|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4338397A
(en)
*
|
1980-04-11 |
1982-07-06 |
President And Fellows Of Harvard College |
Mature protein synthesis
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4755465A
(en)
*
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
US4710457A
(en)
*
|
1983-06-29 |
1987-12-01 |
Sloan-Kettering Institute For Cancer Research |
Monoclonal antibody for human hematopoietic glycoproteins and method
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
EP0143949B1
(en)
|
1983-11-01 |
1988-10-12 |
TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION |
Pharmaceutical composition containing urokinase
|
|
US4740461A
(en)
|
1983-12-27 |
1988-04-26 |
Genetics Institute, Inc. |
Vectors and methods for transformation of eucaryotic cells
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
WO1986000922A1
(en)
|
1984-07-30 |
1986-02-13 |
The Salk Institute For Biological Studies |
Retroviral gene transfer vectors
|
|
US4699880A
(en)
|
1984-09-25 |
1987-10-13 |
Immunomedics, Inc. |
Method of producing monoclonal anti-idiotype antibody
|
|
US5900400A
(en)
|
1984-12-06 |
1999-05-04 |
Amgen Inc. |
Serine protease inhibitor analogs
|
|
US4760130A
(en)
|
1984-12-06 |
1988-07-26 |
Synergen Biologicals, Inc. |
Serine protease inhibitors and methods for isolation of same
|
|
JPS6291197A
(ja)
|
1985-10-17 |
1987-04-25 |
Dainippon Pharmaceut Co Ltd |
抗ヒトインタ−ロイキン1抗体,その製法及びその使用法
|
|
US6410516B1
(en)
|
1986-01-09 |
2002-06-25 |
President & Fellows Of Harvard College |
Nuclear factors associated with transcriptional regulation
|
|
US4959455A
(en)
|
1986-07-14 |
1990-09-25 |
Genetics Institute, Inc. |
Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
|
|
US4935343A
(en)
|
1986-08-08 |
1990-06-19 |
Syntex (U.S.A.) Inc. |
Monoclonal antibodies for interleukin-1β
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
DK590387A
(da)
|
1986-11-13 |
1988-05-14 |
Otsuka Pharma Co Ltd |
Antistoffer mod interleukin-1
|
|
US4912040A
(en)
|
1986-11-14 |
1990-03-27 |
Genetics Institute, Inc. |
Eucaryotic expression system
|
|
US5359032A
(en)
|
1987-08-26 |
1994-10-25 |
Biogen Inc. |
Interkeukin-1 inhibitor
|
|
IL98078A0
(en)
|
1991-05-07 |
1992-06-21 |
Yeda Res & Dev |
Pharmaceutical compositions comprising an anticytokyne
|
|
US5512544A
(en)
|
1987-09-13 |
1996-04-30 |
Yeda Research And Development Co. Ltd. |
Pharmaceutical compositions comprising an anticytokine
|
|
IL83878A
(en)
|
1987-09-13 |
1995-07-31 |
Yeda Res & Dev |
Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
|
|
US5158881A
(en)
|
1987-11-17 |
1992-10-27 |
Brown University Research Foundation |
Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
|
|
US4892538A
(en)
|
1987-11-17 |
1990-01-09 |
Brown University Research Foundation |
In vivo delivery of neurotransmitters by implanted, encapsulated cells
|
|
US5106627A
(en)
|
1987-11-17 |
1992-04-21 |
Brown University Research Foundation |
Neurological therapy devices
|
|
WO1989004838A1
(en)
|
1987-11-25 |
1989-06-01 |
Immunex Corporation |
Interleukin-1 receptors
|
|
US5319071A
(en)
|
1987-11-25 |
1994-06-07 |
Immunex Corporation |
Soluble interleukin-1 receptors
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
US5846534A
(en)
*
|
1988-02-12 |
1998-12-08 |
British Technology Group Limited |
Antibodies to the antigen campath-1
|
|
US4942184A
(en)
*
|
1988-03-07 |
1990-07-17 |
The United States Of America As Represented By The Department Of Health And Human Services |
Water soluble, antineoplastic derivatives of taxol
|
|
GB8807803D0
(en)
|
1988-03-31 |
1988-05-05 |
Glaxo Group Ltd |
Biochemical product
|
|
US5075222A
(en)
|
1988-05-27 |
1991-12-24 |
Synergen, Inc. |
Interleukin-1 inhibitors
|
|
BR8907457A
(pt)
|
1988-05-27 |
1991-04-02 |
Synergen Inc |
Inibidores de interleucina-1
|
|
US5011472A
(en)
|
1988-09-06 |
1991-04-30 |
Brown University Research Foundation |
Implantable delivery system for biological factors
|
|
US5359037A
(en)
|
1988-09-12 |
1994-10-25 |
Yeda Research And Development Co. Ltd. |
Antibodies to TNF binding protein I
|
|
IL94039A
(en)
|
1989-08-06 |
2006-09-05 |
Yeda Res & Dev |
Antibodies to tbp - 1 and their use
|
|
US5811261A
(en)
|
1988-09-12 |
1998-09-22 |
Yeda Research And Development Co. Ltd. |
Expression of the recombinant tumor necrosis factor binding protein I (TBP-I)
|
|
EP0364778B1
(en)
|
1988-10-01 |
1996-03-13 |
Otsuka Pharmaceutical Co., Ltd. |
Antibody against interleukin-1beta
|
|
FR2640146B1
(fr)
|
1988-12-08 |
1993-12-24 |
Commissariat A Energie Atomique |
Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
ATE289350T1
(de)
|
1989-04-21 |
2005-03-15 |
Amgen Inc |
Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas
|
|
DE3922089A1
(de)
|
1989-05-09 |
1990-12-13 |
Basf Ag |
Neue proteine und ihre herstellung
|
|
IL107267A
(en)
|
1993-10-12 |
2009-07-20 |
Yeda Res & Dev |
Ligand to a member of the tnf/ngf receptor family
|
|
ES2072330T5
(es)
|
1989-05-18 |
2013-06-24 |
Yeda Research And Development Co., Ltd. |
Proteínas de unión II al Factor de Necrosis Tumoral, su purificación y anticuerpos frente a los mismos
|
|
JP2877509B2
(ja)
|
1989-05-19 |
1999-03-31 |
アムジエン・インコーポレーテツド |
メタロプロテイナーゼ阻害剤
|
|
US5627262A
(en)
|
1989-07-05 |
1997-05-06 |
The Board Of Regents Of The University Of Oklahoma |
Method and composition for the treatment of septic shock
|
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
Method for the production of a human recombinant tumor necrosis factor inhibitor
|
|
AU630497B2
(en)
|
1989-09-05 |
1992-10-29 |
Immunex Corporation |
Tumor necrosis factor-alpha and -beta receptors
|
|
US5395760A
(en)
|
1989-09-05 |
1995-03-07 |
Immunex Corporation |
DNA encoding tumor necrosis factor-α and -β receptors
|
|
ATE194384T1
(de)
|
1989-09-12 |
2000-07-15 |
Hoffmann La Roche |
Tnf-bindende proteine
|
|
JPH03127800A
(ja)
|
1989-10-13 |
1991-05-30 |
Teijin Ltd |
腫瘍壊死因子活性抑制物質
|
|
BR9007883A
(pt)
|
1989-11-29 |
1992-09-29 |
Synergen Inc |
Producao de inibidor de interleucina-1 humana recombinante
|
|
CA2032191C
(en)
|
1989-12-13 |
1999-05-18 |
David Wallach |
Expression of the recombinant tumor necrosis factor binding protein i (tbp-i)
|
|
US5136021A
(en)
|
1990-02-27 |
1992-08-04 |
Health Research, Inc. |
TNF-inhibitory protein and a method of production
|
|
AU649245B2
(en)
|
1990-04-02 |
1994-05-19 |
Amgen, Inc. |
Methods for treating interleukin-1 mediated diseases
|
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
WO1991017184A1
(en)
|
1990-04-27 |
1991-11-14 |
The Upjohn Company |
Modified interleukin-1 inhibitors
|
|
CA2081774A1
(en)
|
1990-05-01 |
1991-11-02 |
John Stephen Haskill |
Interleukin-1 antagonist and uses thereof
|
|
US5872095A
(en)
|
1990-05-01 |
1999-02-16 |
Chiron Corporation |
IL-1 receptor antagonists medicaments
|
|
US5350683A
(en)
|
1990-06-05 |
1994-09-27 |
Immunex Corporation |
DNA encoding type II interleukin-1 receptors
|
|
GB2246569A
(en)
|
1990-06-15 |
1992-02-05 |
Charing Cross Sunley Research |
Tumour necrosis factor - alpha binding protein
|
|
US7253264B1
(en)
|
1990-06-28 |
2007-08-07 |
Sanofi-Arentideutschland GmbH |
Immunoglobulin fusion proteins, their production and use
|
|
ES2120949T4
(es)
|
1990-06-28 |
2011-12-29 |
Sanofi-Aventis Deutschland Gmbh 50% |
Proteinas de fusión con porciones de inmunoglobulinas, su preparación y empleo.
|
|
WO1992001002A1
(en)
|
1990-07-11 |
1992-01-23 |
Teijin Limited |
Tumor necrosis factor activity inhibitor and production thereof
|
|
WO1992002220A1
(en)
|
1990-08-03 |
1992-02-20 |
Smithkline Beecham Corporation |
Tnf inhibitors
|
|
US5747444A
(en)
|
1990-10-09 |
1998-05-05 |
Chiron Corporation |
Method of treating graft-versus-host disease
|
|
GB9022648D0
(en)
|
1990-10-18 |
1990-11-28 |
Charing Cross Sunley Research |
Polypeptide and its use
|
|
US5858355A
(en)
|
1990-12-20 |
1999-01-12 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
IRAP gene as treatment for arthritis
|
|
NZ241311A
(en)
|
1991-01-17 |
1995-03-28 |
Gen Hospital Corp |
Rna sequence having trans-splicing activity, plant strains
|
|
ATE190629T1
(de)
|
1991-01-18 |
2000-04-15 |
Amgen Inc |
Methoden zur behandlung von durch den tumor nekrose faktor ausgelösten krankheiten
|
|
DK0575545T3
(da)
|
1991-03-15 |
2003-09-15 |
Amgen Inc |
Pegylering af polypeptider
|
|
US6565841B1
(en)
|
1991-03-15 |
2003-05-20 |
Amgen, Inc. |
Pulmonary administration of granulocyte colony stimulating factor
|
|
IL99120A0
(en)
|
1991-08-07 |
1992-07-15 |
Yeda Res & Dev |
Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
|
|
WO1993007863A1
(en)
|
1991-10-15 |
1993-04-29 |
Mullarkey Michael F |
Methods and compositions for treating allergic reactions
|
|
US5961974A
(en)
|
1991-10-25 |
1999-10-05 |
Immunex Corporation |
Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same
|
|
AU661360B2
(en)
|
1991-10-25 |
1995-07-20 |
Immunex Corporation |
Novel cytokine
|
|
ES2038546B1
(es)
|
1991-11-08 |
1994-02-16 |
Andromaco Lab |
Procedimiento de obtencion de un producto de naturaleza polipeptidica con actividad inhibidora de la hiperproduccion del factor de necrosis tumoral.
