IL116109A - תרכובות ביניים להכנת sic- נוקליאוסידים ואנלוגים של נוקליאוסידבעלי פעילות אופטית - Google Patents
תרכובות ביניים להכנת sic- נוקליאוסידים ואנלוגים של נוקליאוסידבעלי פעילות אופטיתInfo
- Publication number
- IL116109A IL116109A IL11610992A IL11610992A IL116109A IL 116109 A IL116109 A IL 116109A IL 11610992 A IL11610992 A IL 11610992A IL 11610992 A IL11610992 A IL 11610992A IL 116109 A IL116109 A IL 116109A
- Authority
- IL
- Israel
- Prior art keywords
- formula
- cis
- carbonyl
- derivative
- choh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Catalysts (AREA)
- Furan Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Vehicle Step Arrangements And Article Storage (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70337991A | 1991-05-21 | 1991-05-21 | |
IL10193192A IL101931A (he) | 1991-05-21 | 1992-05-20 | תהליכים לסינתיזה דיאסטיריאוסלקטיביתשל sic- נוקליאוסידים ואנלוגים של נוקליאוסיד |
Publications (1)
Publication Number | Publication Date |
---|---|
IL116109A true IL116109A (he) | 1998-12-27 |
Family
ID=24825144
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11610992A IL116109A (he) | 1991-05-21 | 1992-05-20 | תרכובות ביניים להכנת sic- נוקליאוסידים ואנלוגים של נוקליאוסידבעלי פעילות אופטית |
IL10193192A IL101931A (he) | 1991-05-21 | 1992-05-20 | תהליכים לסינתיזה דיאסטיריאוסלקטיביתשל sic- נוקליאוסידים ואנלוגים של נוקליאוסיד |
IL116176A IL116176A (he) | 1991-05-21 | 1992-05-20 | תרכובות אמצעיות עבור סינתיזה דיאסטיריוסלקטיבית של אנאלוגים של sic - נוקלאוסיד |
IL101932A IL101932A (en) | 1991-05-21 | 1992-05-20 | Processes for the diastereoselective synthesis of cis-nucleoside analogues |
IL11610995A IL116109A0 (en) | 1991-05-21 | 1995-11-23 | Intermediate compounds for the diastereoselective synthesis of cis-nucleosides |
IL11617695A IL116176A0 (en) | 1991-05-21 | 1995-11-28 | Intermediate compounds for the diastereoselective synthesis of cis-nucleoside analogues |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10193192A IL101931A (he) | 1991-05-21 | 1992-05-20 | תהליכים לסינתיזה דיאסטיריאוסלקטיביתשל sic- נוקליאוסידים ואנלוגים של נוקליאוסיד |
IL116176A IL116176A (he) | 1991-05-21 | 1992-05-20 | תרכובות אמצעיות עבור סינתיזה דיאסטיריוסלקטיבית של אנאלוגים של sic - נוקלאוסיד |
IL101932A IL101932A (en) | 1991-05-21 | 1992-05-20 | Processes for the diastereoselective synthesis of cis-nucleoside analogues |
IL11610995A IL116109A0 (en) | 1991-05-21 | 1995-11-23 | Intermediate compounds for the diastereoselective synthesis of cis-nucleosides |
IL11617695A IL116176A0 (en) | 1991-05-21 | 1995-11-28 | Intermediate compounds for the diastereoselective synthesis of cis-nucleoside analogues |
Country Status (34)
Country | Link |
---|---|
US (5) | US5756706A (he) |
EP (2) | EP0515157B1 (he) |
JP (3) | JP3330972B2 (he) |
KR (3) | KR0160144B1 (he) |
CN (6) | CN1035555C (he) |
AT (2) | ATE133958T1 (he) |
AU (4) | AU655973B2 (he) |
BG (2) | BG61696B1 (he) |
CA (2) | CA2069063C (he) |
CZ (3) | CZ222496A3 (he) |
DE (2) | DE69221936T2 (he) |
DK (2) | DK0515156T3 (he) |
EE (1) | EE03044B1 (he) |
ES (2) | ES2104832T3 (he) |
FI (3) | FI109025B (he) |
GR (2) | GR3018941T3 (he) |
GT (1) | GT199800047A (he) |
HK (2) | HK132196A (he) |
HU (2) | HU221850B1 (he) |
IE (2) | IE921618A1 (he) |
IL (6) | IL116109A (he) |
MD (1) | MD1155C2 (he) |
MX (2) | MX9202395A (he) |
NO (2) | NO300593B1 (he) |
NZ (2) | NZ242817A (he) |
OA (1) | OA10212A (he) |
PL (3) | PL176026B1 (he) |
RO (1) | RO116812B1 (he) |
RU (4) | RU2223960C2 (he) |
SG (1) | SG43863A1 (he) |
SK (2) | SK281954B6 (he) |
TW (4) | TW366350B (he) |
WO (2) | WO1992020669A1 (he) |
ZA (2) | ZA923641B (he) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5466806A (en) * | 1989-02-08 | 1995-11-14 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6350753B1 (en) | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6903224B2 (en) | 1988-04-11 | 2005-06-07 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes |
PT674634E (pt) * | 1989-02-08 | 2003-09-30 | Iaf Biochem Int | Processos para preparar 1,3-oxatiolanos substituidos com propriedades antivirais |
US6642245B1 (en) | 1990-02-01 | 2003-11-04 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane |
US5827727A (en) * | 1990-02-01 | 1998-10-27 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US6703396B1 (en) | 1990-02-01 | 2004-03-09 | Emory University | Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
US5444063A (en) * | 1990-12-05 | 1995-08-22 | Emory University | Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity |
US5925643A (en) * | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
US5817667A (en) * | 1991-04-17 | 1998-10-06 | University Of Georgia Research Foudation | Compounds and methods for the treatment of cancer |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
US6005107A (en) * | 1992-12-23 | 1999-12-21 | Biochem Pharma, Inc. | Antiviral compounds |
US6444656B1 (en) | 1992-12-23 | 2002-09-03 | Biochem Pharma, Inc. | Antiviral phosphonate nucleotides |
GB9226879D0 (en) * | 1992-12-23 | 1993-02-17 | Iaf Biochem Int | Anti-viral compounds |
GB9226927D0 (en) * | 1992-12-24 | 1993-02-17 | Iaf Biochem Int | Dideoxy nucleoside analogues |
US5627160A (en) * | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
TW374087B (en) * | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
GB9311709D0 (en) * | 1993-06-07 | 1993-07-21 | Iaf Biochem Int | Stereoselective synthesis of nucleoside analogues using bicycle intermediate |
US20020120130A1 (en) | 1993-09-10 | 2002-08-29 | Gilles Gosselin | 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents |
JPH09504785A (ja) | 1993-09-10 | 1997-05-13 | エモリー、ユニバーシティー | 抗b型肝炎ウイルス活性を有するヌクレオシド |
US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
IL113432A (en) * | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
US6448235B1 (en) | 1994-07-11 | 2002-09-10 | University Of Virginia Patent Foundation | Method for treating restenosis with A2A adenosine receptor agonists |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
US6391859B1 (en) | 1995-01-27 | 2002-05-21 | Emory University | [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US5808040A (en) * | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
GB9506644D0 (en) * | 1995-03-31 | 1995-05-24 | Wellcome Found | Preparation of nucleoside analogues |
EP0831852B1 (en) | 1995-06-07 | 2006-11-29 | Emory University | Nucleosides with anti-hepatitis b virus activity |
KR100213932B1 (ko) * | 1995-11-02 | 1999-08-02 | 김충환 | 새로운 뉴클레오시드 유도체 및 그 제조방법 |
GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
EP0799834A1 (en) * | 1996-04-04 | 1997-10-08 | Novartis AG | Modified nucleotides |
US6005097A (en) * | 1996-06-14 | 1999-12-21 | Vion Pharmaceuticals, Inc. | Processes for high-yield diastereoselective synthesis of dideoxynucleosides |
