|
US4039388A
(en)
|
1976-06-04 |
1977-08-02 |
The United States Of America As Represented By The Government |
Diagnostic test for Niemann-Pick disease
|
|
US4501729A
(en)
|
1982-12-13 |
1985-02-26 |
Research Corporation |
Aerosolized amiloride treatment of retained pulmonary secretions
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
AU7966987A
(en)
|
1986-09-08 |
1988-04-07 |
Applied Biotechnology, Inc. |
Empty viral capsid vaccines
|
|
US4968603A
(en)
|
1986-12-31 |
1990-11-06 |
The Regents Of The University Of California |
Determination of status in neoplastic disease
|
|
EP0442926A1
(en)
|
1988-11-10 |
1991-08-28 |
Imperial Cancer Research Technology Limited |
Polypeptides
|
|
US5916563A
(en)
|
1988-11-14 |
1999-06-29 |
United States Of America |
Parvovirus protein presenting capsids
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
|
ES2026826A6
(es)
|
1991-03-26 |
1992-05-01 |
Ercros Sa |
Procedimiento para la produccion de una vacuna subunidad contra el parvovirus canino y otros virus relacionados.
|
|
US5773278A
(en)
|
1991-05-03 |
1998-06-30 |
Mount Sinai Medical Center |
Acid sphingomyelinase gene
|
|
US5858784A
(en)
|
1991-12-17 |
1999-01-12 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol- and liposome-based delivery
|
|
US5478745A
(en)
|
1992-12-04 |
1995-12-26 |
University Of Pittsburgh |
Recombinant viral vector system
|
|
EP0733103B1
(en)
|
1993-11-09 |
2004-03-03 |
Targeted Genetics Corporation |
Generation of high titers of recombinant aav vectors
|
|
US5869248A
(en)
|
1994-03-07 |
1999-02-09 |
Yale University |
Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
|
|
JPH10501686A
(ja)
|
1994-04-13 |
1998-02-17 |
ザ ロックフェラー ユニヴァーシティ |
神経系の細胞へのdnaのaav仲介送達
|
|
US6204059B1
(en)
|
1994-06-30 |
2001-03-20 |
University Of Pittsburgh |
AAV capsid vehicles for molecular transfer
|
|
US5599706A
(en)
|
1994-09-23 |
1997-02-04 |
Stinchcomb; Dan T. |
Ribozymes targeted to apo(a) mRNA
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
US6040183A
(en)
|
1995-06-07 |
2000-03-21 |
University Of North Carloina At Chapel Hill |
Helper virus-free AAV production
|
|
IL122206A0
(en)
|
1995-06-07 |
1998-04-05 |
Univ North Carolina |
Adeno-associated virus vectors for gene expression
|
|
US6083702A
(en)
|
1995-12-15 |
2000-07-04 |
Intronn Holdings Llc |
Methods and compositions for use in spliceosome mediated RNA trans-splicing
|
|
EP0883344B2
(en)
|
1995-12-15 |
2010-06-09 |
VIRxSYS Corporation |
Therapeutic molecules generated by trans-splicing
|
|
US5962313A
(en)
|
1996-01-18 |
1999-10-05 |
Avigen, Inc. |
Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme
|
|
AU4645697A
(en)
|
1996-09-11 |
1998-04-02 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Aav4 vector and uses thereof
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
WO1999001555A1
(en)
|
1997-07-03 |
1999-01-14 |
The United States Of America Represented By The Secretary, Department Of Health And Human Services |
Genes for niemann-pick type c disease
|
|
US6984517B1
(en)
|
1998-05-28 |
2006-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector and uses thereof
|
|
DE69939169D1
(de)
|
1998-05-28 |
2008-09-04 |
Us Gov Health & Human Serv |
Aav5 vektoren und deren verwendung
|
|
US6562958B1
(en)
|
1998-06-09 |
2003-05-13 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics
|
|
US8299321B2
(en)
|
1998-06-16 |
2012-10-30 |
Monsanto Technology Llc |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US20100293663A2
(en)
|
1998-06-16 |
2010-11-18 |
Thomas La Rosa |
Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US6544785B1
(en)
|
1998-09-14 |
2003-04-08 |
Mount Sinai School Of Medicine Of New York University |
Helper-free rescue of recombinant negative strand RNA viruses
|
|
AU774706B2
(en)
|
1998-09-22 |
2004-07-08 |
Johns Hopkins University, The |
Methods for large-scale production of recombinant AAV vectors
|
|
GB9822763D0
(en)
|
1998-10-20 |
1998-12-16 |
Univ Sheffield |
Immunoglobin variant
|
|
DE69936104T2
(de)
|
1998-11-05 |
2008-01-17 |
The Trustees Of The University Of Pennsylvania |
Nukleinsäuresequenzen des adeno-assoziierten virus des serotyps i, und vektoren und wirtszellen, die diese enthalten
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
EP1135468B1
(en)
|
1998-11-10 |
2010-01-06 |
University Of North Carolina At Chapel Hill |
Virus vectors and methods of making and administering the same