|
|
JPH05244982A
(ja)
|
1991-12-06 |
1993-09-24 |
Sumitomo Chem Co Ltd |
擬人化b−b10
|
|
CA2124967C
(en)
|
1991-12-17 |
2008-04-08 |
Nils Lonberg |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
MX9300141A
(es)
|
1992-01-13 |
1994-07-29 |
Smithkline Beecham Corp |
Compuestos de imidazol novedosos, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
|
|
WO1993015722A1
(en)
|
1992-02-07 |
1993-08-19 |
Syntex (Usa) Inc. |
Controlled delivery of pharmaceuticals from preformed porous microparticles
|
|
DE69332634T2
(de)
|
1992-03-04 |
2003-05-08 |
Cell Therapeutics, Inc. |
Enantiomere hydroxylierte xanthinverbindungen
|
|
NZ251820A
(en)
|
1992-03-30 |
1996-07-26 |
Immunex Corp |
Fusion proteins with tnf-r (tumour necrosis factor-receptor) peptide linked to another tnf-r or an il-1r (interleukin-1-receptor) peptide
|
|
JPH07509223A
(ja)
|
1992-04-30 |
1995-10-12 |
アムジェン インコーポレイテッド |
インターロイキン−1媒介疾患および腫瘍壊死因子媒介疾患の治療方法
|
|
JPH05312248A
(ja)
|
1992-05-08 |
1993-11-22 |
Nissan Motor Co Ltd |
シフトレバー装置
|
|
DE4219626A1
(de)
|
1992-06-16 |
1993-12-23 |
Wehling Peter Priv Doz Dr Med |
Methode zur Einschleusung therapeutisch relevanter Gene in Körperzellen
|
|
JPH0630788A
(ja)
|
1992-07-16 |
1994-02-08 |
Otsuka Pharmaceut Co Ltd |
ヒトインターロイキン−1に対する組換え抗体
|
|
US5545716A
(en)
|
1992-09-08 |
1996-08-13 |
University Of Florida |
Superantigen agonist and antagonist peptides
|
|
RU2126262C1
(ru)
|
1992-09-17 |
1999-02-20 |
Амген Боулдер Инк. |
Фармацевтическая композиция
|
|
JPH06111399A
(ja)
|
1992-09-30 |
1994-04-22 |
Sony Corp |
光磁気記録媒体及びその製造方法
|
|
WO1994007498A1
(fr)
|
1992-10-07 |
1994-04-14 |
Sumitomo Pharmaceuticals Company, Limited |
Composition pharmaceutique utilisee pour inhiber la production des facteurs de necrose tumorale
|
|
ATE240394T1
(de)
|
1992-10-23 |
2003-05-15 |
Immunex Corp |
Methoden zur herstellung löslicher, oligomerer proteine
|
|
US5891438A
(en)
*
|
1992-10-30 |
1999-04-06 |
The Regents Of The University Of California |
Method for stimulating production of variable region gene family restricted antibodies through B-cell superantigen vaccination
|
|
US5866576A
(en)
|
1992-12-16 |
1999-02-02 |
Cell Therapeutics, Inc. |
Epoxide-containing compounds
|
|
DE59407414D1
(de)
|
1993-01-08 |
1999-01-21 |
Hoechst Ag |
Verwendung von Leflunomid zur Hemmung von Tumornekrosefaktor alpha
|
|
ES2159529T5
(es)
|
1993-03-05 |
2011-03-09 |
Bayer Corporation |
Anticuerpos monoclonales humanos anti-tnf alfa.
|
|
JPH08511507A
(ja)
|
1993-03-08 |
1996-12-03 |
ユニバーシティー オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション |
哺乳動物宿主の結合組織を処置するための遺伝子導入
|
|
PT689449E
(pt)
|
1993-03-19 |
2003-03-31 |
Vacsyn Sa |
Composicoes para aplicacao em terapeutica humana caracterizadas pela associacao de um peptido de muramilo a uma citoquina
|
|
US6326353B1
(en)
|
1993-03-23 |
2001-12-04 |
Sequus Pharmaceuticals, Inc. |
Enhanced circulation effector composition and method
|
|
US5843905A
(en)
|
1993-06-04 |
1998-12-01 |
Vertex Pharmaceuticals, Incorporated |
Peptidic phosphinyloxymethyl ketones as interleukin-1β-converting enzyme inhibitors
|
|
FR2706772A1
(en)
|
1993-06-22 |
1994-12-30 |
Vacsyn Sa |
Prevention and treatment of septic syndrome with an immunosuppressant, in particular cyclosporin.
|
|
US5698579A
(en)
|
1993-07-02 |
1997-12-16 |
Celgene Corporation |
Cyclic amides
|
|
WO1995001997A1
(en)
|
1993-07-09 |
1995-01-19 |
Smithkline Beecham Corporation |
RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
|
|
CA2160928C
(en)
|
1993-07-28 |
2005-07-05 |
Garry Fenton |
Compounds as pde iv and tnf inhibitors
|
|
ATE177083T1
(de)
|
1993-11-29 |
1999-03-15 |
Merrell Pharma Inc |
Benzolsulfonyliminderivate als inhibitoren der il-1 wirkung
|
|
CA2138305A1
(en)
|
1993-12-28 |
1995-06-29 |
Naohito Ohashi |
Tumor necrosis factor production inhibitors
|
|
GB9401460D0
(en)
|
1994-01-26 |
1994-03-23 |
Rhone Poulenc Rorer Ltd |
Compositions of matter
|
|
US5608035A
(en)
|
1994-02-02 |
1997-03-04 |
Affymax Technologies N.V. |
Peptides and compounds that bind to the IL-1 receptor
|
|
WO1995022546A1
(en)
|
1994-02-18 |
1995-08-24 |
Cell Therapeutics, Inc. |
Intracellular signalling mediators
|
|
ATE169009T1
(de)
|
1994-03-09 |
1998-08-15 |
Pfizer |
Isoxazoline verbindung zur hemmung tnf-freigabe
|
|
US5708142A
(en)
|
1994-05-27 |
1998-01-13 |
Genentech, Inc. |
Tumor necrosis factor receptor-associated factors
|
|
US5741667A
(en)
|
1994-05-27 |
1998-04-21 |
Genentech, Inc. |
