|
EP0127839B1
(en)
|
1983-05-27 |
1992-07-15 |
THE TEXAS A&M UNIVERSITY SYSTEM |
Method for producing a recombinant baculovirus expression vector
|
|
ZA848495B
(en)
|
1984-01-31 |
1985-09-25 |
Idaho Res Found |
Production of polypeptides in insect cells
|
|
US5449616A
(en)
|
1990-05-23 |
1995-09-12 |
University Of Iowa Research Foundation |
Nucleic acid encoding dystrophin-associated protein
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
CN1127524A
(zh)
|
1993-07-23 |
1996-07-24 |
尤尼剑马化学股份有限公司 |
生产透明皂材料的方法
|
|
JPH09509564A
(ja)
|
1993-11-09 |
1997-09-30 |
ターゲテッド ジェネティックス コーポレイション |
高力価組換えaavベクターの生成
|
|
WO1995013392A1
(en)
|
1993-11-09 |
1995-05-18 |
Medical College Of Ohio |
Stable cell lines capable of expressing the adeno-associated virus replication gene
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
EP0796339A1
(en)
|
1994-12-06 |
1997-09-24 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
FR2737730B1
(fr)
|
1995-08-10 |
1997-09-05 |
Pasteur Merieux Serums Vacc |
Procede de purification de virus par chromatographie
|
|
WO1997008298A1
(en)
|
1995-08-30 |
1997-03-06 |
Genzyme Corporation |
Chromatographic purification of adenovirus and aav
|
|
JPH11514853A
(ja)
|
1995-09-08 |
1999-12-21 |
ジエンザイム コーポレイション |
遺伝子治療のための改良されたaavベクター
|
|
US5672694A
(en)
|
1995-10-24 |
1997-09-30 |
University Of Iowa Research Foundation |
β-sarcoglycan nucleic acid sequence, and nucleic acid probes
|
|
US5910434A
(en)
|
1995-12-15 |
1999-06-08 |
Systemix, Inc. |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
|
|
WO1998009657A2
(en)
|
1996-09-06 |
1998-03-12 |
Trustees Of The University Of Pennsylvania |
Method for recombinant adeno-associated virus-directed gene therapy
|
|
US5843078A
(en)
|
1997-07-01 |
1998-12-01 |
Sharkey; Hugh R. |
Radio frequency device for resurfacing skin and method
|
|
CA2682108C
(en)
|
1997-09-05 |
2013-12-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of recombinant aav vectors
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
AU2882899A
(en)
|
1998-02-26 |
1999-09-15 |
Trustees Of The University Of Pennsylvania, The |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
US6262035B1
(en)
|
1998-10-01 |
2001-07-17 |
University Of Iowa Research Foundation |
Gene replacement therapy for muscular dystrophy
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6632800B1
(en)
|
1999-08-17 |
2003-10-14 |
Mayo Foundation For Medical Education And Research |
System for monitoring the expression of transgenes
|
|
JP4520569B2
(ja)
|
2000-02-18 |
2010-08-04 |
照彦 豊岡 |
拡張型心筋症の遺伝子治療剤
|
|
WO2001083692A2
(en)
|
2000-04-28 |
2001-11-08 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
|
|
US6962815B2
(en)
|
2001-01-05 |
2005-11-08 |
Children's Hopital Inc. |
AAV2 vectors and methods
|
|
US20040126762A1
(en)
|
2002-12-17 |
2004-07-01 |
Morris David W. |
Novel compositions and methods in cancer
|
|
JP4810062B2
(ja)
|
2001-12-17 |
2011-11-09 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
アデノ随伴ウイルス(aav)血清型8の配列
|
|
AU2003212708A1
(en)
|
2002-03-05 |
2003-09-16 |
Stichting Voor De Technische Wetenschappen |
Baculovirus expression system
|
|
AU2003223775A1
(en)
|
2002-04-30 |
2003-11-17 |
Duke University |
Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use
