JP2008518628A5 - - Google Patents
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- Publication number
- JP2008518628A5 JP2008518628A5 JP2007540139A JP2007540139A JP2008518628A5 JP 2008518628 A5 JP2008518628 A5 JP 2008518628A5 JP 2007540139 A JP2007540139 A JP 2007540139A JP 2007540139 A JP2007540139 A JP 2007540139A JP 2008518628 A5 JP2008518628 A5 JP 2008518628A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- desaturase
- elongase
- gene
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 87
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 50
- 238000004519 manufacturing process Methods 0.000 claims description 48
- 235000021342 arachidonic acid Nutrition 0.000 claims description 25
- 229940114079 arachidonic acid Drugs 0.000 claims description 25
- 230000000813 microbial effect Effects 0.000 claims description 24
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 241000235013 Yarrowia Species 0.000 claims description 15
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 claims description 14
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 claims description 14
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 13
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 12
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 12
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 12
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 12
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 12
- 229940033080 omega-6 fatty acid Drugs 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 claims description 8
- 108010054662 2-acylglycerophosphate acyltransferase Proteins 0.000 claims description 8
- 101710091951 Glycerol-3-phosphate acyltransferase Proteins 0.000 claims description 8
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 claims description 7
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 claims description 7
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 5
- KPULXFNPTWGJQH-UHFFFAOYSA-N 3-hydroxy-4-oxo-4-propan-2-yloxybutanoic acid Chemical compound CC(C)OC(=O)C(O)CC(O)=O KPULXFNPTWGJQH-UHFFFAOYSA-N 0.000 claims description 4
- 239000002028 Biomass Substances 0.000 claims description 4
- 101710088194 Dehydrogenase Proteins 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 235000015872 dietary supplement Nutrition 0.000 claims description 4
- 102000002774 saccharopine dehydrogenase Human genes 0.000 claims description 4
- 108020000318 saccharopine dehydrogenase Proteins 0.000 claims description 4
- 102100034543 Fatty acid desaturase 3 Human genes 0.000 claims description 3
- 108010087894 Fatty acid desaturases Proteins 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 235000013350 formula milk Nutrition 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims description 2
- 101150102441 ACO3 gene Proteins 0.000 claims description 2
- 101710103615 Acyl-coenzyme A oxidase 2 Proteins 0.000 claims description 2
- 101710084373 Lipase 1 Proteins 0.000 claims description 2
- 101710084378 Lipase 2 Proteins 0.000 claims description 2
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 claims description 2
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 claims description 2
- 102100026795 Peroxisomal acyl-coenzyme A oxidase 2 Human genes 0.000 claims description 2
- 102000015439 Phospholipases Human genes 0.000 claims description 2
- 108010064785 Phospholipases Proteins 0.000 claims description 2
- 101100433922 Solanum lycopersicum ACO4 gene Proteins 0.000 claims description 2
- 102000014384 Type C Phospholipases Human genes 0.000 claims description 2
- 108010079194 Type C Phospholipases Proteins 0.000 claims description 2
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 108010054300 peroxisomal acyl-CoA oxidase Proteins 0.000 claims description 2
