|
GB9206016D0
(en)
|
1992-03-19 |
1992-04-29 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
|
US5639872A
(en)
|
1993-07-27 |
1997-06-17 |
Hybridon, Inc. |
Human VEGF-specific oligonucleotides
|
|
US6440425B1
(en)
|
1995-05-01 |
2002-08-27 |
Aventis Pasteur Limited |
High molecular weight major outer membrane protein of moraxella
|
|
US6001650A
(en)
|
1995-08-03 |
1999-12-14 |
Avigen, Inc. |
High-efficiency wild-type-free AAV helper functions
|
|
AU1686997A
(en)
|
1995-12-08 |
1997-06-27 |
Hybridon, Inc. |
Modified vegf antisense oligonucleotides for treatment of skin disorders
|
|
US6096548A
(en)
|
1996-03-25 |
2000-08-01 |
Maxygen, Inc. |
Method for directing evolution of a virus
|
|
CA2251738A1
(en)
|
1996-04-16 |
1997-10-23 |
Immusol Incorporated |
Targeted viral vectors
|
|
US6710036B2
(en)
|
1997-07-25 |
2004-03-23 |
Avigen, Inc. |
Induction of immune response to antigens expressed by recombinant adeno-associated virus
|
|
CA2303768C
(en)
|
1997-09-19 |
2009-11-24 |
The Trustees Of The University Of Pennsylvania |
Methods and vector constructs useful for production of recombinant aav
|
|
EP1690868A1
(en)
|
1997-10-31 |
2006-08-16 |
Maxygen, Inc. |
Modification of virus tropism and host range by viral genome shuffling
|
|
US6410300B1
(en)
|
1998-01-12 |
2002-06-25 |
The University Of North Carolina At Chapel Hill |
Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
DE19827457C1
(de)
|
1998-06-19 |
2000-03-02 |
Medigene Ag |
Strukturprotein von AAV, seine Herstellung und Verwendung
|
|
CA2342283C
(en)
|
1998-09-11 |
2004-05-25 |
The Regents Of The University Of California |
Recombinant adenovirus for tissue specific expression in heart
|
|
ATE454445T1
(de)
|
1998-11-10 |
2010-01-15 |
Univ North Carolina |
Virusvektoren und verfahren für ihre herstellung und verabreichung.
|
|
US6943153B1
(en)
|
1999-03-15 |
2005-09-13 |
The Regents Of The University Of California |
Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7314912B1
(en)
|
1999-06-21 |
2008-01-01 |
Medigene Aktiengesellschaft |
AAv scleroprotein, production and use thereof
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
DE19933719A1
(de)
|
1999-07-19 |
2001-01-25 |
Medigene Ag |
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
|
|
US8232081B2
(en)
|
1999-09-21 |
2012-07-31 |
Basf Se |
Methods and microorganisms for production of panto-compounds
|
|
DE19961180C2
(de)
|
1999-12-18 |
2002-02-28 |
Daimler Chrysler Ag |
Dünnschichtwiderstand mit hohem Temperaturkoeffizienten als passives Halbleiterbauelement für integrierte Schaltungen und Herstellungsverfahren
|
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
|
US6855314B1
(en)
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US20030149235A1
(en)
|
2000-11-17 |
2003-08-07 |
Baker Andrew Howard |
Targeting peptides
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20030144221A1
(en)
|
2001-07-17 |
2003-07-31 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL2-associated X protein expression
|
|
US7647184B2
(en)
|
2001-08-27 |
2010-01-12 |
Hanall Pharmaceuticals, Co. Ltd |
High throughput directed evolution by rational mutagenesis
|
|
US20030129203A1
(en)
|
2001-08-27 |
2003-07-10 |
Nautilus Biotech S.A. |
Mutant recombinant adeno-associated viruses