|
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
|
HUE060433T2
(hu)
|
2004-06-01 |
2023-03-28 |
Genzyme Corp |
Készítmények és eljárások AAV vektor aggregációjának megelõzésére
|
|
US7972593B2
(en)
|
2004-06-10 |
2011-07-05 |
Saint Louis University |
Delivery of therapeutic agents to the bone
|
|
WO2006039218A2
(en)
|
2004-09-30 |
2006-04-13 |
The Trustees Of The University Of Pennsylvania |
Perfusion circuit and use therein in targeted delivery of macromolecules
|
|
US7883858B2
(en)
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
|
US7788045B2
(en)
|
2005-09-01 |
2010-08-31 |
Meditasks, Llc |
Systems and method for homeostatic blood states
|
|
US20070099251A1
(en)
|
2005-10-17 |
2007-05-03 |
Institute For Systems Biology |
Tissue-and serum-derived glycoproteins and methods of their use
|
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
|
JP5268890B2
(ja)
|
2006-04-28 |
2013-08-21 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
Aavの規模適応性の製造方法
|
|
WO2008016356A2
(en)
|
2006-08-02 |
2008-02-07 |
Genizon Biosciences |
Genemap of the human genes associated with psoriasis
|
|
AU2007284651B2
(en)
|
2006-08-09 |
2014-03-20 |
Institute For Systems Biology |
Organ-specific proteins and methods of their use
|
|
US20100093089A1
(en)
|
2006-11-09 |
2010-04-15 |
Eduardo Marban |
Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells
|
|
CN101711164B
(zh)
|
2007-01-18 |
2014-06-04 |
密苏里-哥伦比亚大学 |
可修复肌纤维膜中的神经元型一氧化氮合酶的合成小/微-抗肌萎缩蛋白基因
|
|
FR2919305B1
(fr)
|
2007-07-26 |
2009-09-18 |
Genethon Ass Loi De 1901 |
Vecteurs viraux adeno-associes pour l'expression de la dysferline.
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
CN101896186A
(zh)
|
2007-10-26 |
2010-11-24 |
莱顿教学医院 |
对抗肌肉病症的方式和方法
|
|
AU2009223115B2
(en)
|
2008-03-14 |
2015-09-24 |
Humanzyme, Inc. |
Recombinant production of authentic human proteins using human cell expression systems
|
|
US20090280103A1
(en)
|
2008-04-04 |
2009-11-12 |
Martin Flueck |
Regulation of muscle repair
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US8236557B2
(en)
|
2008-05-28 |
2012-08-07 |
University Of Missouri-Columbia |
Hybrid-AAV vectors to deliver large gene expression cassette
|
|
US20100026655A1
(en)
|
2008-07-31 |
2010-02-04 |
Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. |
Capacitive Touchscreen or Touchpad for Finger or Stylus
|
|
US8729041B2
(en)
|
2008-12-03 |
2014-05-20 |
The Johns Hopkins University |
Compositions and methods for treating hepatic neoplasia
|
|
US20110023139A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20100247495A1
(en)
|
2009-03-30 |
2010-09-30 |
Tom Ichim |
Treatment of Muscular Dystrophy
|
|
WO2011044138A1
(en)
|
2009-10-05 |
2011-04-14 |
Catabasis Pharmaceuticals, Inc. |
Lipoic acid acylated salicylate derivatives and their uses
|
|
WO2011056867A1
(en)
|
2009-11-03 |
2011-05-12 |
The Regents Of The University Of California |
High brightness light emitting diode covered by zinc oxide layers on multiple surfaces grown in low temperature aqueous solution
|
|
FR2962041B1
(fr)
|
2010-07-01 |
2012-07-27 |
Genethon |
Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies
|
|
CA3106285A1
(en)
|
2011-07-25 |