|
|
US6822071B1
(en)
|
1998-11-12 |
2004-11-23 |
The Regents Of The University Of California |
Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
|
|
EP1887081A2
(en)
|
1999-02-25 |
2008-02-13 |
Ceres Incorporated |
DNA Sequences
|
|
EP1033405A3
(en)
|
1999-02-25 |
2001-08-01 |
Ceres Incorporated |
Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
|
|
US20090087878A9
(en)
|
1999-05-06 |
2009-04-02 |
La Rosa Thomas J |
Nucleic acid molecules associated with plants
|
|
US20080229439A1
(en)
|
1999-05-06 |
2008-09-18 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement
|
|
US20110093981A9
(en)
|
1999-05-06 |
2011-04-21 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with transcription in plants and uses thereof for plant improvement
|
|
US20040031072A1
(en)
|
1999-05-06 |
2004-02-12 |
La Rosa Thomas J. |
Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
|
|
US20110214206A1
(en)
|
1999-05-06 |
2011-09-01 |
La Rosa Thomas J |
Nucleic acid molecules and other molecules associated with plants
|
|
US20130326723A1
(en)
|
1999-05-06 |
2013-12-05 |
Thomas J. La Rosa |
Soy nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7314912B1
(en)
|
1999-06-21 |
2008-01-01 |
Medigene Aktiengesellschaft |
AAv scleroprotein, production and use thereof
|
|
DE19933288A1
(de)
|
1999-07-15 |
2001-01-18 |
Medigene Ag |
Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung
|
|
US6596535B1
(en)
|
1999-08-09 |
2003-07-22 |
Targeted Genetics Corporation |
Metabolically activated recombinant viral vectors and methods for the preparation and use
|
|
WO2001046226A2
(en)
|
1999-12-22 |
2001-06-28 |
Aventis Pasteur Limited |
Chlamydia antigens and corresponding dna fragments and uses thereof
|
|
US6468524B1
(en)
|
2000-03-22 |
2002-10-22 |
The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
AAV4 vector and uses thereof
|
|
US20110131679A2
(en)
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
US20140130203A1
(en)
|
2000-04-19 |
2014-05-08 |
Thomas J. La Rosa |
Rice nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
JP2004520803A
(ja)
|
2000-04-21 |
2004-07-15 |
コリクサ コーポレイション |
尋常性挫瘡の治療および診断のための組成物および方法
|
|
US7465583B2
(en)
|
2000-06-01 |
2008-12-16 |
The University Of North Carolina At Chapel Hill |
Duplexed parvovirus vectors
|
|
AU6814901A
(en)
|
2000-06-01 |
2001-12-11 |
Univ North Carolina |
Methods and compounds for controlled release of recombinant parvovirus vectors
|
|
US7214786B2
(en)
|
2000-12-14 |
2007-05-08 |
Kovalic David K |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
US7749492B2
(en)
|
2001-01-05 |
2010-07-06 |
Nationwide Children's Hospital, Inc. |
AAV vectors and methods
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
EP1437938A2
(en)
|
2001-04-30 |
2004-07-21 |
Cell Genesys, Inc. |
Viral-mediated delivery and in vivo expression of polynucleotides encoding anti-angiogenic proteins
|
|
AU2002345250A1
(en)
|
2001-06-22 |
2003-01-08 |
Syngenta Participations Ag |
Plant disease resistance genes
|
|
WO2003008540A2
(en)
|
2001-06-22 |
2003-01-30 |
Syngenta Participations Ag |
Abiotic stress responsive polynucleotides and polypeptides
|
|
US6623729B2
(en)
|
2001-07-09 |
2003-09-23 |
Korea Advanced Institute Of Science And Technology |
Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
|
|
AU2001289843A1
(en)
|
2001-08-28 |
2002-02-13 |
Bayer Cropscience Ag |
Polypeptides for identifying herbicidally active compounds
|
|
WO2003033515A1
(en)
|
2001-10-15 |
2003-04-24 |
Corixa Corporation |
Compositions and methods for the therapy and diagnosis of acne vulgaris
|
|
EP1572893B1
(en)
|
2001-11-09 |
2009-01-07 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Production of adeno-associated virus in insect cells
|
|
CN103589692B
(zh)
|
2001-11-13 |
2018-07-24 |
宾夕法尼亚大学托管会 |
检测和/或鉴定腺伴随病毒(aav)序列以及分离所鉴定的新型序列的方法
|
|
DK2359869T3
(en)
|
2001-12-17 |
2019-04-15 |
Univ Pennsylvania |
Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof
|
|
EP1463805B1
(en)
|
2001-12-17 |
2014-10-22 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
US7071172B2
(en)
|
2002-04-30 |
2006-07-04 |
The University Of North Carolina At Chapel Hill |
Secretion signal vectors
|
|
SI1496944T1
(sl)
|
2002-05-01 |
2009-02-28 |
Univ Florida |
Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov
|
|
ITRM20020253A1
(it)
|
2002-05-08 |
2003-11-10 |
Univ Roma |
Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche.