|
|
WO2003042361A2
(en)
|
2001-11-09 |
2003-05-22 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
CN103555677B
(zh)
|
2001-11-13 |
2018-01-30 |
宾夕法尼亚大学托管会 |
检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
|
|
EP1456383B1
(en)
|
2001-12-21 |
2014-03-12 |
Medigene AG |
A library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism
|
|
US6846666B2
(en)
|
2002-03-21 |
2005-01-25 |
Council Of Scientific And Industrial Research |
Bacterial strain MTCC 5098 and a method of reducing total dissolved solids (TDS) from pulp and paper wastewater effluents using the said strain
|
|
WO2003089612A2
(en)
|
2002-04-17 |
2003-10-30 |
University Of Florida Research Foundation, Inc. |
IMPROVED rAAV VECTORS
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
WO2003093295A2
(en)
|
2002-04-30 |
2003-11-13 |
University Of North Carolina At Chapel Hill |
Secretion signal vectors
|
|
AU2003237159A1
(en)
|
2002-04-30 |
2003-11-17 |
University Of Florida |
Treatment for phenylketonuria
|
|
US20060127358A1
(en)
|
2002-05-01 |
2006-06-15 |
Nicholas Muzyczka |
Raav expression systems and methods for enhancing transduction of mammalian neural cells
|
|
US7254489B2
(en)
|
2002-05-31 |
2007-08-07 |
Microsoft Corporation |
Systems, methods and apparatus for reconstructing phylogentic trees
|
|
US7148342B2
(en)
|
2002-07-24 |
2006-12-12 |
The Trustees Of The University Of Pennyslvania |
Compositions and methods for sirna inhibition of angiogenesis
|
|
AU2003265855A1
(en)
|
2002-08-28 |
2004-03-19 |
University Of Florida |
Modified aav
|
|
WO2004083441A2
(en)
*
|
2003-03-19 |
2004-09-30 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Random peptide library displayed on aav vectors
|
|
WO2004108922A2
(en)
|
2003-04-25 |
2004-12-16 |
The Trustees Of The University Of Pennsylvania |
Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver
|
|
EP1486567A1
(en)
|
2003-06-11 |
2004-12-15 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Improved adeno-associated virus (AAV) vector for gene therapy
|
|
JP2007524386A
(ja)
|
2003-06-19 |
2007-08-30 |
アビジェン， インコーポレイテッド |
減少した免疫反応性を有するａａｖビリオン、およびその使用
|
|
US7368428B2
(en)
|
2003-06-23 |
2008-05-06 |
A&G Pharmaceutical, Inc. |
Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US20050019927A1
(en)
|
2003-07-13 |
2005-01-27 |
Markus Hildinger |
DECREASING GENE EXPRESSION IN A MAMMALIAN SUBJECT IN VIVO VIA AAV-MEDIATED RNAi EXPRESSION CASSETTE TRANSFER
|
|
US8106180B2
(en)
|
2003-08-07 |
2012-01-31 |
Whitehead Institute For Biomedical Research |
Methods and products for expression of micro RNAs
|
|
US20050142581A1
(en)
|
2003-09-04 |
2005-06-30 |
Griffey Richard H. |
Microrna as ligands and target molecules
|
|
CA2539947A1
(en)
|
2003-09-24 |
2005-04-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Igf-1 instructs multipotent adult cns neural stem cells to an oligodendroglial lineage
|
|
DK3211085T3
(da)
|
2003-09-30 |
2021-06-21 |
Univ Pennsylvania |
Klader af adeno-associeret virus (aav), sekvenser, vektorer indeholdende disse og anvendelser deraf
|
|
WO2005056761A2
(en)
|
2003-12-05 |
2005-06-23 |
Massachusetts Institute Of Technology |
REAGENTS AND METHODS FOR IDENTIFICATION OF RNAi PATHWAY GENES AND CHEMICAL MODULATORS OF RNAi
|
|
WO2005089224A2
(en)
|
