ES2380621T3 - Anticuerpos monoclonales humanos contra CD20 - Google Patents

Anticuerpos monoclonales humanos contra CD20 Download PDF

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Publication number
ES2380621T3
ES2380621T3 ES03809145T ES03809145T ES2380621T3 ES 2380621 T3 ES2380621 T3 ES 2380621T3 ES 03809145 T ES03809145 T ES 03809145T ES 03809145 T ES03809145 T ES 03809145T ES 2380621 T3 ES2380621 T3 ES 2380621T3
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Prior art keywords
antibody
cells
human
antibodies
lymphoma
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Expired - Lifetime
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ES03809145T
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Spanish (es)
Inventor
JessicaWoodmill Cottage TEELING
Sigrid Ruuls
Martin Glennie
Jan G. J. Van De Winkel
Paul Parren
Jorgen Petersen
Ole D. M. Sc. Baadsgaard
Haichun Huang
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Genmab AS
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Genmab AS
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Publication of ES2380621T3 publication Critical patent/ES2380621T3/es
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
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    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • G01N33/686Anti-idiotype
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
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  • Endocrinology (AREA)
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  • Dermatology (AREA)
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ES03809145T 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20 Expired - Lifetime ES2380621T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41916302P 2002-10-17 2002-10-17
US419163P 2002-10-17
US46002803P 2003-04-02 2003-04-02
US460028P 2003-04-02
PCT/US2003/033057 WO2004035607A2 (en) 2002-10-17 2003-10-17 Human monoclonal antibodies against cd20

Publications (1)

Publication Number Publication Date
ES2380621T3 true ES2380621T3 (es) 2012-05-16

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ID=32110219

Family Applications (3)

Application Number Title Priority Date Filing Date
ES03809145T Expired - Lifetime ES2380621T3 (es) 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20
ES17179855T Expired - Lifetime ES2744275T3 (es) 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple
ES10013084.8T Expired - Lifetime ES2524694T3 (es) 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES17179855T Expired - Lifetime ES2744275T3 (es) 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple
ES10013084.8T Expired - Lifetime ES2524694T3 (es) 2002-10-17 2003-10-17 Anticuerpos monoclonales humanos contra CD20

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US (3) US8529902B2 (cg-RX-API-DMAC7.html)
EP (4) EP3284753B1 (cg-RX-API-DMAC7.html)
JP (3) JP4662473B2 (cg-RX-API-DMAC7.html)
KR (7) KR100932340B1 (cg-RX-API-DMAC7.html)
CN (3) CN103709250B (cg-RX-API-DMAC7.html)
AT (1) ATE540978T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003301445A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0315295C1 (cg-RX-API-DMAC7.html)
CA (2) CA2502552C (cg-RX-API-DMAC7.html)
CY (2) CY1112750T1 (cg-RX-API-DMAC7.html)
DK (2) DK3284753T3 (cg-RX-API-DMAC7.html)
EA (2) EA021644B1 (cg-RX-API-DMAC7.html)
ES (3) ES2380621T3 (cg-RX-API-DMAC7.html)
FR (1) FR21C1028I1 (cg-RX-API-DMAC7.html)
HU (2) HUE046695T2 (cg-RX-API-DMAC7.html)
IL (2) IL167851A (cg-RX-API-DMAC7.html)
LT (2) LT3284753T (cg-RX-API-DMAC7.html)
LU (1) LU92041I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA05004022A (cg-RX-API-DMAC7.html)
NZ (2) NZ568769A (cg-RX-API-DMAC7.html)
PL (2) PL216630B1 (cg-RX-API-DMAC7.html)
PT (2) PT1558648E (cg-RX-API-DMAC7.html)
SI (1) SI1558648T1 (cg-RX-API-DMAC7.html)
WO (1) WO2004035607A2 (cg-RX-API-DMAC7.html)

Families Citing this family (486)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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