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 claims 1
- 102100035762 Diacylglycerol O-acyltransferase 2 Human genes 0.000 claims 1
- 101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 claims 1
- 101000930020 Homo sapiens Diacylglycerol O-acyltransferase 2 Proteins 0.000 claims 1
- 101710133727 Phospholipid:diacylglycerol acyltransferase Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 108030002650 Phospholipid:diacylglycerol acyltransferases Proteins 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 4
- 150000007523 nucleic acids Chemical group 0.000 description 3
- 241000235015 Yarrowia lipolytica Species 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229940098330 gamma linoleic acid Drugs 0.000 description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 description 1
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- 101150072531 10 gene Proteins 0.000 description 1
- 101150066838 12 gene Proteins 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 101150102653 Dgat2 gene Proteins 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62481204P | 2004-11-04 | 2004-11-04 | |
| US60/624,812 | 2004-11-04 | ||
| PCT/US2005/040306 WO2006055322A2 (en) | 2004-11-04 | 2005-11-03 | High arachidonic acid producing strains of yarrowia lipolytica |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518628A JP2008518628A (ja) | 2008-06-05 |
| JP2008518628A5 true JP2008518628A5 (enExample) | 2008-09-25 |
| JP5139806B2 JP5139806B2 (ja) | 2013-02-06 |
Family
ID=36337096
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540127A Expired - Fee Related JP5080979B2 (ja) | 2004-11-04 | 2005-11-03 | ドコサヘキサエン酸生成ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）株 |
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
| JP2007540139A Expired - Fee Related JP5139806B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高アラキドン酸生成株 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540127A Expired - Fee Related JP5080979B2 (ja) | 2004-11-04 | 2005-11-03 | ドコサヘキサエン酸生成ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）株 |
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US7550286B2 (enExample) |
| EP (5) | EP1807526A4 (enExample) |
| JP (3) | JP5080979B2 (enExample) |
| KR (3) | KR20070085665A (enExample) |
| CN (4) | CN101111601B (enExample) |
| CA (3) | CA2585235C (enExample) |
| DK (4) | DK1809756T3 (enExample) |
| NO (3) | NO20072517L (enExample) |
| WO (3) | WO2006052871A2 (enExample) |
Families Citing this family (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| NO347177B1 (no) | 2003-08-01 | 2023-06-19 | Basf Plant Science Gmbh | Fremgangsmåte for fremstilling av flerumettede fettsyrer i transgene organismer |
| JP4567047B2 (ja) | 2004-02-27 | 2010-10-20 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | トランスジェニック植物における多価不飽和脂肪酸の製造方法 |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2005118814A2 (en) * | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US20060094102A1 (en) * | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7879591B2 (en) | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| GB0503657D0 (en) | 2005-02-22 | 2005-03-30 | Fluxome Sciences As | Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof |
| US7470532B2 (en) * | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| CA2624661C (en) | 2005-11-23 | 2015-06-30 | E.I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| US7465793B2 (en) | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| EP2012828A2 (en) * | 2006-04-28 | 2009-01-14 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| GB0614442D0 (en) | 2006-07-20 | 2006-08-30 | Fluxome Sciences As | Metabolically engineered cells for the production of pinosylvin |
| CA2659993C (en) | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| US20080095711A1 (en) * | 2006-08-31 | 2008-04-24 | Falck John R | Modulators of Pulmonary Hypertension |