Tumor necrosis factor receptor-associated factors
|
|
US5817822A
(en)
|
1994-06-24 |
1998-10-06 |
Novartis Corporation |
Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids
|
|
IL114417A0
(en)
|
1994-07-07 |
1995-10-31 |
Res Dev Foundation |
Tumor necrosis factor receptor-I associated proteins and protein kinase and methods for their use
|
|
US5877180A
(en)
|
1994-07-11 |
1999-03-02 |
University Of Virginia Patent Foundation |
Method for treating inflammatory diseases with A2a adenosine receptor agonists
|
|
DE69519454T2
(de)
|
1994-07-14 |
2001-05-03 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama |
Protein, das Interferon-Gamma Herstellung induziert und monoklonaler Antikörper dagegen
|
|
US5641747A
(en)
|
1994-07-25 |
1997-06-24 |
Temple University-Of The Commonwealth System Of Higher Education |
Treatment of osteopetrotic diseases
|
|
US5633227A
(en)
|
1994-09-12 |
1997-05-27 |
Miles, Inc. |
Secretory leukocyte protease inhibitor as an inhibitor of tryptase
|
|
IT1269989B
(it)
|
1994-09-21 |
1997-04-16 |
Dompe Spa |
Antagonisti recettoriali di il-1 ad aumentata attivita' inibitoria
|
|
BR9509237A
(pt)
|
1994-10-05 |
1997-10-21 |
Chiroscience Ltd |
Compostos peptidila e seu uso terapêutico como inibidores de metaloproteases
|
|
US5852173A
(en)
|
1994-10-19 |
1998-12-22 |
Genetics Institute, Inc. |
TNF receptor death ligand proteins and inhibitors of ligand binding
|
|
TW581771B
(en)
|
1994-11-15 |
2004-04-01 |
Hayashibara Biochem Lab |
Recombinant production of a polypeptide for inducing interferon-gamma production, and monoclonal antibody against the polypeptide
|
|
WO1996019990A1
(en)
|
1994-12-23 |
1996-07-04 |
Smithkline Beecham Corporation |
4,4-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds
|
|
ZA9510826B
(en)
|
1994-12-23 |
1996-06-20 |
Smithkline Beecham Corp |
3,3-(disubstituted)cyclohexan-1-ol monomers and related compounds
|
|
US6323201B1
(en)
|
1994-12-29 |
2001-11-27 |
The Regents Of The University Of California |
Compounds for inhibition of ceramide-mediated signal transduction
|
|
US6429221B1
(en)
|
1994-12-30 |
2002-08-06 |
Celgene Corporation |
Substituted imides
|
|
CN1177296A
(zh)
|
1995-01-09 |
1998-03-25 |
大制药株式会社 |
TNF-α抑制剂
|
|
PE64396A1
(es)
|
1995-01-23 |
1997-01-28 |
Hoffmann La Roche |
Proteina accesoria del receptor de la interleucina 1
|
|
IL117175A
(en)
|
1995-02-20 |
2005-11-20 |
Sankyo Co |
Osteoclastogenesis inhibitory factor protein
|
|
US6001349A
(en)
|
1995-02-22 |
1999-12-14 |
Therion Biologics Corporation |
Generation of human cytotoxic T-cells specific for carcinoma self-associated antigens and uses thereof
|
|
BR9607336A
(pt)
|
1995-02-23 |
1997-11-25 |
Novartis Nutrition Ag |
Composições de aminoácidos e utilidades das mesmas em nutrição clinica
|
|
WO1996028546A1
(en)
|
1995-03-15 |
1996-09-19 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor
|
|
EP0737471A3
(fr)
|
1995-04-10 |
2000-12-06 |
L'oreal |
Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue
|
|
DK0821671T3
(da)
|
1995-04-20 |
2001-04-23 |
Pfizer |
Arylsulfonylhydroxamsyrederivater som MMP- og TNF-inhibitorer
|
|
WO1996034095A1
(en)
|
1995-04-27 |
1996-10-31 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptors
|
|
JPH11505532A
(ja)
|
1995-05-10 |
1999-05-21 |
カイロサイエンス・リミテッド |
金属プロテアーゼとtnfの放出を抑制するペプチド化合物およびその治療的使用
|
|
AR004471A1
(es)
|
1995-05-31 |
1998-12-16 |
Smithkline Beecham Corp |
Compuestos de ciclohexan-1-ol-4,4-disustituidos, utiles en el tratamiento de enfermedades alergicas e inflamatorias y composiciones farmaceuticas que lascontienen
|
|
US5739143A
(en)
|
1995-06-07 |
1998-04-14 |
Smithkline Beecham Corporation |
Imidazole compounds and compositions
|
|
US5817476A
(en)
|
1995-06-07 |
1998-10-06 |
Genetics Institute, Inc. |
Polynucleotides encoding interleukin-1 receptor intracellular ligand proteins
|
|
MX9709447A
(es)
|
1995-06-07 |
1998-02-28 |
Immunex Corp |
Nueva muteina cd4ol.
|
|
US5843901A
(en)
|
1995-06-07 |
1998-12-01 |
Advanced Research & Technology Institute |
LHRH antagonist peptides
|
|
US5830742A
(en)
|
1995-06-08 |
1998-11-03 |
Immunex Corporation |
TNF-α converting enzyme
|
|
AU708239B2
(en)
|
1995-06-29 |
1999-07-29 |
Immunex Corporation |
Cytokine that induces apoptosis
|
|
US6127977A
(en)
|
1996-11-08 |
2000-10-03 |
Cohen; Nathan |
Microstrip patch antenna with fractal structure
|
|
ZA966663B
(en)
|
1995-08-17 |
1998-02-06 |
Genentech Inc |
Traf Inhibitors.
