JP2008520193A5 - - Google Patents
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- Publication number
- JP2008520193A5 JP2008520193A5 JP2007540127A JP2007540127A JP2008520193A5 JP 2008520193 A5 JP2008520193 A5 JP 2008520193A5 JP 2007540127 A JP2007540127 A JP 2007540127A JP 2007540127 A JP2007540127 A JP 2007540127A JP 2008520193 A5 JP2008520193 A5 JP 2008520193A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- desaturase
- elongase
- gene
- microbial oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 161
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 67
- 238000004519 manufacturing process Methods 0.000 claims description 60
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 34
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 33
- 230000000813 microbial effect Effects 0.000 claims description 29
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 22
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 21
- 101000912235 Rebecca salina Acyl-lipid (7-3)-desaturase Proteins 0.000 claims description 19
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 claims description 19
- 241000235013 Yarrowia Species 0.000 claims description 19
- 241001465754 Metazoa Species 0.000 claims description 18
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 claims description 16
- 235000013305 food Nutrition 0.000 claims description 15
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 claims description 14
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 claims description 14
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 14
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 14
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 14
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 14
- 229940033080 omega-6 fatty acid Drugs 0.000 claims description 14
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 claims description 13
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 claims description 13
- 108010011713 delta-15 desaturase Proteins 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 101710091951 Glycerol-3-phosphate acyltransferase Proteins 0.000 claims description 10
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 10
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 claims description 8
- 108010054662 2-acylglycerophosphate acyltransferase Proteins 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 239000002028 Biomass Substances 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 235000015872 dietary supplement Nutrition 0.000 claims description 5
- KPULXFNPTWGJQH-UHFFFAOYSA-N 3-hydroxy-4-oxo-4-propan-2-yloxybutanoic acid Chemical compound CC(C)OC(=O)C(O)CC(O)=O KPULXFNPTWGJQH-UHFFFAOYSA-N 0.000 claims description 4
- 102000004539 Acyl-CoA Oxidase Human genes 0.000 claims description 4
- 108020001558 Acyl-CoA oxidase Proteins 0.000 claims description 4
- 101710088194 Dehydrogenase Proteins 0.000 claims description 4
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 claims description 4
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 claims description 4
- 235000013350 formula milk Nutrition 0.000 claims description 4
- YAFQFNOUYXZVPZ-UHFFFAOYSA-N liproxstatin-1 Chemical compound ClC1=CC=CC(CNC=2C3(CCNCC3)NC3=CC=CC=C3N=2)=C1 YAFQFNOUYXZVPZ-UHFFFAOYSA-N 0.000 claims description 4
- 102100034543 Fatty acid desaturase 3 Human genes 0.000 claims description 3
- 108010087894 Fatty acid desaturases Proteins 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims description 2
- 101150102441 ACO3 gene Proteins 0.000 claims description 2
- 101710103615 Acyl-coenzyme A oxidase 2 Proteins 0.000 claims description 2
- 101710084373 Lipase 1 Proteins 0.000 claims description 2
- 101710084378 Lipase 2 Proteins 0.000 claims description 2
- 101710098556 Lipase A Proteins 0.000 claims description 2
- 101710099648 Lysosomal acid lipase/cholesteryl ester hydrolase Proteins 0.000 claims description 2
- 102100026001 Lysosomal acid lipase/cholesteryl ester hydrolase Human genes 0.000 claims description 2
- 101100005882 Mus musculus Cel gene Proteins 0.000 claims description 2
- 101100289046 Mus musculus Lias gene Proteins 0.000 claims description 2
- 102100026795 Peroxisomal acyl-coenzyme A oxidase 2 Human genes 0.000 claims description 2
- 102000015439 Phospholipases Human genes 0.000 claims description 2
- 108010064785 Phospholipases Proteins 0.000 claims description 2
- 101100433922 Solanum lycopersicum ACO4 gene Proteins 0.000 claims description 2
- 102000014384 Type C Phospholipases Human genes 0.000 claims description 2
- 108010079194 Type C Phospholipases Proteins 0.000 claims description 2
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 101150091094 lipA gene Proteins 0.000 claims description 2
- 108010054300 peroxisomal acyl-CoA oxidase Proteins 0.000 claims description 2
- 102000002774 saccharopine dehydrogenase Human genes 0.000 claims description 2
- 108020000318 saccharopine dehydrogenase Proteins 0.000 claims description 2
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 claims 1
- 102100035762 Diacylglycerol O-acyltransferase 2 Human genes 0.000 claims 1
- 101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 claims 1
- 101000930020 Homo sapiens Diacylglycerol O-acyltransferase 2 Proteins 0.000 claims 1