|
|
JP2005185101A
(ja)
|
2002-05-30 |
2005-07-14 |
National Institute Of Agrobiological Sciences |
植物の全長cDNAおよびその利用
|
|
AU2003274397A1
(en)
|
2002-06-05 |
2003-12-22 |
University Of Florida |
Production of pseudotyped recombinant aav virions
|
|
US7306913B2
(en)
|
2002-12-20 |
2007-12-11 |
Applera Corporation |
Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof
|
|
DK1575517T3
(da)
|
2002-12-24 |
2012-05-14 |
Rinat Neuroscience Corp |
Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme
|
|
CA2528012C
(en)
|
2003-06-02 |
2015-11-24 |
University Of Massachusetts |
Methods and compositions for controlling efficacy of rna silencing
|
|
PL2657248T3
(pl)
|
2003-06-19 |
2017-09-29 |
Genzyme Corporation |
Wiriony AAV o zmniejszonej immunoreaktywności i ich zastosowanie
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US7473531B1
(en)
|
2003-08-08 |
2009-01-06 |
Colora Corporation |
Pancreatic cancer targets and uses thereof
|
|
US20060107345A1
(en)
|
2003-09-30 |
2006-05-18 |
Nickolai Alexandrov |
Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
|
|
EP1668143B1
(en)
|
2003-09-30 |
2013-03-20 |
The Trustees of The University of Pennsylvania |
Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor
|
|
KR101637908B1
(ko)
|
2004-04-07 |
2016-07-11 |
리나트 뉴로사이언스 코프. |
신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법
|
|
US20060171926A1
(en)
|
2004-04-30 |
2006-08-03 |
Passini Marco A |
Gene therapy for neurometabolic disorders
|
|
FR2874384B1
(fr)
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
CA2579519A1
(en)
|
2004-09-09 |
2006-03-16 |
The General Hospital Corporation |
Modulating phosphatase activity in cardiac cells
|
|
EP1828390B1
(en)
|
2004-12-15 |
2012-06-13 |
The University Of North Carolina At Chapel Hill |
Chimeric vectors
|
|
US20080213759A1
(en)
|
2005-01-05 |
2008-09-04 |
Shionogi & Co., Ltd. |
Novel Angiogenesis Inhibitor
|
|
WO2006092449A2
(en)
|
2005-03-02 |
2006-09-08 |
Metanomics Gmbh |
Process for the production of fine chemicals
|
|
US20140199313A1
(en)
|
2005-03-02 |
2014-07-17 |
Metanomics Gmbh |
Process for the Production of Fine Chemicals
|
|
AU2006242371A1
(en)
|
2005-04-29 |
2006-11-09 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for regulated expression of nucleic acid at post-transcriptional level
|
|
US8283151B2
(en)
|
2005-04-29 |
2012-10-09 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
|
|
EP1882392A4
(en)
|
2005-05-10 |
2009-07-01 |
Monsanto Technology Llc |
GENES AND THEIR USES FOR PLANT IMPROVEMENTS
|
|
WO2007011682A2
(en)
|
2005-07-15 |
2007-01-25 |
Regents Of The University Of California |
Methods and reagents for screening new drugs and for treating ion pump associated disorders and diseases
|
|
WO2007084773A2
(en)
|
2006-01-20 |
2007-07-26 |
University Of North Carolina At Chapel Hill |
Enhanced production of infectious parvovirus vectors in insect cells
|
|
US7867484B2
(en)
|
2006-01-27 |
2011-01-11 |
University Of North Carolina At Chapel Hill |
Heparin and heparan sulfate binding chimeric vectors
|
|
SI1986661T1
(sl)
|
2006-02-08 |
2018-12-31 |
Genzyme Corporation |
Genska terapija za Niemann-Pickovo bolezen tipa A
|
|
JP2009525757A
(ja)
|
2006-02-10 |
2009-07-16 |
ザ ユニバーシティ オブ シンシナティ |
心機能のレギュレータとしてのホスファターゼインヒビタープロテイン−1
|
|
US7588772B2
(en)
|
2006-03-30 |
2009-09-15 |
Board Of Trustees Of The Leland Stamford Junior University |
AAV capsid library and AAV capsid proteins
|
|
JP2009535339A
(ja)
|
2006-04-28 |
2009-10-01 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
低下されたキャプシド免疫原性を有する改変aavベクターおよびその使用
|
|
CN101528916B
(zh)
|
2006-04-28 |
2013-09-04 |
宾夕法尼亚大学托管会 |
规模可调的aav生产方法
|
|
WO2007148971A2
(en)
|
2006-06-21 |
2007-12-27 |
Amsterdam Molecular Therapeutics B.V. |
Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav in insect cells
|
|
WO2008088895A2
(en)
|
2007-01-18 |
2008-07-24 |
University Of Missouri-Columbia |
Synthetic mini/micro-dystrophin genes to restore nnos to the sarcolemma
|
|
US20120322861A1
(en)
|
2007-02-23 |
2012-12-20 |
Barry John Byrne |
Compositions and Methods for Treating Diseases
|
|
DK2623605T3
(en)
|
2007-04-09 |
2019-03-25 |
Univ Florida |
RAAV VECTOR COMPOSITIONS WITH TYROSIN MODIFIED CAPSIDE PROTEINS AND PROCEDURES FOR USE THEREOF
|
|
US9611302B2
(en)
|
2007-04-09 |
2017-04-04 |
University Of Florida Research Foundation, Inc. |
