|
EP0127839B1
(en)
|
1983-05-27 |
1992-07-15 |
THE TEXAS A&M UNIVERSITY SYSTEM |
Method for producing a recombinant baculovirus expression vector
|
|
ZA848495B
(en)
|
1984-01-31 |
1985-09-25 |
Idaho Res Found |
Production of polypeptides in insect cells
|
|
US5449616A
(en)
|
1990-05-23 |
1995-09-12 |
University Of Iowa Research Foundation |
Nucleic acid encoding dystrophin-associated protein
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
EP0710276A1
(en)
|
1993-07-23 |
1996-05-08 |
Unichema Chemie B.V. |
Process for producing transparent soap material
|
|
WO1995013392A1
(en)
|
1993-11-09 |
1995-05-18 |
Medical College Of Ohio |
Stable cell lines capable of expressing the adeno-associated virus replication gene
|
|
DE69433592T2
(de)
|
1993-11-09 |
2005-02-10 |
Targeted Genetics Corp., Seattle |
Die erzielung hoher titer des rekombinanten aav-vektors
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
EP0796339A1
(en)
|
1994-12-06 |
1997-09-24 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
FR2737730B1
(fr)
|
1995-08-10 |
1997-09-05 |
Pasteur Merieux Serums Vacc |
Procede de purification de virus par chromatographie
|
|
AU722196B2
(en)
|
1995-08-30 |
2000-07-27 |
Genzyme Corporation |
Chromatographic purification of adenovirus and AAV
|
|
CA2230758A1
(en)
|
1995-09-08 |
1997-03-13 |
Genzyme Corporation |
Improved aav vectors for gene therapy
|
|
US5672694A
(en)
|
1995-10-24 |
1997-09-30 |
University Of Iowa Research Foundation |
β-sarcoglycan nucleic acid sequence, and nucleic acid probes
|
|
US5910434A
(en)
|
1995-12-15 |
1999-06-08 |
Systemix, Inc. |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
|
|
CN1233291A
(zh)
|
1996-09-06 |
1999-10-27 |
宾西法尼亚大学托管会 |
重组腺伴随病毒定向基因治疗的方法
|
|
US5843078A
(en)
|
1997-07-01 |
1998-12-01 |
Sharkey; Hugh R. |
Radio frequency device for resurfacing skin and method
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
WO1999011764A2
(en)
|
1997-09-05 |
1999-03-11 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of recombinant aav vectors
|
|
AU2882899A
(en)
|
1998-02-26 |
1999-09-15 |
Trustees Of The University Of Pennsylvania, The |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
US6262035B1
(en)
*
|
1998-10-01 |
2001-07-17 |
University Of Iowa Research Foundation |
Gene replacement therapy for muscular dystrophy
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6632800B1
(en)
|
1999-08-17 |
2003-10-14 |
Mayo Foundation For Medical Education And Research |
System for monitoring the expression of transgenes
|
|
JP4520569B2
(ja)
|
2000-02-18 |
2010-08-04 |
照彦 豊岡 |
拡張型心筋症の遺伝子治療剤
|
|
JP2004514407A
(ja)
*
|
2000-04-28 |
2004-05-20 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
異種キャプシド中にシュードタイピングされたａａｖ５キャプシドおよびａａｖ５ベクターを含む組換えａａｖベクター
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20040126762A1
(en)
|
2002-12-17 |
2004-07-01 |
Morris David W. |
Novel compositions and methods in cancer
|
|
WO2003052051A2
(en)
|
2001-12-17 |
2003-06-26 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 8 sequences
|
|
WO2003074714A1
(en)
|
2002-03-05 |
2003-09-12 |
Stichting Voor De Technische Wetenschappen |
Baculovirus expression system
|
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
MXPA06014030A
(es)
|
2004-06-01 |
2007-10-08 |
Genzyme Corp |
Composiciones y metodos para evitar la agregacion del vector aav.
|
|
US7972593B2
(en)
|
2004-06-10 |
2011-07-05 |
Saint Louis University |
Delivery of therapeutic agents to the bone
|
|
WO2006039218A2
(en)
|
2004-09-30 |
2006-04-13 |
The Trustees Of The University Of Pennsylvania |
Perfusion circuit and use therein in targeted delivery of macromolecules
|
|
JP2006121961A
(ja)
|
2004-10-28 |
2006-05-18 |
Univ Of Tokushima |
顎骨骨幹異形成症ｇｄｄの原因遺伝子ｇｄｄ１とその用途
|
|
US7883858B2
(en)
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
|
US7788045B2
(en)
|
2005-09-01 |
2010-08-31 |
Meditasks, Llc |
Systems and method for homeostatic blood states
|
|
AU2006304605A1
(en)
|
2005-10-17 |
2007-04-26 |
Institute For Systems Biology |
Tissue-and serum-derived glycoproteins and methods of their use
|
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
|
EP2018421B1
(en)
|
2006-04-28 |
2012-12-19 |
The Trustees of the University of Pennsylvania |
Scalable production method for aav
|
|
US20100120627A1
(en)
|
2006-08-02 |
2010-05-13 |
Abdelmajid Belouchi |
Genemap of the human genes associated with psoriasis
|
|
WO2008021290A2
(en)
|
2006-08-09 |
2008-02-21 |
Homestead Clinical Corporation |
Organ-specific proteins and methods of their use
|
|
KR101240487B1
(ko)
|
2006-11-09 |
2013-03-08 |
더 존스 홉킨스 유니버시티 |
성체 포유동물 심근세포의 심장 줄기 세포로의 역분화
|
|
WO2008088895A2
(en)
|
2007-01-18 |
2008-07-24 |
University Of Missouri-Columbia |
Synthetic mini/micro-dystrophin genes to restore nnos to the sarcolemma
|
|
FR2919305B1
(fr)
|
2007-07-26 |
2009-09-18 |
Genethon Ass Loi De 1901 |
Vecteurs viraux adeno-associes pour l'expression de la dysferline.
