|
FR2640638B1
(fr)
|
1988-12-20 |
1991-02-15 |
Commissariat Energie Atomique |
Bioreacteur et dispositif pour la culture de cellules animales
|
|
WO1991018088A1
(en)
|
1990-05-23 |
1991-11-28 |
The United States Of America, Represented By The Secretary, United States Department Of Commerce |
Adeno-associated virus (aav)-based eucaryotic vectors
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5252479A
(en)
|
1991-11-08 |
1993-10-12 |
Research Corporation Technologies, Inc. |
Safe vector for gene therapy
|
|
US5587308A
(en)
|
1992-06-02 |
1996-12-24 |
The United States Of America As Represented By The Department Of Health & Human Services |
Modified adeno-associated virus vector capable of expression from a novel promoter
|
|
US6268213B1
(en)
|
1992-06-03 |
2001-07-31 |
Richard Jude Samulski |
Adeno-associated virus vector and cis-acting regulatory and promoter elements capable of expressing at least one gene and method of using same for gene therapy
|
|
US5387484A
(en)
|
1992-07-07 |
1995-02-07 |
International Business Machines Corporation |
Two-sided mask for patterning of materials with electromagnetic radiation
|
|
US5693531A
(en)
|
1993-11-24 |
1997-12-02 |
The United States Of America As Represented By The Department Of Health And Human Services |
Vector systems for the generation of adeno-associated virus particles
|
|
EP0755454B1
(en)
|
1994-04-13 |
2008-02-13 |
The Rockefeller University |
Aav-mediated delivery of dna to cells of the nervous system
|
|
US20020159979A1
(en)
|
1994-06-06 |
2002-10-31 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US5658785A
(en)
|
1994-06-06 |
1997-08-19 |
Children's Hospital, Inc. |
Adeno-associated virus materials and methods
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5856152A
(en)
|
1994-10-28 |
1999-01-05 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV vector and methods of use therefor
|
|
US5625048A
(en)
|
1994-11-10 |
1997-04-29 |
The Regents Of The University Of California |
Modified green fluorescent proteins
|
|
EP0796339A1
(en)
|
1994-12-06 |
1997-09-24 |
Targeted Genetics Corporation |
Packaging cell lines for generation of high titers of recombinant aav vectors
|
|
US5652224A
(en)
|
1995-02-24 |
1997-07-29 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
|
|
US5741657A
(en)
|
1995-03-20 |
1998-04-21 |
The Regents Of The University Of California |
Fluorogenic substrates for β-lactamase and methods of use
|
|
US5756283A
(en)
|
1995-06-05 |
1998-05-26 |
The Trustees Of The University Of Pennsylvania |
Method for improved production of recombinant adeno-associated viruses for gene therapy
|
|
US6281010B1
(en)
|
1995-06-05 |
2001-08-28 |
The Trustees Of The University Of Pennsylvania |
Adenovirus gene therapy vehicle and cell line
|
|
US5741683A
(en)
|
1995-06-07 |
1998-04-21 |
The Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US6506379B1
(en)
|
1995-06-07 |
2003-01-14 |
Ariad Gene Therapeutics, Inc. |
Intramuscular delivery of recombinant AAV
|
|
US5688676A
(en)
|
1995-06-07 |
1997-11-18 |
Research Foundation Of State University Of New York |
In vitro packaging of adeno-associated virus DNA
|
|
US6197293B1
(en)
|
1997-03-03 |
2001-03-06 |
Calydon, Inc. |
Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof
|
|
US6676935B2
(en)
|
1995-06-27 |
2004-01-13 |
Cell Genesys, Inc. |
Tissue specific adenoviral vectors
|
|
JPH11511326A
(ja)
|
1995-08-30 |
1999-10-05 |
ジエンザイム コーポレイション |
アデノウィルスおよびａａｖの精製
|
|
US6265389B1
(en)
|
1995-08-31 |
2001-07-24 |
Alkermes Controlled Therapeutics, Inc. |
Microencapsulation and sustained release of oligonucleotides
|
|
US5846528A
(en)
|
1996-01-18 |
1998-12-08 |
Avigen, Inc. |
Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
US5858351A
(en)
|
1996-01-18 |
1999-01-12 |
Avigen, Inc. |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
|
|
US5952221A
(en)
|
1996-03-06 |
1999-09-14 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a first and second nucleic acid sequence
|
|
US7026468B2
(en)
|
1996-07-19 |
2006-04-11 |
Valentis, Inc. |
Process and equipment for plasmid purification
|
|
AU722375B2
(en)
|
1996-09-06 |
2000-08-03 |
Trustees Of The University Of Pennsylvania, The |
Methods using cre-lox for production of recombinant adeno-associated viruses
|
|
US5866552A
(en)
|
1996-09-06 |
1999-02-02 |
The Trustees Of The University Of Pennsylvania |
Method for expressing a gene in the absence of an immune response
|
|
EP0931158A1
(en)
|
1996-09-06 |
1999-07-28 |
The Trustees Of The University Of Pennsylvania |
An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
|
|
WO1998010087A1
(en)
|
1996-09-06 |
1998-03-12 |
Trustees Of The University Of Pennsylvania |
Chimpanzee adenovirus vectors
|
|
ATE465267T1
(de)
|
1996-09-06 |
2010-05-15 |
Univ Pennsylvania |
Rekombinante aav zur herstellung eines medikaments für die gentherapie von muskelzellen
|
|
EP0932694A2
(en)
|
1996-09-11 |
1999-08-04 |
THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Aav4 vector and uses thereof
|
|
AU732703B2
(en)
|
1996-11-20 |
2001-04-26 |
Crucell Holland B.V. |
An improved method for the production and purification of adenoviral vectors
|
|
US7732129B1
(en)
|
1998-12-01 |
2010-06-08 |
Crucell Holland B.V. |
Method for the production and purification of adenoviral vectors
|
|
CA2270285A1
(en)
|
1996-12-18 |
1998-06-25 |
Targeted Genetics Corporation |
Aav split-packaging genes and cell lines comprising such genes for use in the production of recombinant aav vectors
|
|
US6436708B1
(en)
|
1997-04-17 |
2002-08-20 |
Paola Leone |
Delivery system for gene therapy to the brain
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
US6710036B2
(en)
|
1997-07-25 |
2004-03-23 |
Avigen, Inc. |
Induction of immune response to antigens expressed by recombinant adeno-associated virus
|
|
US6251677B1
(en)
|
1997-08-25 |
2001-06-26 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV virus and methods of use thereof
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6989264B2
(en)
|
1997-09-05 |
2006-01-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
JP2001517454A
(ja)
|
1997-09-19 |
2001-10-09 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスの産生に有用な方法および細胞株
|
|
AU9319198A
(en)
|
1997-09-19 |
1999-04-05 |
Trustees Of The University Of Pennsylvania, The |
Methods and vector constructs useful for production of recombinant aav
|
|
US6642051B1
(en)
|
1997-10-21 |
2003-11-04 |
Targeted Genetics Corporation |
Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
|
|
IT1297074B1
(it)
|
1997-11-21 |
1999-08-03 |
Angeletti P Ist Richerche Bio |
Forme ormone-dipendenti delle proteine rep del virus adeno-associato (aav-2), sequenze di dna codificanti per esse, vettori che le
|
|
JP2001526900A
(ja)
|
1997-12-23 |
2001-12-25 |
イントロヘーネ ベスローテン フェンノートシャップ |
標的細胞の染色体ｄｎａへの外来遺伝子情報の組み込みに有用な、アデノ随伴ウイルスおよびアデノウイルスのキメラ組換えウイルス
|
|
US6410300B1
(en)
|
1998-01-12 |
2002-06-25 |
The University Of North Carolina At Chapel Hill |
Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV
|
|
WO1999043360A1
(en)
|
1998-02-26 |
1999-09-02 |
The Trustees Of The University Of Pennsylvania |
Stable protection from dystrophic sarcolemmal degeneration and restoration of the sarcoglycan complex
|
|
EP1064393B1
(en)
|
1998-03-20 |
2004-12-29 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6953690B1
(en)
|
1998-03-20 |
2005-10-11 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
US6521426B1
(en)
|
1998-04-08 |
2003-02-18 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
Preparation of recombinant adenovirus carrying a rep gene of adeno-associated virus
|
|
FR2778413B1
(fr)
|
1998-05-07 |
2000-08-04 |
Immunotech Sa |
Nouveaux reactifs et methode de lyse des erythrocytes
|
|
EP1078096A1
(en)
|
1998-05-11 |
2001-02-28 |
Ariad Gene Therapeutics, Inc. |
Multiviral compositions and uses thereof
|
|
EP1849872A1
(en)
|
1998-05-20 |
2007-10-31 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
US6436392B1
(en)
|
1998-05-20 |
2002-08-20 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors
|
|
JP2002516345A
(ja)
|
1998-05-27 |
2002-06-04 |
セル ジェネシス インコーポレイテッド |
第ｖｉｉｉ因子活性のアデノ随伴ウイルスベクター媒介性発現
|
|
US6146874A
(en)
|
1998-05-27 |
2000-11-14 |
University Of Florida |
Method of preparing recombinant adeno-associated virus compositions
|
|
ES2313784T3
(es)
|
1998-05-28 |
2009-03-01 |
The Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services |
Vector aav5 y usos del mismo.