High-transduction-efficiency RAAV vectors, compositions, and methods of use
|
|
US9725485B2
(en)
|
2012-05-15 |
2017-08-08 |
University Of Florida Research Foundation, Inc. |
AAV vectors with high transduction efficiency and uses thereof for gene therapy
|
|
KR100911624B1
(ko)
|
2007-05-14 |
2009-08-12 |
연세대학교 산학협력단 |
Il-12 및 il-23의 효율적인 공동발현 방법
|
|
BRPI0817005A2
(pt)
|
2007-09-18 |
2019-09-24 |
Basf Plant Science Gmbh |
método para produzir uma célula de planta transgênica, uma planta ou uma parte da mesma com rendimento aumentado, molécula de ácido nucleico, construção de ácido nucleico, vetor, célula hospedeira, processo para produzir um polipeptídeo, polipeptídeo, anticorpo, núcleo de célula de planta transgênica, célula de planta, tecido de planta, material de propagação, material colhido, planta ou parte da mesma, semente, processo para identificar um composto, método para produzir uma composição agrícola, composição, e, uso de uma molécula de ácido nucleico
|
|
EP2058401A1
(en)
|
2007-10-05 |
2009-05-13 |
Genethon |
Widespread gene delivery to motor neurons using peripheral injection of AAV vectors
|
|
US10526627B2
(en)
|
2007-11-30 |
2020-01-07 |
Corn Products Development, Inc |
Method for producing high molecular weight reduced viscosity starch pastes
|
|
EP2250268A4
(en)
|
2008-02-20 |
2011-08-24 |
Ceres Inc |
IMPROVED NITROGEN USE OF EFFICIENCY PROPERTIES IN PLANT NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES
|
|
US20090221620A1
(en)
|
2008-02-20 |
2009-09-03 |
Celera Corporation |
Gentic polymorphisms associated with stroke, methods of detection and uses thereof
|
|
WO2009108274A2
(en)
|
2008-02-26 |
2009-09-03 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for adeno-associated virus (aav) with hi loop mutations
|
|
EP2910637A1
(en)
|
2008-05-20 |
2015-08-26 |
University of Florida Research Foundation, Inc. |
Vectors for delivery of light-sensitive proteins and methods of use
|
|
JP2010002479A
(ja)
|
2008-06-18 |
2010-01-07 |
Crossfor:Kk |
メガネレンズ用装飾体およびメガネ用装飾体装着具
|
|
US9415121B2
(en)
|
2008-12-19 |
2016-08-16 |
Nationwide Children's Hospital |
Delivery of MECP2 polynucleotide using recombinant AAV9
|
|
EP2396343B1
(en)
|
2009-02-11 |
2017-05-17 |
The University of North Carolina At Chapel Hill |
Modified virus vectors and methods of making and using the same
|
|
US8679837B2
(en)
|
2009-04-02 |
2014-03-25 |
University Of Florida Research Foundation, Inc. |
Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors
|
|
SI3988660T1
(sl)
|
2009-05-02 |
2025-09-30 |
Genzyme Corporation |
Genska terapija za nevrodegenerativne motnje
|
|
US8734809B2
(en)
|
2009-05-28 |
2014-05-27 |
University Of Massachusetts |
AAV's and uses thereof
|
|
WO2011020118A1
(en)
|
2009-08-14 |
2011-02-17 |
Theramind Research, Llc |
Methods and compositions for treatment of tuberous sclerosis complex
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
WO2011122950A1
(en)
|
2010-04-01 |
2011-10-06 |
Amsterdam Molecular Therapeutics (Amt) Ip B.V. |
Monomeric duplex aav vectors
|
|
DK2561073T3
(en)
|
2010-04-23 |
2016-12-12 |
Univ Massachusetts |
Aav vectors targeted to central nervous system and methods of use thereof
|
|
US8628966B2
(en)
|
2010-04-30 |
2014-01-14 |
City Of Hope |
CD34-derived recombinant adeno-associated vectors for stem cell transduction and systemic therapeutic gene transfer
|
|
US8927514B2
(en)
|
2010-04-30 |
2015-01-06 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
US9839696B2
(en)
|
2010-04-30 |
2017-12-12 |
City Of Hope |
Recombinant adeno-associated vectors for targeted treatment
|
|
WO2011140279A1
(en)
|
2010-05-04 |
2011-11-10 |
Wayne State University |
Aav-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
|
|
US10738326B2
(en)
|
2010-10-27 |
2020-08-11 |
Jichi Medical University |
Adeno-associated virus vector for gene transfer to nervous system cells
|
|
US10568307B2
(en)
|
2010-11-05 |
2020-02-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Stabilized step function opsin proteins and methods of using the same
|
|
US10415056B2
(en)
|
2010-11-10 |
2019-09-17 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
|
|
CA2826273C
(en)
|
2011-02-10 |
2021-11-02 |
The University Of North Carolina At Chapel Hill |
Viral vectors with modified transduction profiles and methods of making and using the same
|
|
ES2685611T3
(es)
|
2011-02-14 |
2018-10-10 |