|
|
US5728844A
(en)
|
1995-08-29 |
1998-03-17 |
Celgene Corporation |
Immunotherapeutic agents
|
|
JPH11511463A
(ja)
|
1995-08-31 |
1999-10-05 |
スミスクライン・ビーチャム・コーポレイション |
インターロイキン変換酵素およびアポプトーシス
|
|
IL115245A
(en)
|
1995-09-11 |
2002-12-01 |
Yissum Res Dev Co |
Tumor necrosis factor inhibiting pharmaceuticals
|
|
WO1997012244A1
(en)
|
1995-09-27 |
1997-04-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for determining t-cell profiles of immunocompromised subjects
|
|
HUP0003760A3
(en)
|
1995-10-05 |
2001-05-28 |
Darwin Discovery Ltd Cambridge |
Thio-substituted peptides as inhibitors for metalloproteinases and tnf liberation, process for production thereof and their use
|
|
DE19540475A1
(de)
|
1995-10-20 |
1997-04-24 |
Schering Ag |
Chirale Methylphenyloxazolidinone
|
|
EE9800115A
(et)
|
1995-11-14 |
1998-10-15 |
The Du Pont Merck Pharmaceutical Company |
Uudsed makrotsüklilised ühendid kui metalloproteaasi inhibiitorid
|
|
US6281352B1
(en)
|
1995-11-14 |
2001-08-28 |
Dupont Pharmaceuticals Company |
Macrocyclic compounds as metalloprotease inhibitors
|
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
|
CO4750805A1
(es)
*
|
1995-12-13 |
1999-03-31 |
Sumitomo Chemical Co |
Compuesto para champu
|
|
US5869315A
(en)
|
1995-12-18 |
1999-02-09 |
Basf Aktiengesellschaft |
Modified interleukin-1β converting enzyme with increased stability
|
|
US5990119A
(en)
|
1995-12-21 |
1999-11-23 |
Smithkline Beecham Corporation |
1,4,4-(trisubstituted)cyclohexane monomers and related compounds
|
|
US5891883A
(en)
|
1995-12-21 |
1999-04-06 |
Smithkline Beecham Corporation |
4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds
|
|
US5869677A
(en)
|
1995-12-21 |
1999-02-09 |
Smithkline Beecham Corporation |
3,3-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds
|
|
US6369027B1
(en)
|
1995-12-22 |
2002-04-09 |
Amgen Inc. |
Osteoprotegerin
|
|
US6613544B1
(en)
*
|
1995-12-22 |
2003-09-02 |
Amgen Inc. |
Osteoprotegerin
|
|
WO1997024441A1
(en)
|
1995-12-29 |
1997-07-10 |
Incyte Pharmaceuticals, Inc. |
Nucleic acids encoding interferon gamma inducing factor-2
|
|
US6046048A
(en)
|
1996-01-09 |
2000-04-04 |
Genetech, Inc. |
Apo-2 ligand
|
|
DK0929578T3
(da)
|
1996-02-09 |
2003-08-25 |
Abbott Lab Bermuda Ltd |
Humane antistoffer, der binder human TNFalfa
|
|
CA2244664C
(en)
|
1996-02-09 |
2008-06-03 |
Amgen Inc. |
Composition comprising interleukin-1 inhibitor and controlled release polymer
|
|
US5994351A
(en)
|
1998-07-27 |
1999-11-30 |
Pfizer Inc. |
Arylsulfonylamino hydroxamic acid derivatives
|
|
US5981220A
(en)
|
1996-03-27 |
1999-11-09 |
Human Genome Sciences, Inc. |
Epidermal differentiation factor
|
|
GB9607249D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
|
GB9607119D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
|
GB9607120D0
(en)
|
1996-04-04 |
1996-06-12 |
Chiroscience Ltd |
Compounds
|
|
US5710013A
(en)
|
1996-04-19 |
1998-01-20 |
Tularik Inc. |
Tumor necrosis factor receptor associated factor 6 (TRAF6)
|
|
GB9609795D0
(en)
|
1996-05-10 |
1996-07-17 |
Smithkline Beecham Plc |
Novel compounds
|
|
AUPO048296A0
(en)
|
1996-06-14 |
1996-07-11 |
Fujisawa Pharmaceutical Co., Ltd. |
New compound and its preparation
|
|
EP0816499A3
(en)
|
1996-06-27 |
1999-10-27 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma
|
|
EP0818439B1
(en)
|
1996-07-02 |
1999-10-13 |
Nisshin Flour Milling Co., Ltd. |
Imide derivatives
|
|
TW555765B
(en)
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
|
JPH10130149A
(ja)
|
1996-07-12 |
1998-05-19 |
Sankyo Co Ltd |
Tnf産生抑制剤
|
|
US5853977A
(en)
|
1996-07-12 |
1998-12-29 |
Schering Corporation |
Mammalian TNF-α convertases
|
|
US5877222A
(en)
|
1996-07-19 |
1999-03-02 |
The Regents Of The University Of California |
Method for treating aids-associated dementia
|
|
GB9616643D0
(en)
|
1996-08-08 |
1996-09-25 |
Chiroscience Ltd |
Compounds
|
|
RU2188819C2
(ru)
|
1996-08-12 |
2002-09-10 |
Селджин Корпорейшн |
НОВЫЕ ИММУНОТЕРАПЕВТИЧЕСКИЕ СОЕДИНЕНИЯ, СОДЕРЖАЩАЯ ИХ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ СНИЖЕНИЯ УРОВНЕЙ ФДЭ, TNFα И NFκB
|
|
US6069132A
(en)
|
1996-08-14 |
2000-05-30 |
Revanker; Ganapathi R. |
Phosphazole compounds
|
|
KR100517452B1
(ko)
|
1996-09-25 |
2007-03-15 |
히사미쓰 메디카루 가부시키가이샤 |
치환 비닐피리딘 유도체 및 이를 함유하는 의약
|
|
US5962481A
(en)
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
GB9621859D0
(en)
|
1996-10-21 |
1996-12-11 |
Xenova Ltd |
Cytokine production inhibitors
|
|
GB9712761D0
(en)
|
1997-06-17 |
1997-08-20 |
Chiroscience Ltd |
Quinolines and their therapeutic use
|
|
JPH10147531A
(ja)
|
1996-11-19 |
1998-06-02 |
Otsuka Pharmaceut Co Ltd |
TNF−α産生抑制剤
|
|
US5955480A
(en)
|
1996-11-20 |
1999-09-21 |
Merck & Co., Inc. |
Triaryl substituted imidazoles, compositions containing such compounds and methods of use
|
|
WO1998021957A1
(en)
|
1996-11-20 |
1998-05-28 |
Merck & Co., Inc. |
Triaryl substituted imidazoles, compositions containing such compounds and methods of use
|
|
US5834435A
(en)
|
1996-11-27 |
1998-11-10 |
Slesarev; Vladimir I. |
Inhibition of TNF-α pleiotropic and cytotoxic effects
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
JP2001513754A
(ja)
|
1996-12-06 |
2001-09-04 |
アムジェン インコーポレイテッド |
Tnf媒介疾患を処置するためのtnf結合タンパク質を使用する組み合わせ治療
|
|
