ATE294874T1 - Rekombinante adenovirus für gewebespezifische genexpression ins herz - Google Patents

Rekombinante adenovirus für gewebespezifische genexpression ins herz

Info

Publication number
ATE294874T1
ATE294874T1 AT99945628T AT99945628T ATE294874T1 AT E294874 T1 ATE294874 T1 AT E294874T1 AT 99945628 T AT99945628 T AT 99945628T AT 99945628 T AT99945628 T AT 99945628T AT E294874 T1 ATE294874 T1 AT E294874T1
Authority
AT
Austria
Prior art keywords
recombinant adenovirus
tissue
heart
gene expression
specific gene
Prior art date
Application number
AT99945628T
Other languages
English (en)
Inventor
Kenneth R Chien
Yibin Wang
Sylvia Evans
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE294874T1 publication Critical patent/ATE294874T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99945628T 1998-09-11 1999-09-10 Rekombinante adenovirus für gewebespezifische genexpression ins herz ATE294874T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9996098P 1998-09-11 1998-09-11
PCT/US1999/020730 WO2000015821A1 (en) 1998-09-11 1999-09-10 Recombinant adenovirus for tissue specific expression in heart

Publications (1)

Publication Number Publication Date
ATE294874T1 true ATE294874T1 (de) 2005-05-15

Family

ID=22277433

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99945628T ATE294874T1 (de) 1998-09-11 1999-09-10 Rekombinante adenovirus für gewebespezifische genexpression ins herz

Country Status (10)

Country Link
US (1) US6451594B1 (de)
EP (1) EP1109925B1 (de)
JP (1) JP2002525064A (de)
CN (1) CN1159445C (de)
AT (1) ATE294874T1 (de)
AU (1) AU5819599A (de)
CA (1) CA2342283C (de)
DE (1) DE69925134T2 (de)
HK (1) HK1039795A1 (de)
WO (1) WO2000015821A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745416B2 (en) * 1995-04-11 2010-06-29 The Regents Of The University Of California Method for in vivo regulation of cardiac muscle contractility
US20090239940A1 (en) * 1997-07-22 2009-09-24 Del Monte Federica Treating heart failure and ventricular arrhythmias
CZ20031569A3 (cs) * 2000-12-07 2003-11-12 Gencell S. A. Polynukleotidy obsahující fragment sekvence v protisměru od genu CARP, vektory a expresní kazety, které je obsahují, a jejich použití
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
EP1477556A1 (de) * 2003-05-16 2004-11-17 Heart Biosystems GmbH Verfahren zur Selektion von kardiomyogenen Zellen oder Herzmuskelzellen aus gemischten Zellpopulationen
WO2005023292A1 (en) 2003-09-03 2005-03-17 The General Hospital Corporation Methods of treating restenosis
US20050244377A1 (en) * 2003-12-24 2005-11-03 Daniel Sigg Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel
US8859273B2 (en) * 2003-12-24 2014-10-14 Medtronic, Inc. Methods of using HCN genes to treat cardiac arrhythmias
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7828711B2 (en) 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
WO2010138555A2 (en) * 2009-05-26 2010-12-02 University Of Florida Research Foundation, Inc. Small peptide expression system in mammalian cells
LT3254703T (lt) * 2011-04-22 2020-05-25 The Regents Of The University Of California Adenoasocijuoto viruso virionai su variantine kapside ir jų panaudojimo būdai
CN103946230B (zh) * 2011-05-26 2017-02-08 华盛顿大学 改善心脏功能的基于细胞和基因的方法
US9066966B2 (en) 2013-02-01 2015-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods and pharmaceutical compositions for the treatment of cardiomyopathy due to friedreich ataxia
WO2014164703A1 (en) 2013-03-11 2014-10-09 University Of Florida Research Foundation, Inc. Delivery of card protein as therapy for occular inflammation
WO2014194132A1 (en) 2013-05-31 2014-12-04 The Regents Of The University Of California Adeno-associated virus variants and methods of use thereof
WO2015124546A1 (en) * 2014-02-19 2015-08-27 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii- Cnic Aav vectors for the treatment of ischemic and non-ischemic heart disease
WO2015127094A1 (en) 2014-02-19 2015-08-27 University Of Florida Research Foundation, Inc. Delivery of nrf2 as therapy for protection against reactive oxygen species
ES2911714T3 (es) 2014-03-11 2022-05-20 Univ Florida Proteína M013 expresada por AAV como un terapéutico antiinflamatorio para su uso en un método de tratamiento de enfermedad ocular inflamatoria
CA2942776C (en) 2014-03-17 2023-01-24 Adverum Biotechnologies, Inc. Polyneucleotide cassette and expression vector for expression of a gene in cone cells using truncated m-opsin promoter
WO2015162161A1 (en) 2014-04-22 2015-10-29 Medizinische Hochschule Hannover Lncrnas for therapy and diagnosis of cardiac hypertrophy
KR20170137730A (ko) 2015-03-02 2017-12-13 애드베룸 바이오테크놀로지스, 인코포레이티드 망막 추상체에 폴리뉴클레오타이드의 유리체 내 전달을 위한 조성물 및 방법
WO2016154344A1 (en) 2015-03-24 2016-09-29 The Regents Of The University Of California Adeno-associated virus variants and methods of use thereof
CN105754997B (zh) * 2016-03-30 2019-02-26 华中农业大学 狂犬病毒drv-ah08株的先导rna及其在制备预防与治疗狂犬病毒的药品中的应用
KR20230039779A (ko) 2016-07-29 2023-03-21 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법
EP3528785A4 (de) 2016-10-19 2020-12-02 Adverum Biotechnologies, Inc. Modifizierte aav-kaspide und verwendungen davon
CN110461368A (zh) 2017-06-30 2019-11-15 加利福尼亚大学董事会 具有变异衣壳的腺相关病毒病毒体及其使用方法
EP3676373A4 (de) 2017-08-28 2021-06-09 The Regents of The University of California Capsid-varianten von adeno-assoziierten viren und verfahren zur verwendung davon
CN110823870A (zh) * 2018-08-10 2020-02-21 武汉大学人民医院（湖北省人民医院） 一种基于上转化发光技术的心脏节律与功能的光控制系统
CN116698827A (zh) * 2023-07-01 2023-09-05 复旦大学附属中山医院 MYL7(MLC2a)基因在制备治疗扩张性心肌病的药物中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE307212T1 (de) * 1992-11-18 2005-11-15 Arch Dev Corp Adenovirus-gelenkter gen-transfer zum herz-und glatten vaskulären muskel
US5747245A (en) 1994-06-14 1998-05-05 La Jolla Cancer Research Foundation Nucleic acids encoding Fas associated proteins and screening assays using same
US5856152A (en) 1994-10-28 1999-01-05 The Trustees Of The University Of Pennsylvania Hybrid adenovirus-AAV vector and methods of use therefor
US5834306A (en) * 1994-12-23 1998-11-10 Sri International Tissue specific hypoxia regulated therapeutic constructs
US5652224A (en) 1995-02-24 1997-07-29 The Trustees Of The University Of Pennsylvania Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
US5792453A (en) 1995-02-28 1998-08-11 The Regents Of The University Of California Gene transfer-mediated angiogenesis therapy
JP2001500015A (ja) * 1996-09-06 2001-01-09 トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Ｔ７ポリメラーゼを利用する組換えアデノ随伴ウイルスの誘導可能な製造方法
US5772993A (en) 1997-01-21 1998-06-30 The University Of Virginia Patent Foundation Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues

Also Published As

Publication number Publication date
CN1325451A (zh) 2001-12-05
JP2002525064A (ja) 2002-08-13
WO2000015821A1 (en) 2000-03-23
DE69925134D1 (de) 2005-06-09
CA2342283C (en) 2004-05-25
HK1039795A1 (zh) 2002-05-10
CA2342283A1 (en) 2000-03-23
EP1109925A1 (de) 2001-06-27
DE69925134T2 (de) 2006-01-19
US6451594B1 (en) 2002-09-17
AU5819599A (en) 2000-04-03
CN1159445C (zh) 2004-07-28
EP1109925B1 (de) 2005-05-04

Similar Documents

Publication Publication Date Title
ATE294874T1 (de) Rekombinante adenovirus für gewebespezifische genexpression ins herz
Saaristo et al. Adenoviral VEGF‐C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
William Petersen et al. The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion
Ye et al. Expression of midkine in the early stage of carcinogenesis in human colorectal cancer
ES2629086T3 (es) Sustancia farmacéutica para promover la regeneración funcional de tejido dañado
Nusse The int genes in mammary tumorigenesis and in normal development
DE69133372D1 (de) Transgenes, nicht-menschliches säugetier das die amyloidbildende pathologie der alzheimerschen krankheit zeigt
JP2001524828A (ja) 切断型ｖｅｇｆ関連蛋白質
Mahony et al. Tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis
ATE312935T1 (de) Regulatorische sequenzen für die in-vivo- expression einer heterologen dns-sequenz in endothelzellen und ihre verwendungen.
RU2005137697A (ru) Синтетический ген, кодирующий человеческий раково-эмбриональный антиген, и его применение
KR970706397A (ko) IV a2 유전자가 불활성화된 결손 재조합 아데노바이러스(DEFECTIVE RECOMBINANT ADENOVIRUSES WITH AN INACTIVATED IV a2 GENE)
NZ529915A (en) Stimulation of vascularization of ischemic tissue by angiogenesis with VEGF-B186
PE20010610A1 (es) Vectores adenovirales recombinantes y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar y cicatrices hipertroficas
Sadano et al. Newly identified type of β actin reduces invasiveness of mouse B16‐melanoma
Wang et al. Expression of human tissue kallikrein in rat salivary glands and its secretion into circulation following adenovirus-mediated gene transfer
CN111465697B (zh) 用于预防或治疗心力衰竭的药物组合物
Chen et al. The potential of the human osteopontin promoter and single-nucleotide polymorphisms for targeted cancer gene therapy
MXPA03005039A (es) Secuencias anteriores al gen prac, vectores que las contienen y usos de las mismas.
Lodde et al. A recombinant adenoviral vector encoding functional vasoactive intestinal peptide
WO2002089727A2 (en) Methods of using cytokine c17
CA2326053A1 (en) Use of scatter factor to enhance angiogenesis
RU2788124C2 (ru) Фармацевтическая композиция для профилактики или лечения сердечной недостаточности
WO2011125055A2 (en) Synthetic constructs for polynucleotide and protein expression
CN117965451A (zh) 人精炼凝血因子ix介导间充质干细胞制剂的制备方法及应用

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties