HRP20120004T4 - Inhibitori dipeptidil peptidaze za lijeäśenje dijabetesa - Google Patents
Inhibitori dipeptidil peptidaze za lijeäśenje dijabetesa Download PDFInfo
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- HRP20120004T4 HRP20120004T4 HRP20120004TT HRP20120004T HRP20120004T4 HR P20120004 T4 HRP20120004 T4 HR P20120004T4 HR P20120004T T HRP20120004T T HR P20120004TT HR P20120004 T HRP20120004 T HR P20120004T HR P20120004 T4 HRP20120004 T4 HR P20120004T4
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- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 title 1
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 53
- 239000008194 pharmaceutical composition Substances 0.000 claims 50
- 239000002552 dosage form Substances 0.000 claims 31
- 239000003472 antidiabetic agent Substances 0.000 claims 20
- 230000003178 anti-diabetic effect Effects 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 8
- 239000003112 inhibitor Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical group N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000000536 PPAR gamma Human genes 0.000 claims 2
- 108010016731 PPAR gamma Proteins 0.000 claims 2
- 239000003888 alpha glucosidase inhibitor Substances 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 229940125708 antidiabetic agent Drugs 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
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- 229960004580 glibenclamide Drugs 0.000 claims 2
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 2
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 1
- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 claims 1
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- -1 2,4-dioxo-5-thiazolidinyl Chemical group 0.000 claims 1
- NFFXEUUOMTXWCX-UHFFFAOYSA-N 5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxy-n-[[4-(trifluoromethyl)phenyl]methyl]benzamide Chemical compound C1=C(C(=O)NCC=2C=CC(=CC=2)C(F)(F)F)C(OC)=CC=C1CC1SC(=O)NC1=O NFFXEUUOMTXWCX-UHFFFAOYSA-N 0.000 claims 1
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- PCAZCAZVHLGDBA-UHFFFAOYSA-N 5-[[4-(2-indol-1-ylethoxy)phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC(C=C1)=CC=C1OCCN1C2=CC=CC=C2C=C1 PCAZCAZVHLGDBA-UHFFFAOYSA-N 0.000 claims 1
- ITLAZBMGSXRIEF-UHFFFAOYSA-N 5-naphthalen-2-ylsulfonyl-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1S(=O)(=O)C1=CC=C(C=CC=C2)C2=C1 ITLAZBMGSXRIEF-UHFFFAOYSA-N 0.000 claims 1
- 229940123208 Biguanide Drugs 0.000 claims 1
- RKWGIWYCVPQPMF-UHFFFAOYSA-N Chloropropamide Chemical compound CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1 RKWGIWYCVPQPMF-UHFFFAOYSA-N 0.000 claims 1
- 102000027487 Fructose-Bisphosphatase Human genes 0.000 claims 1
- 108010017464 Fructose-Bisphosphatase Proteins 0.000 claims 1
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 1
- 229940122904 Glucagon receptor antagonist Drugs 0.000 claims 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 1
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- 102000003638 Glucose-6-Phosphatase Human genes 0.000 claims 1
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- 102000007390 Glycogen Phosphorylase Human genes 0.000 claims 1
- 108010046163 Glycogen Phosphorylase Proteins 0.000 claims 1
- 102000002254 Glycogen Synthase Kinase 3 Human genes 0.000 claims 1
- 108010014905 Glycogen Synthase Kinase 3 Proteins 0.000 claims 1
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- 229940123464 Thiazolidinedione Drugs 0.000 claims 1
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- 229960003468 gliquidone Drugs 0.000 claims 1
- 229960003236 glisoxepide Drugs 0.000 claims 1
- ZKUDBRCEOBOWLF-UHFFFAOYSA-N glisoxepide Chemical compound O1C(C)=CC(C(=O)NCCC=2C=CC(=CC=2)S(=O)(=O)NC(=O)NN2CCCCCC2)=N1 ZKUDBRCEOBOWLF-UHFFFAOYSA-N 0.000 claims 1
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- NFRPNQDSKJJQGV-UHFFFAOYSA-N glyhexamide Chemical compound C=1C=C2CCCC2=CC=1S(=O)(=O)NC(=O)NC1CCCCC1 NFRPNQDSKJJQGV-UHFFFAOYSA-N 0.000 claims 1
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- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims 1
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- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Claims (45)
1. Farmaceutska kompozicija formulirana u pojedinačnom doznom obliku, pri čemu takav pojedinačni dozni oblik sadrži između 1 mg i 250 mg spoja I, pri čemu spoj I ima formulu
[image]
2. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži između 5 mg i 200 mg spoja I.
3. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži između 5 mg i 150 mg spoja I.
4. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži između 15 mg i 100 mg spoja 1.
5. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži 5 mg spoja I.
6. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži 6.25 mg spoja I.
7. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time e što takav pojedinačni dozni oblik sadrži 10 mg spoja I.
8. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži 20 mg spoja I.
9. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži 25 mg spoja I.
10. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadrži 50 mg spoja I.