EP1803816A3
(en)
|
1996-12-13 |
2007-09-26 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
DE19652227A1
(de)
|
1996-12-16 |
1998-06-18 |
Bosch Gmbh Robert |
Verfahren und Vorrichtung zum Zuordnen einer Fernbedienung zu einer Basisstation
|
|
JPH10231285A
(ja)
|
1996-12-17 |
1998-09-02 |
Ishihara Sangyo Kaisha Ltd |
フタルイミド誘導体又はその塩、それらの製造方法及びそれらを含有する医薬組成物
|
|
AU5901598A
(en)
|
1996-12-20 |
1998-07-17 |
Board Of Regents, The University Of Texas System |
Compositions and methods of use for osteoclast inhibitory factors
|
|
US6271349B1
(en)
|
1996-12-23 |
2001-08-07 |
Immunex Corporation |
Receptor activator of NF-κB
|
|
US6242213B1
(en)
*
|
1996-12-23 |
2001-06-05 |
Immunex Corporation |
Isolated DNA molecules encoding RANK-L
|
|
WO1999058674A2
(en)
|
1998-05-14 |
1999-11-18 |
Immunex Corporation |
Method of inhibiting osteoclast activity
|
|
US7141393B2
(en)
|
1996-12-26 |
2006-11-28 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
Interleukin-18-receptor proteins
|
|
PT853083E
(pt)
|
1997-01-06 |
2001-12-28 |
Pfizer |
Composto de piridilfurano e piridiltiofeno e sua utilizacao farmaceutica
|
|
US5952320A
(en)
|
1997-01-07 |
1999-09-14 |
Abbott Laboratories |
Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
|
|
ZA9818B
(en)
|
1997-01-07 |
1998-07-02 |
Abbott Lab |
C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
|
|
US6054559A
(en)
|
1997-01-28 |
2000-04-25 |
Smithkline Beecham Corporation |
Interleukin-1 receptor antagonist beta (IL-1raβ)
|
|
PT1270565E
(pt)
|
1997-01-29 |
2004-09-30 |
Pfizer |
Furano-2-sulfonamida 4-substituida e sua utilizacao na preparacao de derivados de sulfonilureia
|
|
JP3955352B2
(ja)
|
1997-02-25 |
2007-08-08 |
株式会社林原生物化学研究所 |
破骨細胞形成阻害剤
|
|
US5969102A
(en)
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
|
US6476027B1
(en)
|
1997-03-04 |
2002-11-05 |
Monsanto Company |
N-hydroxy 4-sulfonyl butanamide compounds
|
|
US6362183B1
(en)
|
1997-03-04 |
2002-03-26 |
G. D. Searle & Company |
Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
|
|
WO1998039315A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
|
|
DK0977745T3
(da)
|
1997-03-04 |
2005-03-14 |
Pharmacia Corp |
Thioarylsulfonamidhydroxamsyreforbindelser
|
|
US6380258B2
(en)
|
1997-03-04 |
2002-04-30 |
G. D. Searle, L.L.C. |
Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds
|
|
US6087116A
(en)
|
1997-03-12 |
2000-07-11 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
Interleukin-18 (IL-18) receptor polypeptides and their uses
|
|
SK122199A3
(en)
|
1997-03-18 |
2000-12-11 |
Basf Ag |
Methods and compositions for modulating responsiveness to corticosteroids
|
|
JPH10259140A
(ja)
|
1997-03-18 |
1998-09-29 |
Sumitomo Pharmaceut Co Ltd |
腫瘍壊死因子産生抑制剤
|
|
US6054487A
(en)
|
1997-03-18 |
2000-04-25 |
Basf Aktiengesellschaft |
Methods and compositions for modulating responsiveness to corticosteroids
|
|
WO1998042325A2
(en)
|
1997-03-21 |
1998-10-01 |
Cistron Biotechnology, Inc. |
INHIBITION OF THE CLEAVAGE OF PRECURSOR IL-1$g(b)
|
|
GB9706255D0
(en)
|
1997-03-26 |
1997-05-14 |
Smithkline Beecham Plc |
Novel compounds
|
|
AU6843298A
(en)
|
1997-03-28 |
1998-10-22 |
Zeneca Limited |
Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
|
|
JP2001517225A
(ja)
|
1997-03-28 |
2001-10-02 |
ゼネカ リミテッド |
N−(3−ヒドロキシ−スクシニル)−アミノ酸誘導体調製のためのプロセス
|
|
NZ337698A
(en)
|
1997-04-04 |
2001-07-27 |
Pfizer Prod Inc |
Nicotinamide derivatives for selective inhibition of phosphodiesterase type 4 (PDE4) and the production of tumour necrosis factor (TNF) useful for the treatment of respiratory, rheumatoid and allergic diseases
|
|
US6297248B1
(en)
|
1997-04-06 |
2001-10-02 |
Suntory Limited |
1-aryl-1,8-naphthylidin-4-one derivative as type IV phosphodiesterase inhibitor
|
|
EP0979099B1
(en)
|
1997-04-10 |
2005-06-15 |
Agennix, Inc. |
Use of lactoferin in the treatment of allergen induced disorders
|
|
KR100496063B1
(ko)
|
1997-04-15 |
2005-06-21 |
산쿄 가부시키가이샤 |
신규단백질 및 그 제조방법
|
|
WO1998046757A2
(en)
|
1997-04-15 |
1998-10-22 |
Genetics Institute, Inc. |
Secreted proteins and polynucleotides encoding them
|
|
EP0975754B2
(en)
*
|
1997-04-16 |
2016-01-06 |
Amgen Inc., |
Osteoprotegerin binding proteins and their receptors
|
|
US5843678A
(en)
*
|
1997-04-16 |
1998-12-01 |
Amgen Inc. |
Osteoprotegerin binding proteins
|
|
US6316408B1
(en)
|
1997-04-16 |
2001-11-13 |
Amgen Inc. |
Methods of use for osetoprotegerin binding protein receptors
|
|
FR2762315B1
(fr)
|
1997-04-22 |
1999-05-28 |
Logeais Labor Jacques |
Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha
|
|
RU2222534C2
(ru)
|
1997-04-24 |
2004-01-27 |
Орто-Макнейл Фармасьютикал, Инк. |
Замещенные имидазолы, способ их получения, фармацевтическая композиция на их основе, способы лечения цитокин-опосредованных заболеваний
|
|
CA2229449A1
(en)
|
1997-04-25 |
1998-10-25 |
Takeda Chemical Industries, Ltd. |
Novel receptor protein and its use
|
|
FR2762514B1
(fr)
|
1997-04-29 |
1999-10-22 |
Sanofi Sa |
Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
|
|
JP3776203B2
(ja)
|
1997-05-13 |
2006-05-17 |
第一製薬株式会社 |
Icam−1産生阻害剤
|
|
EP0983260A2
(en)
|
1997-05-22 |
2000-03-08 |
G.D. Searle & Co. |
3(5)-HETEROARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS
|
|
WO1998054201A1
(en)
|
1997-05-29 |
