HRP20220365T1 - Farmaceutski pripravak, postupci za liječenje i njegove uporabe - Google Patents
Farmaceutski pripravak, postupci za liječenje i njegove uporabe Download PDFInfo
- Publication number
- HRP20220365T1 HRP20220365T1 HRP20220365TT HRP20220365T HRP20220365T1 HR P20220365 T1 HRP20220365 T1 HR P20220365T1 HR P20220365T T HRP20220365T T HR P20220365TT HR P20220365 T HRP20220365 T HR P20220365T HR P20220365 T1 HRP20220365 T1 HR P20220365T1
- Authority
- HR
- Croatia
- Prior art keywords
- empagliflozin
- patient
- disease
- different therapeutic
- therapeutic substances
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 11
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- OBWASQILIWPZMG-QZMOQZSNSA-N empagliflozin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=CC=C(Cl)C(CC=2C=CC(O[C@@H]3COCC3)=CC=2)=C1 OBWASQILIWPZMG-QZMOQZSNSA-N 0.000 claims 13
- 229960003345 empagliflozin Drugs 0.000 claims 13
- 239000000126 substance Substances 0.000 claims 5
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 210000004204 blood vessel Anatomy 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 200000000007 Arterial disease Diseases 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims 2
- 208000032382 Ischaemic stroke Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 210000004351 coronary vessel Anatomy 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims 2
- 230000000302 ischemic effect Effects 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 238000013146 percutaneous coronary intervention Methods 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 102000008873 Angiotensin II receptor Human genes 0.000 claims 1
- 108050000824 Angiotensin II receptor Proteins 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 201000001431 Hyperuricemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000001280 Prediabetic State Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 230000003178 anti-diabetic effect Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 235000019504 cigarettes Nutrition 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 230000037213 diet Effects 0.000 claims 1
- 235000005911 diet Nutrition 0.000 claims 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 229960002397 linagliptin Drugs 0.000 claims 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 1
- 229960003105 metformin Drugs 0.000 claims 1
- 229940036944 metformin and linagliptin Drugs 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 239000003087 receptor blocking agent Substances 0.000 claims 1
- 239000002461 renin inhibitor Substances 0.000 claims 1
- 229940086526 renin-inhibitors Drugs 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (10)
1. Empagliflozin, naznačen time, da je za uporabu u postupku zaštite protiv ili odgode pojavljivanja udvostručenja razine kreatinina u serumu, praćeno sa eGFR (na temelju formule modificiranja dijete kod renalne bolesti (MDRD)) ≤45 mL/min/1,73m2, kod pacijenta, pri čemu navedeni postupak obuhvaća davanje pacijentu empagliflozina, opcionalno u kombinaciji s jednom ili više drugačijih terapijskih supstanci.
2. Empagliflozin za uporabu prema patentnom zahtjevu 1, naznačen time, da pacijent ima kroničnu bolest bubrega.
3. Empagliflozin za uporabu u postupku prema patentnom zahtjevu 1 ili 2, naznačen time, da pacijent je pacijent s predijabetesom, dijabetesom tipa 1 ili tipa 2.
4. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da pacijent ima kardiovaskularnu bolest ili je u riziku za dobivanje kardiovaskularne bolesti.
5. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da pacijent je pacijent s jednim ili više kardiovaskularnih rizičnih faktora koji se biraju od A), B), C) i D):
A) prethodna ili postojeća vaskularna bolest odabrana od infarkta miokarda, koronarne arterijske bolesti, perkutane koronarne intervencije, usađivanja premosnice koronarne arterije, ishemijskog ili hemoragijskog moždanog udara, kongestivnog zatajenja srca, i periferne okluzijske arterijske bolesti,
B) uznapredovala dob >/= 60-70 godina, i
C) jedan ili više kardiovaskularnih rizičnih faktora odabranih od sljedećih:
- uznapredovali dijabetes tipa 1 ili tipa 2 > 10 godina trajanja,
- hipertenzija,
- sadašnje svakodnevno pušenje cigareta,
- dislipidemija,
- pretilost,
- dob >/= 40,
- metabolički sindrom, hiperinzulinemija ili otpornost na inzulin, i
- hiperurikemija, erektilna disfunkcija, sindrom policističnih jajnika, apneja kod spavanja, ili obiteljska povijest vaskularne bolesti ili kardiomiopatije kod izravne krvne rodbine;
D) jedno ili više od sljedećih:
- potvrđena povijest infarkta miokarda,
- nestabilna angina s dokumentiranom koronarnom bolešću više krvnih žila ili pozitivan test na stres,
- perkutana koronarna intervencija u više krvnih žila,
- usađivanje koronarne arterijske premosnice kod više krvnih žila (CABG),
- povijest ishemijskog ili hemoragijskog moždanog udara,
- periferna okluzijska arterijska bolest.
6. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se jedna ili više drugačijih terapijskih supstanci biraju od nekih drugih antidijabetičkih supstanci.
7. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da obuhvaća davanje empagliflozina u kombinaciji s metforminom, s linagliptinom, ili s metforminom i linagliptinom.
8. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da jedna ili više drugačijih terapijskih supstanci jest RAAS inhibitor.
9. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da jedna ili više drugačijih terapijskih supstanci je direktni renin inhibitor, inhibitor angiotenzin-konvertirajućeg enzima (ACE) i/ili blokator angiotenzinskog II receptora (ARB).
10. Empagliflozin za uporabu u postupku prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time, da se empagliflozin daje oralno u ukupnoj dnevnoj količini od 10 mg ili 25 mg.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361813223P | 2013-04-18 | 2013-04-18 | |
| US201361823045P | 2013-05-14 | 2013-05-14 | |
| PCT/EP2014/057754 WO2014170383A1 (en) | 2013-04-18 | 2014-04-16 | Pharmaceutical composition, methods for treating and uses thereof |
| EP14718957.5A EP2986304B1 (en) | 2013-04-18 | 2014-04-16 | Pharmaceutical composition, methods for treating and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220365T1 true HRP20220365T1 (hr) | 2022-05-13 |
Family
ID=50543578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220365TT HRP20220365T1 (hr) | 2013-04-18 | 2014-04-16 | Farmaceutski pripravak, postupci za liječenje i njegove uporabe |
Country Status (23)
| Country | Link |
|---|---|
| US (9) | US20140315832A1 (hr) |
| EP (2) | EP4000608A1 (hr) |
| JP (2) | JP2016520564A (hr) |
| KR (1) | KR102309654B1 (hr) |
| CN (2) | CN113181161A (hr) |
| AU (2) | AU2014255727B2 (hr) |
| CA (2) | CA2909728C (hr) |
| CL (1) | CL2015003022A1 (hr) |
| CY (1) | CY1125144T1 (hr) |
| DK (1) | DK2986304T3 (hr) |
| EA (1) | EA033286B1 (hr) |
| ES (1) | ES2906115T3 (hr) |
| HK (1) | HK1215378A1 (hr) |
| HR (1) | HRP20220365T1 (hr) |
| HU (1) | HUE058731T2 (hr) |
| LT (1) | LT2986304T (hr) |
| MX (2) | MX2015014512A (hr) |
| PH (1) | PH12015502310A1 (hr) |
| PL (1) | PL2986304T3 (hr) |
| PT (1) | PT2986304T (hr) |
| RS (1) | RS63042B1 (hr) |
| SI (1) | SI2986304T1 (hr) |
| WO (1) | WO2014170383A1 (hr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| NO347644B1 (no) | 2006-05-04 | 2024-02-12 | Boehringer Ingelheim Int | Polymorfer |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| CN104906582A (zh) | 2009-02-13 | 2015-09-16 | 勃林格殷格翰国际有限公司 | 包含sglt2抑制剂、dpp-iv抑制剂和任选的另一种抗糖尿病药的药物组合物及其用途 |
| EP2486029B1 (en) | 2009-09-30 | 2015-06-10 | Boehringer Ingelheim International GmbH | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives |
| UY32919A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos |
| AU2010323068B2 (en) | 2009-11-27 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
| WO2011138421A1 (en) | 2010-05-05 | 2011-11-10 | Boehringer Ingelheim International Gmbh | Combination therapy |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| AR085689A1 (es) | 2011-03-07 | 2013-10-23 | Boehringer Ingelheim Int | Composiciones farmaceuticas de metformina, linagliptina y un inhibidor de sglt-2 |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| EP2849755A1 (en) | 2012-05-14 | 2015-03-25 | Boehringer Ingelheim International GmbH | A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome |
| TR201901110T4 (tr) | 2013-04-05 | 2019-02-21 | Boehringer Ingelheim Int | Empagliflozinin terapötik kullanımları. |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| SI2986304T1 (sl) | 2013-04-18 | 2022-04-29 | Boehringer Ingelheim International Gmbh | Farmacevtski sestavek, postopki za zdravljenje in njegove uporabe |
| US9902751B2 (en) | 2013-12-30 | 2018-02-27 | Mylan Laboratories Limited | Process for the preparation of empagliflozin |
| EP3217987A4 (en) * | 2014-11-10 | 2018-06-20 | Merck Sharp & Dohme Corp. | Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease |
| WO2016174155A1 (en) * | 2015-04-30 | 2016-11-03 | Boehringer Ingelheim International Gmbh | Methods and pharmaceutical compositions comprising a sglt2 inhibitor for treating or improving erectile dysfunction |
| MX2018011088A (es) * | 2016-03-16 | 2018-11-22 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende empagliflozina y sus usos. |
| US10155000B2 (en) * | 2016-06-10 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Medical use of pharmaceutical combination or composition |
| US10344002B2 (en) | 2016-09-26 | 2019-07-09 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
| KR20230162125A (ko) * | 2016-11-10 | 2023-11-28 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물, 치료 방법 및 이의 용도 |
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| CA3083327A1 (en) * | 2017-11-30 | 2019-06-06 | Idorsia Pharmaceuticals Ltd | Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases |
| WO2019244171A1 (en) * | 2018-06-20 | 2019-12-26 | Alkem Laboratories Ltd. | Stable oral pharmaceutical composition of amorphous empagliflozin and process for preparing thereof |
| US11534021B2 (en) * | 2018-10-31 | 2022-12-27 | Hamilton Beach Brands, Inc. | Methods for measuring usage of consumables in kitchen appliances |
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