MX2023004937A - Formas en estado solido de pirazolopirimidinas sustituidas y usos de estas. - Google Patents

Formas en estado solido de pirazolopirimidinas sustituidas y usos de estas.

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Publication number
MX2023004937A
MX2023004937A MX2023004937A MX2023004937A MX2023004937A MX 2023004937 A MX2023004937 A MX 2023004937A MX 2023004937 A MX2023004937 A MX 2023004937A MX 2023004937 A MX2023004937 A MX 2023004937A MX 2023004937 A MX2023004937 A MX 2023004937A
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MX
Mexico
Prior art keywords
compound
formula
solid state
state forms
iii
Prior art date
Application number
MX2023004937A
Other languages
English (en)
Inventor
Hanlan Liu
Jeremy Clinton Wilt
Friedrich Blatter
Giuseppe Lapadula
Original Assignee
Ksq Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ksq Therapeutics Inc filed Critical Ksq Therapeutics Inc
Publication of MX2023004937A publication Critical patent/MX2023004937A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/05Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing at least two sulfo groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04Monocyclic monocarboxylic acids
    • C07C63/06Benzoic acid
    • C07C63/08Salts thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10Salicylic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente descripción está relacionada con: a) formas en estado sólido de un compuesto con la Fórmula (I), un compuesto con la Fórmula (II) y un compuesto con la Fórmula (III); b) composiciones farmacéuticas que comprenden una o más formas en estado sólido de un compuesto con la Fórmula (I), un compuesto con la Fórmula (II) y un compuesto con la Fórmula (III) y, opcionalmente, un vehículo o diluyente farmacéuticamente aceptable; c) métodos de tratamiento de tumores o cánceres mediante la administración de una o más formas en estado sólido de un compuesto con la Fórmula (I), un compuesto con la Fórmula (II) y un compuesto con la Fórmula (III) a un sujeto que lo necesite; y d) métodos para la preparación de formas en estado sólido de un compuesto con la Fórmula (I), un compuesto con la Fórmula (II) y un compuesto con la Fórmula (III).
MX2023004937A 2020-10-30 2021-10-28 Formas en estado solido de pirazolopirimidinas sustituidas y usos de estas. MX2023004937A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063107765P 2020-10-30 2020-10-30
PCT/US2021/057072 WO2022094096A1 (en) 2020-10-30 2021-10-28 Solid state forms of substituted pyrazolopyrimidines and uses thereof

Publications (1)

Publication Number Publication Date
MX2023004937A true MX2023004937A (es) 2023-05-17

Family

ID=81384285

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023004937A MX2023004937A (es) 2020-10-30 2021-10-28 Formas en estado solido de pirazolopirimidinas sustituidas y usos de estas.

Country Status (11)

Country Link
US (2) US11718624B2 (es)
EP (1) EP4236958A1 (es)
JP (1) JP2023548148A (es)
KR (1) KR20230098186A (es)
CN (1) CN116615424A (es)
AU (1) AU2021371305A1 (es)
CA (1) CA3196564A1 (es)
IL (1) IL302352A (es)
MX (1) MX2023004937A (es)
TW (1) TW202233621A (es)
WO (1) WO2022094096A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220140732A (ko) * 2020-02-14 2022-10-18 케이에스큐 세러퓨틱스 인코포레이티드 유비퀴틴-특이적-프로세싱 프로테아제 1(usp1) 억제제 및 폴리 (adp-리보스) 중합효소(parp) 억제제를 포함하는 치료학적 조합물
AU2022387669A1 (en) * 2021-11-12 2024-05-16 Insilico Medicine Ip Limited Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
CA3235765A1 (en) 2021-11-12 2023-05-19 Jianping Wu Small molecule inhibitors of ubiquitin specific protease 1 (usp1) and uses thereof
WO2023208130A1 (zh) * 2022-04-29 2023-11-02 江苏亚虹医药科技股份有限公司 嘧啶类化合物、其制备方法及其医药用途

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Also Published As

Publication number Publication date
KR20230098186A (ko) 2023-07-03
IL302352A (en) 2023-06-01
WO2022094096A1 (en) 2022-05-05
CA3196564A1 (en) 2022-05-05
EP4236958A1 (en) 2023-09-06
CN116615424A (zh) 2023-08-18
TW202233621A (zh) 2022-09-01
JP2023548148A (ja) 2023-11-15
US11718624B2 (en) 2023-08-08
AU2021371305A1 (en) 2023-06-15
US20240034738A1 (en) 2024-02-01
US20220162213A1 (en) 2022-05-26

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