1998-12-03 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like protein 8
|
|
US6265535B1
(en)
|
1997-05-30 |
2001-07-24 |
The Trustees Of The University Of Pennsylvania |
Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses
|
|
JPH111481A
(ja)
|
1997-06-10 |
1999-01-06 |
Sumitomo Pharmaceut Co Ltd |
ピペリジニルフタラジン誘導体
|
|
KR100704059B1
(ko)
|
1997-06-12 |
2007-04-05 |
롱프랑 로라 리미티드 |
이미다졸릴-사이클릭 아세탈
|
|
KR19990001101A
(ko)
|
1997-06-12 |
1999-01-15 |
손경식 |
캐테콜 아미노산 유도체, 이의 제조방법 및 그를 함유한 약제 조성물
|
|
CA2294057A1
(en)
|
1997-06-13 |
1998-12-17 |
Smithkline Beecham Corporation |
Novel pyrazole and pyrazoline substituted compounds
|
|
JPH119269A
(ja)
|
1997-06-19 |
1999-01-19 |
Kaken Pharmaceut Co Ltd |
破骨細胞系細胞
|
|
GB9713732D0
(en)
|
1997-06-27 |
1997-09-03 |
Pharmacia & Upjohn Spa |
Substituted triazinic compounds
|
|
GB9713733D0
(en)
|
1997-06-27 |
1997-09-03 |
Pharmacia & Upjohn Spa |
Poly-branched polycarboxamido compounds
|
|
EP0994858A1
(en)
|
1997-06-30 |
2000-04-26 |
Ortho-McNeil Pharmaceutical, Inc. |
2-substituted imidazoles useful in the treatment of inflammatory diseases
|
|
GB9713726D0
(en)
|
1997-06-30 |
1997-09-03 |
Ciba Geigy Ag |
Organic compounds
|
|
US6235787B1
(en)
|
1997-06-30 |
2001-05-22 |
Hoffmann-La Roche Inc. |
Hydrazine derivatives
|
|
WO1999001139A1
(en)
|
1997-07-03 |
1999-01-14 |
Thomas Jefferson University |
An improved method for design and selection of efficacious antisense oligonucleotides
|
|
US5843721A
(en)
|
1997-07-03 |
1998-12-01 |
Tularik Inc. |
Nucleic acids encoding human NIK protein
|
|
AU8858398A
(en)
|
1997-07-10 |
1999-02-08 |
Pharmacia & Upjohn S.P.A. |
Matrix metalloproteinase inhibitors
|
|
DE19731521A1
(de)
|
1997-07-23 |
1999-01-28 |
Byk Gulden Lomberg Chem Fab |
Budipin bei der Behandlung entzündlicher Erkrankungen des Nervensystems
|
|
FR2766822B1
(fr)
|
1997-07-30 |
2001-02-23 |
Adir |
Nouveaux derives de benzimidazole, de benzoxazole et de benzothiazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
AR016551A1
(es)
|
1997-07-30 |
2001-07-25 |
Smithkline Beecham Corp |
Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos
|
|
CA2295295A1
(en)
|
1997-07-31 |
1999-02-11 |
Celgene Corporation |
Substituted alkanohydroxamic acids and method of reducing tnf.alpha. levels
|
|
AU751396B2
(en)
|
1997-08-04 |
2002-08-15 |
Millennium Pharmaceuticals, Inc. |
Novel molecules of the Tango-77 related protein family and uses thereof
|
|
AU8766498A
(en)
|
1997-08-04 |
1999-02-22 |
Amgen, Inc. |
Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors
|
|
PT895988E
(pt)
|
1997-08-08 |
2002-09-30 |
Pfizer Prod Inc |
Derivados do acido arilsulfonilamino-hidroxamico
|
|
WO1999007679A1
(en)
|
1997-08-08 |
1999-02-18 |
Chiroscience Limited |
Peptidyl compounds having mmp and tnf inhibitory activity
|
|
IL121860A0
(en)
|
1997-08-14 |
1998-02-22 |
Yeda Res & Dev |
Interleukin-18 binding proteins their preparation and use
|
|
US5994396A
(en)
|
1997-08-18 |
1999-11-30 |
Centaur Pharmaceuticals, Inc. |
Furansulfonic acid derivatives and pharmaceutical compositions containing the same
|
|
WO1999009965A2
(en)
|
1997-08-21 |
1999-03-04 |
Takeda Chemical Industries, Ltd. |
Anti-inflammatory agent
|
|
JPH11139994A
(ja)
|
1997-10-31 |
1999-05-25 |
Kureha Chem Ind Co Ltd |
抗腫瘍剤
|
|
AU751524B2
(en)
|
1997-11-03 |
2002-08-22 |
Trustees Of The University Of Pennsylvania, The |
Method and compositions for inhibiting angiogenesis and treating cancer
|
|
US5955476A
(en)
|
1997-11-18 |
1999-09-21 |
Celgene Corporation |
Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
|
|
WO1999029865A2
(en)
|
1997-12-12 |
1999-06-17 |
The Rockefeller University |
A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof
|
|
NZ505757A
(en)
|
1998-01-16 |
2002-09-27 |
Centaur Pharmaceuticals Inc |
Thioether furan nitrone compounds and pharmaceuticals thereof; useful for the treatment or prophylaxis of neurodegenerative, autoimmune and inflammatory conditions
|
|
JP2002509153A
(ja)
|
1998-01-20 |
2002-03-26 |
ワーナー−ランバート・カンパニー |
インターロイキン−1β変換酵素(ICE)のインビボ阻害剤としてのN−[2−(5−ベンジルオキシカルボニル−アミノ−6−オキソ−2−(4−フルオロフェニル)−1,6−ジヒドロ−1−ピリミジニル)アセトキシル]−L−アスパラギン酸アルデヒド
|
|
EP1047781B1
(en)
|
1998-01-23 |
2004-07-28 |
Immunex Corporation |
Il-18 receptors
|
|
AU750767B2
(en)
|
1998-01-23 |
2002-07-25 |
Immunex Corporation |
ACPL DNA and polypeptides
|
|
CN1293663A
(zh)
|
1998-01-27 |
2001-05-02 |
美国氰胺公司 |
为基质金属蛋白酶抑制剂的2,3,4,5-四氢-1h-[1,4]苯并二氮杂䓬-3-异羟肟酸
|
|
AU2472899A
(en)
|
1998-01-27 |
1999-08-09 |
Millennium Pharmaceuticals, Inc. |
Novel molecules of the tnf receptor superfamily and uses therefor
|
|
DE69925581T2
(de)
|
1998-03-09 |
2006-04-27 |
Vertex Pharmaceuticals Inc., Cambridge |
1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms
|
|
CN1297354A
(zh)
|
1998-03-16 |
2001-05-30 |
西托维亚公司 |
二肽卡斯帕酶抑制剂及其用途
|
|
DK1064298T3
(da)
|
1998-03-19 |
2009-01-19 |
Vertex Pharma |
Inhibitorer af caspaser
|
|
IL126024A0
(en)
|
1998-03-19 |
1999-05-09 |
Yeda Res & Dev |
Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
|
|
JPH11266872A
(ja)
|
1998-03-20 |
1999-10-05 |
Suntory Ltd |
NF−κBの活性化を抑制する物質のスクリーニング方法
|
|
ES2255251T3
(es)
|
1998-03-20 |
2006-06-16 |
Daiichi Asubio Pharma Co., Ltd. |
Inhibidores de nf-kb que contienen derivados de benzoquinona.