The Children's Hospital Of Philadelphia |
Vector VAA8 mejorado con una actividad funcional aumentada y métodos de utilización del mismo
|
|
US9598468B2
(en)
|
2011-05-18 |
2017-03-21 |
University Of Florida Research Foundation, Incorporated |
Polypeptides and vectors for targeting HER2/neu expressing cells and uses thereof
|
|
WO2012178173A1
(en)
|
2011-06-24 |
2012-12-27 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
WO2013016315A1
(en)
|
2011-07-28 |
2013-01-31 |
Trustees Of Dartmouth College |
Methods for treating niemann-pick type c disease
|
|
AU2012298157B9
(en)
|
2011-08-23 |
2019-05-02 |
Evogene Ltd. |
Isolated polynucleotides and polypeptides, and methods of using same for increasing plant yield and/or agricultural characteristics
|
|
EP2782596A4
(en)
|
2011-11-22 |
2015-07-29 |
Philadelphia Children Hospital |
VIRUS VECTORS FOR HIGHLY EFFICIENT TRANSGENIC ADMINISTRATION
|
|
FI124176B
(en)
|
2011-12-01 |
2014-04-15 |
Helsingin Yliopisto |
Polypeptide, polynucleotide, expression cassette, vector, host cell, plant and uses
|
|
US20140350087A9
(en)
|
2012-03-22 |
2014-11-27 |
Halozyme, Inc. |
Oncovector Nucleic Acid Molecules and Methods of Use
|
|
ES2660129T3
(es)
|
2012-03-27 |
2018-03-20 |
Curevac Ag |
Moléculas de ácido nucleico artificiales que comprenden un 5'UTR-TOP
|
|
JP6342886B2
(ja)
|
2012-04-18 |
2018-06-13 |
ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアThe Children’S Hospital Of Philadelphia |
Aavカプシドバリアントを使用した高効率な遺伝子導入のための組成物及び方法
|
|
EP2660325A3
(en)
|
2012-05-02 |
2014-02-12 |
Christian Medical College |
AAV vectors and corresponding nucleotide sequences and methods
|
|
EP3470523A1
(en)
|
2012-05-09 |
2019-04-17 |
Oregon Health & Science University |
Adeno associated virus plasmids and vectors
|
|
TWI698240B
(zh)
|
2012-05-15 |
2020-07-11 |
澳大利亞商艾佛蘭屈澳洲私營有限公司 |
使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
|
|
US10294281B2
(en)
|
2012-05-15 |
2019-05-21 |
University Of Florida Research Foundation, Incorporated |
High-transduction-efficiency rAAV vectors, compositions, and methods of use
|
|
EP2492347A1
(en)
|
2012-05-22 |
2012-08-29 |
Laboratorios Del. Dr. Esteve, S.A. |
Methods for the production of vectors
|
|
CN104704123A
(zh)
|
2012-06-21 |
2015-06-10 |
肌肉学研究协会 |
基因治疗载体的广泛的基因递送
|
|
HK1210214A1
(en)
|
2012-07-06 |
2016-04-15 |
University Of Iowa Research Foundation |
Modified adeno-associated virus vector compositions
|
|
HUE051612T2
(hu)
|
2012-07-11 |
2021-03-01 |
Sangamo Therapeutics Inc |
Eljárások és készítmények lizoszomális tárolási betegségek kezelésére
|
|
JP5971661B2
(ja)
|
2012-09-19 |
2016-08-17 |
国立大学法人 東京大学 |
神経活動依存的プロモータ活性を有するdna、及びこれを含むベクター
|
|
US9683268B2
(en)
|
2012-09-19 |
2017-06-20 |
Beth Israel Deaconess |
Viruses associated with immunodeficiency and enteropathy and methods using same
|
|
PL2900686T3
(pl)
|
2012-09-28 |
2021-01-25 |
The University Of North Carolina At Chapel Hill |
Wektory aav ukierunkowane na oligodendrocyty
|
|
US9066966B2
(en)
|
2013-02-01 |
2015-06-30 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia
|
|
US10266845B2
(en)
|
2013-02-08 |
2019-04-23 |
The Trustees Of The University Of Pennsylvania |
Enhanced AAV-mediated gene transfer for retinal therapies
|
|
WO2014124282A1
(en)
|
2013-02-08 |
2014-08-14 |
The Trustees Of The University Of Pennsylvania |
Enhanced aav-mediated gene transfer for retinal therapies
|
|
WO2014153083A1
(en)
|
2013-03-14 |
2014-09-25 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for predicting age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect
|
|
ES2926774T3
(es)
|
2013-03-15 |
2022-10-28 |
Univ North Carolina Chapel Hill |
Métodos y composiciones para vectores AAV de doble unión de glicano
|
|
KR102298579B1
(ko)
|
2013-05-21 |
2021-09-07 |
유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 |
캡시드-변형된 raav3 벡터 조성물, 및 인간 간암의 유전자 요법에서의 용도
|
|
US11136557B2
(en)
|
2013-05-31 |
2021-10-05 |
The Regents Of The University Of California |
Adeno-associated virus variants and methods of use thereof
|
|
NZ716102A
(en)
|
2013-07-22 |
2021-12-24 |
The Children’S Hospital Of Philadelphia |
Variant aav and compositions, methods and uses for gene transfer to cells, organs and tissues
|
|
EP3564379A1
(en)
|
2013-09-13 |
2019-11-06 |
California Institute of Technology |
Selective recovery
|
|
EP3049527A4
(en)
|
2013-09-26 |
2017-08-16 |
