogenetics, Llc |
Bioinformatic processes for determination of peptide binding
|
|
ES2716615T3
(es)
|
2013-06-28 |
2019-06-13 |
Inst Nat Sante Rech Med |
Métodos para expresar un polinucleótido de interés en la retina de un sujeto
|
|
WO2015012501A1
(ko)
|
2013-07-25 |
2015-01-29 |
주식회사 스마트캐스터 |
비공기압 바퀴
|
|
US20160369298A1
(en)
|
2013-09-26 |
2016-12-22 |
University Of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
CN115141258B
(zh)
|
2013-10-11 |
2025-05-20 |
马萨诸塞眼科耳科诊所 |
预测祖先病毒序列的方法及其用途
|
|
WO2015089486A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
JP6689249B2
(ja)
|
2014-03-17 |
2020-05-20 |
アドヴェラム バイオテクノロジーズ, インコーポレイテッド |
錐体細胞における増強された遺伝子発現のための組成物および方法
|
|
PE20170260A1
(es)
*
|
2014-05-02 |
2017-04-12 |
Genzyme Corp |
Vectores de aav para la terapia genica de la retina y el snc
|
|
WO2015191693A2
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
DE102014217790A1
(de)
|
2014-09-05 |
2016-03-10 |
Evonik Degussa Gmbh |
Verfahren zur Herstellung von hydrosilylierbaren Eugenol-Polyethern und Eugenol-Polyethersiloxanen sowie deren Verwendung
|
|
CA2977355A1
(en)
*
|
2015-02-20 |
2016-08-25 |
University Of Iowa Research Foundation |
Methods and compositions for treating genetic eye diseases
|
|
AU2016226289B2
(en)
|
2015-03-02 |
2021-04-29 |
Adverum Biotechnologies, Inc. |
Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
|
|
HUE051491T2
(hu)
|
2015-03-06 |
2021-03-01 |
Massachusetts Eye & Ear Infirmary |
Gén-augmentációs terápiák a PRPF31 gén mutációi által okozott öröklött retina degenerációra
|
|
US10883117B2
(en)
|
2015-03-24 |
2021-01-05 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
US20190000940A1
(en)
|
2015-07-31 |
2019-01-03 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of aadc deficiency
|
|
DK4206216T3
(da)
*
|
2016-05-13 |
2025-12-01 |
4D Molecular Therapeutics Inc |
Adeno-associerede virusvarianter og fremgangsmåder til brug deraf
|
|
MA44546B1
(fr)
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
KR20230039779A
(ko)
|
2016-07-29 |
2023-03-21 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법
|
|
CA3059995A1
(en)
|
2017-08-28 |
2019-03-07 |
The Regents Of The University Of California |
Adeno-associated virus capsid variants and methods of use thereof
|