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
DK2203173T3
(en)
|
2007-10-26 |
2016-02-29 |
Academisch Ziekenhuis Leiden |
Materials and methods for prevention of muscle diseases
|
|
US8236527B2
(en)
|
2008-03-14 |
2012-08-07 |
Humanzyme Limited |
Recombinant production of authentic human proteins using human cell expression systems
|
|
US20090280103A1
(en)
|
2008-04-04 |
2009-11-12 |
Martin Flueck |
Regulation of muscle repair
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US8236557B2
(en)
|
2008-05-28 |
2012-08-07 |
University Of Missouri-Columbia |
Hybrid-AAV vectors to deliver large gene expression cassette
|
|
US20100026655A1
(en)
|
2008-07-31 |
2010-02-04 |
Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. |
Capacitive Touchscreen or Touchpad for Finger or Stylus
|
|
US8729041B2
(en)
|
2008-12-03 |
2014-05-20 |
The Johns Hopkins University |
Compositions and methods for treating hepatic neoplasia
|
|
US20110023139A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20100247495A1
(en)
*
|
2009-03-30 |
2010-09-30 |
Tom Ichim |
Treatment of Muscular Dystrophy
|
|
US8637334B2
(en)
|
2009-11-03 |
2014-01-28 |
The Regents Of The University Of California |
High brightness light emitting diode covered by zinc oxide layers on multiple surfaces grown in low temperature aqueous solution
|
|
WO2011044138A1
(en)
|
2009-10-05 |
2011-04-14 |
Catabasis Pharmaceuticals, Inc. |
Lipoic acid acylated salicylate derivatives and their uses
|
|
FR2962041B1
(fr)
|
2010-07-01 |
2012-07-27 |
Genethon |
Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies
|
|
CA2842798C
(en)
|
2011-07-25 |
2021-02-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
WO2013075008A1
(en)
|
2011-11-16 |
2013-05-23 |
University Of Florida Research Foundation Inc. |
Aav dual vector systems for gene therapy
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
WO2013123503A1
(en)
|
2012-02-17 |
2013-08-22 |
The Children's Hospital Of Philadelphia |
Aav vector compositions and methods for gene transfer to cells, organs and tissues
|
|
EP2834259A4
(en)
|
2012-04-02 |
2016-08-24 |
Moderna Therapeutics Inc |
MODIFIED POLYNUCLEOTIDES
|
|
US9254311B2
(en)
*
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
PL4289948T3
(pl)
|
2012-05-25 |
2025-06-02 |
The Regents Of The University Of California |
Sposoby i kompozycje do modyfikacji kierowanego na rna docelowego dna i do nakierowanej na rna modulacji transkrypcji
|
|
WO2014037526A1
(en)
|
2012-09-07 |
2014-03-13 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
In vitro genetic diagnostic of inherited neuromuscular disorders
|
|
MX369519B
(es)
|
2012-09-25 |
2019-11-11 |
Genzyme Corp |
Oligonucleotidos antisentido morfolino unidos a peptido para el tratamiento de distrofia miotonica.
