MX2019007057A - Composiciones de adenovirus. - Google Patents
Composiciones de adenovirus.Info
- Publication number
- MX2019007057A MX2019007057A MX2019007057A MX2019007057A MX2019007057A MX 2019007057 A MX2019007057 A MX 2019007057A MX 2019007057 A MX2019007057 A MX 2019007057A MX 2019007057 A MX2019007057 A MX 2019007057A MX 2019007057 A MX2019007057 A MX 2019007057A
- Authority
- MX
- Mexico
- Prior art keywords
- adenovirus
- tumor
- treatment methods
- fas
- decreasing
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención proporciona un adenovirus que comprende una construcción de ácido nucleico que comprende un gen para quimera de FAS unido operablemente a un promotor específico de células endoteliales. También se proporciona una población homogénea de un adenovirus que comprende un gen para quimera de FAS unido operablemente a un promotor específico de células endoteliales y los usos del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261715206P | 2012-10-17 | 2012-10-17 | |
US201361785287P | 2013-03-14 | 2013-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019007057A true MX2019007057A (es) | 2019-08-29 |
Family
ID=50488836
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004835A MX366163B (es) | 2012-10-17 | 2013-10-17 | Composiciones de adenovirus. |
MX2019007057A MX2019007057A (es) | 2012-10-17 | 2015-04-16 | Composiciones de adenovirus. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015004835A MX366163B (es) | 2012-10-17 | 2013-10-17 | Composiciones de adenovirus. |
Country Status (26)
Country | Link |
---|---|
US (4) | US9200056B2 (es) |
EP (2) | EP3441089B1 (es) |
JP (2) | JP6336459B2 (es) |
KR (2) | KR102229084B1 (es) |
CN (2) | CN107096041A (es) |
AU (3) | AU2013333571B2 (es) |
BR (1) | BR112015008612A2 (es) |
CA (1) | CA2888193A1 (es) |
CY (1) | CY1121185T1 (es) |
DK (1) | DK2908865T3 (es) |
EA (1) | EA034163B1 (es) |
ES (1) | ES2703913T3 (es) |
HK (1) | HK1208625A1 (es) |
HR (1) | HRP20182125T1 (es) |
HU (1) | HUE042262T2 (es) |
IL (2) | IL238313B (es) |
LT (1) | LT2908865T (es) |
MX (2) | MX366163B (es) |
NZ (1) | NZ707336A (es) |
PL (1) | PL2908865T3 (es) |
PT (1) | PT2908865T (es) |
RS (1) | RS58122B1 (es) |
SG (2) | SG11201502941VA (es) |
SI (1) | SI2908865T1 (es) |
WO (1) | WO2014060848A2 (es) |
ZA (1) | ZA201502712B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX338931B (es) | 2010-01-05 | 2016-05-06 | Vascular Biogenics Ltd | Composiciones y metodo para tratar gliobastoma (gbm). |
EP2521776B1 (en) | 2010-01-05 | 2016-11-02 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
PL2908865T3 (pl) | 2012-10-17 | 2019-08-30 | Vascular Biogenics Ltd. | Adenowirus wykazujący ekspresję chimery Fas i jego zastosowanie w sposobach leczenia raka |
US9682154B2 (en) * | 2013-02-04 | 2017-06-20 | Vascular Biogenics Ltd. | Methods of inducing responsiveness to anti-angiogenic agent |
WO2015152409A1 (ja) * | 2014-04-04 | 2015-10-08 | 大鵬薬品工業株式会社 | タキサン系化合物を含有する抗腫瘍剤及び抗腫瘍効果増強剤 |
EP3131922B1 (en) * | 2014-04-17 | 2020-05-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Polypeptides and uses thereof for reducing cd95-mediated cell motility |
FI127460B (en) * | 2016-01-15 | 2018-06-29 | Targovax Oy | COMBINATION OF ADENOVIRUS AND CHEMOTHERAPY AGENTS FOR CANCER CARE |
EP3565591A1 (en) | 2017-01-06 | 2019-11-13 | Stabilitech Biopharma Ltd | Virus |
CN111356480A (zh) * | 2017-10-20 | 2020-06-30 | 脉管生物生长有限公司 | 用于抗血管生成剂疗法的诊断方法 |
AU2019403393A1 (en) * | 2018-12-20 | 2021-08-05 | The University Of Chicago | Methods and compositions related to therapeutic peptides for cancer therapy |
CN113784730A (zh) * | 2019-03-13 | 2021-12-10 | 脉管生物生长有限公司 | 抗肿瘤疗法的方法 |
MX2021012398A (es) * | 2019-04-12 | 2021-11-12 | Vascular Biogenics Ltd | Metodos de terapia antitumoral. |
KR102601875B1 (ko) * | 2020-03-25 | 2023-11-14 | (주)큐리진 | 면역 회피성 항종양 아데노바이러스 |
WO2022056488A1 (en) * | 2020-09-14 | 2022-03-17 | Genprex, Inc. | Nonviral vectors for increasing fas expression in cancer cells and methods of use thereof |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US3773319A (en) | 1971-12-16 | 1973-11-20 | Fabcor Ind Inc | Corrugated sheet inverting machine |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
UA70909C2 (uk) | 1993-10-25 | 2004-11-15 | Канджи Інк. | Рекомбінантний аденовірусний вектор, фармацевтична композиція, що його містить, та набір для зменшення проліферації пухлинних клітин |
BR9407956A (pt) | 1993-10-25 | 1996-11-26 | Canji Inc | Composiçao farmacêutica vetor de express o de adenovirus recombinante e kit par reduzir a proliferaçao de células tumorais |
US7070771B1 (en) * | 1996-12-09 | 2006-07-04 | Regents Of The University Of California | Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells |
US7067649B2 (en) | 2000-11-17 | 2006-06-27 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US8039261B2 (en) | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20100282634A1 (en) | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20070286845A1 (en) | 2000-11-17 | 2007-12-13 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
WO2003033514A1 (en) | 2001-10-19 | 2003-04-24 | Vascular Biogenics Ltd. | Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy |
CN1294268C (zh) | 2001-09-03 | 2007-01-10 | 上海三维生物技术有限公司 | 可在肿瘤细胞内特异性复制并扩散的重组腺病毒载体 |
KR20070044868A (ko) | 2005-10-26 | 2007-05-02 | 주식회사 바이오인프라 | 스트렙토라이신 o 단백질을 암호화하는 유전자를 발현하는재조합 아데노바이러스 및 이를 유효성분으로 하는 항암용조성물 |
WO2008015675A2 (en) | 2006-07-31 | 2008-02-07 | Vascular Biogenics Ltd. | Polypeptides and polynucleotides encoding same and use thereof in the treatment of medical conditions associated with ischemia |
WO2008074189A1 (fr) | 2006-12-20 | 2008-06-26 | Shenzhen Well.D Genetic Engineering Co., Ltd | Adénovirus recombinant comprenant un gène khp50 recombinant et son procédé de préparation et ses utilisations |
CN101348512B (zh) | 2007-07-20 | 2012-08-15 | 郑州威瑞生物技术有限公司 | 一种抗肿瘤的腺病毒制剂 |
JP4896102B2 (ja) | 2008-09-12 | 2012-03-14 | 富士フイルム株式会社 | レンズ装置 |
KR101248912B1 (ko) | 2009-12-31 | 2013-03-29 | 한양대학교 산학협력단 | 항혈관신생 활성을 가지는 재조합 아데노바이러스 |
MX338931B (es) * | 2010-01-05 | 2016-05-06 | Vascular Biogenics Ltd | Composiciones y metodo para tratar gliobastoma (gbm). |
EP2521776B1 (en) | 2010-01-05 | 2016-11-02 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
EP2523681A1 (en) | 2010-01-12 | 2012-11-21 | Vascular Biogenics Ltd. | Methods of producing adenovirus vectors and viral preparations generated thereby |
KR101253276B1 (ko) | 2010-07-27 | 2013-04-10 | 윤채옥 | 복합 유전자 치료용 항종양 조성물 |
KR101232123B1 (ko) | 2010-10-08 | 2013-02-12 | 연세대학교 산학협력단 | 재조합된 유전자발현 조절서열을 가지는 종양 특이적 발현이 개선된 유전자 전달체 |
US20130320253A1 (en) | 2010-10-18 | 2013-12-05 | Total Research & Trchnogy Feluy | Expandable vinyl aromatic polymers |
WO2012052878A1 (en) | 2010-10-19 | 2012-04-26 | Vascular Biogenics Ltd. | Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells |
