JP2017506230A5 - - Google Patents
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- JP2017506230A5 JP2017506230A5 JP2016550530A JP2016550530A JP2017506230A5 JP 2017506230 A5 JP2017506230 A5 JP 2017506230A5 JP 2016550530 A JP2016550530 A JP 2016550530A JP 2016550530 A JP2016550530 A JP 2016550530A JP 2017506230 A5 JP2017506230 A5 JP 2017506230A5
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- Japan
- Prior art keywords
- pharmaceutical composition
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- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 210000002845 virion Anatomy 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000002780 macular degeneration Diseases 0.000 claims 5
- 101100381481 Caenorhabditis elegans baz-2 gene Proteins 0.000 claims 4
- 101100372762 Rattus norvegicus Flt1 gene Proteins 0.000 claims 4
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 2
- 241000702421 Dependoparvovirus Species 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241001655883 Adeno-associated virus - 1 Species 0.000 claims 1
- 241000202702 Adeno-associated virus - 3 Species 0.000 claims 1
- 241000580270 Adeno-associated virus - 4 Species 0.000 claims 1
- 241001634120 Adeno-associated virus - 5 Species 0.000 claims 1
- 241000972680 Adeno-associated virus - 6 Species 0.000 claims 1
- 241001164823 Adeno-associated virus - 7 Species 0.000 claims 1
- 241001164825 Adeno-associated virus - 8 Species 0.000 claims 1
- 241000649045 Adeno-associated virus 10 Species 0.000 claims 1
- 241000649046 Adeno-associated virus 11 Species 0.000 claims 1
- 241000649047 Adeno-associated virus 12 Species 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 208000001344 Macular Edema Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 206010038848 Retinal detachment Diseases 0.000 claims 1
- 102000016548 Vascular Endothelial Growth Factor Receptor-1 Human genes 0.000 claims 1
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
- 208000000208 Wet Macular Degeneration Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000002301 subretinal fluid Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461936797P | 2014-02-06 | 2014-02-06 | |
| US61/936,797 | 2014-02-06 | ||
| PCT/US2015/014872 WO2015120309A1 (en) | 2014-02-06 | 2015-02-06 | Compositions and methods for treating and preventing macular degeneration |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506230A JP2017506230A (ja) | 2017-03-02 |
| JP2017506230A5 true JP2017506230A5 (enExample) | 2018-03-15 |
| JP6719381B2 JP6719381B2 (ja) | 2020-07-08 |
Family
ID=52589781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016550530A Active JP6719381B2 (ja) | 2014-02-06 | 2015-02-06 | 黄斑変性を処置し、予防するための組成物および方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20170007719A1 (enExample) |
| EP (1) | EP3102246B1 (enExample) |
| JP (1) | JP6719381B2 (enExample) |
| KR (1) | KR102234695B1 (enExample) |
| CN (3) | CN106163573A (enExample) |
| AU (4) | AU2015213770A1 (enExample) |
| BR (1) | BR112016017817A2 (enExample) |
| CA (1) | CA2938828A1 (enExample) |
| IL (1) | IL247116B (enExample) |
| MX (2) | MX2016010215A (enExample) |
| RU (1) | RU2703145C2 (enExample) |
| SG (1) | SG11201606101WA (enExample) |
| TW (1) | TWI687225B (enExample) |
| WO (1) | WO2015120309A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106163573A (zh) * | 2014-02-06 | 2016-11-23 | 建新公司 | 用于治疗和预防黄斑变性的组合物及方法 |
| KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
| CA3054942A1 (en) | 2017-03-17 | 2018-09-20 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression |
| KR102205830B1 (ko) * | 2017-10-26 | 2021-01-21 | 주식회사 큐로진생명과학 | 솔루블 VEGFR-1 변이체 cDNA를 함유하는 rAAV를 포함하는 황반변성 치료용 조성물 |
| KR20200120649A (ko) * | 2018-02-14 | 2020-10-21 | 제너레이션 바이오 컴퍼니 | 비-바이러스 dna 벡터 및 항체 및 융합 단백질 생산을 위한 이의 용도 |
| US20210355504A1 (en) * | 2018-10-11 | 2021-11-18 | Decibel Therapeutics, Inc. | Aav1 vectors and uses thereof for treatment of otic indications |
| KR20220093163A (ko) | 2019-10-31 | 2022-07-05 | 유니버시태트 베른 | 안구 유전자 전달을 위한 aav 벡터 변이체 |
| CN113952473A (zh) * | 2020-07-21 | 2022-01-21 | 英斯培瑞有限公司 | 用于治疗眼部疾病的组合物和方法 |
| CN119656336A (zh) * | 2023-09-21 | 2025-03-21 | 成都弘基生物科技有限公司 | 一种重组腺相关病毒在制备治疗与血管新生相关眼病的药物中的用途 |
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| AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
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| DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US5622856A (en) | 1995-08-03 | 1997-04-22 | Avigen | High efficiency helper system for AAV vector production |
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| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| JP2003505020A (ja) | 1999-07-02 | 2003-02-12 | ジェネンテック・インコーポレーテッド | ペプチドリガンドドメイン及び多量体化ドメインを含む融合ペプチド |
| JP4827353B2 (ja) | 1999-08-09 | 2011-11-30 | ターゲティッド ジェネティクス コーポレイション | 鎖内塩基対を形成するような配列の設計による、組換えウイルスベクターからの一本鎖の異種ヌクレオチド配列の発現の増大 |
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| TWI698240B (zh) * | 2012-05-15 | 2020-07-11 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| CN115715797A (zh) | 2013-04-17 | 2023-02-28 | 建新公司 | 用于治疗和预防黄斑变性的组合物和方法 |
| CN106163573A (zh) | 2014-02-06 | 2016-11-23 | 建新公司 | 用于治疗和预防黄斑变性的组合物及方法 |
-
2015
- 2015-02-06 CN CN201580017612.4A patent/CN106163573A/zh active Pending
- 2015-02-06 US US15/113,720 patent/US20170007719A1/en not_active Abandoned
- 2015-02-06 WO PCT/US2015/014872 patent/WO2015120309A1/en not_active Ceased
- 2015-02-06 KR KR1020167024302A patent/KR102234695B1/ko active Active
- 2015-02-06 CN CN201911282594.9A patent/CN111068072A/zh active Pending
- 2015-02-06 SG SG11201606101WA patent/SG11201606101WA/en unknown
- 2015-02-06 AU AU2015213770A patent/AU2015213770A1/en not_active Abandoned
- 2015-02-06 RU RU2016135771A patent/RU2703145C2/ru active
- 2015-02-06 TW TW104104067A patent/TWI687225B/zh active
- 2015-02-06 CN CN202510316733.4A patent/CN120131999A/zh active Pending
- 2015-02-06 BR BR112016017817A patent/BR112016017817A2/pt not_active Application Discontinuation
- 2015-02-06 EP EP15706595.4A patent/EP3102246B1/en active Active
- 2015-02-06 JP JP2016550530A patent/JP6719381B2/ja active Active
- 2015-02-06 CA CA2938828A patent/CA2938828A1/en active Pending
- 2015-02-06 MX MX2016010215A patent/MX2016010215A/es unknown
-
2016
- 2016-08-04 IL IL247116A patent/IL247116B/en active IP Right Grant
- 2016-08-05 MX MX2023011453A patent/MX2023011453A/es unknown
-
2019
- 2019-05-15 AU AU2019203413A patent/AU2019203413B2/en active Active
-
2021
- 2021-10-15 AU AU2021250986A patent/AU2021250986B2/en active Active
-
2022
- 2022-02-25 US US17/681,468 patent/US12483047B2/en active Active
-
2025
- 2025-05-05 AU AU2025203206A patent/AU2025203206A1/en active Pending
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