|
US4797368A
(en)
|
1985-03-15 |
1989-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adeno-associated virus as eukaryotic expression vector
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US5846946A
(en)
|
1996-06-14 |
1998-12-08 |
Pasteur Merieux Serums Et Vaccins |
Compositions and methods for administering Borrelia DNA
|
|
KR20020013464A
(ko)
|
1998-08-27 |
2002-02-20 |
추후제출 |
이종 유전자의 전달을 위한 표적화된 아데노바이러스 벡터
|
|
DE19933719A1
(de)
|
1999-07-19 |
2001-01-25 |
Medigene Ag |
Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung
|
|
KR20020097200A
(ko)
|
2000-03-21 |
2002-12-31 |
엘리트라 파마슈티컬즈, 인코포레이티드 |
원핵세포에서의 필수유전자의 동정
|
|
US7749492B2
(en)
*
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20040142325A1
(en)
*
|
2001-09-14 |
2004-07-22 |
Liat Mintz |
Methods and systems for annotating biomolecular sequences
|
|
ES2467156T3
(es)
*
|
2001-12-21 |
2014-06-12 |
Medigene Ag |
Una biblioteca de genes estructurales modificados o de partículas modificadas de cápside útiles para la identificación de clones virales con tropismo celular deseado
|
|
WO2005075506A1
(en)
*
|
2004-01-09 |
2005-08-18 |
The Scripps Research Institute |
Identification of endogenous trimerization domains in the adenovirus fiber protein that allow detargeting and retargeting of viral vectors
|
|
ATE527281T1
(de)
|
2004-07-16 |
2011-10-15 |
Us Gov Health & Human Serv |
Impfstoffe gegen aids umfassend cmv/r nucleinsäurekonstrukte
|
|
US8129352B2
(en)
|
2004-09-16 |
2012-03-06 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating ssRNA viral infection
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007093836A1
(en)
|
2006-02-13 |
2007-08-23 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from a xp gene and uses thereof
|
|
WO2008010009A1
(en)
|
2006-07-18 |
2008-01-24 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from a rag gene and uses thereof
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
WO2009013559A1
(en)
|
2007-07-23 |
2009-01-29 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the human hemoglobin beta gene and uses thereof
|
|
WO2009019528A1
(en)
|
2007-08-03 |
2009-02-12 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the human interleukin-2 receptor gamma chain gene and uses thereof
|
|
AU2008346801A1
(en)
|
2007-12-31 |
2009-07-16 |
Nanocor Therapeutics, Inc. |
RNA interference for the treatment of heart failure
|
|
EP2352821B1
(en)
|
2008-09-08 |
2016-11-23 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from a glutamine synthetase gene and uses thereof
|
|
MX345116B
(es)
|
2008-09-15 |
2017-01-17 |
Children's Medical Center Corp |
Modulacion de bcl11a para tratamiento de hemoglobinopatias.
|
|
US20110016540A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
|
US20110023145A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in autism spectrum disorders
|
|
US8592386B2
(en)
|
2008-12-17 |
2013-11-26 |
Sarepta Therapeutics, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
US8476418B2
(en)
|
2009-05-28 |
2013-07-02 |
Deutsches Krebsforschungszentrum |
Modified AAV capsid polypeptides
|
|
EP2569424A1
(en)
|
2010-05-12 |
2013-03-20 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
|
|
US8198429B2
(en)
|
2010-08-09 |
2012-06-12 |
Avi Biopharma, Inc. |
Antisense antiviral compounds and methods for treating a filovirus infection
|
|
US20120204282A1
(en)
|
2011-02-04 |
2012-08-09 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating occular disorders
|
|
CN107012171B
(zh)
|
2011-04-22 |
2021-07-13 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
WO2013082548A1
(en)
|
2011-11-30 |
2013-06-06 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
|
WO2013086441A2
(en)
|
2011-12-08 |
2013-06-13 |
Sarepta Therapeutics, Inc. |
Oligonucleotide analogues targeting human lmna
|
|
DK2836226T3
(en)
|
2012-02-24 |
2017-09-18 |
Hutchinson Fred Cancer Res |
COMPOSITIONS AND PROCEDURES FOR TREATING HEMOGLOBINOPATHY
|
|
NZ629427A
(en)
|
2012-02-29 |
2016-04-29 |
Sangamo Biosciences Inc |
Methods and compositions for treating huntington’s disease
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
EP3470523A1
(en)
*
|
2012-05-09 |
2019-04-17 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
IL239317B
(en)
|
2012-12-12 |
2022-07-01 |
Broad Inst Inc |
Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
HRP20190382T1
(hr)
|
2013-03-14 |
2019-04-19 |
Sarepta Therapeutics, Inc. |
Pripravci koji preskaču ekson za liječenje mišićne distrofije
|
|
EP3564379A1
(en)
|
2013-09-13 |
2019-11-06 |
California Institute of Technology |
Selective recovery