| UA102059C2 (uk) | 2006-10-23 | 2013-06-10 | Е.І. Дю Пон Де Немур Енд Компані | Дельта-8 десатураза та її застосування для одержання поліненасичених жирних кислот |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US7923223B2 (en) | 2006-12-20 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Δ-9 desaturase and its use in making polyunsaturated fatty acids |
| AU2008216707B2 (en) | 2007-02-12 | 2014-06-19 | E. I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| US7790156B2 (en) * | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US7794701B2 (en) * | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US8957280B2 (en) | 2007-05-03 | 2015-02-17 | E. I. Du Pont De Nemours And Company | Delta-5 desaturases and their use in making polyunsaturated fatty acids |
| US8110388B2 (en) * | 2007-05-25 | 2012-02-07 | Suntory Holdings Limited | Lysophosphatidic acid acyltransferase genes |
| EP3546588A3 (en) | 2007-06-01 | 2019-12-18 | Corbion Biotech, Inc. | Recombinant microalgal cell and method of producing lipids using said cell |
| CN101578366B (zh) * | 2007-06-18 | 2012-05-30 | 三得利控股株式会社 | 甘油-3-磷酸酰基转移酶（gpat）同源物及其应用 |
| EP2176433B1 (de) * | 2007-07-31 | 2011-10-12 | BASF Plant Science GmbH | Desaturasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| CN101883843B (zh) * | 2007-10-03 | 2016-03-02 | 纳幕尔杜邦公司 | 破坏过氧化物酶体生物合成因子蛋白(pex)以改变含油真核生物中多不饱和脂肪酸和总脂质含量 |
| US8323935B2 (en) | 2007-10-03 | 2012-12-04 | E I Du Pont De Nemours And Company | Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production |
| US8343753B2 (en) * | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| US8486478B2 (en) | 2007-11-08 | 2013-07-16 | International Great Brands LLC | Structured lipid compositions |
| US7879384B2 (en) | 2007-11-08 | 2011-02-01 | Kraft Foods Global Brands Llc | Structured glycerol esters useful as edible moisture barriers |
| US8206772B2 (en) | 2007-11-08 | 2012-06-26 | Kraft Foods Global Brands Llc | Structured lipid compositions and methods of formulation thereof |
| US8733289B2 (en) * | 2008-04-07 | 2014-05-27 | Rich Products Corporation | Method for preparing edible aquatic animals for storage |
| US20090291479A1 (en) * | 2008-05-23 | 2009-11-26 | E. I. Du Pont De Nemours And Company | Manipulation of acyl-coa binding protein expression for altered lipid production in microbial hosts |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| WO2010004784A1 (ja) * | 2008-07-10 | 2010-01-14 | 株式会社Ｊ－オイルミルズ | 飲食品の呈味向上剤 |
| EP2331695B1 (en) * | 2008-08-26 | 2014-07-23 | BASF Plant Science GmbH | Nucleic acids encoding desaturases and modified plant oil |
| BRPI0913138A2 (pt) * | 2008-08-29 | 2016-05-31 | Du Pont | célula hospedeira eucariótica oleaginosa transgênica, célula de levedura eucariótica oleaginosa transgênica, óleo ou lipídeos, método para aumentar o teor de lipídeo total de uma célula hospedeira eucariótica oleaginosa e método para aumentar o teor total de ácidos graxos poliinsaturados no óleo microbiano |
| US20100303989A1 (en) * | 2008-10-14 | 2010-12-02 | Solazyme, Inc. | Microalgal Flour |
| US20160324167A1 (en) | 2008-10-14 | 2016-11-10 | Terravia Holdings, Inc. | Novel microalgal food compositions |
| US20100297296A1 (en) * | 2008-10-14 | 2010-11-25 | Solazyme, Inc. | Healthier Baked Goods Containing Microalgae |
| DK2358882T3 (da) | 2008-11-18 | 2017-11-06 | Commw Scient Ind Res Org | Enzymer og fremgangsmåder til fremstilling af omega-3 fedtsyrer |
| EP2370555B1 (en) | 2008-11-28 | 2016-04-20 | Solazyme, Inc. | Production of tailored oils in heterotrophic microorganisms |
| EP2358862B1 (en) | 2008-12-18 | 2017-08-02 | E. I. du Pont de Nemours and Company | Reducing byproduction of malonates in a fermentation process |