University of Florida Research Foundation, Inc. |
Synthetic combinatorial aav capsid library for targeted gene therapy
|
|
US20160256571A1
(en)
|
2013-09-30 |
2016-09-08 |
Sanofi |
Invention
|
|
HUE052676T2
(hu)
|
2013-10-11 |
2021-05-28 |
Massachusetts Eye & Ear Infirmary |
Eljárások õsi vírusszekvenciák elõrejelzésére és alkalmazásaik
|
|
GB201403684D0
(en)
|
2014-03-03 |
2014-04-16 |
King S College London |
Vector
|
|
WO2015127128A2
(en)
|
2014-02-19 |
2015-08-27 |
University Of Massachusetts |
Recombinant aavs having useful transcytosis properties
|
|
WO2015126972A1
(en)
|
2014-02-21 |
2015-08-27 |
University Of Florida Research Foundation, Inc. |
Methods and compositions for gene delivery to on bipolar cells
|
|
EP3113787B1
(en)
|
2014-03-04 |
2019-12-04 |
University of Florida Research Foundation, Inc. |
Improved raav vectors and methods for transduction of photoreceptors and rpe cells
|
|
US10746742B2
(en)
|
2014-04-25 |
2020-08-18 |
Oregon Health & Science University |
Methods of viral neutralizing antibody epitope mapping
|
|
LT3137497T
(lt)
|
2014-05-02 |
2021-07-26 |
Genzyme Corporation |
Aav vektoriai, skirti tinklainės ir cns genų terapijai
|
|
SG11201609314XA
(en)
|
2014-05-14 |
2016-12-29 |
Esteve Labor Dr |
Adenoassociated virus vectors for the treatment of lysosomal storage disorders
|
|
US20170088852A1
(en)
|
2014-05-28 |
2017-03-30 |
Evogene Ltd. |
Isolated polynucleotides, polypeptides and methods of using same for increasing abiotic stress tolerance, biomass and yield of plants
|
|
US10577627B2
(en)
|
2014-06-09 |
2020-03-03 |
Voyager Therapeutics, Inc. |
Chimeric capsids
|
|
CA2953341C
(en)
|
2014-06-25 |
2023-01-24 |
Acuitas Therapeutics Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
US9818383B2
(en)
|
2014-07-28 |
2017-11-14 |
University Of Connecticut |
Methods and systems for non-destructive analysis of objects and production of replica objects
|
|
WO2016049230A1
(en)
|
2014-09-24 |
2016-03-31 |
City Of Hope |
Adeno-associated virus vector variants for high efficiency genome editing and methods thereof
|
|
WO2016054557A1
(en)
|
2014-10-03 |
2016-04-07 |
University Of Massachusetts |
Novel high efficiency library-identified aav vectors
|
|
WO2016065001A1
(en)
|
2014-10-21 |
2016-04-28 |
University Of Massachusetts |
Recombinant aav variants and uses thereof
|
|
AU2015349759B2
(en)
|
2014-11-21 |
2022-01-06 |
The University Of North Carolina At Chapel Hill |
Aav vectors targeted to the central nervous system
|
|
AU2016206624B2
(en)
|
2015-01-14 |
2020-08-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
EP3632923A1
(en)
|
2015-01-16 |
2020-04-08 |
Voyager Therapeutics, Inc. |
Central nervous system targeting polynucleotides
|
|
WO2016126857A1
(en)
|
2015-02-03 |
2016-08-11 |
University Of Florida Research Foundation, Inc. |
Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof
|
|
GB201502305D0
(en)
|
2015-02-12 |
2015-04-01 |
Hansa Medical Ab |
Protein
|
|
GB201502306D0
(en)
|
2015-02-12 |
2015-04-01 |
Hansa Medical Ab |
Protein
|
|
WO2016134338A1
(en)
|
2015-02-19 |
2016-08-25 |
University Of Florida Research Foundation, Inc. |
Recombinant aav vectors for gene therapy of human hematopoietic disorders
|
|
FI3265178T3
(fi)
|
2015-03-02 |
2026-08-03 |
Adverum Biotechnologies Inc |
Koostumuksia ja menetelmiä polynukleotidien viemiseksi intravitreaalisesti retinaalisiin tappisoluihin
|
|
WO2016150964A1
(en)
|
2015-03-23 |
2016-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical composition for the treatment and the prevention of neurological phenotype associated with friedreich ataxia
|
|
JP6836999B2
(ja)
|
2015-03-24 |
2021-03-03 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
アデノ随伴ウイルス変異体及びその使用方法
|
|
US10081659B2
(en)
|
2015-04-06 |
2018-09-25 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
Adeno-associated vectors for enhanced transduction and reduced immunogenicity
|
|
EP3280451B8
(en)
*
|
2015-04-08 |
2019-09-25 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Viral gene therapy as treatment for cholesterol storage disease or disorder
|
|
EP3285788B1
(en)
*
|
2015-04-23 |
2024-12-18 |
University of Massachusetts |
Modulation of aav vector transgene expression
|
|
US11046955B2
(en)
|
2015-04-24 |
2021-06-29 |
University Of Massachusetts |
Modified AAV constructs and uses thereof
|
|
AU2016259976B2
(en)
