FI86077B - Monoklonala antikroppar och metod att producera dessa. - Google Patents
Monoklonala antikroppar och metod att producera dessa. Download PDFInfo
- Publication number
- FI86077B FI86077B FI840219A FI840219A FI86077B FI 86077 B FI86077 B FI 86077B FI 840219 A FI840219 A FI 840219A FI 840219 A FI840219 A FI 840219A FI 86077 B FI86077 B FI 86077B
- Authority
- FI
- Finland
- Prior art keywords
- human
- hybridoma
- monoclonal antibodies
- tumor
- cells
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (9)
1. Monoklonala antikroppar för användning in vitro, k ä n n e -tecknade av, att de har framställts av hybridom CLNH5 vars ATCC-nummer är HB8206 eller hybridom CLNH11 vars ATCC-num-mer är HB8307, varvid antikropparna binder sig vid tumör-celler med avsevärt högre specifitet än vad antikroppar binder sig vid non-cancerceller.
2. Användning av monoklonala antikroppar enligt patentkrav 1 eller dess fragment i metod, i vilken in vitro bestämras en tumörs närvaro, i vilken metod: kombineras prov av en värd som misstänks ha tumör med monoklonala antikroppar eller med antikroppsfragment, och observeras närvaron av monoklonala antikroppar eller dess fragment, som kan ästadkomma en signal som kan observeras.
3. Metod enligt patentkrav 2, kännetecknad av, att nämnda tumör är en solid tumör.
4. Metod enligt patentkrav 3, kännetecknad av, att en solid tumör är cervixcarcinom, prostatatumör, tjocktarmscar-cinom, lungcancer, bröstcancer eller melanom.
• 5. Metod att producera humana monoklonala antikroppar specifikä . för neonplastiska celler tili ätskillnad frän normala celler och fria frän non-humana antigener, kännetecknad av, att sammanslagning av B-lymfocyter frän humana lymfnoder, humana lymfkörtlar, människobenmärg, människomjälte eller mänskligt blod, associeras med neoplasm i en mänsklig värd, med en human fusionspartner för producering av hybridom; nämnda hybridom klonas för producering av enskilda kloner; nämnda kloner sorteras för att finna monoklonala antikroppar som är specifika för nämnda tumörceller och för tumörceller frän samma vävnad frän andra värdar; och nämnda specifika kloner od-las, varvid nämnda monoklonala antikroppar produceras och av, att metoder omf attar humanhybridom, i vilka f inns gener frän samma humana neoplastiska värdlymfocyter eller humanhybridom som 16 86077 är deriverade därav.
6. Metod enligt patentkrav 5, kännetecknad av, att nämnda neoplasm är ett prov av en solid tumör frän en human värd.
7. Metod enligt patentkrav 5, kännetecknad av, att nämnda tumör är ett cervixcarcinom.
8. Metod enligt patentkrav 5, kännetecknad av, att nämnda neoplasm är en solid tumör i en human värd.
9. Metod enligt patentkrav 5, kännetecknad av, att hybridomklon, som producerar nämnda monoklonala antikroppar, är hybridom CLNH11, vars ATCC-nummer är HB8307, eller hybridom, vars ATCC-nummer är HB8206. Il
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57084843A JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
| JP8484382 | 1982-05-21 | ||
| PCT/US1983/000781 WO1983004313A1 (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for neoplasms |
| US8300781 | 1983-05-20 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI840219A0 FI840219A0 (fi) | 1984-01-19 |
| FI840219A FI840219A (fi) | 1984-01-19 |
| FI86077B true FI86077B (fi) | 1992-03-31 |
| FI86077C FI86077C (sv) | 1992-07-10 |
Family
ID=13842073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI840219A FI86077C (sv) | 1982-05-21 | 1984-01-19 | Monoklonala antikroppar och metod att producera dessa |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0109441B1 (sv) |
| JP (2) | JPS58201994A (sv) |
| AT (1) | ATE114189T1 (sv) |
| AU (1) | AU560595B2 (sv) |
| CZ (1) | CZ280677B6 (sv) |
| DE (1) | DE3382764T2 (sv) |
| DK (1) | DK164510C (sv) |
| FI (1) | FI86077C (sv) |
| HU (1) | HU190908B (sv) |
| IN (1) | IN157982B (sv) |
| SK (1) | SK356683A3 (sv) |
| WO (1) | WO1983004313A1 (sv) |
| ZA (1) | ZA833686B (sv) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4618577A (en) * | 1983-02-09 | 1986-10-21 | The Regents Of The University Of California | Human-human hybridoma, CLNH5 |
| CA1247538A (en) * | 1982-05-21 | 1988-12-28 | Mark C. Glassy | Human-human hybridomas for solid tumors |