|
|
US9624282B2
(en)
|
2012-11-26 |
2017-04-18 |
The Curators Of The University Of Missouri |
Microdystrophin peptides and methods for treating muscular dystrophy using the same
|
|
CN105658796B
(zh)
|
2012-12-12 |
2021-10-26 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
WO2014093622A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
CN105121648B
(zh)
|
2012-12-12 |
2021-05-07 |
布罗德研究所有限公司 |
用于序列操纵的系统、方法和优化的指导组合物的工程化
|
|
FR3004463A1
(fr)
|
2013-04-11 |
2014-10-17 |
Genethon |
Systeme d'expression pour une therapie genique selective
|
|
CA2915837A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
ES2666322T3
(es)
|
2013-10-08 |
2018-05-04 |
Ystem S.R.L. |
Composiciones farmacéuticas para el tratamiento de trastornos musculares
|
|
US9850497B2
(en)
|
2013-11-04 |
2017-12-26 |
Regents Of The University Of Minnesota |
Gene targeting methods and tools
|
|
JP2017501149A
(ja)
|
2013-12-12 |
2017-01-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
粒子送達構成成分を用いた障害及び疾患の標的化のためのｃｒｉｓｐｒ−ｃａｓ系及び組成物の送達、使用及び治療適用
|
|
WO2015110449A1
(en)
|
2014-01-21 |
2015-07-30 |
Vrije Universiteit Brussel |
Muscle-specific nucleic acid regulatory elements and methods and use thereof
|
|
DE102014207498A1
(de)
|
2014-04-17 |
2015-10-22 |
Universitätsklinikum Hamburg-Eppendorf |
Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
|
|
EP2960336A1
(en)
|
2014-06-27 |
2015-12-30 |
Genethon |
Efficient systemic treatment of dystrophic muscle pathologies
|
|
US10479821B2
(en)
|
2015-01-16 |
2019-11-19 |
University Of Washington |
Micro-dystrophins and related methods of use
|
|
US11617783B2
(en)
|
2015-11-16 |
2023-04-04 |
Research Institute At Nationwide Children's Hospital |
Repairing a mutant human titin gene using CRISPR technology
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
WO2017180857A1
(en)
|
2016-04-15 |
2017-10-19 |
The Trustees Of The University Of Pennsylvania |
Gene therapy for treating hemophilia a
|
|
PL3442600T3
(pl)
|
2016-04-15 |
2024-07-08 |
Research Institute At Nationwide Children's Hospital |
Dostarczanie za pośrednictwem wirusa związanego z adenowirusem wektora b- sarkoglikanu i mikroRNA-29 oraz leczenie dystrofii mięśniowej
|
|
JP7153562B2
(ja)
|
2016-04-15 |
2022-10-14 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーを治療するためのマイクロｒｎａ－２９のアデノ随伴ウイルスベクター送達
|
|
US11078247B2
(en)
*
|
2016-05-04 |
2021-08-03 |
Curevac Ag |
RNA encoding a therapeutic protein
|
|
RU2753194C2
(ru)
|
2016-06-21 |
2021-08-12 |
Бамбу Терапьютикс, Инк. |
Оптимизированные гены и экспрессионные кассеты мини-дистрофина и их применение
|
|
DK3596222T5
(da)
|
2017-03-17 |
2024-09-02 |
Res Inst Nationwide Childrens Hospital |
Adenoassocieret virusvektorfremføring af muskelspecifik mikro-dystrophin til behandling af muskeldystrofi
|
|
WO2019012336A2
(en)
|
2017-03-17 |
2019-01-17 |
Newcastle University |
ADENO-ASSOCIATED VIRAL VECTOR DELIVERY OF A MICRO-DYSTROPHIN FRAGMENT FOR TREATING MUSCLE DYSTROPHY
|
|
JP7213238B2
(ja)
|
2017-10-18 |
2023-01-26 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーを治療するための筋特異的マイクロジストロフィンのアデノ随伴ウイルスベクター送達
|
|
CN111433367A
(zh)
|
2017-10-20 |
2020-07-17 |
全国儿童医院研究所 |
Nt-3基因疗法的方法和材料
|
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
|
AU2019216257B2
(en)
|
2018-01-31 |
2025-11-20 |
Research Institute At Nationwide Children's Hospital |
Gene therapy for limb-girdle muscular dystrophy type 2C
|
|
EP3773605A4
(en)
|
2018-04-03 |
2022-01-05 |
The Curators Of The University Of Missouri |
Hinges 1 and/or 4 modified dystrophins for dystrophinopathy therapy
|
|
US12152242B2
(en)
|
2018-04-23 |
2024-11-26 |
The Curators Of The University Of Missouri |
CRISPR therapy
|
|
EP4591888A3
(en)
|
2018-06-18 |
2026-01-21 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy
|
|
US12391928B2
(en)
|
2018-06-29 |
2025-08-19 |
Research Institute At Nationwide Children's Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2A
|
|
AU2019395388A1
(en)
|
2018-12-12 |
2021-07-29 |
Solid Biosciences Inc. |
Combination therapy for treating muscular dystrophy
|
|
CN113766935A
(zh)
|
2019-02-26 |
2021-12-07 |
全国儿童医院研究所 |
β-肌聚糖的腺相关病毒载体递送和肌营养不良症的治疗
|
|
SI4017871T1
(sl)
|
2019-08-21 |
2024-06-28 |
Research Institute At Nationwide Children's Hospital |
Dostava alfa-sarkoglikana z adeno povezanim virusnim vektorjem in zdravljenje mišične distrofije
|
|
JP2023530974A
(ja)
|
2020-06-15 |
2023-07-20 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーのためのアデノ随伴ウイルスベクター送達
|
|
MX2022016243A
(es)
|
2020-06-17 |
2023-03-08 |
Acceleron Pharma Inc |
Antagonistas de actrii-alk4 y métodos para el tratamiento contra insuficiencia cardíaca.
|