|
2015-05-08 |
2021-10-14 |
Children's Medical Research Institute |
Promoters for expression of heterologous genes
|
|
GB201508026D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Capsid
|
|
GB201508025D0
(en)
|
2015-05-11 |
2015-06-24 |
Ucl Business Plc |
Fabry disease gene therapy
|
|
WO2016183297A1
(en)
|
2015-05-12 |
2016-11-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav isolate and fusion protein comprising nerve growth factor signal peptide and parathyroid hormone
|
|
WO2017015102A1
(en)
|
2015-07-17 |
2017-01-26 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for achieving high levels of transduction in human liver cells
|
|
EP3907231A1
(en)
|
2015-07-19 |
2021-11-10 |
Yeda Research and Development Co., Ltd. |
Selective inhibitors of alpha2-containing isoforms of na,k-atpase and use thereof for reducing intraocular pressure
|
|
CA2988471A1
(en)
|
2015-07-28 |
2017-02-02 |
University Of Massachusetts |
Transgenic expression of dnase i in vivo delivered by an adeno-associated virus vector
|
|
EP4134375A1
(en)
|
2015-07-30 |
2023-02-15 |
Massachusetts Eye & Ear Infirmary |
Ancestral adeno associated virus sequences and uses thereof
|
|
IL314171A
(en)
|
2015-09-28 |
2024-09-01 |
Univ Florida |
Methods and compositions for antibody-evading virus vectors
|
|
WO2017066764A2
(en)
|
2015-10-16 |
2017-04-20 |
William Marsh Rice University |
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
|
|
WO2017070516A1
(en)
|
2015-10-22 |
2017-04-27 |
University Of Massachusetts |
Prostate-targeting adeno-associated virus serotype vectors
|
|
SG10201912763QA
(en)
|
2015-11-05 |
2020-02-27 |
Bamboo Therapeutics Inc |
Modified friedreich ataxia genes and vectors for gene therapy
|
|
EP3384015A4
(en)
|
2015-12-01 |
2019-05-29 |
Spark Therapeutics, Inc. |
SCALABLE PROCESS FOR THE PREPARATION OF A RECOMBINANT ADENO ASSOCIATED VIRAL VECTOR IN A SERUM-FREE SUSPENSION CELL CULTURE SYSTEM SUITABLE FOR THE CLINICAL APPLICATION
|
|
US10406244B2
(en)
|
2015-12-02 |
2019-09-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
AAV vectors with expanded packaging capacity
|
|
WO2017096164A1
(en)
|
2015-12-02 |
2017-06-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Novel recombinant adeno-associated virus capsids with enhanced human skeletal muscle tropism
|
|
AU2016366549B2
(en)
*
|
2015-12-11 |
2022-11-10 |
California Institute Of Technology |
Targeting peptides for directing adeno-associated viruses (AAVs)
|
|
US11124546B2
(en)
|
2015-12-14 |
2021-09-21 |
The University Of North Carolina At Chapel Hill |
Modified capsid proteins for enhanced delivery of parvovirus vectors
|
|
CA3012344A1
(en)
|
2016-02-12 |
2017-08-17 |
University Of Massachusetts |
Anti-angiogenic mirna therapeutics for inhibiting corneal neovascularization
|
|
CA3014637A1
(en)
|
2016-02-16 |
2017-08-24 |
Mark A. Kay |
Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
|
|
CN108697774A
(zh)
|
2016-02-22 |
2018-10-23 |
北卡罗来纳大学教堂山分校 |
治疗mps i-相关失明的aav-idua载体
|
|
CN109661470A
(zh)
|
2016-04-15 |
2019-04-19 |
宾夕法尼亚州大学信托人 |
新型aav8突变衣壳和含有其的组合物
|
|
CN109121395B
(zh)
|
2016-04-15 |
2022-08-09 |
全国儿童医院研究所 |
腺相关病毒载体递送β-肌聚糖和微RNA-29以及肌营养不良症的治疗
|
|
WO2017192750A1
(en)
|
2016-05-04 |
2017-11-09 |
Oregon Health & Science University |
Recombinant adeno-associated viral vectors
|
|
WO2017197355A2
(en)
|
2016-05-13 |
2017-11-16 |
4D Molecular Therapeutics Inc. |
Adeno-associated virus variant capsids and methods of use thereof
|
|
US10584337B2
(en)
|
2016-05-18 |
2020-03-10 |
Voyager Therapeutics, Inc. |
Modulatory polynucleotides
|
|
AU2017299779B2
(en)
|
2016-07-21 |
2021-12-02 |
Spark Therapeutics, Inc. |
Scalable high recovery methods for producing high yield recombinant adeno-associated viral (rAAV) vector and recombinant adeno-associated viral (rAAV) vectors produced thereby
|
|
JP6994018B2
(ja)
|
2016-07-26 |
2022-01-14 |
バイオマリン ファーマシューティカル インコーポレイテッド |
新規アデノ随伴ウイルスキャプシドタンパク質
|
|
CA3033125A1
(en)
|
2016-08-16 |
2018-02-22 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for targeted gene transfer
|
|
SG11201901757YA
(en)
|
2016-09-08 |
2019-03-28 |
Bluebird Bio Inc |
Pd-1 homing endonuclease variants, compositions, and methods of use
|
|
US11078238B2
(en)
|
2016-09-29 |
2021-08-03 |
University Of Florida Research Foundation, Incorporated |
AAVrh.10 variants with host antibody escape capabilities and altered tissue targeting properties