11. Farmaceutska kompozicija prema patentnom zahtjevu 1, naznačena time što takav pojedinačni dozni oblik sadr/i 100 mg spoja 1.
12. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-11, naznačena time što takav pojedinačni dozni oblik dalje sadrži jedan ili više antidijabetičkih spojeva koji se razlikuju od spoja I.
13. Farmaceutska kompozicija formulirana u obliku pojedinačne doze, naznačena time što takav pojedinačni dozni oblik sadrži između 1 mg i 250 mg spoja I i jedan ili više antidijabetičkih spojeva koji se razlikuju od spoja I, pri čemu spoj I ima formulu
[image]
14. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičkih sredstava koji su izabrani iz grupe koju čine modulatori puta prijenosa signala insulina, spoja koji utječe na disreguliranu proizvodnju glukoze u jetri, pojačivači osjetljivosti na insulin i pojačivači izlučivanja insulina.
15. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13. naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičnih spojeva koji su izabrani iz grupe koju čine inhibitori protein tirozin fosfataze, inhibitori glutamin-fruktoza-6-fosfat amidotransferaze, inhibitori glukoza-6-fosfataze, inhibitori fruktoza-1,6-bisfosfataze, inhibitori glikogen fosforilaze, antagonisti receptora za glukagon, inhibitori fosfoenolpiruvat karboksikinaze. inhibitori piruvat dehidrogenaza kinaze, inhibitori alfa-glukozidaze. inhibitori pražnjenja želuca, insulin i α2-adrenergični antagonisti.
16. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedno ili više antidijabetičkih sredstava izabranih iz grupe koju čine inhibitori GSK-3, agonisti receptora za retinoid X, agonisti Beta-3 AR, modulatori UCP, antidijabetički tiazolidindioni, ne-glitazon tip agonisti PPAR gama, dvostruki PPAR gama/PPAR alfa agonisti, antidijabetički spojevi koji sadrže vanadij i biguanidi.
17. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičnih spojeva izabranih iz grupe koju čine (S)-((3,4-dihidro-2-(fenil-metil)-2H-1-benzopiran-6-il)metil-tiazolidin-2,4-dion, 5-{[4-(3-(5-metil-2-fenil-4-oksazolil)-1-okso-propil)-fenil]-metil}-tiazolidin-2,4-dion, 5-{[4-(1-metil-cikloheksil)metoksi)-fenil]metil]-tiazolidin-2,4-dion, 5-{[4-(2-(1-indolil) etoksi)fenil]metil}-tiazolidin-2,4-dion, S-{4-[2-(5-metil-2-fenil-4-oksazolil)-etoksi)]benzil}-tiazolidin -2,4-dion, 5-(2-naftilsulfonil)-tiazolidin-2,4-dion, bis(4-[(2,4-diokso-5-tiazolidinil)-metil|fenil}metan. 5-{4-(2-(5-metil-2-fenil-4-oksazolil)-2-hidroksieloksi]-benzil}-tiazolidin-2,4-dion, 5-[4-(l-fenil-1-ciklo propan karbonil amino)-benzil]-tiazolidin-2,4-dion, S-{[4-(2-(2,3-dihidroindol-1-il)etoksi)fenilmetil)-tiazolidin-2,4-dion, 5-[3-(4-kloro-fenil])-2-propinil]-5-fenilsulfonil)tiazolidin-2,4-dion, 5-[3-(4-klorofenil])-2-propinil]-5-(4-fluorofenil-sulfo nil)tiazolidin-2,4-dion, 5-{[4-(2-(metil-2-piridinil-amino)-etoksi)fenil]metil}-tiazolidin-2,4-dion, 5-([2-(2-naful)-benzoksazol-5-il]-metil}tiazolidin-2,4-dion i 5-(2,4-dioksotiazolidin-5-ilmetil)-2-metoksi-N-(4-trifluoro metil-benzil)benzamid, uključujući sve njihove farmaceutski prihvatljive soli.
18. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži metformin, uključujući sve njegove farmaceutski prihvatljive soli.
19. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži derivat sulfonil uree.
20. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičkih spojeva izabranih iz grupe koju čine glisoksepid, gliburid, glibenklamid, acetoheksamid, kloropropamid, glibornurid, tolbutamid, tolazamid, glipizid, karbutamid, glikvidon, gliheksamid, fenbutamid, tolciklamid, glimepirid i gliklazid, uključujući sve njihove farmaceutski prihvatljive soli.
21. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičkih spojeva izabranih iz grupe koju čine inkretin hormoni ili spojevi koji ga imitiraju, antagonisti receptom za imidazolin beta stanica i insulinski sekretagogi sa kratkim djelovanjem.
22. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-12, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antagonista GLP-1.
23. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni do/ni oblik sadrži ekstendatid.
24. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičkih spojeva izabranih iz grupe koju čine repaglinid, mitiglinid i nateglinid, uključujući sve njihove farmaceutski prihvatljive soli.
25. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni do/ni oblik sadrži jedan ili više inhibitora alfa-Glukozidaze.
26. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži jedan ili više antidijabetičnih spojeva izabranih iz grupe koju čine akarboza, vogliboza i miglitol, uključujući sve njihove farmaceutski prihvatljive soli.
27. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži rosiglitazon, uključujući sve njegove farmaceutski prihvatljive soli.
28. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-13, naznačena time što takav pojedinačni dozni oblik sadrži pioglitazon, uključujući sve njegove farmaceutski prihvatljive soli.
29. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-28, naznačena time što je takav pojedinačni dozni oblik prilagođen za oralnu primjenu.
30. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-28, naznačena time što je takav pojedinačni dozni oblik čvrsta formulacija prilagođena za oralnu primjenu.
31. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-28, naznačena time što je takav pojedinačni dozni oblik tableta ili kapsula prilagođena za oralnu primjenu.
32. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-28, naznačena time što takav pojedinačni dozni oblik sadrži formulaciju sa produženim oslobađanjem prilagođenu za oralnu primjenu.
33. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-32, naznačena time što je spoj I prisutan u farmaceutskoj kompoziciji kao slobodna baza.
34. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-32, naznačena time što je spoj I prisutan u farmaceutskoj kompoziciji u farmaceutski prihvatljivoj soli.
35. Farmaceutska kompozicija prema bilo kojem od patentnih zahtjeva 1-32, naznačena time što je spoj I prisutan u farmaceutskoj kompoziciji u sukcinatnoj soli.
36. Komplet koji sadrži:
višestruke doze farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35; i uputstva koja sadrže jedan ili više oblika informacija izabranih iz grupe koju čine indikacija stanja bolesti za koju se primjenjuje farmaceutska kompozicija, informacije o čuvanju za farmaceutsku kompoziciju, informacije o doziranju i uputstva u svezi s tim kako primjenjivati farmaceutsku kompoziciju.
37. Proizvodni artikl koji sadrži:
višestruke doze farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35; i materijale za pakovanje.
38. Proizvodni artikl prema patentnom zahtjevu 37, naznačen time što materijal za pakovanje sadrži kontejner za smještaj višestrukih doza farmaceutske kompozicije.
39. Proizvodni artikl prema patentnom zahtjevu 38, naznačen time što kontejner sadrži etiketu koja ukazuje na jednog ili više članova grupe koju čine stanje bolesti za koju se spoj primjenjuje, informacije o čuvanju, informacije o doziranju i/ili uputstva vezana za to kako primjenjivati kompoziciju.
40. Uporaba farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 u kombinaciji sa jednim ili više antidijabetičnih spojeva koji se razlikuju od spoja I za proizvodnju lijeka za liječenje dijabetesa tipa II, pri čemu spoj I ima formulu
[image]
41. Uporaba farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 za proizvodnju lijeka koji sadrži kombinaciju spoja I i jednog ili više antidijabetičkih spojeva koji se razlikuju od spoja I za liječenje dijabetesa tipa II, pri čemu spoj I ima formulu
[image]
42. Uporaba jednog ili više antidijabetičkih spojeva koji se razlikuju od spoja I za proizvodnju lijeka koji sadrži kombinaciju farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 i jednog ili više antidijabetičkih spojeva koji se razlikuju od spoja I za liječenje dijabetesa tipa II, pri čemu spoj I ima formulu
[image]
43. Uporaba farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 u kombinaciji sa jednim ili više antidijabetičkih spojeva koji se razlikuju od spoja I za proizvodnju lijeka za liječenje dijabetesa tipa I, pri čemu spoj I ima formulu
[image]
44. Uporaba farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 za proizvodnju lijeka koji sadrži kombinaciju spoja I i jednog ili više antidijabetičkih spojeva koji se razlikuju od spojeva I za liječenje dijabetesa tipa I, pri čemu spoj I ima formulu
[image]
45. Uporaba jednog ili više antidijabetičnih spojeva koji se razlikuju od spoja I za proizvodnju lijeka koji sadrži kombinaciju farmaceutske kompozicije prema bilo kojem od patentnih zahtjeva 1-35 i jednog ili više antidijabetičnih spojeva koji se razlikuju od spoja I za liječenje dijabetesa tipa I. pri čemu spoj I ima formulu
[image]
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US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
BRPI0413452A (pt) | 2003-08-13 | 2006-10-17 | Takeda Pharmaceutical | composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv |
US20050065144A1 (en) * | 2003-09-08 | 2005-03-24 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
JP2007505121A (ja) * | 2003-09-08 | 2007-03-08 | 武田薬品工業株式会社 | ジペプチジルぺプチダーゼ阻害剤 |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
AU2004318013B8 (en) | 2004-03-15 | 2011-10-06 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7931661B2 (en) * | 2004-06-14 | 2011-04-26 | Usgi Medical, Inc. | Apparatus and methods for performing transluminal gastrointestinal procedures |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
EP2805953B1 (en) | 2004-12-21 | 2016-03-09 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
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