JP2008518628A5 - - Google Patents
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- Publication number
- JP2008518628A5 JP2008518628A5 JP2007540139A JP2007540139A JP2008518628A5 JP 2008518628 A5 JP2008518628 A5 JP 2008518628A5 JP 2007540139 A JP2007540139 A JP 2007540139A JP 2007540139 A JP2007540139 A JP 2007540139A JP 2008518628 A5 JP2008518628 A5 JP 2008518628A5
- Authority
- JP
- Japan
- Prior art keywords
- gene encoding
- desaturase
- elongase
- gene
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims description 87
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 50
- 238000004519 manufacturing process Methods 0.000 claims description 48
- 235000021342 arachidonic acid Nutrition 0.000 claims description 25
- 229940114079 arachidonic acid Drugs 0.000 claims description 25
- 230000000813 microbial effect Effects 0.000 claims description 24
- 102100038805 Lysophospholipid acyltransferase 2 Human genes 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 16
- 241000235013 Yarrowia Species 0.000 claims description 15
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 claims description 14
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 claims description 14
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 claims description 13
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 claims description 13
- 241001465754 Metazoa Species 0.000 claims description 12
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 12
- 235000013305 food Nutrition 0.000 claims description 12
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims description 12
- 229940012843 omega-3 fatty acid Drugs 0.000 claims description 12
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 12
- 229940033080 omega-6 fatty acid Drugs 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 10
- 108090000790 Enzymes Proteins 0.000 claims description 10
- 108010052187 1-Acylglycerophosphocholine O-Acyltransferase Proteins 0.000 claims description 8
- 108010054662 2-acylglycerophosphate acyltransferase Proteins 0.000 claims description 8
- 101710091951 Glycerol-3-phosphate acyltransferase Proteins 0.000 claims description 8
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 claims description 7
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 claims description 7
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 5
- KPULXFNPTWGJQH-UHFFFAOYSA-N 3-hydroxy-4-oxo-4-propan-2-yloxybutanoic acid Chemical compound CC(C)OC(=O)C(O)CC(O)=O KPULXFNPTWGJQH-UHFFFAOYSA-N 0.000 claims description 4
- 239000002028 Biomass Substances 0.000 claims description 4
- 101710088194 Dehydrogenase Proteins 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 235000015872 dietary supplement Nutrition 0.000 claims description 4
- 102000002774 saccharopine dehydrogenase Human genes 0.000 claims description 4
- 108020000318 saccharopine dehydrogenase Proteins 0.000 claims description 4
- 102100034543 Fatty acid desaturase 3 Human genes 0.000 claims description 3
- 108010087894 Fatty acid desaturases Proteins 0.000 claims description 3
- 230000000694 effects Effects 0.000 claims description 3
- 235000013350 formula milk Nutrition 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims description 2
- 101150102441 ACO3 gene Proteins 0.000 claims description 2
- 101710103615 Acyl-coenzyme A oxidase 2 Proteins 0.000 claims description 2
- 101710084373 Lipase 1 Proteins 0.000 claims description 2
- 101710084378 Lipase 2 Proteins 0.000 claims description 2
- 102100037214 Orotidine 5'-phosphate decarboxylase Human genes 0.000 claims description 2
- 108010055012 Orotidine-5'-phosphate decarboxylase Proteins 0.000 claims description 2
- 102100026795 Peroxisomal acyl-coenzyme A oxidase 2 Human genes 0.000 claims description 2
- 102000015439 Phospholipases Human genes 0.000 claims description 2
- 108010064785 Phospholipases Proteins 0.000 claims description 2
- 101100433922 Solanum lycopersicum ACO4 gene Proteins 0.000 claims description 2
- 102000014384 Type C Phospholipases Human genes 0.000 claims description 2
- 108010079194 Type C Phospholipases Proteins 0.000 claims description 2
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 108010054300 peroxisomal acyl-CoA oxidase Proteins 0.000 claims description 2
