|
EP0127839B1
(en)
|
1983-05-27 |
1992-07-15 |
THE TEXAS A&M UNIVERSITY SYSTEM |
Method for producing a recombinant baculovirus expression vector
|
|
DK518384A
(da)
|
1984-01-31 |
1985-07-01 |
Idaho Res Found |
Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
|
|
US5449616A
(en)
|
1990-05-23 |
1995-09-12 |
University Of Iowa Research Foundation |
Nucleic acid encoding dystrophin-associated protein
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
CN1127524A
(zh)
|
1993-07-23 |
1996-07-24 |
尤尼剑马化学股份有限公司 |
生产透明皂材料的方法
|
|
DE69433922T2
(de)
|
1993-11-09 |
2005-07-28 |
Medical College Of Ohio, Toledo |
Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren
|
|
EP0733103B1
(en)
|
1993-11-09 |
2004-03-03 |
Targeted Genetics Corporation |
Generation of high titers of recombinant aav vectors
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
WO1996017947A1
(en)
|
1994-12-06 |
1996-06-13 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
FR2737730B1
(fr)
|
1995-08-10 |
1997-09-05 |
Pasteur Merieux Serums Vacc |
Procede de purification de virus par chromatographie
|
|
JPH11511326A
(ja)
|
1995-08-30 |
1999-10-05 |
ジエンザイム コーポレイション |
アデノウィルスおよびaavの精製
|
|
JPH11514853A
(ja)
|
1995-09-08 |
1999-12-21 |
ジエンザイム コーポレイション |
遺伝子治療のための改良されたaavベクター
|
|
US5672694A
(en)
|
1995-10-24 |
1997-09-30 |
University Of Iowa Research Foundation |
β-sarcoglycan nucleic acid sequence, and nucleic acid probes
|
|
US5910434A
(en)
|
1995-12-15 |
1999-06-08 |
Systemix, Inc. |
Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
|
|
EP1696036B1
(en)
|
1996-09-06 |
2010-04-21 |
The Trustees of The University of Pennsylvania |
Use of recombinant adeno-associated virus in the manufacture of a medicament for gene therapy via muscle cells
|
|
US5843078A
(en)
|
1997-07-01 |
1998-12-01 |
Sharkey; Hugh R. |
Radio frequency device for resurfacing skin and method
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
CA2995542A1
(en)
|
1997-09-05 |
1999-03-11 |
Genzyme Corporation |
Methods for generating high titer helper-free preparations of recombinant aav vectors
|
|
WO1999043360A1
(en)
|
1998-02-26 |
1999-09-02 |
The Trustees Of The University Of Pennsylvania |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
US6262035B1
(en)
|
1998-10-01 |
2001-07-17 |
University Of Iowa Research Foundation |
Gene replacement therapy for muscular dystrophy
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6632800B1
(en)
|
1999-08-17 |
2003-10-14 |
Mayo Foundation For Medical Education And Research |
System for monitoring the expression of transgenes
|
|
JP4520569B2
(ja)
|
2000-02-18 |
2010-08-04 |
照彦 豊岡 |
拡張型心筋症の遺伝子治療剤
|
|
JP2004514407A
(ja)
*
|
2000-04-28 |
2004-05-20 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
異種キャプシド中にシュードタイピングされたaav5キャプシドおよびaav5ベクターを含む組換えaavベクター
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US20040126762A1
(en)
|
2002-12-17 |
2004-07-01 |
Morris David W. |
Novel compositions and methods in cancer
|
|
DK2359869T3
(en)
|
2001-12-17 |
2019-04-15 |
Univ Pennsylvania |
Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof
|
|
WO2003074714A1
(en)
|
2002-03-05 |
2003-09-12 |
Stichting Voor De Technische Wetenschappen |
Baculovirus expression system
|
|
US7858367B2
(en)
|
2002-04-30 |
2010-12-28 |
Duke University |
Viral vectors and methods for producing and using the same
|
|
US20030225260A1
(en)
|
2002-04-30 |
2003-12-04 |
Snyder Richard O. |
Production of recombinant AAV virions
|
|
ES2932278T3
(es)
|
2004-06-01 |
2023-01-17 |
Genzyme Corp |
Composiciones y métodos para prevenir la agregación del vector AAV
|
|
US7972593B2
(en)
|
2004-06-10 |
2011-07-05 |
Saint Louis University |
Delivery of therapeutic agents to the bone
|
|
US20090054823A1
(en)
|
2004-09-30 |
2009-02-26 |
The Trustees Of The University Of Pennsylvania |
Perfusion circuit and use therein in targeted delivery of macromolecules
|
|
JP2006121961A
(ja)
|
2004-10-28 |
2006-05-18 |
Univ Of Tokushima |
顎骨骨幹異形成症gddの原因遺伝子gdd1とその用途
|
|
US7883858B2
(en)
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
|
US7788045B2
(en)
|
2005-09-01 |
2010-08-31 |
Meditasks, Llc |
Systems and method for homeostatic blood states
|
|
WO2007047796A2
(en)
|
2005-10-17 |
2007-04-26 |
Institute For Systems Biology |
Tissue-and serum-derived glycoproteins and methods of their use
|
|
WO2007049095A1
(en)
|
2005-10-25 |
2007-05-03 |
Cellectis |
Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
|
|
CN101528916B
(zh)
|
2006-04-28 |
2013-09-04 |
宾夕法尼亚大学托管会 |
规模可调的aav生产方法
|
|
EP2052088A2
(en)
|
2006-08-02 |
2009-04-29 |
Genizon Biosciences |
Genemap of the human genes associated with psoriasis
|
|
CA2660286A1
(en)
|
2006-08-09 |
2008-02-21 |
Homestead Clinical Corporation |
Organ-specific proteins and methods of their use
|
|
EP2518140A1
(en)
|
2006-11-09 |
2012-10-31 |
The Johns Hopkins University |
Dedifferentation of adult mammalian cardiomyocytes into cardiac stem cells
|
|
WO2008088895A2
(en)
|
2007-01-18 |
2008-07-24 |
University Of Missouri-Columbia |
Synthetic mini/micro-dystrophin genes to restore nnos to the sarcolemma
|
|
FR2919305B1
(fr)
|
2007-07-26 |
2009-09-18 |
Genethon Ass Loi De 1901 |
Vecteurs viraux adeno-associes pour l'expression de la dysferline.