|
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
BR112016013547A2
(pt)
|
2013-12-12 |
2017-10-03 |
Broad Inst Inc |
Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
|
|
WO2015116568A2
(en)
*
|
2014-01-28 |
2015-08-06 |
University Of Miami |
Muscle cell-targeting nanoparticles for vaccination and nucleic acid delivery, and methods of production and use thereof
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
EP3129484A1
(en)
|
2014-03-25 |
2017-02-15 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating hiv infection and aids
|
|
WO2015148860A1
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating beta-thalassemia
|
|
WO2015148863A2
(en)
|
2014-03-26 |
2015-10-01 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
WO2015153791A1
(en)
|
2014-04-01 |
2015-10-08 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 2 (hsv-2)
|
|
EP3498845B1
(en)
|
2014-04-01 |
2022-06-22 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating herpes simplex virus type 1 (hsv-1)
|
|
US10577627B2
(en)
*
|
2014-06-09 |
2020-03-03 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
JP6832280B2
(ja)
|
2015-01-16 |
2021-02-24 |
ユニバーシティ オブ ワシントンＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｗａｓｈｉｎｇｔｏｎ |
新規のマイクロジストロフィンおよび使用の関連する方法
|
|
CA2977528A1
(en)
|
2015-02-27 |
2016-09-01 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
ES2860712T3
(es)
|
2015-03-24 |
2021-10-05 |
Univ California |
Variantes de virus adenoasociados y métodos de uso de las mismas
|
|
US11020417B2
(en)
|
2015-06-04 |
2021-06-01 |
Sarepta Therapeutics, Inc |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
|
ES2764460T3
(es)
*
|
2015-06-10 |
2020-06-03 |
Association Inst De Myologie |
Terapia combinada para la distrofia muscular de Duchenne
|
|
WO2017006283A1
(en)
|
2015-07-08 |
2017-01-12 |
Cv6 Therapeutics (Ni) Limited |
Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
|
|
AU2016317667A1
(en)
|
2015-08-28 |
2018-03-22 |
Sarepta Therapeutics, Inc. |
Modified antisense oligomers for exon inclusion in spinal muscular atrophy
|
|
US20190054113A1
(en)
|
2015-09-30 |
2019-02-21 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy
|
|
WO2017062835A2
(en)
|
2015-10-09 |
2017-04-13 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
|
WO2017096164A1
(en)
|
2015-12-02 |
2017-06-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
JP2018538302A
(ja)
|
2015-12-15 |
2018-12-27 |
サレプタ セラピューティクス， インコーポレイテッド |
ペプチドオリゴヌクレオチド複合体
|
|
WO2017165862A1
(en)
|
2016-03-25 |
2017-09-28 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (a1at) deficiency
|
|
MY200252A
(en)
|
2016-04-18 |
2023-12-16 |
Sarepta Therapeutics Inc |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
WO2017197355A2
(en)
|
2016-05-13 |
2017-11-16 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and methods of use thereof
|
|
WO2018119330A2
(en)
|
2016-12-22 |
2018-06-28 |
Oregon Health & Science University |
Adeno associated viral vectors
|
|
US10055384B2
(en)
|
2016-12-31 |
2018-08-21 |
Entefy Inc. |
Advanced zero-knowledge document processing and synchronization
|
|
WO2018189244A1
(en)
|
2017-04-11 |
2018-10-18 |
Ruprecht-Karls-Universität Heidelberg |
Adeno-associated virus library
|
|
US11771662B2
(en)
|
2017-09-05 |
2023-10-03 |
Kansas State University Research Foundation |
Analgesic formulation for control of pain in dogs
|
|
PE20201264A1
(es)
*
|
2017-09-20 |
2020-11-19 |
4D Molecular Therapeutics Inc |
Variantes de capsides de virus adenoasociados y metodos de uso de estas
|
|
EA201991450A1
(ru)
|
2017-09-22 |
2019-12-30 |
Сарепта Терапьютикс, Инк. |
Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
|
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
|
CN112004925B
(zh)
*
|
2018-04-05 |
2024-09-27 |
吉尼松公司 |
具有降低的肝向性的AAV9和AAVrh74的杂合重组腺相关病毒血清型
|
|
CA3097375A1
(en)
*
|
2018-04-27 |
2019-10-31 |
Universitat Heidelberg |
Modified aav capsid polypeptides for treatment of muscular diseases
|
|
JP7438981B2
(ja)
|
2018-05-11 |
2024-02-27 |
マサチューセッツ アイ アンド イヤー インファーマリー |
アデノ随伴ウイルスの肝臓特異的向性
|
|
WO2020160183A1
(en)
|
2019-01-29 |
2020-08-06 |
Holobiome, Inc. |
Methods and compositions for treating and preventing cns disorders and other conditions caused by gut microbial dysbiosis
|
|
CN109897831B
(zh)
|
2019-03-14 |
2021-05-28 |
苏州吉脉基因药物生物科技有限公司 |
具有突变衣壳的腺相关病毒病毒体及其应用
|
|
JP2022547570A
(ja)
*
|
2019-09-12 |
2022-11-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
操作済みのアデノ随伴ウイルスキャプシド
|
|
CA3157333A1
(en)
*
|
2019-10-10 |
2021-04-15 |
Solid Biosciences Inc. |
Modified aav capsids and uses thereof
|