- 102100036869 Diacylglycerol O-acyltransferase 1 Human genes 0.000 claims 1
- 102100035762 Diacylglycerol O-acyltransferase 2 Human genes 0.000 claims 1
- 101000927974 Homo sapiens Diacylglycerol O-acyltransferase 1 Proteins 0.000 claims 1
- 101000930020 Homo sapiens Diacylglycerol O-acyltransferase 2 Proteins 0.000 claims 1
- 101710133727 Phospholipid:diacylglycerol acyltransferase Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 13
- 108030002650 Phospholipid:diacylglycerol acyltransferases Proteins 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 4
- 150000007523 nucleic acids Chemical group 0.000 description 3
- 241000235015 Yarrowia lipolytica Species 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 2
- 244000144974 aquaculture Species 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229940098330 gamma linoleic acid Drugs 0.000 description 2
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 description 2
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 description 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 description 1
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- 101150072531 10 gene Proteins 0.000 description 1
- 101150066838 12 gene Proteins 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 101150102653 Dgat2 gene Proteins 0.000 description 1
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 description 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 241000282849 Ruminantia Species 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 description 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 description 1
- 229960002733 gamolenic acid Drugs 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62481204P | 2004-11-04 | 2004-11-04 | |
| US60/624,812 | 2004-11-04 | ||
| PCT/US2005/040306 WO2006055322A2 (en) | 2004-11-04 | 2005-11-03 | High arachidonic acid producing strains of yarrowia lipolytica |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518628A JP2008518628A (ja) | 2008-06-05 |
| JP2008518628A5 true JP2008518628A5 (enExample) | 2008-09-25 |
| JP5139806B2 JP5139806B2 (ja) | 2013-02-06 |
Family
ID=36337096
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540139A Expired - Fee Related JP5139806B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高アラキドン酸生成株 |
| JP2007540127A Expired - Fee Related JP5080979B2 (ja) | 2004-11-04 | 2005-11-03 | ドコサヘキサエン酸生成ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）株 |
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540127A Expired - Fee Related JP5080979B2 (ja) | 2004-11-04 | 2005-11-03 | ドコサヘキサエン酸生成ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）株 |
| JP2007540126A Expired - Fee Related JP5129574B2 (ja) | 2004-11-04 | 2005-11-03 | ヤロウィア・リポリティカ（ｙａｒｒｏｗｉａｌｉｐｏｌｙｔｉｃａ）の高エイコサペンタエン酸生成株 |
Country Status (9)
| Country | Link |
|---|---|
| US (8) | US7550286B2 (enExample) |
| EP (5) | EP1809756B1 (enExample) |
| JP (3) | JP5139806B2 (enExample) |
| KR (3) | KR20070085649A (enExample) |
| CN (4) | CN101111601B (enExample) |
| CA (3) | CA2585235C (enExample) |
| DK (4) | DK1809756T3 (enExample) |
| NO (3) | NO20072517L (enExample) |
| WO (3) | WO2006055322A2 (enExample) |
Families Citing this family (173)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
| PT2172536T (pt) | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| CN1930277B (zh) | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| AU2005250074B2 (en) * | 2004-06-04 | 2011-04-14 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US20060094102A1 (en) * | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7879591B2 (en) | 2004-11-04 | 2011-02-01 | E.I. Du Pont De Nemours And Company | High eicosapentaenoic acid producing strains of Yarrowia lipolytica |
| GB0503657D0 (en) | 2005-02-22 | 2005-03-30 | Fluxome Sciences As | Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof |
| US7470532B2 (en) * | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| US7465793B2 (en) | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| CA2650607A1 (en) * | 2006-04-28 | 2007-11-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of cardiovascular disease |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