|
|
US6984517B1
(en)
|
1998-05-28 |
2006-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector and uses thereof
|
|
GB2338236B
(en)
|
1998-06-13 |
2003-04-09 |
Aea Technology Plc |
Microbiological cell processing
|
|
WO2000022152A1
(en)
|
1998-10-13 |
2000-04-20 |
Avigen, Inc. |
Compositions and methods for producing recombinant adeno-associated virus
|
|
US6200560B1
(en)
|
1998-10-20 |
2001-03-13 |
Avigen, Inc. |
Adeno-associated virus vectors for expression of factor VIII by target cells
|
|
EP1124976A1
(en)
|
1998-10-27 |
2001-08-22 |
Crucell Holland B.V. |
Improved aav vector production
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
AU780231B2
(en)
|
1998-11-10 |
2005-03-10 |
University Of North Carolina At Chapel Hill, The |
Virus vectors and methods of making and administering the same
|
|
US6689600B1
(en)
|
1998-11-16 |
2004-02-10 |
Introgen Therapeutics, Inc. |
Formulation of adenovirus for gene therapy
|
|
US6225113B1
(en)
|
1998-12-04 |
2001-05-01 |
Genvec, Inc. |
Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus
|
|
US6387368B1
(en)
|
1999-02-08 |
2002-05-14 |
The Trustees Of The University Of Pennsylvania |
Hybrid adenovirus-AAV virus and methods of use thereof
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
US6509150B1
(en)
|
1999-03-05 |
2003-01-21 |
Universite De Nantes |
Compositions and methods for recombinant Adeno-Associated Virus production
|
|
JP4693244B2
(ja)
|
1999-03-18 |
2011-06-01 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法
|
|
US6258595B1
(en)
|
1999-03-18 |
2001-07-10 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for helper-free production of recombinant adeno-associated viruses
|
|
JP2002542805A
(ja)
|
1999-04-30 |
2002-12-17 |
ユニバーシティ オブ フロリダ |
アデノ随伴ウイルス送達リボザイム組成物および使用方法
|
|
JP2003501067A
(ja)
|
1999-06-02 |
2003-01-14 |
トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
ヘルパーウイルスを要求する組み換えウイルス産生のために有用な組成物及び方法
|
|
WO2000075365A2
(en)
|
1999-06-08 |
2000-12-14 |
University Of Iowa Research Foundation |
Compounds and methods to enhance raav transduction
|
|
CA2382483A1
(en)
|
1999-08-20 |
2001-03-01 |
Johns Hopkins University School Of Medicine |
Methods and compositions for the construction and use of fusion libraries
|
|
US6365394B1
(en)
|
1999-09-29 |
2002-04-02 |
The Trustees Of The University Of Pennsylvania |
Cell lines and constructs useful in production of E1-deleted adenoviruses in absence of replication competent adenovirus
|
|
EP1218035A2
(en)
|
1999-09-29 |
2002-07-03 |
The Trustees Of The University Of Pennsylvania |
Rapid peg-modification of viral vectors
|
|
WO2001025465A1
(en)
|
1999-10-07 |
2001-04-12 |
University Of Iowa Research Foundation |
Adeno-associated viruses and uses thereof
|
|
US7241447B1
(en)
|
1999-10-07 |
2007-07-10 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors and uses thereof
|
|
WO2001032711A2
(en)
|
1999-10-21 |
2001-05-10 |
Board Of Trustees Of The University Of Arkansas |
Adeno-associated virus aav rep78 major regulatory protein, mutants thereof and uses thereof
|
|
WO2001036623A2
(en)
|
1999-11-05 |
2001-05-25 |
Avigen, Inc. |
Ecdysone-inducible adeno-associated virus expression vectors
|
|
US6582692B1
(en)
|
1999-11-17 |
2003-06-24 |
Avigen, Inc. |
Recombinant adeno-associated virus virions for the treatment of lysosomal disorders
|
|
EP1240345A2
(en)
|
1999-12-10 |
2002-09-18 |
Ariad Gene Therapeutics, Inc. |
Methods for expression of genes in primates
|
|
US7638120B2
(en)
|
2000-03-14 |
2009-12-29 |
Thomas Jefferson University |
High transgene expression of a pseudotyped adeno-associated virus type
|
|
EP1228234A2
(en)
|
2000-03-14 |
2002-08-07 |
Neurologix, Inc. |
Production of chimeric capsid vectors
|
|
US6468524B1
(en)
|
2000-03-22 |
2002-10-22 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
AAV4 vector and uses thereof
|
|
US6855314B1
(en)
|
2000-03-22 |
2005-02-15 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector for transducing brain cells and lung cells
|
|
US7048920B2
(en)
|
2000-03-24 |
2006-05-23 |
Cell Genesys, Inc. |
Recombinant oncolytic adenovirus for human melanoma
|
|
WO2001083797A2
(en)
|
2000-04-28 |
2001-11-08 |
Avigen, Inc. |
Polynucleotides for use in recombinant adeno-associated virus virion production
|
|
CA2406743A1
(en)
|
2000-04-28 |
2001-11-08 |
The Trustees Of The University Of Pennsylvania |
Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
|
|
US20030013189A1
(en)
|
2000-04-28 |
2003-01-16 |
Wilson James M. |
Compositions and methods useful for non-invasive delivery of therapeutic molecules to the bloodstream
|
|
ATE280590T1
(de)
|
2000-05-23 |
2004-11-15 |
Neurologix Inc |
Glutaminsäure decarboxylase (gad) abgabesystem zur behandlung neurodegeneraliver erkrankungen
|
|
AU2001268373A1
(en)
|
2000-06-13 |
2001-12-24 |
The Children's Hospital Of Philadelphia |
Methods for administering recombinant adeno-associated virus virions to humans previously exposed to adeno-associated virus
|
|
WO2002006483A1
(fr)
|
2000-07-18 |
2002-01-24 |
Takeda Chemical Industries, Ltd. |
Nouveau peptide actif sur le plan physiologique et utilisation associee
|
|
US6329181B1
(en)
|
2000-08-07 |
2001-12-11 |
Neurologix, Inc. |
Helper functions for recombinant vector production
|
|
US6593123B1
(en)
|
2000-08-07 |
2003-07-15 |
Avigen, Inc. |
Large-scale recombinant adeno-associated virus (rAAV) production and purification
|
|
WO2002014487A2
(en)
|
2000-08-17 |
2002-02-21 |
Keiya Ozawa |
Adeno-associated virus-mediated delivery of angiogenic factors
|
|
DE10044384A1
(de)
|
2000-09-08 |
2002-04-18 |
Medigene Ag |
Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
|
|
FR2813891B1
(fr)
|
2000-09-14 |
2005-01-14 |
Immunotech Sa |
Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications
|
|
WO2002070719A2
(en)
|
2001-01-19 |
2002-09-12 |
Trustees Of The University Of Pennsylvania |
Regulatable gene expression system
|
|
JP2004532822A
(ja)
|
2001-03-14 |
2004-10-28 |
アビジェン， インコーポレイテッド |
ビリオンの管逆行感染による組換えアデノ随伴ウイルス媒介遺伝子移入
|
|
US7588757B2
(en)
|
2001-03-14 |
2009-09-15 |
Genzyme Corporation |
Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
|
|
EP1390490B1
(en)
|
2001-05-24 |
2009-04-15 |
Genzyme Corporation |
Muscle-specific expression vectors
|
|
ES2375557T3
(es)
|
2001-06-22 |
2012-03-02 |
The Trustees Of The University Of Pennsylvania |
Adenovirus recombinantes que comprenden prote�?nas de adenovirus de simios y usos de los mismos.
|
|
US8241622B2
(en)
|
2001-07-13 |
2012-08-14 |
University Of Iowa Research Foundation |
Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
|
|
EP1279740A1
(en)
|
2001-07-26 |
2003-01-29 |
Vrije Universiteit Brussel |
Recombinant vector derived from adeno-associated virus for gene therapy
|
|
CA2455499C
(en)
|
2001-08-08 |
2011-06-21 |
The Trustees Of The University Of Pennsylvania |
Method for purification of viral vectors having proteins which bind sialic acid
|
|
AU2002360355B2
(en)
|
2001-11-09 |
2005-07-07 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
CA2915124C
(en)
|
2001-11-13 |
2018-08-14 |
The Trustees Of The University Of Pennsylvania |
A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
|
|
EP1944043A1
(en)
|
2001-11-21 |
2008-07-16 |
The Trustees of the University of Pennsylvania |
Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
|
|
KR100987360B1
(ko)
|
2001-11-21 |
2010-10-12 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
원숭이 아데노바이러스 핵산과 아미노산 서열, 이를함유하는 벡터 및 사용방법
|
|
WO2003049763A1
(en)
|
2001-12-12 |
2003-06-19 |
Fh Faulding & Co Limited |
Composition for the preservation of viruses
|
|
ES2602352T3
(es)
|
2001-12-17 |
2017-02-20 |
The Trustees Of The University Of Pennsylvania |
Secuencias de serotipo 8 de virus adenoasociado (VAA), vectores que las contienen y usos de las mismas
|
|
JP4769417B2
(ja)
|
2001-12-17 |
2011-09-07 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
アデノ随伴ウイルス（ａａｖ）血清型９の配列、それを含むベクターおよびその使用
|
|
EP1463530A4
(en)
|
2001-12-19 |
2006-09-06 |
Lijun Wang |
ADENO-ASSOCIATED VIRUS-RELATED DELIVERY OF GDNF TO SKELETAL MUSCLES
|
|
US8110351B2
(en)
|
2002-01-16 |
2012-02-07 |
Invitrogen Dynal As |
Method for isolating nucleic acids and protein from a single sample
|
|
GB0208390D0
(en)
|
2002-04-11 |
2002-05-22 |
Univ London |
Adeno-associated virus producer system
|
|
US20030198620A1
(en)
|
2002-04-16 |
2003-10-23 |
Keiya Ozawa |
Method of treating amino acid metabolic disorders using recombinant adeno-associated virus virions
|
|
ES2280694T3
(es)
|
2002-04-29 |
2007-09-16 |
The Trustees Of The University Of Pennsylvania |
Metodo para la extraccion directa y la amplificacion de virus integrados del adn celular de tejidos.
