BR112022004183A2 - Métodos e composições para modular a interação entre vírus adeno-associado (aav) e receptor de aav (aavr) para biodistribuição alterada de aav - Google Patents

Métodos e composições para modular a interação entre vírus adeno-associado (aav) e receptor de aav (aavr) para biodistribuição alterada de aav

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Publication number
BR112022004183A2
BR112022004183A2 BR112022004183A BR112022004183A BR112022004183A2 BR 112022004183 A2 BR112022004183 A2 BR 112022004183A2 BR 112022004183 A BR112022004183 A BR 112022004183A BR 112022004183 A BR112022004183 A BR 112022004183A BR 112022004183 A2 BR112022004183 A2 BR 112022004183A2
Authority
BR
Brazil
Prior art keywords
aav
adeno
compositions
methods
aavr
Prior art date
Application number
BR112022004183A
Other languages
English (en)
Inventor
Christopher Tipper
Eric Zinn
H Vandenberghe Luk
Original Assignee
Massachusetts Eye & Ear Infirmary
Schepens Eye Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye & Ear Infirmary, Schepens Eye Res Inst filed Critical Massachusetts Eye & Ear Infirmary
Publication of BR112022004183A2 publication Critical patent/BR112022004183A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

métodos e composições para modular a interação entre vírus adeno-associado (aav) e receptor de aav (aavr) para biodistribuição alterada de aav. a presente invenção refere-se a composições e métodos para alterar a biodistribuição de vírus adeno-associados (aavs) em indivíduos.
BR112022004183A 2019-09-09 2020-09-09 Métodos e composições para modular a interação entre vírus adeno-associado (aav) e receptor de aav (aavr) para biodistribuição alterada de aav BR112022004183A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962897973P 2019-09-09 2019-09-09
US201962934996P 2019-11-13 2019-11-13
PCT/US2020/050027 WO2021050614A2 (en) 2019-09-09 2020-09-09 Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav

Publications (1)

Publication Number Publication Date
BR112022004183A2 true BR112022004183A2 (pt) 2022-05-31

Family

ID=72826975

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022004183A BR112022004183A2 (pt) 2019-09-09 2020-09-09 Métodos e composições para modular a interação entre vírus adeno-associado (aav) e receptor de aav (aavr) para biodistribuição alterada de aav

Country Status (10)

Country Link
US (1) US20220411820A1 (pt)
EP (1) EP4028531A2 (pt)
JP (1) JP2022547197A (pt)
KR (1) KR20220054435A (pt)
CN (1) CN114667349A (pt)
AU (1) AU2020347165A1 (pt)
BR (1) BR112022004183A2 (pt)
CA (1) CA3153972A1 (pt)
IL (1) IL291136A (pt)
WO (1) WO2021050614A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11987801B2 (en) 2018-05-11 2024-05-21 Massachusetts Eye And Ear Infirmary Altering tissue tropism of adeno-associated viruses
US20240060087A1 (en) * 2021-01-08 2024-02-22 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav
WO2023023781A1 (en) * 2021-08-25 2023-03-02 Children's Medical Research Institute Modified aav capsid polypeptides and vectors
CA3229969A1 (en) * 2021-08-25 2023-03-02 Marti CABANES CREUS Modified aav capsids and vectors
WO2023095034A1 (en) * 2021-11-24 2023-06-01 Novartis Ag Modulators of adeno-associated virus transduction and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ758021A (en) 2013-10-11 2021-12-24 Massachusetts Eye & Ear Infirmary Methods of predicting ancestral virus sequences and uses thereof
JP7291397B2 (ja) * 2017-02-15 2023-06-15 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 血管系を通過する遺伝子移入の方法および組成物
UA127831C2 (uk) * 2017-11-27 2024-01-17 4Д Молекьюлар Терапьютикс Інк. Капсид аденоасоційованого вірусу та його застосування для інгібування ангіогенезу
US11987801B2 (en) 2018-05-11 2024-05-21 Massachusetts Eye And Ear Infirmary Altering tissue tropism of adeno-associated viruses

Also Published As

Publication number Publication date
EP4028531A2 (en) 2022-07-20
AU2020347165A1 (en) 2022-03-31
US20220411820A1 (en) 2022-12-29
WO2021050614A3 (en) 2021-05-20
CN114667349A (zh) 2022-06-24
KR20220054435A (ko) 2022-05-02
JP2022547197A (ja) 2022-11-10
CA3153972A1 (en) 2021-03-18
IL291136A (en) 2022-05-01
WO2021050614A2 (en) 2021-03-18

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