US5753789A (en) * | 1996-07-26 | 1998-05-19 | Yale University | Oligonucleotides containing L-nucleosides |
US6022876A (en) | 1996-11-15 | 2000-02-08 | Yale University | L-β-dioxolane uridine analogs and methods for treating and preventing Epstein-Barr virus infections |
ATE254131T1 (de) | 1997-02-13 | 2003-11-15 | Glaxo Group Ltd | Benzimidazolderivate |
EP0986375A2 (en) | 1997-04-07 | 2000-03-22 | Triangle Pharmaceuticals Inc. | Use of mkc-442 in combination with other antiviral agents |
WO1998056761A2 (en) | 1997-06-10 | 1998-12-17 | Glaxo Group Limited | Benzimidazole derivatives |
NZ502882A (en) | 1997-07-30 | 2002-02-01 | Glaxo Group Ltd | Lyxofuranosyl benzimidazoles as antiviral agents |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
EP1104415B1 (en) | 1998-08-12 | 2004-11-10 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
HUP0104827A3 (en) | 1998-12-23 | 2002-08-28 | Shire Biochem Inc Laval | Antiviral nucleoside analogues |
US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US7115584B2 (en) | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
YU25500A (sh) | 1999-05-11 | 2003-08-29 | Pfizer Products Inc. | Postupak za sintezu analoga nukleozida |
US6322771B1 (en) | 1999-06-18 | 2001-11-27 | University Of Virginia Patent Foundation | Induction of pharmacological stress with adenosine receptor agonists |
ATE269081T1 (de) * | 1999-09-24 | 2004-07-15 | Shire Biochem Inc | Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen |
EP1225899A2 (en) | 1999-11-04 | 2002-07-31 | Virochem Pharma Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
US6436948B1 (en) | 2000-03-03 | 2002-08-20 | University Of Georgia Research Foundation Inc. | Method for the treatment of psoriasis and genital warts |
CA2308559C (en) * | 2000-05-16 | 2005-07-26 | Brantford Chemicals Inc. | 1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues |
KR100927024B1 (ko) * | 2001-03-01 | 2009-11-17 | 아보트 래버러토리즈 | 시스-ftc의 다형 및 기타 결정형 |
CA2351049C (en) | 2001-06-18 | 2007-03-13 | Brantford Chemicals Inc. | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers |
CA2460911C (en) * | 2001-10-01 | 2011-08-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
EP1714977B1 (en) | 2001-10-19 | 2009-03-11 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
ITMI20012317A1 (it) * | 2001-11-06 | 2003-05-06 | Recordati Ind Chimica E Farma | Processo diastereoselettivo per la preparazione del'agente antivirale4-amino-1-(2r-idrossimetil-/1,3/ossatiolan-5s-i1)-1h-pirimidin-2-one |
CN1620295A (zh) * | 2001-12-14 | 2005-05-25 | 法玛塞特有限公司 | 制备用于合成抗病毒核苷的中间体 |
EP1467990B1 (en) | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Process for producing dioxolane nucleoside analogue precursors |
US7365173B2 (en) * | 2002-02-04 | 2008-04-29 | American National Red Cross | Method for the production of pure virally inactivated butyrylcholinesterase |
CA2494183C (en) | 2002-08-06 | 2012-01-03 | Kyoichi A. Watanabe | Processes for preparing 1,3-dioxolane nucleosides |
PL378368A1 (pl) * | 2003-01-14 | 2006-04-03 | Gilead Sciences, Inc. | Kompozycje i sposoby wykorzystywane w skojarzonej terapii przeciwwirusowej |
ITMI20030578A1 (it) * | 2003-03-24 | 2004-09-25 | Clariant Lsm Italia Spa | Processo ed intermedi per la preparazione di emtricitabina |
KR101157468B1 (ko) | 2004-02-03 | 2012-07-06 | 에모리 유니버시티 | 1,3-디옥솔란 뉴클레오시드 제조방법 |