|
|
ATE427990T1
(de)
|
2002-04-30 |
2009-04-15 |
Oncolytics Biotech Inc |
Verbesserte reinigungsmethode fur viren
|
|
WO2003097797A2
(en)
|
2002-05-14 |
2003-11-27 |
Merck & Co., Inc. |
Methods of adenovirus purification
|
|
US7419817B2
(en)
|
2002-05-17 |
2008-09-02 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
|
|
WO2003104413A2
(en)
|
2002-06-05 |
2003-12-18 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
EP1418185A1
(en)
|
2002-11-11 |
2004-05-12 |
Aventis Pharma Deutschland GmbH |
Use of EDG2 receptor in an animal model of heart failure
|
|
US7169612B2
(en)
|
2002-11-11 |
2007-01-30 |
Sanofi-Aventis Deutschland Gmbh |
Use of EDG2 receptor in an animal model of heart failure
|
|
US7605249B2
(en)
|
2002-11-26 |
2009-10-20 |
Medtronic, Inc. |
Treatment of neurodegenerative disease through intracranial delivery of siRNA
|
|
US20050014264A1
(en)
|
2002-12-11 |
2005-01-20 |
University Of Massachusetts |
Method of introducing siRNA into adipocytes
|
|
US8946151B2
(en)
|
2003-02-24 |
2015-02-03 |
Northern Bristol N.H.S. Trust Frenchay Hospital |
Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
|
|
US7510872B2
(en)
|
2003-02-26 |
2009-03-31 |
Nationwide Children's Hospital |
Recombinant adeno-associated virus production
|
|
US20070172460A1
(en)
|
2003-03-19 |
2007-07-26 |
Jurgen Kleinschmidt |
Random peptide library displayed on aav vectors
|
|
WO2004108922A2
(en)
|
2003-04-25 |
2004-12-16 |
The Trustees Of The University Of Pennsylvania |
Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver
|
|
WO2005017101A2
(en)
|
2003-05-19 |
2005-02-24 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH |
Avian adenoassociated virus (aaav) and uses thereof
|
|
PT1625210E
(pt)
|
2003-05-21 |
2011-03-15 |
Genzyme Corp |
Métodos para produzir preparações de vírions de aav recombinantes substancialmente livres de capsídeos vazios
|
|
EP1486567A1
(en)
|
2003-06-11 |
2004-12-15 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Improved adeno-associated virus (AAV) vector for gene therapy
|
|
JP4888876B2
(ja)
|
2003-06-13 |
2012-02-29 |
田平 武 |
アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
|
|
PL3235827T3
(pl)
|
2003-06-19 |
2021-07-05 |
Genzyme Corporation |
Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowania
|
|
US7291498B2
(en)
|
2003-06-20 |
2007-11-06 |
The Trustees Of The University Of Pennsylvania |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
|
|
US7491508B2
(en)
|
2003-06-20 |
2009-02-17 |
The Trustees Of The University Of Pennsylvania |
Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
ES2391975T3
(es)
|
2003-07-25 |
2012-12-03 |
Genvec, Inc. |
Vacunas a base de vector adenovírico
|
|
EP2298926A1
(en)
|
2003-09-30 |
2011-03-23 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
US8137960B2
(en)
|
2003-12-04 |
2012-03-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Bovine adeno-associated viral (BAAV) vector and uses thereof
|
|
US20060166363A1
(en)
|
2004-01-27 |
2006-07-27 |
Sergei Zolotukhin |
Modified baculovirus expression system for production of pseudotyped rAAV vector
|
|
WO2006078279A2
(en)
|
2004-04-28 |
2006-07-27 |
The Trustees Of The University Of Pennsylvania |
Sequential delivery of immunogenic molecules via adenovirus and adeno-associated virus-mediated administrations
|
|
AU2005248147A1
(en)
|
2004-05-11 |
2005-12-08 |
Alphagen Co., Ltd. |
Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same
|
|
EP4170024A1
(en)
|
2004-06-01 |
2023-04-26 |
Genzyme Corporation |
Compositions and methods to prevent aav vector aggregation
|
|
US7427396B2
(en)
|
2004-06-03 |
2008-09-23 |
Genzyme Corporation |
AAV vectors for gene delivery to the lung
|
|
US7901921B2
(en)
|
2004-10-22 |
2011-03-08 |
Oncolytics Biotech Inc. |
Viral purification methods
|
|
CN1286981C
(zh)
|
2004-11-30 |
2006-11-29 |
华中科技大学同济医学院附属同济医院 |
表达人类cyp2j2反义基因的重组腺相关病毒及其制备方法
|
|
US8614101B2
(en)
|
2008-05-20 |
2013-12-24 |
Rapid Pathogen Screening, Inc. |
In situ lysis of cells in lateral flow immunoassays
|
|
US7625570B1
(en)
|
2005-03-10 |
2009-12-01 |
The Regents Of The University Of California |
Methods for purifying adeno-associated virus
|
|
WO2006102072A2
(en)
|
2005-03-23 |
2006-09-28 |
The Trustees Of The University Of Pennsylvania |
Use of a pa131 polypeptide in treatment of atherosclerosis
|
|
EP2357010B1
(en)
|
2005-04-07 |
2013-06-12 |
The Trustees of The University of Pennsylvania |
Method of increasing the function of an AAV vector
|
|
US8283151B2
(en)
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