|
|
GB0715087D0
(en)
|
2007-08-03 |
2007-09-12 |
Summit Corp Plc |
Drug combinations for the treatment of duchenne muscular dystrophy
|
|
NZ584793A
(en)
|
2007-10-26 |
2012-05-25 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US8236527B2
(en)
|
2008-03-14 |
2012-08-07 |
Humanzyme Limited |
Recombinant production of authentic human proteins using human cell expression systems
|
|
US20090280103A1
(en)
|
2008-04-04 |
2009-11-12 |
Martin Flueck |
Regulation of muscle repair
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US8236557B2
(en)
|
2008-05-28 |
2012-08-07 |
University Of Missouri-Columbia |
Hybrid-AAV vectors to deliver large gene expression cassette
|
|
US20100026655A1
(en)
|
2008-07-31 |
2010-02-04 |
Avago Technologies Ecbu Ip (Singapore) Pte. Ltd. |
Capacitive Touchscreen or Touchpad for Finger or Stylus
|
|
US8729041B2
(en)
|
2008-12-03 |
2014-05-20 |
The Johns Hopkins University |
Compositions and methods for treating hepatic neoplasia
|
|
US20110023139A1
(en)
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
|
US20100247495A1
(en)
*
|
2009-03-30 |
2010-09-30 |
Tom Ichim |
Treatment of Muscular Dystrophy
|
|
US8946451B2
(en)
|
2009-10-05 |
2015-02-03 |
Catabasis Pharmaceuticals, Inc. |
Lipoic acid acylated salicylate derivatives and their uses
|
|
CN102598270A
(zh)
|
2009-11-03 |
2012-07-18 |
加利福尼亚大学董事会 |
在多个表面上由在低温水性溶液中生长的氧化锌层覆盖的高亮度发光二极管
|
|
FR2962041B1
(fr)
|
2010-07-01 |
2012-07-27 |
Genethon |
Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies
|
|
CA2842798C
(en)
|
2011-07-25 |
2021-02-23 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of dux4
|
|
WO2013075008A1
(en)
|
2011-11-16 |
2013-05-23 |
University Of Florida Research Foundation Inc. |
Aav dual vector systems for gene therapy
|
|
US9434928B2
(en)
|
2011-11-23 |
2016-09-06 |
Nationwide Children's Hospital, Inc. |
Recombinant adeno-associated virus delivery of alpha-sarcoglycan polynucleotides
|
|
BR112014020325A2
(pt)
|
2012-02-17 |
2017-08-08 |
Childrens Hospital Philadelphia |
composições de vetor do aav e métodos para a transferência de gene para as células, órgãos e tecidos
|
|
WO2013151664A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
US10501512B2
(en)
*
|
2012-04-02 |
2019-12-10 |
Modernatx, Inc. |
Modified polynucleotides
|
|
ES2728782T3
(es)
|
2012-05-25 |
2019-10-28 |
Univ California |
Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN
|
|
US20150247196A1
(en)
|
2012-09-07 |
2015-09-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
In vitro genetic diagnostic of inherited neuromuscular disorders
|
|
US10111962B2
(en)
|
2012-09-25 |
2018-10-30 |
Genzyme Corporation |
Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
|
|
US9624282B2
(en)
|
2012-11-26 |
2017-04-18 |
The Curators Of The University Of Missouri |
Microdystrophin peptides and methods for treating muscular dystrophy using the same
|
|
MX380562B
(es)
|
2012-12-12 |
2025-03-12 |
Broad Inst Inc |
Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias.