| ATE56046T1 (de) * | 1983-03-04 | 1990-09-15 | Health Research Inc | Monoklonale antikoerper gegen humane brustkarzinomzellen und ihre verwendung in der diagnose und therapie. |
| US4939240A (en) * | 1983-03-04 | 1990-07-03 | Health Research, Inc. | Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy |
| US4613576A (en) * | 1983-03-09 | 1986-09-23 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cancer cells |
| US4693966A (en) * | 1983-03-11 | 1987-09-15 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies from lymphocytes of patients with malignant melanoma |
| GB2140030A (en) * | 1983-04-08 | 1984-11-21 | Kureha Chemical Ind Co Ltd | Monoclonal antibody to human urinary bladder cancer |
| EP0162070A1 (en) * | 1983-11-25 | 1985-11-27 | The University Of Melbourne | Cell line and monoclonal antibody |
| NZ210867A (en) * | 1984-01-31 | 1989-01-06 | Litton Bionetics Inc | Tumour-specific monoclonal antibodies, production thereof and use |
| US4886745A (en) * | 1984-03-30 | 1989-12-12 | Syntex Inc. | Monoclonal antibody specific for human basal cell surface antigen |
| DK144485A (da) * | 1984-03-30 | 1985-10-01 | Syntex Inc | Monoklonale antistoffer |
| JPS6133125A (ja) * | 1984-07-25 | 1986-02-17 | Morinaga & Co Ltd | ヒト単クロ−ン性抗肺ガン細胞抗体 |
| US4761377A (en) * | 1984-10-15 | 1988-08-02 | The Regents Of The University Of California | Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells |
| JPS61130300A (ja) * | 1984-11-27 | 1986-06-18 | ザ ボ−ド オブ トラステイ−ズ オブ ザ レランド スタンフオ−ド ジユニア ユニバ−シテイ | ヒトモノクロ−ナル抗体 |
| US5106746A (en) * | 1985-05-22 | 1992-04-21 | E. I. Du Pont De Nemours And Company | Process for the in vitro immunization of human splenocytes against tumor associated antigens |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
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| EP0222360A3 (en) * | 1985-11-12 | 1989-03-15 | Biotherapeutics Inc. | A method of producing a patient-specific cytotoxic reagent and composition |
| JPH0767388B2 (ja) * | 1986-01-13 | 1995-07-26 | 三菱化学株式会社 | 抗体産生細胞株の樹立方法 |
| US5434076A (en) * | 1989-12-18 | 1995-07-18 | Board Of Regents, The University Of Texas System | Tumor-specific, cell surface-binding monoclonal antibodies |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57502090A (sv) * | 1980-07-18 | 1982-11-25 | ||
| NZ198851A (en) * | 1980-11-07 | 1984-07-31 | Wistar Inst | Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line |
-
1982
- 1982-05-21 JP JP57084843A patent/JPS58201994A/ja active Granted
-
1983
- 1983-05-19 CZ CS833566A patent/CZ280677B6/cs not_active IP Right Cessation
- 1983-05-19 SK SK3566-83A patent/SK356683A3/sk unknown
- 1983-05-20 HU HU832697A patent/HU190908B/hu not_active IP Right Cessation
- 1983-05-20 AU AU17729/83A patent/AU560595B2/en not_active Expired
- 1983-05-20 AT AT83902157T patent/ATE114189T1/de not_active IP Right Cessation
- 1983-05-20 EP EP83902157A patent/EP0109441B1/en not_active Expired - Lifetime
- 1983-05-20 JP JP58502264A patent/JPS60501359A/ja active Pending
- 1983-05-20 WO PCT/US1983/000781 patent/WO1983004313A1/en active IP Right Grant
- 1983-05-20 DE DE3382764T patent/DE3382764T2/de not_active Expired - Lifetime
- 1983-05-23 ZA ZA833686A patent/ZA833686B/xx unknown
- 1983-05-31 IN IN683/CAL/83A patent/IN157982B/en unknown
-
1984
- 1984-01-19 FI FI840219A patent/FI86077C/sv not_active IP Right Cessation
- 1984-01-20 DK DK025084A patent/DK164510C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3382764D1 (de) | 1994-12-22 |
| AU560595B2 (en) | 1987-04-09 |
| FI86077C (sv) | 1992-07-10 |
| EP0109441A4 (en) | 1986-09-22 |
| SK279249B6 (sk) | 1998-08-05 |
| ZA833686B (en) | 1984-09-26 |
| DE3382764T2 (de) | 1995-03-16 |
| WO1983004313A1 (en) | 1983-12-08 |
| EP0109441A1 (en) | 1984-05-30 |
| JPS60501359A (ja) | 1985-08-22 |
| JPS58201994A (ja) | 1983-11-25 |
| JPH0159878B2 (sv) | 1989-12-20 |
| ATE114189T1 (de) | 1994-12-15 |
| FI840219A0 (fi) | 1984-01-19 |
| SK356683A3 (en) | 1998-08-05 |
| DK25084D0 (da) | 1984-01-20 |
| AU1772983A (en) | 1983-12-16 |
| CZ280677B6 (cs) | 1996-04-17 |
| EP0109441B1 (en) | 1994-11-17 |
| IN157982B (sv) | 1986-08-09 |
| FI840219A (fi) | 1984-01-19 |
| DK25084A (da) | 1984-01-20 |
| DK164510B (da) | 1992-07-06 |
| DK164510C (da) | 1992-11-23 |
| CZ356683A3 (en) | 1995-11-15 |
| HU190908B (en) | 1986-12-28 |
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Owner name: THE REGENTS OF THE UNIVERSITY OF |