CN107007842A
(zh)
|
2005-05-02 |
2017-08-04 |
建新公司 |
神经代谢疾病的基因治疗
|
|
WO2007024841A2
(en)
|
2005-08-23 |
2007-03-01 |
The Regents Of The University Of California |
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
|
|
EP1857552A1
(en)
|
2006-05-20 |
2007-11-21 |
Cargill Incorporated |
Thermostable xylose isomerase enzyme
|
|
WO2007046703A2
(en)
|
2005-10-20 |
2007-04-26 |
Amsterdam Molecular Therapeutics B.V. |
Improved aav vectors produced in insect cells
|
|
CA2623616A1
(en)
|
2005-11-29 |
2007-06-07 |
Surgi-Vision, Inc. |
Mri-guided localization and/or lead placement systems, related methods, devices and computer program products
|
|
EP2007795B1
(en)
|
2006-03-30 |
2016-11-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Aav capsid proteins
|
|
US20080003565A1
(en)
|
2006-05-02 |
2008-01-03 |
Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services |
Viral nucleic acid microarray and method of use
|
|
US8512981B2
(en)
|
2006-06-21 |
2013-08-20 |
Amsterdam Molecular Therapeutics B.V. |
Vectors with modified initiation codon for the translation of AAV-Rep78 useful for production of AAV
|
|
GB0613753D0
(en)
|
2006-07-11 |
2006-08-23 |
Norwegian Radium Hospital Res |
Method
|
|
WO2008018795A1
(en)
|
2006-08-11 |
2008-02-14 |
Prosensa Technologies B.V. |
Methods and means for treating dna repeat instability associated genetic disorders
|
|
WO2008144585A1
(en)
|
2007-05-17 |
2008-11-27 |
Medgenesis Therapeutix Inc. |
Convection-enhanced delivery catheter with removable stiffening member and method for using same
|
|
EP2158211B1
(en)
|
2007-05-31 |
2016-08-10 |
Medigene AG |
Mutated structural protein of a parvovirus
|
|
US8175677B2
(en)
|
2007-06-07 |
2012-05-08 |
MRI Interventions, Inc. |
MRI-guided medical interventional systems and methods
|
|
RU2491344C2
(ru)
|
2007-06-29 |
2013-08-27 |
Ф.Хоффманн-Ля Рош Аг |
Промотор
|
|
ES2615180T3
(es)
|
2007-07-14 |
2017-06-05 |
University Of Iowa Research Foundation |
Métodos y composiciones para el tratamiento de enfermedades cerebrales
|
|
EP2019143A1
(en)
|
2007-07-23 |
2009-01-28 |
Genethon |
CNS gene delivery using peripheral administration of AAV vectors
|
|
KR101597695B1
(ko)
|
2007-07-26 |
2016-02-25 |
유니큐어 아이피 비.브이. |
차등 코돈 바이어스를 갖는 반복 암호 서열을 포함하는 배큘로바이러스 벡터
|
|
US8420372B2
(en)
|
2007-09-04 |
2013-04-16 |
Alexander Bello |
Porcine adeno-associated viruses
|
|
US9115373B2
(en)
|
2007-09-19 |
2015-08-25 |
Uniqure Ip B.V. |
Use of AAV replication machinery for improved protein production
|
|
US8099150B2
(en)
|
2007-09-24 |
2012-01-17 |
MRI Interventions, Inc. |
MRI-compatible head fixation frame with cooperating head coil apparatus
|
|
US8548569B2
(en)
|
2007-09-24 |
2013-10-01 |
MRI Interventions, Inc. |
Head fixation assemblies for medical procedures
|
|
CA2700523A1
(en)
|
2007-09-24 |
2009-04-02 |
Surgivision, Inc. |
Mri-guided medical interventional systems and methods
|
|
EP2058401A1
(en)
|
2007-10-05 |
2009-05-13 |
Genethon |
Widespread gene delivery to motor neurons using peripheral injection of AAV vectors
|
|
US8340743B2
(en)
|
2007-11-21 |
2012-12-25 |
MRI Interventions, Inc. |
Methods, systems and computer program products for positioning a guidance apparatus relative to a patient
|
|
CA2706257C
(en)
|
2007-11-28 |
2017-06-06 |
The Trustees Of The University Of Pennsylvania |
Simian subfamily b adenovirus sadv-28, -27, -29, -32, -33 and -35 and uses thereof
|
|
EP2220217A2
(en)
|
2007-11-28 |
2010-08-25 |
The Trustees of the University of Pennsylvania |
Simian subfamily c adenoviruses sadv-40, -31, and-34 and uses thereof
|
|
CN101883858B
(zh)
|
2007-11-28 |
2015-07-22 |
宾夕法尼亚大学托管会 |
猿猴亚家族E腺病毒SAdV-39、-25.2、-26、-30、-37和-38及其应用
|
|
WO2009104964A1
(en)
|
2008-02-19 |
2009-08-27 |
Amsterdam Molecular Therapeutics B.V. |
Optimisation of expression of parvoviral rep and cap proteins in insect cells
|
|
CN102016011B
(zh)
|
2008-03-04 |
2013-12-11 |
宾夕法尼亚大学托管会 |
猿猴腺病毒sadv-36、-42.1、-42.2和-44及其应用
|
|
WO2009134681A2
(en)
|
2008-04-30 |
2009-11-05 |
The Trustees Of The University Of Pennsylvania |
Aav7 viral vectors for targeted delivery of rpe cells
|
|
US8632764B2
(en)
|
2008-04-30 |
2014-01-21 |
University Of North Carolina At Chapel Hill |
Directed evolution and in vivo panning of virus vectors
|
|
US9217155B2
(en)
|
2008-05-28 |
2015-12-22 |
University Of Massachusetts |
Isolation of novel AAV'S and uses thereof
|
|
MX2011003229A
(es)
|
2008-09-29 |
2011-09-06 |
Proyecto Biomedicina Cima Sl |
Terapia genica con porfobilinogeno desaminasa.