2004-03-12 |
2005-09-29 |
Alnylam Pharmaceuticals, Inc. |
iRNA AGENTS TARGETING VEGF
|
|
KR100614827B1
(ko)
|
2004-05-06 |
2006-08-25 |
재단법인서울대학교산학협력재단 |
양방향 은닉 마코프 모델을 이용한 완숙한마이크로알엔에이 위치예측방법 및 이를 구현하기 위한컴퓨터 프로그램을 기록한 저장매체
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
US7892809B2
(en)
|
2004-12-15 |
2011-02-22 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
US20100172871A1
(en)
|
2005-02-17 |
2010-07-08 |
Flannery John G |
Muller Cell Specific Gene Therapy
|
|
US8999678B2
(en)
|
2005-04-07 |
2015-04-07 |
The Trustees Of The University Of Pennsylvania |
Method of increasing the function of an AAV vector
|
|
EP1919497B1
(en)
|
2005-07-22 |
2020-02-12 |
The Board of Trustees of the Leland Stanford Junior University |
Light-activated cation channel and uses thereof
|
|
WO2007089632A2
(en)
|
2006-01-27 |
2007-08-09 |
The University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
EP3437473A1
(en)
|
2006-05-04 |
2019-02-06 |
Wayne State University |
Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
|
|
US7872118B2
(en)
|
2006-09-08 |
2011-01-18 |
Opko Ophthalmics, Llc |
siRNA and methods of manufacture
|
|
CN1966082B
(zh)
|
2006-11-03 |
2010-06-30 |
许瑞安 |
一种防治结直肠癌的基因药物及其制备方法和用途
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
WO2008127702A2
(en)
|
2007-04-13 |
2008-10-23 |
Catalyst Biosciences, Inc. |
Modified factor vii polypetides and uses thereof
|
|
EP1985708B1
(en)
|
2007-04-27 |
2015-04-15 |
Universität Rostock |
Selective targeting of viruses to neural precursor cells
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
CN102159713A
(zh)
|
2008-05-20 |
2011-08-17 |
Eos神经科学公司 |
用于递送光敏蛋白的载体和使用方法
|
|
US20110171262A1
(en)
|
2008-06-17 |
2011-07-14 |
Andrew Christian Bakker |
Parvoviral capsid with incorporated gly-ala repeat region
|
|
EP2396343B1
(en)
|
2009-02-11 |
2017-05-17 |
The University of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
CN101532024A
(zh)
|
2009-04-30 |
2009-09-16 |
许瑞安 |
一种用于基因治疗的新型细胞特异性内含microRNA结合序列的基因HAAVmir
|
|
WO2010138263A2
(en)
|
2009-05-28 |
2010-12-02 |
University Of Massachusetts |
Novel aav 's and uses thereof
|
|
EP2547762B1
(en)
|
2010-03-17 |
2018-04-25 |
The Board of Trustees of the Leland Stanford Junior University |
Light-sensitive ion-passing molecules
|
|
WO2011117258A2
(en)
|
2010-03-22 |
2011-09-29 |
Association Institut De Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
US8263396B2
(en)
|
2010-04-01 |
2012-09-11 |
Weidong Xiao |
Methods and compositions for the production of recombinant virus vectors
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
EP2634253B1
(en)
|
2010-10-27 |
2016-05-11 |
Jichi Medical University |
Adeno-associated virus virions for transferring genes into neural cells
|
|
CA2816990A1
(en)
|
2010-11-05 |
2012-05-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Stabilized step function opsin proteins and methods of using the same
|
|
CN106947741A
(zh)
|
2010-11-05 |
2017-07-14 |
斯坦福大学托管董事会 |
光活化嵌合视蛋白及其使用方法
|
|
DK4005603T3
(da)
|
2011-04-22 |
2024-11-25 |
Univ California |
Adeno-associerede virus-virioner med variant kapsid og fremgangsmåder til anvendelse heraf
|
|
US9169299B2
(en)
|
2011-08-24 |
2015-10-27 |
The Board Of Trustees Of The Leleand Stanford Junior University |