US7442687B2 (en) * | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
SG155182A1 (en) * | 2004-08-02 | 2009-09-30 | Univ Virginia | 2-propynyl adenosine analogs with modified 5æ-ribose groups having a2a agonist activity |
US7576069B2 (en) * | 2004-08-02 | 2009-08-18 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
US7837651B2 (en) * | 2004-08-31 | 2010-11-23 | Ethicon Endo-Surgery, Inc. | Infusion pump |
US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
WO2007077505A2 (en) * | 2005-12-30 | 2007-07-12 | Ranbaxy Laboratories Limited | Crystalline l-menthyl (2r, 5s)-5-(4-amino-5-fluoro-2-oxo-2h-pyrimidin-1-yl)[1, 3]oxathiolan-2-carboxylate and process for preparation thereof |
WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
CA2667891A1 (en) * | 2006-10-30 | 2008-05-08 | Lupin Limited | An improved process for the manufacture of lamivudine |
RU2488591C2 (ru) | 2007-09-26 | 2013-07-27 | Маунт Синай Скул Оф Медсин | Аналоги азацитидина и их применение |
WO2009069011A1 (en) * | 2007-11-29 | 2009-06-04 | Ranbaxy Laboratories Limited | Process for the preparation of substituted 1,3-oxathiolanes |
BRPI0820224A2 (pt) * | 2007-11-29 | 2015-06-16 | Ranbaxy Lab Ltd | Composto de fórmula iii ou seus estereoisômeros; processo para sua preparação e seu uso; uso de um composto de formula iii(a) ou iii(b) em um processo para a preparação de lamivudina de fórmula i(a) ou um composto de fórmula i(c); processo para preparação de lamivudina de fórmula i(a) |
WO2009084033A2 (en) * | 2007-12-07 | 2009-07-09 | Matrix Laboratories Limited | Process for producing 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yi]cytosine |
US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
KR101784647B1 (ko) | 2008-05-02 | 2017-10-11 | 길리애드 사이언시즈, 인코포레이티드 | 제약 제제의 가공성 향상을 위한 고체 담체 입자의 용도 |
US20110282046A1 (en) | 2009-01-19 | 2011-11-17 | Rama Shankar | Process for preparation of cis-nucleoside derivative |
KR101738325B1 (ko) | 2009-02-06 | 2017-05-19 | 길리애드 사이언시즈, 인코포레이티드 | 조합 요법용 정제 |
EP2521729A4 (en) * | 2010-01-08 | 2013-07-31 | Hetero Research Foundation | IMPROVED METHOD FOR NUCLEOSIDES |
PT2531027E (pt) | 2010-01-27 | 2015-09-16 | Viiv Healthcare Co | Combinação terapêutica compreendendo dolutegravir, abacavir e lamivudina |
US20120295930A1 (en) * | 2010-02-03 | 2012-11-22 | Shankar Rama | Novel process for the preparation of cis-nucleoside derivative |
CA2792044A1 (en) | 2010-03-04 | 2011-09-09 | Ranbaxy Laboratories Limited | A process for stereoselective synthesis of 5-fluoro-1-(2r,5s)-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine |
EP2377862A1 (en) | 2010-03-29 | 2011-10-19 | Esteve Química, S.A. | Process for obtaining emtricitabine |
WO2011141805A2 (en) | 2010-05-14 | 2011-11-17 | Lupin Limited | An improved process for the manufacture of lamivudine |
CN103221037A (zh) | 2010-11-12 | 2013-07-24 | 葛兰素惠尔康制造业私人有限公司 | 新药物组合物 |
US20130296562A1 (en) | 2011-08-05 | 2013-11-07 | Lupin Limited | Stereoselective process for preparation of 1,3-oxathiolane nucleosides |
CN108635367B (zh) | 2011-08-30 | 2020-08-21 | 阿斯泰克斯制药公司 | 地西他滨衍生物制剂 |
CN103242243B (zh) * | 2013-01-08 | 2015-08-19 | 北京大学 | 一种碱基乙酸甘油醚酯分子,其化学合成方法及其在基因治疗领域的应用 |
CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
CN105037340B (zh) * | 2015-07-14 | 2018-08-10 | 福建广生堂药业股份有限公司 | 一种拉米夫定关键中间体手性异构体杂质的制备方法 |