|
|
DK2350269T3
(en)
|
2008-10-31 |
2015-12-07 |
Univ Pennsylvania |
ABE ADENOVIRUS WITH SADV-46 HEXONCAPSIDE PROTEINS AND APPLICATIONS THEREOF
|
|
ES2634118T3
(es)
|
2009-02-11 |
2017-09-26 |
The University Of North Carolina At Chapel Hill |
Vectores de virus modificados y métodos para fabricar y utilizar los mismos
|
|
MX2011009193A
(es)
|
2009-03-04 |
2011-12-16 |
Deutsches Krebsforsch |
Proteina activadora del ensamblaje (aap) y su uso para la fabricacion de particulas de parvovirus que consisten esencialmente de vp3.
|
|
MX2011010097A
(es)
|
2009-03-27 |
2011-10-19 |
Proyecto Biomedicina Cima Sl |
Metodos y composiciones para el tratamiento de cirrosis y fibrosis hepatica.
|
|
ES2927225T3
(es)
|
2009-04-17 |
2022-11-03 |
Univ Oxford Innovation Ltd |
Composición para entrega de material genético
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
CA2762203A1
(en)
|
2009-05-29 |
2010-12-02 |
Soumitra Roy |
Simian adenovirus 41 and uses thereof
|
|
WO2012116265A2
(en)
|
2011-02-24 |
2012-08-30 |
MRI Interventions, Inc. |
Mri-guided catheters
|
|
CN102803478B
(zh)
|
2009-06-16 |
2016-04-27 |
建新公司 |
用于纯化重组aav载体的改进方法
|
|
EP2442717B1
(en)
|
2009-06-16 |
2020-11-25 |
ClearPoint Neuro, Inc. |
Mri-guided devices and mri-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
|
|
WO2011008495A2
(en)
|
2009-06-29 |
2011-01-20 |
The Board Of Regents Of The University Of Texas System |
Arginase formulations and methods
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
WO2011038187A1
(en)
|
2009-09-25 |
2011-03-31 |
The Trustees Of The University Of Pennsylvania |
Controlled adeno-associated virus (aav) diversification and libraries prepared therefrom
|
|
US20120309816A1
(en)
|
2009-11-09 |
2012-12-06 |
Genepod Therapeutics Ab |
Novel viral vector construct for neuron specific optimized continuous DOPA synthesis in vivo
|
|
ES2683695T3
(es)
|
2010-01-12 |
2018-09-27 |
The University Of North Carolina At Chapel Hill |
Repeticiones terminales invertidas restrictivas para vectores virales
|
|
CA2788682C
(en)
|
2010-02-05 |
2019-03-05 |
The University Of North Carolina At Chapel Hill |
Compositions and methods for enhanced parvovirus transduction
|
|
WO2011097641A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Methods and compositions useful in treatment of diseases or conditions related to repeat expansion
|
|
WO2011097614A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Mehods and compositions useful in diseases or conditions related to repeat expansion
|
|
WO2011101869A1
(en)
|
2010-02-22 |
2011-08-25 |
Transgene Biotek Ltd. |
Adeno-associated virus 2/8 - micro rna-101 therapy for liver cancer
|
|
EP2550021A2
(en)
|
2010-03-22 |
2013-01-30 |
Association Institut de Myologie |
Methods of increasing efficiency of vector penetration of target tissue
|
|
WO2011122950A1
(en)
|
2010-04-01 |
2011-10-06 |
Amsterdam Molecular Therapeutics (Amt) Ip B.V. |
Monomeric duplex aav vectors
|
|
WO2011130107A2
(en)
|
2010-04-16 |
2011-10-20 |
Surgivision, Inc. |
Mri surgical systems including mri-compatible surgical cannulae for transferring a substance to and/or from a patient
|
|
WO2011133874A1
(en)
|
2010-04-23 |
2011-10-27 |
University Of Massachusetts |
Multicistronic expression constructs
|
|
EP3514232A1
(en)
|
2010-04-23 |
2019-07-24 |
University of Massachusetts |
Cns targeting aav vectors and methods of use thereof
|
|
US8927514B2
(en)
|
2010-04-30 |
2015-01-06 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
EP2394667A1
(en)
|
2010-06-10 |
2011-12-14 |
Laboratorios Del Dr. Esteve, S.A. |
Vectors and sequences for the treatment of diseases
|
|
KR20180105730A
(ko)
|
2010-07-19 |
2018-09-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
근육긴장성 이영양증-단백질 키나제(dmpk) 발현의 조절 방법
|
|
US8808684B2
(en)
|
2010-09-10 |
2014-08-19 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction
|
|
CN103080314B
(zh)
|
2010-09-30 |
2016-04-13 |
Lsip基金运营联合公司 |
显性突变基因表达抑制剂
|
|
EP2612909B1
(en)
|
2010-10-05 |
2015-02-25 |
Takara Bio, Inc. |
Method for producing virus vector
|
|
CN107828820B
(zh)
|
2010-10-27 |
2022-06-07 |
学校法人自治医科大学 |
用于向神经系统细胞导入基因的腺相关病毒粒子
|
|
EP3075860A1
(en)
|
2010-11-23 |
2016-10-05 |
The Trustees of the University of Pennsylvania |
Subfamily e simian adenovirus a1295 and uses thereof
|
|
GB201103062D0
(en)
|
2011-02-22 |
2011-04-06 |
Isis Innovation |
Method
|
|
JP6091435B2
(ja)
|
2011-02-22 |
2017-03-08 |
カリフォルニア インスティチュート オブ テクノロジー |
アデノ随伴ウイルス（ａａｖ）ベクターを用いたタンパク質の送達
|
|
EP2500434A1
(en)
|
2011-03-12 |
2012-09-19 |
Association Institut de Myologie |
Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
|
|
EP2700399B1
(en)