| GB0614442D0 (en) | 2006-07-20 | 2006-08-30 | Fluxome Sciences As | Metabolically engineered cells for the production of pinosylvin |
| CA2659993C (en) * | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| US20080095711A1 (en) * | 2006-08-31 | 2008-04-24 | Falck John R | Modulators of Pulmonary Hypertension |
| CA2663768A1 (en) | 2006-10-23 | 2008-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US8846374B2 (en) * | 2006-12-12 | 2014-09-30 | E I Du Pont De Nemours And Company | Carotenoid production in a recombinant oleaginous yeast |
| US7923223B2 (en) | 2006-12-20 | 2011-04-12 | E. I. Du Pont De Nemours And Company | Δ-9 desaturase and its use in making polyunsaturated fatty acids |
| EP2121934A2 (en) | 2007-02-12 | 2009-11-25 | E. I. Du Pont de Nemours and Company | Production of arachidonic acid in oilseed plants |
| US8188338B2 (en) | 2007-04-10 | 2012-05-29 | E. I. Du Pont De Nemours And Company | Delta-8 desaturases and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| US8110388B2 (en) * | 2007-05-25 | 2012-02-07 | Suntory Holdings Limited | Lysophosphatidic acid acyltransferase genes |
| JP2010528627A (ja) | 2007-06-01 | 2010-08-26 | ソラザイム、インク | 微生物による油の生産 |
| JP5451387B2 (ja) * | 2007-06-18 | 2014-03-26 | サントリーホールディングス株式会社 | グリセロール−３−リン酸アシル基転移酵素（ｇｐａｔ）ホモログとその利用 |
| CA2694661C (en) * | 2007-07-31 | 2017-10-03 | Basf Plant Science Gmbh | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
| US8323935B2 (en) * | 2007-10-03 | 2012-12-04 | E I Du Pont De Nemours And Company | Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production |
| CA2701130A1 (en) * | 2007-10-03 | 2009-04-09 | E.I. Du Pont De Nemours And Company | Peroxisome biogenesis factor protein (pex) disruptions for altering the content of polyunsaturated fatty acids and the total lipid content in oleaginous eukaryotic organisms |
| US8343753B2 (en) * | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| US8486478B2 (en) | 2007-11-08 | 2013-07-16 | International Great Brands LLC | Structured lipid compositions |
| US8206772B2 (en) | 2007-11-08 | 2012-06-26 | Kraft Foods Global Brands Llc | Structured lipid compositions and methods of formulation thereof |
| US7879384B2 (en) | 2007-11-08 | 2011-02-01 | Kraft Foods Global Brands Llc | Structured glycerol esters useful as edible moisture barriers |
| US8733289B2 (en) * | 2008-04-07 | 2014-05-27 | Rich Products Corporation | Method for preparing edible aquatic animals for storage |
| US20090291479A1 (en) * | 2008-05-23 | 2009-11-26 | E. I. Du Pont De Nemours And Company | Manipulation of acyl-coa binding protein expression for altered lipid production in microbial hosts |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| CN102088869B (zh) * | 2008-07-10 | 2013-10-30 | J-制油株式会社 | 饮食品的呈味提高剂 |
| EP2331695B1 (en) * | 2008-08-26 | 2014-07-23 | BASF Plant Science GmbH | Nucleic acids encoding desaturases and modified plant oil |
| EP2324120B1 (en) * | 2008-08-29 | 2016-01-27 | E. I. du Pont de Nemours and Company | Manipulation of snf1 protein kinase activity for altered oil content in oleaginous organisms |
| US20160324167A1 (en) | 2008-10-14 | 2016-11-10 | Terravia Holdings, Inc. | Novel microalgal food compositions |
| US20100297296A1 (en) * | 2008-10-14 | 2010-11-25 | Solazyme, Inc. | Healthier Baked Goods Containing Microalgae |
| US20100303989A1 (en) | 2008-10-14 | 2010-12-02 | Solazyme, Inc. | Microalgal Flour |
| CA3015426C (en) | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| ES2583639T3 (es) | 2008-11-28 | 2016-09-21 | Terravia Holdings, Inc. | Producción de aceites específicos en microorganismos heterótrofos |
| CA2744716C (en) | 2008-12-18 | 2017-05-23 | E.I. Du Pont De Nemours And Company | Reducing byproduction of malonates in a fermentation process |
| AU2010225738B2 (en) | 2009-03-18 | 2015-01-29 | Suntory Holdings Limited | Novel acetyl-CoA carboxylase |
| US8207363B2 (en) * | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| AU2010226320A1 (en) * | 2009-03-19 | 2011-10-13 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Vaccine compositions and methods for treatment of Mucormycosis and other fungal diseases |
