CN102014631A - 酪氨酸激酶抑制剂 - Google Patents
酪氨酸激酶抑制剂 Download PDFInfo
- Publication number
- CN102014631A CN102014631A CN2009801158039A CN200980115803A CN102014631A CN 102014631 A CN102014631 A CN 102014631A CN 2009801158039 A CN2009801158039 A CN 2009801158039A CN 200980115803 A CN200980115803 A CN 200980115803A CN 102014631 A CN102014631 A CN 102014631A
- Authority
- CN
- China
- Prior art keywords
- unit
- group
- aryl
- thiazolinyl
- hydrocarbon radical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(*)(*)[n]1nnc2c1nc(*)nc2* Chemical compound *C(*)(*)[n]1nnc2c1nc(*)nc2* 0.000 description 2
- DXVZLYSJXJRKFV-UHFFFAOYSA-N C1C=Cc2c[nH]cc2C1 Chemical compound C1C=Cc2c[nH]cc2C1 DXVZLYSJXJRKFV-UHFFFAOYSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- BRNULMACUQOKMR-UHFFFAOYSA-N C1NCCSC1 Chemical compound C1NCCSC1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 description 1
- PENNPXKQBCPQLF-UHFFFAOYSA-N Cc(cc(cccn1)c1c1)c1F Chemical compound Cc(cc(cccn1)c1c1)c1F PENNPXKQBCPQLF-UHFFFAOYSA-N 0.000 description 1
- RLRFWXHJSUVJDI-UHFFFAOYSA-N Nc1ncc2nn[n](Cc(cc3)cc4c3nccc4)c2n1 Chemical compound Nc1ncc2nn[n](Cc(cc3)cc4c3nccc4)c2n1 RLRFWXHJSUVJDI-UHFFFAOYSA-N 0.000 description 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N c1n[nH]c2ccccc12 Chemical compound c1n[nH]c2ccccc12 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
- KNYHISBJRQVMAZ-UHFFFAOYSA-N c1n[nH]c2cnccc12 Chemical compound c1n[nH]c2cnccc12 KNYHISBJRQVMAZ-UHFFFAOYSA-N 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N c1nc(ncnc2)c2[nH]1 Chemical compound c1nc(ncnc2)c2[nH]1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6788908P | 2008-03-03 | 2008-03-03 | |
US61/067,889 | 2008-03-03 | ||
PCT/US2009/035608 WO2009111354A2 (en) | 2008-03-03 | 2009-02-28 | Tyrosine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102014631A true CN102014631A (zh) | 2011-04-13 |
Family
ID=41056574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801158039A Pending CN102014631A (zh) | 2008-03-03 | 2009-02-28 | 酪氨酸激酶抑制剂 |
Country Status (8)
Country | Link |
---|---|
US (1) | US8598184B2 (zh) |
EP (1) | EP2247185B1 (zh) |
JP (1) | JP2011515343A (zh) |
KR (1) | KR20100126467A (zh) |
CN (1) | CN102014631A (zh) |
AU (1) | AU2009222122A1 (zh) |
CA (1) | CA2717509A1 (zh) |
WO (1) | WO2009111354A2 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103930426A (zh) * | 2011-11-08 | 2014-07-16 | 霍夫曼-拉罗奇有限公司 | 作为大麻素受体2激动剂的[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
CN105503880A (zh) * | 2015-12-15 | 2016-04-20 | 李志刚 | 一种治疗呼吸道疾病的药物组合物 |
CN113164485A (zh) * | 2018-12-20 | 2021-07-23 | Ksq治疗公司 | 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA025281B9 (ru) | 2010-05-17 | 2017-08-31 | Инкозен Терапьютикс Пвт. Лтд. | СОЕДИНЕНИЯ 3,5-ДИЗАМЕЩЕННОГО-3H-ИМИДАЗО[4,5-b]ПИРИДИНА И 3,5-ДИЗАМЕЩЕННОГО-3H-[1,2,3]ТРИАЗОЛО[4,5-b]ПИРИДИНА КАК МОДУЛЯТОРЫ ПРОТЕИНКИНАЗ |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
MX2023004937A (es) | 2020-10-30 | 2023-05-17 | Ksq Therapeutics Inc | Formas en estado solido de pirazolopirimidinas sustituidas y usos de estas. |
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UA41251C2 (uk) | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
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- 2009-02-28 EP EP09718416.2A patent/EP2247185B1/en not_active Not-in-force
- 2009-02-28 CA CA2717509A patent/CA2717509A1/en not_active Abandoned
- 2009-02-28 US US12/919,216 patent/US8598184B2/en not_active Expired - Fee Related
- 2009-02-28 WO PCT/US2009/035608 patent/WO2009111354A2/en active Application Filing
- 2009-02-28 AU AU2009222122A patent/AU2009222122A1/en not_active Abandoned
- 2009-02-28 JP JP2010549770A patent/JP2011515343A/ja not_active Ceased
- 2009-02-28 CN CN2009801158039A patent/CN102014631A/zh active Pending
- 2009-02-28 KR KR1020107022072A patent/KR20100126467A/ko not_active Application Discontinuation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103930426A (zh) * | 2011-11-08 | 2014-07-16 | 霍夫曼-拉罗奇有限公司 | 作为大麻素受体2激动剂的[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
CN103930426B (zh) * | 2011-11-08 | 2016-05-11 | 霍夫曼-拉罗奇有限公司 | 作为大麻素受体2激动剂的[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
TWI639600B (zh) * | 2011-11-08 | 2018-11-01 | 赫孚孟拉羅股份公司 | 新穎[1,2,3]三唑并[4,5-d]嘧啶衍生物 |
CN105503880A (zh) * | 2015-12-15 | 2016-04-20 | 李志刚 | 一种治疗呼吸道疾病的药物组合物 |
CN113164485A (zh) * | 2018-12-20 | 2021-07-23 | Ksq治疗公司 | 被取代的吡唑并嘧啶和被取代的嘌呤以及其作为泛素特异性加工蛋白酶1(usp1)抑制剂的用途 |
Also Published As
Publication number | Publication date |
---|---|
KR20100126467A (ko) | 2010-12-01 |
WO2009111354A2 (en) | 2009-09-11 |
EP2247185B1 (en) | 2014-04-16 |
EP2247185A4 (en) | 2012-01-25 |
AU2009222122A1 (en) | 2009-09-11 |
WO2009111354A3 (en) | 2009-12-30 |
EP2247185A2 (en) | 2010-11-10 |
US8598184B2 (en) | 2013-12-03 |
JP2011515343A (ja) | 2011-05-19 |
US20100324074A1 (en) | 2010-12-23 |
CA2717509A1 (en) | 2009-09-11 |
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