|
2011-04-18 |
2017-05-31 |
National Center of Neurology and Psychiatry |
Drug delivery particles and method for producing same
|
|
ES2623780T3
(es)
|
2011-07-27 |
2017-07-12 |
Genethon |
Sistemas de expresión de baculovirus mejorados
|
|
CA3125150A1
(en)
|
2011-08-01 |
2013-02-07 |
Alcyone Lifesciences, Inc. |
Microfluidic drug delivery devices
|
|
ES2857773T5
(es)
|
2011-08-24 |
2024-06-04 |
Univ Leland Stanford Junior |
Nuevas proteínas de la cápside de AAV para la transferencia de ácidos nucleicos
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
WO2013036889A1
(en)
|
2011-09-09 |
2013-03-14 |
University Of Washington |
Retrograde transport peptide and use of same for delivery to central nervous system
|
|
JP6165752B2
(ja)
|
2011-10-28 |
2017-07-19 |
ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
アデノ随伴ウイルスの産生のための細胞株
|
|
WO2013078199A2
(en)
|
2011-11-23 |
2013-05-30 |
Children's Medical Center Corporation |
Methods for enhanced in vivo delivery of synthetic, modified rnas
|
|
WO2013096955A1
(en)
|
2011-12-23 |
2013-06-27 |
Case Western Reserve University |
Targeted gene modification using hybrid recombinant adeno-associated virus
|
|
BR112014020325A2
(pt)
|
2012-02-17 |
2017-08-08 |
Childrens Hospital Philadelphia |
composições de vetor do aav e métodos para a transferência de gene para as células, órgãos e tecidos
|
|
US20140162319A2
(en)
|
2012-05-02 |
2014-06-12 |
Sangeetha Hareendran |
Nucleotide sequences, methods, kit and a recombinant cell thereof
|
|
US9163259B2
(en)
|
2012-05-04 |
2015-10-20 |
Novartis Ag |
Viral vectors for the treatment of retinal dystrophy
|
|
EP2847337A4
(en)
|
2012-05-09 |
2016-04-27 |
Univ Oregon Health & Science |
ADENO ASSOCIATED VIRUS PLASMIDS AND VECTORS
|
|
JP6293738B2
(ja)
|
2012-05-18 |
2018-03-14 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
亜科ｅサルアデノウイルスａ１３０２、ａ１３２０、ａ１３３１及びａ１３３７ならびにそれらの使用
|
|
US9192393B2
(en)
|
2012-05-31 |
2015-11-24 |
MRI Interventions, Inc. |
MRI compatible surgical drills and related methods
|
|
WO2014007120A1
(ja)
|
2012-07-06 |
2014-01-09 |
タカラバイオ株式会社 |
アデノ随伴ウイルスベクターの産生細胞
|
|
US9498290B2
(en)
|
2012-07-19 |
2016-11-22 |
MRI Interventions, Inc. |
Surgical navigation devices and methods
|
|
US10206693B2
(en)
|
2012-07-19 |
2019-02-19 |
MRI Interventions, Inc. |
MRI-guided medical interventional systems and methods
|
|
US9031636B2
(en)
|
2012-07-19 |
2015-05-12 |
MRI Interventions, Inc. |
MRI-compatible head fixation apparatus
|
|
EP3769789A1
(en)
|
2012-08-01 |
2021-01-27 |
Nationwide Children's Hospital |
Intrathecal delivery of recombinant adeno-associated virus 9
|
|
US9192446B2
(en)
|
2012-09-05 |
2015-11-24 |
MRI Interventions, Inc. |
Trajectory guide frame for MRI-guided surgeries
|
|
EP2900821B1
(en)
|
2012-09-25 |
2020-04-01 |
Genzyme Corporation |
Peptide-linked morpholino antisense oligonucleotides for treatment of myotonic dystrophy
|
|
JP6387350B2
(ja)
|
2012-09-28 |
2018-09-05 |
ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル |
希突起神経膠細胞を標的とするアデノ随伴ウイルスベクター
|
|
US9567376B2
(en)
|
2013-02-08 |
2017-02-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
US9572928B2
(en)
|
2013-03-13 |
2017-02-21 |
MRI Interventions, Inc. |
Substance delivery devices, systems and methods
|
|
EP2970946A4
(en)
|
2013-03-13 |
2016-09-07 |
Philadelphia Children Hospital |
ADENOASSOZED VIRUS VECTORS AND METHOD FOR USE THEREOF
|
|
US9498575B2
(en)
|
2013-03-14 |
2016-11-22 |
MRI Interventions, Inc. |
Substance delivery devices, systems and methods
|
|
CA2904396A1
(en)
|
2013-03-15 |
2014-09-18 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for dual glycan binding aav vectors
|
|
US9618590B2
(en)
|
2013-03-15 |
2017-04-11 |
MRI Interventions, Inc. |
Tip assembly for MRI-compatible medical devices and MRI-compatible medical devices incorporating same
|
|
EP2983707B1
(en)
|
2013-04-08 |
2019-06-12 |
University of Iowa Research Foundation |
Chimeric adeno-associated virus/ bocavirus parvovirus vector
|
|
WO2014167074A1
(en)
|
2013-04-12 |
2014-10-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for modulating rna alternative splicing in a subject in need thereof
|
|
EP2792742A1
(en)
|
2013-04-17 |
2014-10-22 |
Universitätsklinikum Hamburg-Eppendorf (UKE) |
Gene-therapy vectors for treating cardiomyopathy
|
|
US10494645B2
(en)
|
2013-04-18 |
2019-12-03 |
Fondazione Telethon |
Effective delivery of large genes by dual AAV vectors
|
|
MX388221B
(es)
|
2013-04-20 |
2025-03-19 |
Res Institute At Nationwide Children´S Hospital |
ADMINISTRACIÓN DE VIRUS ADENO-ASOCIADO RECOMBINANTE DE CONSTRUCCIONES DE POLINUCLÉOTIDOS U7snRNA DIRIGIDA AL EXÓN 2.
|
|
WO2015012924A2
(en)
|
2013-04-29 |
2015-01-29 |
The Trustees Of The University Of Pennsylvania |
Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
|
|
AU2013388083B2
(en)
|
2013-05-01 |
2019-08-22 |
Genzyme Corporation |
Compositions and methods for treating spinal muscular atrophy
|
|
RU2692251C2
(ru)
|
2013-05-15 |
2019-06-24 |
Риджентс Оф Зэ Юниверсити Оф Миннесота |
Опосредованный аденоассоциированным вирусом перенос генов в центральную нервную систему
|
|
WO2014186746A1
(en)
|
2013-05-16 |
2014-11-20 |
University Of Florida Research Foundation, Inc. |
HAIRPIN mRNA ELEMENTS AND METHODS FOR THE REGULATION OF PROTEIN TRANSLATION
|
|
ES2897508T3
(es)
|
2013-05-31 |
2022-03-01 |
Univ California |
Variantes de virus adenoasociados y métodos de uso de las mismas
|
|
WO2014201252A2
(en)
|
2013-06-13 |
2014-12-18 |
Shire Human Genetic Therapies, Inc. |
Messenger rna based viral production
|
|
ITTO20130669A1
(it)
|
2013-08-05 |
2015-02-06 |
Consiglio Nazionale Ricerche |
Vettore adeno-associato ricombinante muscolo-specifico e suo impiego nel trattamento di patologie muscolari
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
US11078464B2
(en)
|
2013-08-30 |
2021-08-03 |
Amgen Inc. |
High titer recombinant AAV vector production in adherent and suspension cells
|
|
US20160355573A1
(en)
|
2013-09-05 |
2016-12-08 |
Cornell University |
Gene therapy for alzheimer's and other neurodegenerative diseases and conditions
|
|
US9585971B2
(en)
*
|
2013-09-13 |
2017-03-07 |
California Institute Of Technology |
Recombinant AAV capsid protein
|
|
US20160354489A1
(en)
|
2013-09-26 |
2016-12-08 |
Universitat Autònome de Barcelona |
Gene therapy compositions for use in the prevention and/or treatment of non-alcoholic fatty liver disease
|
|
JP6985795B2
(ja)
|
2013-09-26 |
2021-12-22 |
ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド |
標的遺伝子治療のための合成コンビナトリアルａａｖカプシドライブラリー
|
|
WO2015057807A1
(en)
|
2013-10-16 |
2015-04-23 |
MRI Interventions, Inc. |
Surgical navigation systems, related devices and methods
|
|
CA2927366A1
(en)
|
2013-10-24 |
2015-04-30 |
Uniqure Ip B.V. |
Aav-5 pseudotyped vector for gene therapy for neurological diseases
|
|
US10087224B2
(en)
|
2013-11-01 |
2018-10-02 |
Cornell University |
Gene therapy for Alzheimer's and other neurodegenerative diseases and conditions
|
|
WO2015108610A1
(en)
|
2013-11-08 |
2015-07-23 |
The Board Of Trustees Of The University Of Arkansas |
Adeno-associated virus "x" oncogene
|
|
GB201401707D0
(en)
|
2014-01-31 |
2014-03-19 |
Sec Dep For Health The |
Adeno-associated viral vectors
|
|
US10595744B2
(en)
|
2014-02-14 |
2020-03-24 |
MRI Interventions, Inc. |
Surgical tool-positioning devices and related methods
|
|
GB201403684D0
(en)
*
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
WO2015124546A1
(en)
|
2014-02-19 |
2015-08-27 |
Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii- Cnic |
Aav vectors for the treatment of ischemic and non-ischemic heart disease
|
|
WO2015127128A2
(en)
|
2014-02-19 |
2015-08-27 |
University Of Massachusetts |
Recombinant aavs having useful transcytosis properties
|
|
PL3117005T3
(pl)
|
2014-03-10 |
2024-11-04 |
Uniqure Ip B.V. |
Dodatkowo ulepszone wektory aav produkowane w komórkach owadzich
|
|
WO2015164778A1
(en)
|
2014-04-25 |
2015-10-29 |
The Trustees Of The University Of Pennysylvania |
Ldlr variants and their use in compositions for reducing cholesterol levels
|
|
EP4600255A3
(en)
|
2014-05-02 |
2025-10-22 |
Genzyme Corporation |
Aav vectors for retinal and cns gene therapy
|
|
MX381946B
(es)
|
2014-05-23 |
2025-03-13 |
Genzyme Corp |
Restos oligonucleotidicos multiples sobre soporte peptidico.
|
|
WO2015191508A1
(en)
|
2014-06-09 |
2015-12-17 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
WO2015196179A1
(en)
|
2014-06-20 |
2015-12-23 |
University Of Florida Research Foundation, Inc. |
Methods of packaging multiple adeno-associated virus vectors
|
|
WO2016006658A1
(ja)
|
2014-07-10 |
2016-01-14 |
タカラバイオ株式会社 |
非エンベロープウイルス粒子の製造方法
|
|
WO2016019364A1
(en)
|
2014-08-01 |
2016-02-04 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for self-regulated inducible gene expression
|
|
EP3800260A1
(en)
|
2014-09-24 |
2021-04-07 |
City of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
US10370432B2
(en)
|
2014-10-03 |
2019-08-06 |
University Of Massachusetts |
Heterologous targeting peptide grafted AAVS
|
|
US10711270B2
(en)
|
2014-10-03 |
2020-07-14 |
University Of Massachusetts |
High efficiency library-identified AAV vectors
|
|
RU2020140209A
(ru)
|
2014-10-21 |
2021-01-25 |
Юниверсити Оф Массачусетс |
Варианты рекомбинантных aav и их применения
|
|
RU2727015C2
(ru)
|
2014-11-21 |
2020-07-17 |
Дзе Юниверсити Оф Норт Каролина Эт Чепел Хилл |
Векторы aav, нацеленные на центральную нервную систему
|
|
US10900053B2
(en)
|
2014-11-21 |
2021-01-26 |
University Of Florida Research Foundation, Incorporated |
Genome-modified recombinant adeno-associated virus vectors
|
|
WO2016115382A1
(en)
|
2015-01-14 |
2016-07-21 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
MX2017009336A
(es)
*
|
2015-01-16 |
2017-11-15 |
Voyager Therapeutics Inc |
Polinucleótidos dirigidos al sistema nervioso central.