MX2020001233A (es) | 2017-08-03 | 2020-07-20 | Otsuka Pharma Co Ltd | Compuesto farmaceutico y metodos de purificacion del mismo. |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1445013A (fr) * | 1964-07-09 | 1966-07-08 | Thomae Gmbh Dr K | Procédé pour fabriquer des nouveaux acides dioxolano-2-carboxyliques |
US4383114A (en) * | 1977-02-09 | 1983-05-10 | Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine arabinonucleosides |
US4231945A (en) * | 1978-11-08 | 1980-11-04 | Schering Corporation | S-5-(Azidomethyl or aminomethyl)-2-lower-alkoxytetrahydrofurans |
US4479942A (en) * | 1981-08-10 | 1984-10-30 | Fujisawa Pharmaceutical Co., Ltd. | Tetrahydrofurnancarboxylic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof |
US4855304A (en) * | 1985-01-10 | 1989-08-08 | Repligen Corporation | Dinucleoside pyrophosphates and pyrophosphate homologs as plant antivirals |
DK363987A (da) * | 1986-08-08 | 1988-02-09 | Hoffmann La Roche | Pyrimidinderivater |
GB8621268D0 (en) * | 1986-09-03 | 1986-10-08 | Univ Strathclyde | Separation of substances |
US4997818A (en) * | 1987-09-21 | 1991-03-05 | The University Hospital | Therapeutic method for selectively treating terminal deoxynucleotidyl transferase-positive neoplastic leukemias and lymphomas |
SE8704298D0 (sv) * | 1987-11-03 | 1987-11-03 | Astra Ab | Compounds for use in therapy |
US4997926A (en) * | 1987-11-18 | 1991-03-05 | Scripps Clinic And Research Foundation | Deaminase-stable anti-retroviral 2-halo-2',3'-dideoxy |
JPH022349A (ja) * | 1988-02-17 | 1990-01-08 | Takeda Chem Ind Ltd | ピリミジンアナログ耐性化遺伝子dnaおよびその用途 |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
NZ228645A (en) * | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
DE3823127A1 (de) * | 1988-07-08 | 1990-01-11 | Rheinische Braunkohlenw Ag | Vorrichtung und verfahren zur reinigung von abwasser |
US4987224A (en) * | 1988-08-02 | 1991-01-22 | University Of Georgia Research Foundation, Inc. | Method of preparation of 2',3'-dideoxynucleosides |
DE3827134A1 (de) * | 1988-08-10 | 1990-03-15 | Bayer Ag | Substituierte triazolyl- bzw. imidazolyl-hydroxyalkyldioxolane, verfahren zu ihrer herstellung und ihre verwendung als mikrobizide, oxiranyldioxolane, dioxolanylketone, oxiranylketone und (alpha)-halogenketone als zwischenprodukte und verfahren zu deren herstellung |
US5075225A (en) * | 1989-04-06 | 1991-12-24 | The Texas A&M University System | Process for the enzymatic synthesis of nucleosides |
NZ233197A (en) * | 1989-04-13 | 1991-11-26 | Richard Thomas Walker | Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions |
NZ234534A (en) * | 1989-07-17 | 1994-12-22 | Univ Birmingham | Pyrimidine 4'-thionucleoside derivatives and their preparation; intermediates therefor |
IE904378A1 (en) * | 1989-12-20 | 1991-07-03 | Abbott Lab | Analogs of oxetanyl purines and pyrimidines |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
GB9014090D0 (en) * | 1990-06-25 | 1990-08-15 | Zaadunie Bv | Improvements in or relating to organic compounds |
WO1992010496A1 (en) * | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES |
IL100965A (he) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2 - הידרוקסימתיל - 5 - )5 - פלואורוציטוסין - 1 - איל( - 1, 3 - אוקסאתיולאן, הרזולוציה שלו ותכשירי רוקחות המכילים אותו |
WO1992018517A1 (en) * | 1991-04-17 | 1992-10-29 | Yale University | Method of treating or preventing hepatitis b virus |