| AU2010225738B2 (en) | 2009-03-18 | 2015-01-29 | Suntory Holdings Limited | Novel acetyl-CoA carboxylase |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| JP2012520878A (ja) * | 2009-03-19 | 2012-09-10 | ロサンゼルス ビオメドイカル リサーチ インストイトウテ アト ハルボル‐ユーシーエルエー メドイカル センテル | ムコール菌症、及びその他の真菌疾患の治療のためのワクチン組成物、及び方法 |
| DK2676554T3 (da) * | 2009-03-26 | 2015-02-09 | Suntory Holdings Ltd | Ny lysophospholipidacyltransferase |
| US8637298B2 (en) * | 2009-06-16 | 2014-01-28 | E I Du Pont De Nemours And Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| BRPI1009649A2 (pt) | 2009-06-16 | 2016-03-15 | Du Pont | célula hospedeira yarrowia sp, recombinante, método para fabricar um óleo microbiano e célula hospedeira recombinante para produção de um óleo |
| JP5931721B2 (ja) * | 2009-06-16 | 2016-06-08 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | アシルＣｏＡリゾリン脂質アシルトランスフェラーゼの発現による長鎖オメガ−３及びオメガ−６多価不飽和脂肪酸生合成の改良 |
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-
2005
- 2005-11-01 US US11/264,737 patent/US7550286B2/en not_active Expired - Fee Related
- 2005-11-01 US US11/264,784 patent/US7588931B2/en not_active Expired - Fee Related
- 2005-11-02 US US11/265,761 patent/US7932077B2/en not_active Expired - Fee Related
- 2005-11-03 EP EP05818267A patent/EP1807526A4/en not_active Withdrawn
- 2005-11-03 JP JP2007540127A patent/JP5080979B2/ja not_active Expired - Fee Related
- 2005-11-03 DK DK05818385.6T patent/DK1809756T3/en active
- 2005-11-03 KR KR1020077012473A patent/KR20070085665A/ko not_active Ceased
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- 2005-11-03 CN CN200580045823.5A patent/CN101111601B/zh not_active Expired - Fee Related
- 2005-11-03 JP JP2007540126A patent/JP5129574B2/ja not_active Expired - Fee Related
- 2005-11-03 CN CNA2005800459100A patent/CN101437952A/zh active Pending
- 2005-11-03 WO PCT/US2005/040256 patent/WO2006052871A2/en not_active Ceased
- 2005-11-03 DK DK13161757.3T patent/DK2649887T3/en active
- 2005-11-03 CA CA2584719A patent/CA2584719C/en not_active Expired - Fee Related
- 2005-11-03 DK DK12152258.5T patent/DK2458000T3/da active
- 2005-11-03 JP JP2007540139A patent/JP5139806B2/ja not_active Expired - Fee Related
- 2005-11-03 EP EP13161757.3A patent/EP2649887B1/en not_active Expired - Lifetime
- 2005-11-03 WO PCT/US2005/040255 patent/WO2006052870A2/en not_active Ceased
- 2005-11-03 EP EP05818385.6A patent/EP1809756B1/en not_active Expired - Lifetime
- 2005-11-03 KR KR1020077012441A patent/KR20070085649A/ko not_active Ceased
- 2005-11-03 CA CA2585178A patent/CA2585178C/en not_active Expired - Fee Related
- 2005-11-03 DK DK05851406.8T patent/DK1807527T3/da active
- 2005-11-03 KR KR1020077012480A patent/KR20070085669A/ko not_active Ceased
- 2005-11-03 WO PCT/US2005/040306 patent/WO2006055322A2/en not_active Ceased
- 2005-11-03 CN CNA2005800457798A patent/CN101437951A/zh active Pending
- 2005-11-03 CN CN2005800459172A patent/CN101437953B/zh not_active Expired - Fee Related
- 2005-11-03 EP EP05851406.8A patent/EP1807527B1/en not_active Expired - Lifetime
- 2005-11-03 EP EP12152258.5A patent/EP2458000B1/en not_active Expired - Lifetime
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2007
- 2007-05-15 NO NO20072517A patent/NO20072517L/no not_active Application Discontinuation
- 2007-05-16 NO NO20072516A patent/NO20072516L/no not_active Application Discontinuation
- 2007-05-21 NO NO20072575A patent/NO20072575L/no not_active Application Discontinuation
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2009
- 2009-05-14 US US12/466,072 patent/US8685682B2/en not_active Expired - Fee Related
- 2009-07-30 US US12/512,507 patent/US20100022647A1/en not_active Abandoned
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- 2012-11-13 US US13/675,144 patent/US20130123361A1/en not_active Abandoned
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