|
|
EP3250279B1
(en)
|
2015-01-30 |
2020-08-19 |
The Regents of the University of California |
Spinal subpial gene delivery system
|
|
US20180030096A1
(en)
|
2015-02-03 |
2018-02-01 |
University Of Florida Research Foundation, Inc. |
Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof
|
|
AU2016219398A1
(en)
|
2015-02-10 |
2017-09-28 |
Genzyme Corporation |
Enhanced delivery of viral particles to the striatum and cortex
|
|
CA2977355A1
(en)
|
2015-02-20 |
2016-08-25 |
University Of Iowa Research Foundation |
Methods and compositions for treating genetic eye diseases
|
|
US20180245073A1
(en)
|
2015-02-23 |
2018-08-30 |
Voyager Therapeutics, Inc. |
Regulatable expression using adeno-associated virus (aav)
|
|
EP3268475B1
(en)
|
2015-03-11 |
2020-10-21 |
Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. |
Decoy oligonucleotides for the treatment of diseases
|
|
CN107614008A
(zh)
|
2015-03-20 |
2018-01-19 |
蓝鸟生物公司 |
载体制剂
|
|
EP3273999A1
(en)
*
|
2015-03-23 |
2018-01-31 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia
|
|
EP3277819B1
(en)
|
2015-03-24 |
2021-03-03 |
The Regents of The University of California |
Adeno-associated virus variants and methods of use thereof
|
|
TWI707951B
(zh)
|
2015-04-08 |
2020-10-21 |
美商健臻公司 |
過大腺相關載體之製造
|
|
US10058624B2
(en)
|
2015-04-16 |
2018-08-28 |
Emory University |
Recombinant promoters and vectors for protein expression in liver and use thereof
|
|
US11020443B2
(en)
|
2015-04-23 |
2021-06-01 |
University Of Massachusetts |
Modulation of AAV vector transgene expression
|
|
WO2016172008A1
(en)
|
2015-04-24 |
2016-10-27 |
University Of Massachusetts |
Modified aav constructions and uses thereof
|
|
EP3286321A4
(en)
*
|
2015-04-24 |
2018-10-17 |
University of Florida Research Foundation, Inc. |
Aav vector for treatment of friedreich's ataxia
|
|
EP3291765A4
(en)
|
2015-05-07 |
2019-01-23 |
Massachusetts Eye & Ear Infirmary |
METHOD FOR THE DELIVERY OF AN ACTIVE SUBSTANCE TO THE EYE
|
|
CA2985786A1
(en)
|
2015-05-12 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav isolate and fusion protein comprising nerve growth factor signal peptide and parathyroid hormone
|
|
WO2016191418A1
(en)
|
2015-05-26 |
2016-12-01 |
Salk Institute For Biological Studies |
Motor neuron-specific expression vectors
|
|
WO2016196507A1
(en)
|
2015-05-29 |
2016-12-08 |
University Of Iowa Research Foundation |
Methods of delivery of transgenes for treating brain diseases
|
|
US11266748B2
(en)
|
2015-07-02 |
2022-03-08 |
University Of Florida Research Foundation, Incorporated |
Recombinant adeno-associated virus vectors to target medullary thyroid carcinoma
|
|
ES2895652T3
(es)
|
2015-07-07 |
2022-02-22 |
Inst Nat Sante Rech Med |
Métodos y composiciones farmacéuticas para expresar un polinucleótido de interés en el sistema nervioso periférico de un sujeto
|
|
US20180216133A1
(en)
|
2015-07-17 |
2018-08-02 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
US20180214576A1
(en)
|
2015-07-28 |
2018-08-02 |
University Of Massachusetts |
Transgenic expression of dnasei in vivo delivered by an adeno-associated virus vector
|
|
LT3872085T
(lt)
|
2015-07-30 |
2023-05-10 |
Massachusetts Eye & Ear Infirmary |
Viruso prototipo sekos ir jų panaudojimas
|
|
US11116843B2
(en)
|
2015-09-25 |
2021-09-14 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
|
EP3831842A1
(en)
|
2015-09-28 |
2021-06-09 |
The University of North Carolina at Chapel Hill |
Methods and compositions for antibody-evading virus vectors
|
|
WO2017066764A2
(en)
|
2015-10-16 |
2017-04-20 |
William Marsh Rice University |
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
|
|
CA3002982A1
(en)
|
2015-10-22 |
2017-04-27 |
University Of Massachusetts |
Methods and compositions for treating metabolic imbalance in neurodegenerative disease
|
|
US12188037B2
(en)
|
2015-10-22 |
2025-01-07 |
University Of Florida Research Foundation, Incorporated |
Synthetic combinatorial AAV3 capsid library
|
|
US11426469B2
(en)
|
2015-10-22 |
2022-08-30 |
University Of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
WO2017070678A1
(en)
|
2015-10-23 |
2017-04-27 |
University Of Iowa Research Foundation |
Methods for treating neurodegenerative diseases using gene therapy to delay disease onset and progression while providing cognitive protection
|
|
EP3368054A4
(en)
|
2015-10-28 |
2019-07-03 |
Voyager Therapeutics, Inc. |
REGULATORY EXPRESSION USING THE ADENO-ASSOCIATED VIRUS (AAV)
|
|
WO2017075338A2
(en)
|
2015-10-29 |
2017-05-04 |
Voyager Therapeutics, Inc. |
Delivery of central nervous system targeting polynucleotides
|
|
US10633662B2
(en)
|
2015-11-10 |
2020-04-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for modulating AAV infection
|
|
EP3374494A4
(en)
|
2015-11-11 |
2019-05-01 |
Coda Biotherapeutics, Inc. |
CRISPR COMPOSITIONS AND METHODS OF USE FOR GENE THERAPY
|
|
US10240145B2
(en)
|
2015-11-25 |
2019-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer
|
|
KR20180091863A
(ko)
|
2015-12-01 |
2018-08-16 |
스파크 테라퓨틱스, 인코포레이티드 |
임상적 사용에 적합한 무혈청 현탁 세포 배양 시스템에서 재조합 아데노-관련 바이러스(aav) 벡터를 생성하기 위한 확장가능한 방법
|
|
EP3383896A1
(en)
|
2015-12-03 |
2018-10-10 |
Genethon |
Compositions and methods for improving viral vector efficiency
|
|
AU2016366549B2
(en)
*
|
2015-12-11 |
2022-11-10 |
California Institute Of Technology |
Targeting peptides for directing adeno-associated viruses (AAVs)
|
|
WO2017100674A1
(en)
|
2015-12-11 |
2017-06-15 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aav1
|
|
ES2934848T3
(es)
|
2015-12-11 |
2023-02-27 |
Univ Pennsylvania |
Método de purificación escalable para AAV8
|
|
WO2017100704A1
(en)
|
2015-12-11 |
2017-06-15 |
The Trustees Of The University Of Pennsylvania |
Scalable purification method for aavrh10
|
|
GB201605126D0
(en)
|
2016-03-24 |
2016-05-11 |
Univ Nottingham |
Inhibitors and their uses
|
|
US10940161B2
(en)
|
2016-04-04 |
2021-03-09 |
University Of Florida Research Foundation, Incorporated |
Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
|
|
WO2017182581A1
(en)
|
2016-04-20 |
2017-10-26 |
Universität Basel |
A method for evaluating a candidate compound (t) for treating myotonic dystrophy type i (dm1)
|
|
ES2659845B1
(es)
|
2016-09-19 |
2019-01-04 |
Univ Valencia |
Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello
|
|
WO2018115477A1
(en)
|
2016-12-23 |
2018-06-28 |
Universite De Strasbourg |
Dynamin 2 inhibitor for the treatment of myotonic dystrophy
|
|
WO2018129384A1
(en)
|
2017-01-06 |
2018-07-12 |
Avidity Biosciences Llc |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
US11274300B2
(en)
|
2017-01-19 |
2022-03-15 |
Proqr Therapeutics Ii B.V. |
Oligonucleotide complexes for use in RNA editing
|
|
EP3662060A2
(en)
|
2017-08-03 |
2020-06-10 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|
|
US11680249B2
(en)
|
2017-08-28 |
2023-06-20 |
The Regents Of The University Of California |
Adeno-associated virus capsid variants and methods of use thereof
|
|
EP3687582A4
(en)
*
|
2017-09-29 |
2021-07-14 |
Voyager Therapeutics, Inc. |
RESCUE OF CENTRAL AND PERIPHERAL NEUROLOGICAL PHENOTYPE OF FRIEDREICH ATAXIA BY INTRAVENOUS ADMINISTRATION
|
|
TW202015742A
(zh)
*
|
2018-05-15 |
2020-05-01 |
美商航海家醫療公司 |
投遞腺相關病毒（ａａｖ）之組成物和方法
|
|
SG11202103151RA
(en)
|
2018-09-28 |
2021-04-29 |
Voyager Therapeutics Inc |
Frataxin expression constructs having engineered promoters and methods of use thereof
|
|
WO2020077165A1
(en)
|
2018-10-12 |
2020-04-16 |
Voyager Therapeutics, Inc. |
Compositions and methods for delivery of aav
|