GB9109506D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Therapeutic nucleosides |
ZA923641B (en) * | 1991-05-21 | 1993-02-24 | Iaf Biochem Int | Processes for the diastereoselective synthesis of nucleosides |
-
1992
- 1992-05-19 ZA ZA923641A patent/ZA923641B/xx unknown
- 1992-05-19 ZA ZA923640A patent/ZA923640B/xx unknown
- 1992-05-20 RU RU99115480/04A patent/RU2223960C2/ru active
- 1992-05-20 NZ NZ242817A patent/NZ242817A/en not_active IP Right Cessation
- 1992-05-20 PL PL92309052A patent/PL176026B1/pl unknown
- 1992-05-20 HU HU9303297A patent/HU221850B1/hu active IP Right Grant
- 1992-05-20 WO PCT/CA1992/000211 patent/WO1992020669A1/en active IP Right Grant
- 1992-05-20 CZ CZ962224A patent/CZ222496A3/cs not_active IP Right Cessation
- 1992-05-20 SK SK1294-93A patent/SK281954B6/sk not_active IP Right Cessation
- 1992-05-20 CA CA002069063A patent/CA2069063C/en not_active Expired - Lifetime
- 1992-05-20 AU AU16394/92A patent/AU655973B2/en not_active Expired
- 1992-05-20 AT AT92304551T patent/ATE133958T1/de not_active IP Right Cessation
- 1992-05-20 PL PL92301339A patent/PL168910B1/pl not_active IP Right Cessation
- 1992-05-20 DK DK92304551.2T patent/DK0515156T3/da active
- 1992-05-20 AT AT92304552T patent/ATE157662T1/de active
- 1992-05-20 RU RU93058554A patent/RU2105009C1/ru not_active IP Right Cessation
- 1992-05-20 KR KR1019920008507A patent/KR0160144B1/ko not_active IP Right Cessation
- 1992-05-20 KR KR1019920008694A patent/KR100232012B1/ko not_active IP Right Cessation
- 1992-05-20 US US08/142,389 patent/US5756706A/en not_active Expired - Fee Related
- 1992-05-20 DK DK92304552.0T patent/DK0515157T3/da active
- 1992-05-20 NO NO921989A patent/NO300593B1/no unknown
- 1992-05-20 SG SG1996003228A patent/SG43863A1/en unknown
- 1992-05-20 SK SK1293-93A patent/SK279438B6/sk not_active IP Right Cessation
- 1992-05-20 IL IL11610992A patent/IL116109A/he not_active IP Right Cessation
- 1992-05-20 CZ CZ932492A patent/CZ285220B6/cs not_active IP Right Cessation
- 1992-05-20 ES ES92304552T patent/ES2104832T3/es not_active Expired - Lifetime
- 1992-05-20 NZ NZ242818A patent/NZ242818A/en not_active IP Right Cessation
- 1992-05-20 MD MD95-0172A patent/MD1155C2/ro unknown
- 1992-05-20 WO PCT/CA1992/000209 patent/WO1992020696A1/en active IP Right Grant
- 1992-05-20 NO NO921988A patent/NO301010B1/no not_active IP Right Cessation
- 1992-05-20 HU HU9303296A patent/HU223838B1/hu not_active IP Right Cessation
- 1992-05-20 PL PL92301340A patent/PL170869B1/pl unknown
- 1992-05-20 RO RO93-01554A patent/RO116812B1/ro unknown
- 1992-05-20 AU AU16913/92A patent/AU1691392A/en not_active Abandoned
- 1992-05-20 RU RU93058362A patent/RU2140925C1/ru active
- 1992-05-20 EP EP92304552A patent/EP0515157B1/en not_active Expired - Lifetime
- 1992-05-20 IL IL10193192A patent/IL101931A/he not_active IP Right Cessation
- 1992-05-20 AU AU16395/92A patent/AU668086B2/en not_active Ceased
- 1992-05-20 EP EP92304551A patent/EP0515156B1/en not_active Expired - Lifetime
- 1992-05-20 IL IL116176A patent/IL116176A/he not_active IP Right Cessation
- 1992-05-20 IL IL101932A patent/IL101932A/xx not_active IP Right Cessation
- 1992-05-20 AU AU16908/92A patent/AU1690892A/en not_active Abandoned
- 1992-05-20 CA CA002069024A patent/CA2069024C/en not_active Expired - Fee Related
- 1992-05-20 CZ CZ932493A patent/CZ280857B6/cs not_active IP Right Cessation
