ES2565238T3 - Inhibidores de la c-fms quinasa - Google Patents

Inhibidores de la c-fms quinasa Download PDF

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Publication number
ES2565238T3
ES2565238T3 ES07760840.4T ES07760840T ES2565238T3 ES 2565238 T3 ES2565238 T3 ES 2565238T3 ES 07760840 T ES07760840 T ES 07760840T ES 2565238 T3 ES2565238 T3 ES 2565238T3
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Prior art keywords
alkyl
phenyl
amide
cyano
formula
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Spanish (es)
Inventor
Carl R. Illig
Shelley K. Ballentine
Jinsheng Chen
Renee Louise Desjarlais
Sanath K. Meegalla
Bruce E. Tomczuk
Mark Wall
Kenneth Wilson
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment

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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
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  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
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  • Biotechnology (AREA)
  • Virology (AREA)
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  • Pain & Pain Management (AREA)
ES07760840.4T 2006-04-20 2007-04-18 Inhibidores de la c-fms quinasa Active ES2565238T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79366706P 2006-04-20 2006-04-20
US793667P 2006-04-20
PCT/US2007/066868 WO2007124319A1 (en) 2006-04-20 2007-04-18 Inhibitors of c-fms kinase

Publications (1)

Publication Number Publication Date
ES2565238T3 true ES2565238T3 (es) 2016-04-01

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Family Applications (3)

Application Number Title Priority Date Filing Date
ES07760840.4T Active ES2565238T3 (es) 2006-04-20 2007-04-18 Inhibidores de la c-fms quinasa
ES07760846.1T Active ES2566772T3 (es) 2006-04-20 2007-04-18 Inhibidores de la quinasa c-fms
ES07760842.0T Active ES2564781T3 (es) 2006-04-20 2007-04-18 Inhibidores de la c-fms quinasa

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Application Number Title Priority Date Filing Date
ES07760846.1T Active ES2566772T3 (es) 2006-04-20 2007-04-18 Inhibidores de la quinasa c-fms
ES07760842.0T Active ES2564781T3 (es) 2006-04-20 2007-04-18 Inhibidores de la c-fms quinasa

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Country Link
US (7) US8815867B2 (enExample)
EP (3) EP2016070B1 (enExample)
JP (3) JP5331681B2 (enExample)
KR (3) KR101406877B1 (enExample)
CN (1) CN101472914B (enExample)
AR (3) AR060612A1 (enExample)
AU (3) AU2007240443B2 (enExample)
BR (1) BRPI0710548B8 (enExample)
CA (3) CA2649739C (enExample)
ES (3) ES2565238T3 (enExample)
IL (1) IL194845A (enExample)
MX (3) MX2008013529A (enExample)
NO (1) NO20084896L (enExample)
NZ (3) NZ572070A (enExample)
PE (1) PE20080074A1 (enExample)
RU (1) RU2475483C2 (enExample)
SG (1) SG171593A1 (enExample)
TW (3) TWI411612B (enExample)
UA (1) UA93085C2 (enExample)
UY (1) UY30297A1 (enExample)
WO (3) WO2007124321A1 (enExample)
ZA (1) ZA200809873B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
RU2470665C2 (ru) * 2006-01-05 2012-12-27 Новартис Аг Способы профилактики и лечения ракового метастаза и разрежения кости, связанного с раковым метастазом
NZ572200A (en) * 2006-04-20 2011-09-30 Janssen Pharmaceutica Nv Method of inhibiting c-kit kinase
US8697716B2 (en) * 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
NZ572201A (en) * 2006-04-20 2011-09-30 Janssen Pharmaceutica Nv Inhibitors of c-fms kinase
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SG171593A1 (en) 2011-06-29
US9394289B2 (en) 2016-07-19
TW200815414A (en) 2008-04-01
EP2016074B1 (en) 2016-01-13
CA2650057A1 (en) 2007-11-01
IL194845A0 (en) 2009-08-03
US20070249685A1 (en) 2007-10-25
TW200806659A (en) 2008-02-01
EP2016058A1 (en) 2009-01-21
AU2007240443A1 (en) 2007-11-01
ES2564781T3 (es) 2016-03-29
CA2649739C (en) 2015-09-01
IL194845A (en) 2014-11-30
CA2649924C (en) 2014-08-19
EP2016070B1 (en) 2016-01-13
JP2009534407A (ja) 2009-09-24
NZ572072A (en) 2011-09-30
US20160122334A1 (en) 2016-05-05
US20140378457A1 (en) 2014-12-25
JP5331680B2 (ja) 2013-10-30
ES2566772T3 (es) 2016-04-15
US9266866B2 (en) 2016-02-23
EP2016074A1 (en) 2009-01-21
AU2007240443B2 (en) 2012-11-01
BRPI0710548B8 (pt) 2021-05-25
CN101472914A (zh) 2009-07-01
TWI411612B (zh) 2013-10-11
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US9403804B2 (en) 2016-08-02
UA93085C2 (en) 2011-01-10

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