2013-01-31 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
WO2013075008A1
(en)
|
2011-11-16 |
2013-05-23 |
University Of Florida Research Foundation Inc. |
Aav dual vector systems for gene therapy
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
CN104520428B
(zh)
|
2012-02-17 |
2018-09-21 |
费城儿童医院 |
将基因转移到细胞、器官和组织的aav载体组合物和方法
|
|
AU2013243952A1
(en)
|
2012-04-02 |
2014-10-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
US10501512B2
(en)
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
DE102012007232B4
(de)
|
2012-04-07 |
2014-03-13 |
Susanne Weller |
Verfahren zur Herstellung von rotierenden elektrischen Maschinen
|
|
SI3401400T1
(sl)
|
2012-05-25 |
2019-10-30 |
Univ California |
Postopki in sestavki za RNA usmerjeno modifikacijo tarčne DNA in za RNA usmerjeno modulacijo prepisovanja
|
|
DK3421602T3
(da)
|
2012-09-06 |
2021-05-10 |
Univ Chicago |
Antisense polynucleotides to induce exon skipping and methods of treating dystrophies
|
|
US20150247196A1
(en)
|
2012-09-07 |
2015-09-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
In vitro genetic diagnostic of inherited neuromuscular disorders
|
|
KR102240217B1
(ko)
|
2012-09-25 |
2021-04-14 |
젠자임 코포레이션 |
근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드
|
|
US9624282B2
(en)
|
2012-11-26 |
2017-04-18 |
The Curators Of The University Of Missouri |
Microdystrophin peptides and methods for treating muscular dystrophy using the same
|
|
ES2536353T3
(es)
|
2012-12-12 |
2015-05-22 |
The Broad Institute, Inc. |
Ingeniería de sistemas, métodos y composiciones de guía optimizadas para manipulación de secuencias
|
|
CN105658796B
(zh)
|
2012-12-12 |
2021-10-26 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
BR112015013784A2
(pt)
|
2012-12-12 |
2017-07-11 |
Massachusetts Inst Technology |
aplicação, manipulação e otimização de sistemas, métodos e composições para manipulação de sequência e aplicações terapêuticas
|
|
FR3004463A1
(fr)
|
2013-04-11 |
2014-10-17 |
Genethon |
Systeme d'expression pour une therapie genique selective
|
|
EP3011030B1
(en)
|
2013-06-17 |
2023-11-08 |
The Broad Institute, Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
JP2015092462A
(ja)
|
2013-09-30 |
2015-05-14 |
Tdk株式会社 |
正極及びそれを用いたリチウムイオン二次電池
|
|
ES2666322T3
(es)
|
2013-10-08 |
2018-05-04 |
Ystem S.R.L. |
Composiciones farmacéuticas para el tratamiento de trastornos musculares
|
|
US9850497B2
(en)
|
2013-11-04 |
2017-12-26 |
Regents Of The University Of Minnesota |
Gene targeting methods and tools
|
|
JP2017501149A
(ja)
|
2013-12-12 |
2017-01-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
粒子送達構成成分を用いた障害及び疾患の標的化のためのcrispr−cas系及び組成物の送達、使用及び治療適用
|
|
CA2936726C
(en)
|
2014-01-21 |
2024-04-30 |
Vrije Universiteit Brussel |
Muscle-specific nucleic acid regulatory elements and methods and use thereof
|
|
JP6202701B2
(ja)
|
2014-03-21 |
2017-09-27 |
株式会社日立国際電気 |
基板処理装置、半導体装置の製造方法及びプログラム
|
|
DE102014207498A1
(de)
|
2014-04-17 |
2015-10-22 |
Universitätsklinikum Hamburg-Eppendorf |
Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
|
|
EP2960336A1
(en)
|
2014-06-27 |
2015-12-30 |
Genethon |
Efficient systemic treatment of dystrophic muscle pathologies
|
|
JP6197169B2
(ja)
|
2014-09-29 |
2017-09-20 |
東芝メモリ株式会社 |
半導体装置の製造方法
|
|
