WO2009054435A1 - 増強されたエフェクター機能を有するポリペプチド - Google Patents

増強されたエフェクター機能を有するポリペプチド Download PDF

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Publication number
WO2009054435A1
WO2009054435A1 PCT/JP2008/069189 JP2008069189W WO2009054435A1 WO 2009054435 A1 WO2009054435 A1 WO 2009054435A1 JP 2008069189 W JP2008069189 W JP 2008069189W WO 2009054435 A1 WO2009054435 A1 WO 2009054435A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
effector function
producing
enhanced effector
antibody
Prior art date
Application number
PCT/JP2008/069189
Other languages
English (en)
French (fr)
Inventor
Takashi Tsuji
Yasuhiro Kajihara
Katsunari Tezuka
Yuri Nambu
Kazuhiro Fukae
Hiroaki Asai
Original Assignee
Otsuka Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co., Ltd. filed Critical Otsuka Chemical Co., Ltd.
Priority to EP08842029A priority Critical patent/EP2230300A4/en
Priority to JP2009538244A priority patent/JP5620106B2/ja
Priority to US12/739,480 priority patent/US20120047586A9/en
Publication of WO2009054435A1 publication Critical patent/WO2009054435A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明は、エフェクター機能が増強されたポリペプチドを提供する。すなわち、本発明は、改変されたＦｃ領域を有するポリペプチド、これをコードする核酸、該核酸を含むベクター、該ベクターを有する宿主細胞または宿主生物、前記ポリペプチドを含む医薬組成物、前記ポリペプチドの製造方法、抗体のエフェクター機能を高める方法、および高エフェクター機能抗体産生細胞の作製方法に関する。
PCT/JP2008/069189 2007-10-24 2008-10-23 増強されたエフェクター機能を有するポリペプチド WO2009054435A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08842029A EP2230300A4 (en) 2007-10-24 2008-10-23 POLYPEPTIDE WITH IMPROVED EFFECTOR FUNCTION
JP2009538244A JP5620106B2 (ja) 2007-10-24 2008-10-23 増強されたエフェクター機能を有するポリペプチド
US12/739,480 US20120047586A9 (en) 2007-10-24 2008-10-23 Polypeptide having enhanced effector function

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-276935 2007-10-24
JP2007276935 2007-10-24

Publications (1)

Publication Number Publication Date
WO2009054435A1 true WO2009054435A1 (ja) 2009-04-30

Family

ID=40579537

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/069189 WO2009054435A1 (ja) 2007-10-24 2008-10-23 増強されたエフェクター機能を有するポリペプチド

Country Status (4)

Country Link
US (1) US20120047586A9 (ja)
EP (1) EP2230300A4 (ja)
JP (1) JP5620106B2 (ja)
WO (1) WO2009054435A1 (ja)

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WO2015123565A1 (en) * 2014-02-14 2015-08-20 The General Hospital Corporation Methods for diagnosing igg4-related disease
WO2015136472A1 (en) * 2014-03-12 2015-09-17 Prothena Biosciences Limited Anti-laminin4 antibodies specific for lg4-5
US10407507B2 (en) 2012-09-10 2019-09-10 Prothena Biosciences Limited Anti-MCAM antibodies and associated methods of use
US10407506B2 (en) 2014-03-12 2019-09-10 Prothena Biosciences Limited Anti-MCAM antibodies and associated methods of use

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TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US9345727B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
US20220002387A1 (en) * 2018-11-06 2022-01-06 University Of Miami Compositions and Production of Recombinant AAV Viral Vectors Capable of Glycoengineering In Vivo

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JPH05336963A (ja) 1991-12-17 1993-12-21 Kyowa Hakko Kogyo Co Ltd 新規α２→３シアリルトランスフェラーゼ
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