AAV capsid proteins for nucleic acid transfer
|
|
RU2683497C2
(ru)
|
2012-04-18 |
2019-03-28 |
Дзе Чилдрен'З Хоспитал Оф Филадельфия |
Композиция и способы высокоэффективного переноса генов с помощью вариантов капсида aav
|
|
WO2013170078A1
(en)
|
2012-05-09 |
2013-11-14 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
TWI702955B
(zh)
|
2012-05-15 |
2020-09-01 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒（ａａｖ）ｓｆｌｔ-１治療老年性黃斑部退化（ａｍｄ）
|
|
EP2940131B1
(en)
*
|
2012-12-25 |
2019-02-20 |
Takara Bio Inc. |
Aav variant
|
|
US9567376B2
(en)
*
|
2013-02-08 |
2017-02-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
CA2913869C
(en)
|
2013-05-29 |
2023-01-24 |
Cellectis |
New compact scaffold of cas9 in the type ii crispr system
|
|
CA2907799A1
(en)
|
2013-05-31 |
2014-12-04 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
US12374421B2
(en)
|
2013-06-10 |
2025-07-29 |
Iogenetics, Llc |
Bioinformatic processes for determination of peptide binding
|
|
EP3013946B8
(en)
|
2013-06-28 |
2019-04-10 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for expressing a polynucleotide of interest in the retina of a subject
|
|
WO2015012501A1
(ko)
|
2013-07-25 |
2015-01-29 |
주식회사 스마트캐스터 |
비공기압 바퀴
|
|
WO2015048534A1
(en)
|
2013-09-26 |
2015-04-02 |
University Of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
ES2857751T3
(es)
|
2013-10-11 |
2021-09-29 |
Massachusetts Eye & Ear Infirmary |
Métodos para predecir secuencias de virus ancestrales y usos de los mismos
|
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
|
GB201403684D0
(en)
*
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
ES3042252T3
(en)
|
2014-03-17 |
2025-11-19 |
Adverum Biotechnologies Inc |
Compositions and methods for enhanced gene expression in cone cells
|
|
WO2015168666A2
(en)
*
|
2014-05-02 |
2015-11-05 |
Genzyme Corporation |
Aav vectors for retinal and cns gene therapy
|
|
CA2951707A1
(en)
|
2014-06-10 |
2015-12-17 |
Massachusetts Institute Of Technology |
Method for gene editing
|
|
DE102014217790A1
(de)
|
2014-09-05 |
2016-03-10 |
Evonik Degussa Gmbh |
Verfahren zur Herstellung von hydrosilylierbaren Eugenol-Polyethern und Eugenol-Polyethersiloxanen sowie deren Verwendung
|
|
CN108347932B
(zh)
*
|
2015-02-20 |
2022-09-13 |
衣阿华大学研究基金会 |
用于治疗遗传性眼病的方法和组合物
|
|
CN114480502A
(zh)
|
2015-03-02 |
2022-05-13 |
阿德夫拉姆生物技术股份有限公司 |
用于将多核苷酸玻璃体内递送到视网膜视锥的组合物和方法
|
|
PT3265568T
(pt)
|
2015-03-06 |
2020-08-20 |
Massachusetts Eye & Ear Infirmary |
Terapias de aumento de genes para a degeneração hereditária da retina causada por mutações no gene prpf31
|
|
WO2016154344A1
(en)
|
2015-03-24 |
2016-09-29 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
US20190000940A1
(en)
|
2015-07-31 |
2019-01-03 |
Voyager Therapeutics, Inc. |
Compositions and methods for the treatment of aadc deficiency
|
|
CN116333057A
(zh)
|
2016-05-13 |
2023-06-27 |
4D分子治疗有限公司 |
腺相关病毒变体衣壳和其使用方法
|
|
MA44546B1
(fr)
|
2016-06-15 |
2021-03-31 |
Univ California |
Virus adéno-associés variants et procédés d'utilisation
|
|
CA3029833A1
(en)
|
2016-07-29 |
2018-02-01 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
EP3676373A4
(en)
|
2017-08-28 |
2021-06-09 |
The Regents of The University of California |
Adeno-associated virus capsid variants and methods of use thereof
|