CA2972811A1
(en)
|
2015-01-16 |
2016-07-21 |
University Of Washington |
Novel micro-dystrophins and related methods of use
|
|
HK1257955A1
(zh)
|
2015-11-16 |
2019-11-01 |
The Research Institute At Nationwide Children's Hospital |
用於治疗肌联蛋白类肌病和其他肌联蛋白病变的材料和方法
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
KR102450833B1
(ko)
|
2016-04-15 |
2022-10-05 |
더 트러스티스 오브 더 유니버시티 오브 펜실베니아 |
혈우병 a 치료용 유전자 요법
|
|
CA3021057A1
(en)
|
2016-04-15 |
2017-10-19 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and microrna-29 and the treatment of muscular dystrophy
|
|
MA45477A
(fr)
|
2016-04-15 |
2019-02-20 |
Res Inst Nationwide Childrens Hospital |
Administration à vecteurs de virus adéno-associé de microarn-29 et micro-dystrophine pour traiter la dystrophie musculaire
|
|
CA2971303A1
(en)
|
2016-06-21 |
2017-12-21 |
Bamboo Therapeutics, Inc. |
Optimized mini-dystrophin genes and expression cassettes and their use
|
|
IL311713B2
(en)
|
2017-03-17 |
2025-10-01 |
Res Inst Nationwide Childrens Hospital |
Muscle-specific delivery of microdystrophin using an adeno-associated virus vector for the treatment of muscular dystrophy
|
|
US11338045B2
(en)
|
2017-03-17 |
2022-05-24 |
Newcastle University |
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
|
|
JP7213238B2
(ja)
|
2017-10-18 |
2023-01-26 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
筋ジストロフィーを治療するための筋特異的マイクロジストロフィンのアデノ随伴ウイルスベクター送達
|
|
CN119193705A
(zh)
|
2017-10-20 |
2024-12-27 |
全国儿童医院研究所 |
Nt-3基因疗法的方法和材料
|
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
|
KR102824021B1
(ko)
|
2018-01-31 |
2025-06-24 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
2c형 지대근이영양증에 대한 유전자 치료
|
|
US20210139550A1
(en)
|
2018-04-03 |
2021-05-13 |
Curators Of The University Of Missouri |
Hinges 1 and/or 4 modified dystrophins for dystrophinopathy therapy
|
|
US12152242B2
(en)
|
2018-04-23 |
2024-11-26 |
The Curators Of The University Of Missouri |
CRISPR therapy
|
|
US12491265B2
(en)
|
2018-06-18 |
2025-12-09 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of muscle specific micro-dystrophin to treat muscular dystrophy
|
|
MX2020014119A
(es)
|
2018-06-29 |
2021-06-18 |
Res Inst Nationwide Childrens Hospital |
Productos y métodos de virus adenoasociado recombinante para el tratamiento de la distrofia muscular de cinturas 2a.
|
|
AU2019395388A1
(en)
|
2018-12-12 |
2021-07-29 |
Solid Biosciences Inc. |
Combination therapy for treating muscular dystrophy
|
|
MX2021010356A
(es)
|
2019-02-26 |
2022-03-04 |
Res Inst Nationwide Childrens Hospital |
SUMINISTRO DE ß-SARCOGLICANO MEDIANTE VECTORES DE VIRUS ADENOASOCIADO Y EL TRATAMIENTO DE LA DISTROFIA MUSCULAR.
|
|
CN120400170A
(zh)
|
2019-08-21 |
2025-08-01 |
全国儿童医院研究所 |
Α-肌聚糖的腺相关病毒载体递送和肌营养不良症的治疗
|
|
KR20230035043A
(ko)
|
2020-06-15 |
2023-03-10 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
근이영양증을 위한 아데노-연관 바이러스 벡터 전달
|
|
US20240252628A1
(en)
*
|
2020-06-17 |
2024-08-01 |
Acceleron Pharma Inc. |
Actrii-alk4 antagonists and methods of treating heart failure
|
|
US20230390417A1
(en)
|
2022-06-02 |
2023-12-07 |
Research Institute At Nationwide Children's Hospital |
Recombinant Adeno-Associated Virus Products and Methods for Treating Limb Girdle Muscular Dystrophy 2A
|