- 101710133727 Phospholipid:diacylglycerol acyltransferase Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 18
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 8
- 108030002650 Phospholipid:diacylglycerol acyltransferases Proteins 0.000 description 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 5
- 229960004488 linolenic acid Drugs 0.000 description 5
- 230000001588 bifunctional effect Effects 0.000 description 4
- 241000235015 Yarrowia lipolytica Species 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 229940098330 gamma linoleic acid Drugs 0.000 description 3
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 3
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 3
- 150000007523 nucleic acids Chemical group 0.000 description 3
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 2
- 102100023441 Centromere protein J Human genes 0.000 description 2
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 description 2
- 101000907924 Homo sapiens Centromere protein J Proteins 0.000 description 2
- 101000600189 Homo sapiens Peroxisomal membrane protein PEX16 Proteins 0.000 description 2
- 101000693082 Homo sapiens Serine/threonine-protein kinase 11-interacting protein Proteins 0.000 description 2
- 102100037479 Peroxisomal membrane protein PEX16 Human genes 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 description 1
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- 101150040471 19 gene Proteins 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 101150102653 Dgat2 gene Proteins 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 101000813109 Rattus norvegicus Elongation of very long chain fatty acids protein 6 Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 101100382243 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YAT1 gene Proteins 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62481204P | 2004-11-04 | 2004-11-04 | |
| US60/624,812 | 2004-11-04 | ||
| PCT/US2005/040256 WO2006052871A2 (en) | 2004-11-04 | 2005-11-03 | Docosahexaenoic acid producing strains of yarrowia lipolytica |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008520193A JP2008520193A (ja) | 2008-06-19 |
| JP2008520193A5 true JP2008520193A5 (enExample) | 2008-10-02 |
| JP5080979B2 JP5080979B2 (ja) | 2012-11-21 |
Family
ID=36337096
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540139A Expired - Fee Related JP5139806B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高アラキドン酸生成株 |
| JP2007540127A Expired - Fee Related JP5080979B2 (ja) | 2004-11-04 | 2005-11-03 | ドコサヘキサエン酸生成ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）株 |
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540139A Expired - Fee Related JP5139806B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高アラキドン酸生成株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US7550286B2 (enExample) |
| EP (5) | EP1809756B1 (enExample) |
| JP (3) | JP5139806B2 (enExample) |
| KR (3) | KR20070085649A (enExample) |
| CN (4) | CN101111601B (enExample) |
| CA (3) | CA2585235C (enExample) |
| DK (4) | DK1809756T3 (enExample) |
| NO (3) | NO20072517L (enExample) |
| WO (3) | WO2006055322A2 (enExample) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
| PT2172536T (pt) | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| CN1930277B (zh) | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| AU2005250074B2 (en) * | 2004-06-04 | 2011-04-14 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US20060094102A1 (en) * | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7879591B2 (en) | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| GB0503657D0 (en) | 2005-02-22 | 2005-03-30 | Fluxome Sciences As | Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof |
| US7470532B2 (en) * | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| US7465793B2 (en) | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| GB0614442D0 (en) | 2006-07-20 | 2006-08-30 | Fluxome Sciences As | Metabolically engineered cells for the production of pinosylvin |
| CA2659993C (en) * | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| US20080095711A1 (en) * | 2006-08-31 | 2008-04-24 | Falck John R | Modulators of Pulmonary Hypertension |
| CA2663768A1 (en) | 2006-10-23 | 2008-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US7923223B2 (en) | 2006-12-20 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Δ-9 desaturase and its use in making polyunsaturated fatty acids |
| EP2121934A2 (en) | 2007-02-12 | 2009-11-25 | E. I. Du Pont de Nemours and Company | Production of arachidonic acid in oilseed plants |
| US8188338B2 (en) | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| US8110388B2 (en) * | 2007-05-25 | 2012-02-07 | Suntory Holdings Limited | Lysophosphatidic acid acyltransferase genes |
| JP2010528627A (ja) | 2007-06-01 | 2010-08-26 | ソラザイム、インク | 微生物による油の生産 |
| JP5451387B2 (ja) * | 2007-06-18 | 2014-03-26 | サントリーホールディングス株式会社 | グリセロール−３−リン酸アシル基転移酵素（ｇｐａｔ）ホモログとその利用 |
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- 2005-11-03 DK DK05818385.6T patent/DK1809756T3/en active
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-
2012
- 2012-11-13 US US13/675,144 patent/US20130123361A1/en not_active Abandoned
-
2013
- 2013-07-17 US US13/943,992 patent/US8815566B2/en not_active Expired - Lifetime
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