MX369550B - Gen de fusion del receptor de factor de crecimiento de fibroblastos 3 (fgfr3) y medicamentos farmaceutico para tratar el mismo. - Google Patents

Gen de fusion del receptor de factor de crecimiento de fibroblastos 3 (fgfr3) y medicamentos farmaceutico para tratar el mismo.

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Publication number
MX369550B
MX369550B MX2015003744A MX2015003744A MX369550B MX 369550 B MX369550 B MX 369550B MX 2015003744 A MX2015003744 A MX 2015003744A MX 2015003744 A MX2015003744 A MX 2015003744A MX 369550 B MX369550 B MX 369550B
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MX
Mexico
Prior art keywords
polypeptide
fusion gene
drug targeting
pharmaceutical drug
fgfr
Prior art date
Application number
MX2015003744A
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English (en)
Other versions
MX2015003744A (es
Inventor
Nakanishi Yoshito
Akiyama Nukinori
Nishito Yukari
Original Assignee
Chugai Pharmaceutical Co Ltd
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50388416&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX369550(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2015003744A publication Critical patent/MX2015003744A/es
Publication of MX369550B publication Critical patent/MX369550B/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

La presente invención se refiere al gen que codifica para FGFR con respecto a su expresión, hiperamplificación, mutación, translocación o similares en diversas células cancerosas, como un resultado, se identificaron y aislaron polipéptidos de fusión novedosos en los cuales el polipéptido FGFR3 está fusionado con un polipéptido diferente, a partir de diversos tipos de células derivadas de cáncer de vejiga y células de cáncer de pulmón. El uso de un polipéptido de fusión de la presente invención como un biomarcador en un tratamiento contra el cáncer basado en inhibidor de FGFR permite evitar los efectos secundarios en el tratamiento contra el cáncer y controlar la condición terapéutica para producir el mejor efecto terapéutico y de esta manera se habilita medicina individualizada.
MX2015003744A 2012-09-27 2013-09-27 Gen de fusion del receptor de factor de crecimiento de fibroblastos 3 (fgfr3) y medicamentos farmaceutico para tratar el mismo. MX369550B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012214739 2012-09-27
JP2013149217 2013-07-18
PCT/JP2013/076200 WO2014051022A1 (ja) 2012-09-27 2013-09-27 Fgfr3融合遺伝子およびそれを標的とする医薬

Publications (2)

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MX2015003744A MX2015003744A (es) 2015-06-24
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