|
|
CN1305846C
(zh)
|
1998-03-26 |
2007-03-21 |
参天制药株式会社 |
脲衍生物
|
|
HUP0102782A3
(en)
|
1998-06-19 |
2002-12-28 |
Smithkline Beecham Corp |
Salycilanilide as inhibitors of transcription factor nf-kb
|
|
HUP0102492A2
(hu)
|
1998-06-19 |
2001-11-28 |
Smithkline Beecham Corp. |
Amino-indanon származékok alkalmazása NF-kB transzkripciós faktor inhibitor hatású gyógyszerkészítmények előállítására
|
|
CA2276216A1
(en)
|
1998-06-24 |
1999-12-24 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
An artificial peptide capable of neutralizing the biological activity of interleukin-18
|
|
US6210924B1
(en)
|
1998-08-11 |
2001-04-03 |
Amgen Inc. |
Overexpressing cyclin D 1 in a eukaryotic cell line
|
|
CA2340579A1
(en)
|
1998-09-01 |
2000-03-09 |
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo |
Interleukin 18-binding protein
|
|
CN1318105A
(zh)
|
1998-09-15 |
2001-10-17 |
M&E生物技术公司 |
负调节Osteoprotegerin配体活性的方法
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
DK1141028T3
(da)
*
|
1998-12-23 |
2010-05-25 |
Pfizer |
Humane monoklonale antistoffer til CTLA-4
|
|
DK1149114T3
(da)
|
1999-02-03 |
2014-06-23 |
Amgen Inc |
Polypeptider, der er involveret ved et immunrespons
|
|
WO2000047740A2
(en)
|
1999-02-12 |
2000-08-17 |
Amgen Inc. |
Tnf-related proteins
|
|
AUPQ314799A0
(en)
|
1999-09-29 |
1999-10-21 |
University Of Western Australia, The |
Bone cell factor
|
|
AU2262501A
(en)
|
1999-12-16 |
2001-06-25 |
Amgen, Inc. |
Tnfr/opg-like molecules and uses thereof
|
|
CA2400214A1
(en)
|
2000-02-11 |
2001-11-15 |
Amgen Inc. |
Fusion receptor from tnf family
|
|
US20030103978A1
(en)
|
2000-02-23 |
2003-06-05 |
Amgen Inc. |
Selective binding agents of osteoprotegerin binding protein
|
|
DK2105449T3
(da)
†
|
2000-02-23 |
2019-10-07 |
Amgen Inc |
Antagonistiske selektive bindemidler af osteoprotegerinbindende protein
|
|
AU5943201A
(en)
|
2000-05-03 |
2001-11-12 |
Amgen Inc |
Modified peptides as therapeutic agents
|
|
US7102050B1
(en)
|
2000-05-04 |
2006-09-05 |
Exxonmobil Chemical Patents Inc. |
Multiple riser reactor
|
|
JP2003534022A
(ja)
*
|
2000-05-26 |
2003-11-18 |
スミスクライン・ビーチャム・コーポレイション |
Rankリガンド介在障害の治療に有用な抗−rankリガンドモノクローナル抗体
|
|
US7405734B2
(en)
*
|
2000-07-18 |
2008-07-29 |
Silicon Graphics, Inc. |
Method and system for presenting three-dimensional computer graphics images using multiple graphics processing units
|
|
DE10039710B4
(de)
|
2000-08-14 |
2017-06-22 |
United Monolithic Semiconductors Gmbh |
Verfahren zur Herstellung passiver Bauelemente auf einem Halbleitersubstrat
|
|
WO2002016551A2
(en)
*
|
2000-08-18 |
2002-02-28 |
University Of Massachusetts Medical Center |
Trance regulation of chondrocyte differentiation
|
|
AU2001288342A1
(en)
|
2000-08-21 |
2002-03-04 |
Smith Kline Beecham Corporation |
Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders
|
|
ATE366306T1
(de)
|
2000-09-22 |
2007-07-15 |
Immunex Corp |
Screeningverfahren für agonisten und antagonisten des rezeptoraktivators von nf-kappa b
|
|
BRPI0116728B1
(pt)
|
2001-01-05 |
2018-10-30 |
Pfizer Inc. |
anticorpos para receptor de fator de crescimento i semelhante à insulina
|
|
US20030017151A1
(en)
|
2001-05-17 |
2003-01-23 |
Dougall William C. |
Therapeutic use of rank antagonists
|
|
CA2449658A1
(en)
|
2001-06-06 |
2002-12-12 |
Immunex Corporation |
Use of rank antagonists to treat cancer
|
|
PH12012502440A1
(en)
*
|
2001-06-26 |
2013-06-17 |
Amgen Inc |
Antibodies to opgl
|
|
WO2003086289A2
(en)
*
|
2002-04-05 |
2003-10-23 |
Amgen Inc. |
Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors
|
|
WO2013180295A1
(ja)
|
2012-06-01 |
2013-12-05 |
日本電信電話株式会社 |
パケット転送処理方法およびパケット転送処理装置
|
|
US9300829B2
(en)
|
2014-04-04 |
2016-03-29 |
Canon Kabushiki Kaisha |
Image reading apparatus and correction method thereof
|