|
|
AU2017345470B2
(en)
|
2016-10-19 |
2023-08-03 |
Adverum Biotechnologies, Inc. |
Modified AAV capsids and uses thereof
|
|
US20230048025A1
(en)
|
2016-12-22 |
2023-02-16 |
Oregon Health & Science University |
Adeno associated viral vectors
|
|
EP3583220A4
(en)
|
2017-02-15 |
2021-07-07 |
The University of North Carolina at Chapel Hill |
PROCEDURES AND COMPOSITIONS FOR GENERAL TRANSFER IN THE VASCULAR SYSTEM
|
|
RS65241B1
(sr)
|
2017-02-28 |
2024-03-29 |
Univ Pennsylvania |
Vektor adeno-asociranih virusa (aav) iz podgrupe f i njegove upotrebe
|
|
US10550405B2
(en)
|
2017-03-15 |
2020-02-04 |
The University Of North Carolina At Chapel Hill |
Rational polyploid adeno-associated virus vectors and methods of making and using the same
|
|
WO2018170310A1
(en)
|
2017-03-15 |
2018-09-20 |
The University Of North Carolina At Chapel Hill |
Polyploid adeno-associated virus vectors and methods of making and using the same
|
|
US20210254056A1
(en)
|
2017-05-05 |
2021-08-19 |
Camp4 Therapeutics Corporation |
Identification and targeted modulation of gene signaling networks
|
|
WO2018209154A1
(en)
|
2017-05-10 |
2018-11-15 |
Massachusetts Eye And Ear Infirmary |
Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses
|
|
BR112019024608A2
(pt)
|
2017-05-24 |
2020-06-23 |
Universitat Autonoma De Barcelona |
Construto de expressão viral que compreende uma sequência de codificação do fator de crescimento de fibroblastos 21 (fgf21)
|
|
EP3635122A4
(en)
|
2017-06-06 |
2021-03-31 |
University of Massachusetts |
SELF-REGULATING AAV VECTORS FOR THE SAFE EXPRESSION OF MECP2 IN RETT SYNDROME
|
|
CA3068010A1
(en)
|
2017-06-20 |
2018-12-27 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Codon-optimized human npc1 genes for the treatment of niemann-pick type c1 deficiency and related conditions
|
|
CN111511375A
(zh)
|
2017-06-30 |
2020-08-07 |
因提玛生物科学公司 |
用于基因治疗的腺相关病毒载体
|
|
US20210228738A1
(en)
|
2017-07-17 |
2021-07-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Compositions and methods for increasing or enhancing transduction of gene therapy vectors and for removing or reducing immunoglobulins
|
|
CA3071769A1
(en)
*
|
2017-07-31 |
2019-02-07 |
Reflection Biotechnologies Limited |
Cellular models of and therapies for ocular diseases
|
|
JP7389040B2
(ja)
|
2018-01-17 |
2023-11-29 |
メイラジーティーエックス・ユーケー・ザ・セカンド・リミテッド |
遺伝子治療のための修飾rAAVキャプシドタンパク質
|
|
EP3768695A4
(en)
|
2018-02-27 |
2022-04-06 |
The Trustees of the University of Pennsylvania |
NOVEL ADENO-ASSOCIATED VIRUS (AAV) VECTORS, AAV VECTORS WITH REDUCED CAPSIID DEAMIDATION AND USES THEREOF
|
|
IL276859B2
(en)
|
2018-02-27 |
2025-12-01 |
Univ Pennsylvania |
Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor
|
|
CA3092107A1
(en)
|
2018-02-28 |
2019-09-06 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for antibody-evading virus vectors
|
|
EP3762500A1
(en)
|
2018-03-06 |
2021-01-13 |
Voyager Therapeutics, Inc. |
Insect cell manufactured partial self-complementary aav genomes
|
|
US11905524B2
(en)
|
2018-03-06 |
2024-02-20 |
University Of Florida Research Foundation, Incorporated |
AAV chimeras
|
|
IL277270B2
(en)
|
2018-03-16 |
2025-05-01 |
Res Inst Nationwide Childrens Hospital |
Increasing tissue-specific gene delivery through capsid modification
|
|
BR112020020266A2
(pt)
|
2018-04-03 |
2021-01-19 |
Stridebio, Inc. |
Vetores de vírus com evasão de anticorpos
|
|
CA3095179A1
(en)
|
2018-04-03 |
2019-10-10 |
Stridebio, Inc. |
Antibody-evading virus vectors
|
|
MX2020010465A
(es)
|
2018-04-03 |
2021-01-08 |
|
Vectores de virus para direccionamiento a tejidos oftalmicos.
|
|
WO2019222444A2
(en)
|
2018-05-16 |
2019-11-21 |
Voyager Therapeutics, Inc. |
Directed evolution
|
|
MX2021005997A
(es)
|
2018-11-21 |
2021-08-11 |
|
Vectores virales recombinantes y acidos nucleicos para producirlos.
|
|
KR20210112339A
(ko)
|
2019-01-04 |
2021-09-14 |
울트라제닉스 파마수티컬 인코포레이티드 |
윌슨병을 치료하기 위한 유전자 요법 구축물
|
|
CN113727992A
(zh)
|
2019-03-21 |
2021-11-30 |
斯特里迪比奥公司 |
重组腺相关病毒载体
|
|
MX2021013913A
(es)
|
2019-05-14 |
2022-03-17 |
Univ Duke |
Composiciones y metodos para el tratamiento de enfermedades mediadas por atpasa.
|
|
CN114787180A
(zh)
|
2019-10-17 |
2022-07-22 |
斯特里迪比奥公司 |
用于治疗c型尼曼-匹克病的腺相关病毒载体
|
|
JP2023542614A
(ja)
|
2020-08-19 |
2023-10-11 |
サレプタ セラピューティクス, インコーポレイテッド |
レット症候群の治療のためのアデノ随伴ウイルスベクター
|