EA201500334A1 - Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него - Google Patents

Fgfr3 гибридный ген и лекарственный препарат, нацеленный на него

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Publication number
EA201500334A1
EA201500334A1 EA201500334A EA201500334A EA201500334A1 EA 201500334 A1 EA201500334 A1 EA 201500334A1 EA 201500334 A EA201500334 A EA 201500334A EA 201500334 A EA201500334 A EA 201500334A EA 201500334 A1 EA201500334 A1 EA 201500334A1
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EA
Eurasian Patent Office
Prior art keywords
fgfr3
polypeptide
opportunity
malignant neoplasm
cancer cells
Prior art date
Application number
EA201500334A
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English (en)
Other versions
EA031631B1 (ru
Inventor
Йошито Наканиши
Нукинори Акияма
Юкари Нишито
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Чугаи Сеияку Кабушики Каиша
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Application filed by Чугаи Сеияку Кабушики Каиша filed Critical Чугаи Сеияку Кабушики Каиша
Publication of EA201500334A1 publication Critical patent/EA201500334A1/ru
Publication of EA031631B1 publication Critical patent/EA031631B1/ru

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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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Abstract

Подробно исследовали ген, кодирующий FGFR, относительно его экспрессии, гиперамплификации, мутации, транслокации или др. в различных раковых клетках. В результате исследований были идентифицированы новые гибридные полипептиды, в которых FGFR3 полипептид гибридизирован с другим полипептидом, и были выделены из клеток нескольких типов, имеющих происхождение из рака мочевого пузыря и клеток рака легких. Применение гибридного полипептида в соответствии с настоящим изобретением в качестве биомаркера в терапии злокачественного новообразования, основывающейся на ингибиторе FGFR, предоставляет возможность избежать побочных действий при терапии злокачественного новообразования и контролировать терапевтическое состояние для получения наилучшего терапевтического эффекта, таким образом предоставляя возможность индивидуализировать медицину.
EA201500334A 2012-09-27 2013-09-27 Способ лечения или предупреждения злокачественного новообразования, способ отбора пациента, способ тестирования предрасположенности к злокачественному новообразованию у субъекта, гибридный полипептид и его применения EA031631B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012214739 2012-09-27
JP2013149217 2013-07-18
PCT/JP2013/076200 WO2014051022A1 (ja) 2012-09-27 2013-09-27 Fgfr3融合遺伝子およびそれを標的とする医薬

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EA201500334A1 true EA201500334A1 (ru) 2016-01-29
EA031631B1 EA031631B1 (ru) 2019-01-31

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