ES2311571T3 - Derivados de bencenosulfonamida sustituidos como profarmacos de inhibidores de cox-2. - Google Patents

Derivados de bencenosulfonamida sustituidos como profarmacos de inhibidores de cox-2. Download PDF

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Publication number
ES2311571T3
ES2311571T3 ES02025005T ES02025005T ES2311571T3 ES 2311571 T3 ES2311571 T3 ES 2311571T3 ES 02025005 T ES02025005 T ES 02025005T ES 02025005 T ES02025005 T ES 02025005T ES 2311571 T3 ES2311571 T3 ES 2311571T3
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Prior art keywords
phenyl
sulfonyl
phenylisoxazol
methyl
sodium salt
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ES02025005T
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English (en)
Spanish (es)
Inventor
James W. Malecha
Thomas D. Penning
Ish K. Khanna
Xiangdong Xu
Richard M. Weier
John J. Talley
Stephen Bertenshaw
Matthew J. Graneto
Jeffrey Carter
Jinglin Li
Srinivasan Nagarajan
David L. Brown
Donald J Rogier, Jr.
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GD Searle LLC
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GD Searle LLC
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    • C07—ORGANIC CHEMISTRY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/18—Sulfonamides
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
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    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
ES02025005T 1996-04-12 1997-04-11 Derivados de bencenosulfonamida sustituidos como profarmacos de inhibidores de cox-2. Expired - Lifetime ES2311571T3 (es)

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US63151496A 1996-04-12 1996-04-12
US631514 1996-04-12

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