PE20080074A1 - Derivados de amida como agentes inhibidores de la quinasa c-fms - Google Patents

Derivados de amida como agentes inhibidores de la quinasa c-fms

Info

Publication number
PE20080074A1
PE20080074A1 PE2007000480A PE2007000480A PE20080074A1 PE 20080074 A1 PE20080074 A1 PE 20080074A1 PE 2007000480 A PE2007000480 A PE 2007000480A PE 2007000480 A PE2007000480 A PE 2007000480A PE 20080074 A1 PE20080074 A1 PE 20080074A1
Authority
PE
Peru
Prior art keywords
amide
cyane
cyclohex
hydroxy
phenyl
Prior art date
Application number
PE2007000480A
Other languages
English (en)
Spanish (es)
Inventor
Carl R Illig
Shelley K Ballentine
Jinsheng Chen
Renee Louise Desjarlais
Bruce E Tomczuk
Mark Wall
Kenneth Wilson
Sanath K Meegalla
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20080074A1 publication Critical patent/PE20080074A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
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PE2007000480A 2006-04-20 2007-04-18 Derivados de amida como agentes inhibidores de la quinasa c-fms PE20080074A1 (es)

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US79366706P 2006-04-20 2006-04-20

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PE20080074A1 true PE20080074A1 (es) 2008-02-11

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US (7) US8815867B2 (enExample)
EP (3) EP2016070B1 (enExample)
JP (3) JP5331679B2 (enExample)
KR (3) KR101367646B1 (enExample)
CN (1) CN101472914B (enExample)
AR (3) AR060610A1 (enExample)
AU (3) AU2007240442B2 (enExample)
BR (1) BRPI0710548B8 (enExample)
CA (3) CA2649739C (enExample)
ES (3) ES2564781T3 (enExample)
IL (1) IL194845A (enExample)
MX (3) MX2008013531A (enExample)
NO (1) NO20084896L (enExample)
NZ (3) NZ572070A (enExample)
PE (1) PE20080074A1 (enExample)
RU (1) RU2475483C2 (enExample)
SG (1) SG171593A1 (enExample)
TW (3) TWI411612B (enExample)
UA (1) UA93085C2 (enExample)
UY (1) UY30297A1 (enExample)
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US20060281788A1 (en) * 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
RU2470665C2 (ru) * 2006-01-05 2012-12-27 Новартис Аг Способы профилактики и лечения ракового метастаза и разрежения кости, связанного с раковым метастазом
PL2021335T3 (pl) 2006-04-20 2011-10-31 Janssen Pharmaceutica Nv Związki heterocykliczne jako inhibitory kinazy C-FMS
EP2687516A1 (en) * 2006-04-20 2014-01-22 Janssen Pharmaceutica N.V. Inhibitors of C-FMS Kinase
CN101610768B (zh) * 2006-04-20 2012-03-21 詹森药业有限公司 抑制c kit激酶的方法
WO2007124322A1 (en) 2006-04-20 2007-11-01 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
US8697716B2 (en) * 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
JO3240B1 (ar) * 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
US10106798B2 (en) 2010-01-05 2018-10-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) FLT3 receptor antagonists for the treatment or the prevention of pain disorders
HUE045270T2 (hu) 2010-01-05 2019-12-30 Inst Nat Sante Rech Med FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére
CA2834696C (en) 2011-05-05 2019-07-23 Novartis Ag Csf-1r inhibitors for treatment of brain tumors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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UY30297A1 (es) 2007-08-31
KR20090003343A (ko) 2009-01-09
US9403804B2 (en) 2016-08-02
US20070249685A1 (en) 2007-10-25
MX2008013530A (es) 2009-01-14
CA2649924C (en) 2014-08-19
KR101367646B1 (ko) 2014-02-27
MX2008013529A (es) 2009-01-15
AU2007240443B2 (en) 2012-11-01
US20070249608A1 (en) 2007-10-25
CA2650057C (en) 2014-07-29
BRPI0710548A2 (pt) 2012-06-05
EP2016070A1 (en) 2009-01-21
KR20080110917A (ko) 2008-12-19
WO2007124321A1 (en) 2007-11-01
US8722718B2 (en) 2014-05-13
AU2007240440B2 (en) 2012-09-20
NZ572070A (en) 2011-09-30

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