PL2908865T3 (pl) | 2012-10-17 | 2019-08-30 | Vascular Biogenics Ltd. | Adenowirus wykazujący ekspresję chimery Fas i jego zastosowanie w sposobach leczenia raka |
US9682154B2 (en) | 2013-02-04 | 2017-06-20 | Vascular Biogenics Ltd. | Methods of inducing responsiveness to anti-angiogenic agent |
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2013
- 2013-10-17 PL PL13847711T patent/PL2908865T3/pl unknown
- 2013-10-17 JP JP2015537368A patent/JP6336459B2/ja not_active Expired - Fee Related
- 2013-10-17 LT LTEP13847711.2T patent/LT2908865T/lt unknown
- 2013-10-17 SI SI201331289T patent/SI2908865T1/sl unknown
- 2013-10-17 SG SG11201502941VA patent/SG11201502941VA/en unknown
- 2013-10-17 EP EP18176347.5A patent/EP3441089B1/en active Active
- 2013-10-17 EP EP13847711.2A patent/EP2908865B1/en active Active
- 2013-10-17 EA EA201590747A patent/EA034163B1/ru unknown
- 2013-10-17 KR KR1020197016474A patent/KR102229084B1/ko active IP Right Grant
- 2013-10-17 CN CN201710136048.9A patent/CN107096041A/zh active Pending
- 2013-10-17 ES ES13847711T patent/ES2703913T3/es active Active
- 2013-10-17 MX MX2015004835A patent/MX366163B/es active IP Right Grant
- 2013-10-17 CA CA2888193A patent/CA2888193A1/en not_active Abandoned
- 2013-10-17 BR BR112015008612A patent/BR112015008612A2/pt not_active Application Discontinuation
- 2013-10-17 NZ NZ707336A patent/NZ707336A/en unknown
- 2013-10-17 AU AU2013333571A patent/AU2013333571B2/en not_active Ceased
- 2013-10-17 PT PT13847711T patent/PT2908865T/pt unknown
- 2013-10-17 SG SG10201706485WA patent/SG10201706485WA/en unknown
- 2013-10-17 RS RS20181580A patent/RS58122B1/sr unknown
- 2013-10-17 CN CN201380062233.8A patent/CN105025931B/zh active Active
- 2013-10-17 HU HUE13847711A patent/HUE042262T2/hu unknown
- 2013-10-17 WO PCT/IB2013/003015 patent/WO2014060848A2/en active Application Filing
- 2013-10-17 KR KR1020157012086A patent/KR101989171B1/ko active IP Right Grant
- 2013-10-17 DK DK13847711.2T patent/DK2908865T3/en active
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2014
- 2014-10-29 US US14/527,667 patent/US9200056B2/en not_active Expired - Fee Related
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2015
- 2015-04-15 IL IL238313A patent/IL238313B/en active IP Right Grant
- 2015-04-16 MX MX2019007057A patent/MX2019007057A/es unknown
- 2015-04-21 ZA ZA2015/02712A patent/ZA201502712B/en unknown
- 2015-09-23 HK HK15109326.9A patent/HK1208625A1/xx not_active IP Right Cessation
- 2015-11-23 US US14/949,779 patent/US20160143968A1/en not_active Abandoned
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2017
- 2017-04-18 AU AU2017202492A patent/AU2017202492B2/en not_active Ceased
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2018
- 2018-05-02 JP JP2018088598A patent/JP6630397B2/ja active Active
- 2018-07-23 US US16/042,596 patent/US11311583B2/en active Active
- 2018-11-30 AU AU2018271398A patent/AU2018271398B2/en not_active Ceased
- 2018-12-14 HR HRP20182125TT patent/HRP20182125T1/hr unknown
- 2018-12-21 CY CY20181101385T patent/CY1121185T1/el unknown
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2020
- 2020-07-06 IL IL275874A patent/IL275874A/en unknown
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2022
- 2022-03-22 US US17/701,255 patent/US20220331383A1/en active Pending
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