|
|
KR102955556B1
(ko)
|
2012-12-12 |
2026-04-22 |
더 브로드 인스티튜트, 인코퍼레이티드 |
서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물
|
|
SG10201707569YA
(en)
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
FR3004463A1
(fr)
|
2013-04-11 |
2014-10-17 |
Genethon |
Systeme d'expression pour une therapie genique selective
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
ES2666322T3
(es)
|
2013-10-08 |
2018-05-04 |
Ystem S.R.L. |
Composiciones farmacéuticas para el tratamiento de trastornos musculares
|
|
US9850497B2
(en)
|
2013-11-04 |
2017-12-26 |
Regents Of The University Of Minnesota |
Gene targeting methods and tools
|
|
WO2015089419A2
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
AU2015208247B2
(en)
|
2014-01-21 |
2021-05-27 |
Universiteit Gent |
Muscle-specific nucleic acid regulatory elements and methods and use thereof
|
|
DE102014207498A1
(de)
|
2014-04-17 |
2015-10-22 |
Universitätsklinikum Hamburg-Eppendorf |
Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark
|
|
EP2960336A1
(en)
|
2014-06-27 |
2015-12-30 |
Genethon |
Efficient systemic treatment of dystrophic muscle pathologies
|
|
WO2016115543A2
(en)
|
2015-01-16 |
2016-07-21 |
University Of Washington |
Novel micro-dystrophins and related methods of use
|
|
CN108463211B
(zh)
|
2015-11-16 |
2022-09-27 |
全国儿童医院研究所 |
用于治疗肌联蛋白类肌病和其它肌联蛋白病变的材料和方法
|
|
WO2017165859A1
(en)
|
2016-03-24 |
2017-09-28 |
Research Institute At Nationwide Children's Hospital |
Modified viral capsid proteins
|
|
CN109121395B
(zh)
|
2016-04-15 |
2022-08-09 |
全国儿童医院研究所 |
腺相关病毒载体递送β-肌聚糖和微RNA-29以及肌营养不良症的治疗
|
|
PE20181922A1
(es)
|
2016-04-15 |
2018-12-11 |
Univ Pennsylvania |
Terapia genica para tratar la hemofilia a
|
|
WO2017181011A1
(en)
|
2016-04-15 |
2017-10-19 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
|
|
WO2017191274A2
(en)
*
|
2016-05-04 |
2017-11-09 |
Curevac Ag |
Rna encoding a therapeutic protein
|
|
CA2971303C
(en)
|
2016-06-21 |
2026-03-03 |
Bamboo Therapeutics, Inc. |
Optimized mini-dystrophin genes and expression cassettes and their use
|
|
CN110997923B
(zh)
|
2017-03-17 |
2024-01-02 |
全国儿童医院研究所 |
腺相关病毒载体递送肌肉特异性微肌营养不良蛋白以治疗肌营养不良症
|
|
US11338045B2
(en)
|
2017-03-17 |
2022-05-24 |
Newcastle University |
Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
|
|
WO2019078916A1
(en)
|
2017-10-18 |
2019-04-25 |
Research Institute At Nationwide Children's Hospital |
ADENO-ASSOCIATED VIRUS VECTOR ADMINISTRATION OF MUSCLE-SPECIFIC MICRO-DYSTROPHINE TO TREAT MUSCLE DYSTROPHY
|
|
MX2020004035A
(es)
|
2017-10-20 |
2020-11-09 |
Res Inst Nationwide Childrens Hospital |
Métodos y materiales para terapia génica con nt-3.
|
|
TW201936201A
(zh)
|
2017-12-14 |
2019-09-16 |
美商堅固生物科技公司 |
基因之非病毒生產及遞送
|
|
AU2019216257B2
(en)
|
2018-01-31 |
2025-11-20 |
Research Institute At Nationwide Children's Hospital |
Gene therapy for limb-girdle muscular dystrophy type 2C
|
|
WO2019195362A1
(en)
|
2018-04-03 |
2019-10-10 |
Curators Of The University Of Missouri |
Hinges 1 and/or 4 modified dystrophins for dystrophinopathy therapy
|
|
WO2019209777A1
(en)
|
2018-04-23 |
2019-10-31 |
The Curators Of The University Of Missouri |
Improved crispr therapy
|
|
IL324506A
(en)
|
2018-06-18 |
2026-01-01 |
Res Inst Nationwide Childrens Hospital |
Adeno-associated virus vector for delivery of muscle-specific microdystrophin for the treatment of muscular dystrophy
|
|
IL279789B2
(en)
|
2018-06-29 |
2026-04-01 |
Res Inst Nationwide Childrens Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2A
|
|
CN113646004A
(zh)
|
2018-12-12 |
2021-11-12 |
坚固生物科技公司 |
用于治疗肌营养不良的组合疗法
|
|
KR20210133242A
(ko)
|
2019-02-26 |
2021-11-05 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
B-사르코글리칸의 아데노 관련 바이러스 벡터 전달 및 근이영양증의 치료
|
|
CA3150964A1
(en)
|
2019-08-21 |
2021-02-25 |
Research Institute At Nationwide Children's Hospital |
Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy
|
|
EP4164668A1
(en)
|
2020-06-15 |
2023-04-19 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery for muscular dystrophies
|
|
WO2021257655A1
(en)
|
2020-06-17 |
2021-12-23 |
Acceleron Pharma Inc. |
Actrii-alk4 antagonists and methods of treating heart failure
|