| BRPI1009810A2 (pt) * | 2009-03-26 | 2015-08-25 | Suntory Holdings Ltd | Lisofosfolipídeo aciltransferase. |
| BRPI1009690A2 (pt) * | 2009-06-16 | 2015-08-25 | Du Pont | "célula hospedeira microbiana oleaginosa, óleo, método de elaboração de um óleo, método de aumento da eficiência de conversão de alongamento de c18 para c20 em uma célula hospedeira recombinante microbiana oleaginosa e método de aumento da eficiência de conversão de dessaturação (delta) 4 em uma célula hospedeira recombinante microbiana oleaginosa produtora de ácidos graxos póli-insaturados de cadeia longa" |
| WO2010147907A1 (en) * | 2009-06-16 | 2010-12-23 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of yarrowia lipolytica |
| CN102803289B (zh) * | 2009-06-16 | 2015-07-22 | 纳幕尔杜邦公司 | 用于高水平生产二十碳五烯酸的改善的优化的解脂耶氏酵母菌株 |
| US8399226B2 (en) * | 2009-06-16 | 2013-03-19 | E I Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| RU2499835C1 (ru) | 2009-09-18 | 2013-11-27 | Сантори Холдингз Лимитед | Глицерол-3-фосфатацилтрансфераза |
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-
2005
- 2005-11-01 US US11/264,737 patent/US7550286B2/en not_active Expired - Fee Related
- 2005-11-01 US US11/264,784 patent/US7588931B2/en not_active Expired - Fee Related
- 2005-11-02 US US11/265,761 patent/US7932077B2/en not_active Expired - Fee Related
- 2005-11-03 KR KR1020077012441A patent/KR20070085649A/ko not_active Ceased
- 2005-11-03 EP EP05818385.6A patent/EP1809756B1/en not_active Expired - Lifetime
- 2005-11-03 CA CA2585235A patent/CA2585235C/en not_active Expired - Fee Related
- 2005-11-03 EP EP05851406.8A patent/EP1807527B1/en not_active Expired - Lifetime
- 2005-11-03 JP JP2007540139A patent/JP5139806B2/ja not_active Expired - Fee Related
- 2005-11-03 KR KR1020077012473A patent/KR20070085665A/ko not_active Ceased
- 2005-11-03 EP EP13161757.3A patent/EP2649887B1/en not_active Expired - Lifetime
- 2005-11-03 DK DK05818385.6T patent/DK1809756T3/en active
- 2005-11-03 KR KR1020077012480A patent/KR20070085669A/ko not_active Ceased
- 2005-11-03 WO PCT/US2005/040306 patent/WO2006055322A2/en not_active Ceased
- 2005-11-03 CN CN200580045823.5A patent/CN101111601B/zh not_active Expired - Fee Related
- 2005-11-03 JP JP2007540127A patent/JP5080979B2/ja not_active Expired - Fee Related
- 2005-11-03 CA CA2585178A patent/CA2585178C/en not_active Expired - Fee Related
- 2005-11-03 DK DK13161757.3T patent/DK2649887T3/en active
- 2005-11-03 JP JP2007540126A patent/JP5129574B2/ja not_active Expired - Fee Related
- 2005-11-03 CN CNA2005800459100A patent/CN101437952A/zh active Pending
- 2005-11-03 CN CNA2005800457798A patent/CN101437951A/zh active Pending
- 2005-11-03 CN CN2005800459172A patent/CN101437953B/zh not_active Expired - Fee Related
- 2005-11-03 WO PCT/US2005/040255 patent/WO2006052870A2/en not_active Ceased
- 2005-11-03 DK DK05851406.8T patent/DK1807527T3/da active
- 2005-11-03 DK DK12152258.5T patent/DK2458000T3/da active
- 2005-11-03 EP EP12152258.5A patent/EP2458000B1/en not_active Expired - Lifetime
- 2005-11-03 WO PCT/US2005/040256 patent/WO2006052871A2/en not_active Ceased
- 2005-11-03 EP EP05818267A patent/EP1807526A4/en not_active Withdrawn
- 2005-11-03 CA CA2584719A patent/CA2584719C/en not_active Expired - Fee Related
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2007
- 2007-05-15 NO NO20072517A patent/NO20072517L/no not_active Application Discontinuation
- 2007-05-16 NO NO20072516A patent/NO20072516L/no not_active Application Discontinuation
- 2007-05-21 NO NO20072575A patent/NO20072575L/no not_active Application Discontinuation
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2009
- 2009-05-14 US US12/466,072 patent/US8685682B2/en not_active Expired - Fee Related
- 2009-07-30 US US12/512,507 patent/US20100022647A1/en not_active Abandoned
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2010
- 2010-09-29 US US12/893,469 patent/US8518674B2/en active Active
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2012
- 2012-11-13 US US13/675,144 patent/US20130123361A1/en not_active Abandoned
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2013
- 2013-07-17 US US13/943,992 patent/US8815566B2/en not_active Expired - Lifetime
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