- 1992-05-20 ES ES92304551T patent/ES2084937T3/es not_active Expired - Lifetime
- 1992-05-20 DE DE69221936T patent/DE69221936T2/de not_active Expired - Lifetime
- 1992-05-20 RU RU96119766/04A patent/RU2163909C2/ru not_active IP Right Cessation
- 1992-05-20 DE DE69208144T patent/DE69208144T2/de not_active Expired - Fee Related
- 1992-05-21 US US08/142,387 patent/US5696254A/en not_active Expired - Lifetime
- 1992-05-21 MX MX9202395A patent/MX9202395A/es unknown
- 1992-05-21 JP JP12916392A patent/JP3330972B2/ja not_active Expired - Fee Related
- 1992-05-21 CN CN92103924A patent/CN1035555C/zh not_active Expired - Fee Related
- 1992-05-21 CN CN92103921A patent/CN1038591C/zh not_active Expired - Lifetime
- 1992-05-21 MX MX9202404A patent/MX9202404A/es unknown
- 1992-05-21 JP JP12915592A patent/JP3229013B2/ja not_active Expired - Lifetime
- 1992-06-02 TW TW081104323A patent/TW366350B/zh not_active IP Right Cessation
- 1992-06-02 TW TW088109433A patent/TWI245046B/zh not_active IP Right Cessation
- 1992-06-02 TW TW081104321A patent/TW366349B/zh not_active IP Right Cessation
- 1992-06-02 TW TW088109374A patent/TW467907B/zh not_active IP Right Cessation
- 1992-07-01 IE IE161892A patent/IE921618A1/en not_active IP Right Cessation
- 1992-07-01 IE IE921619A patent/IE76741B1/en not_active IP Right Cessation
-
1993
- 1993-11-19 FI FI935150A patent/FI109025B/fi active
- 1993-11-19 FI FI935151A patent/FI106377B/fi not_active IP Right Cessation
- 1993-11-19 OA OA60440A patent/OA10212A/en unknown
- 1993-12-20 BG BG98311A patent/BG61696B1/bg unknown
- 1993-12-20 BG BG98310A patent/BG61695B1/bg unknown
-
1994
- 1994-10-20 EE EE9400283A patent/EE03044B1/xx unknown
-
1995
- 1995-03-10 CN CN95102412A patent/CN1050603C/zh not_active Expired - Lifetime
- 1995-06-05 US US08/460,856 patent/US5663320A/en not_active Expired - Lifetime
- 1995-06-05 US US08/464,317 patent/US5693787A/en not_active Expired - Lifetime
- 1995-06-05 US US08/464,960 patent/US5744596A/en not_active Expired - Fee Related
- 1995-11-23 IL IL11610995A patent/IL116109A0/xx unknown
- 1995-11-28 IL IL11617695A patent/IL116176A0/xx unknown
-
1996
- 1996-02-08 GR GR960400299T patent/GR3018941T3/el unknown
- 1996-07-18 HK HK132196A patent/HK132196A/xx not_active IP Right Cessation
-
1997
- 1997-09-04 GR GR970400204T patent/GR3024617T3/el unknown
-
1998
- 1998-02-24 HK HK98101405A patent/HK1002431A1/xx not_active IP Right Cessation
- 1998-03-04 GT GT199800047A patent/GT199800047A/es unknown
- 1998-12-03 CN CN98122384A patent/CN1097049C/zh not_active Expired - Lifetime
- 1998-12-03 CN CN98122383A patent/CN1109030C/zh not_active Expired - Lifetime
- 1998-12-03 CN CN98122385A patent/CN1083450C/zh not_active Expired - Lifetime
-
1999
- 1999-07-12 KR KR1019990027976A patent/KR100242921B1/ko not_active IP Right Cessation
-
2000
- 2000-08-29 FI FI20001900A patent/FI20001900A/fi unknown
-
2001
- 2001-05-07 JP JP2001136217A patent/JP3704055B2/ja not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5744596A (en) | Nucleoside analogues and synthetic intermediates | |
SK135596A3 (en) | Process for the diastereoselective synthesis of nucleoside analogues | |
OA10349A (en) | Processes for the diastereoselective synthesis of nucleosides | |
FI102279B (fi) | Välituotteita nukleosidien diastereoselektiivisiin synteesimenetelmiin |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |