ES2160747T3 - 2-(indan-1-ona-2-il-alquil)-1-fenilalquil-piperidinas y procedimientos para su preparacion. - Google Patents
2-(indan-1-ona-2-il-alquil)-1-fenilalquil-piperidinas y procedimientos para su preparacion.Info
- Publication number
- ES2160747T3 ES2160747T3 ES96110252T ES96110252T ES2160747T3 ES 2160747 T3 ES2160747 T3 ES 2160747T3 ES 96110252 T ES96110252 T ES 96110252T ES 96110252 T ES96110252 T ES 96110252T ES 2160747 T3 ES2160747 T3 ES 2160747T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- phenylalquil
- piperidins
- alquil
- indan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- -1 AMINE COMPOUNDS Chemical class 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S152/00—Resilient tires and wheels
- Y10S152/90—Tread pattern having no blocks and having circumferential ribs defined by zig-zag circumferential grooves
Abstract
SE PROPORCIONAN PROCESOS PARA PREPARAR COMPUESTOS DE AMINA CICLICA DEFINIDOS EN LA FORMULA: EN LA QUE J ES INDANILO, INDANONILO, INDENILO, INDENONILO, INDANEDIONILO, TETRALONILO, BENZOSUBERONILO, INDANOLILO O UN GRUPO DIVALENTE DE LOS MISMOS, K ES FENILO, UN ARILALQUILO O CINAMILO, B ES -(CHR22)R-, R22 SIENDO H O METILO, -CO-(CHR22)R-, =(CH-CH=CH)B-, =CH-(CH2)C- O =(CH-CH)D= Y EL ANILLO QUE INCLUYE T Y Q ES PIPERIDINA. EL COMPUESTO ES UTIL PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS Y PARA MEDICAMENTOS EFECTIVOS CONTRA LA DEMENCIA SENIL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15505887 | 1987-06-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2160747T3 true ES2160747T3 (es) | 2001-11-16 |
Family
ID=15597749
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95104080T Expired - Lifetime ES2164720T3 (es) | 1987-06-22 | 1988-06-22 | Derivados de piperidina como agentes anticolinergicos. |
ES93113146T Expired - Lifetime ES2121039T3 (es) | 1987-06-22 | 1988-06-22 | Piperidinas 1,4-substituidos como inhibidores de la acetilcozinesterasa y su utilizacion como inhibidores de la enfermedad de alzheimer. |
ES96110252T Expired - Lifetime ES2160747T3 (es) | 1987-06-22 | 1988-06-22 | 2-(indan-1-ona-2-il-alquil)-1-fenilalquil-piperidinas y procedimientos para su preparacion. |
ES88109924T Expired - Lifetime ES2083359T3 (es) | 1987-06-22 | 1988-06-22 | Piperidinas 1,4-substituidas como inhibidores de la acetilcolinesterasa y su utilizacion en el tratamiento de la enfermedad de alzheimer. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95104080T Expired - Lifetime ES2164720T3 (es) | 1987-06-22 | 1988-06-22 | Derivados de piperidina como agentes anticolinergicos. |
ES93113146T Expired - Lifetime ES2121039T3 (es) | 1987-06-22 | 1988-06-22 | Piperidinas 1,4-substituidos como inhibidores de la acetilcozinesterasa y su utilizacion como inhibidores de la enfermedad de alzheimer. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88109924T Expired - Lifetime ES2083359T3 (es) | 1987-06-22 | 1988-06-22 | Piperidinas 1,4-substituidas como inhibidores de la acetilcolinesterasa y su utilizacion en el tratamiento de la enfermedad de alzheimer. |
Country Status (25)
Country | Link |
---|---|
US (2) | US4895841A (es) |
EP (5) | EP0579263B1 (es) |
JP (3) | JP2578475B2 (es) |
KR (1) | KR910003618B1 (es) |
CN (3) | CN1024547C (es) |
AT (4) | ATE134618T1 (es) |
AU (1) | AU627151B2 (es) |
CA (2) | CA1338808C (es) |
CY (3) | CY1940A (es) |
DD (1) | DD283377A5 (es) |
DE (5) | DE3856251T2 (es) |
DK (3) | DK172337B1 (es) |
ES (4) | ES2164720T3 (es) |
FI (3) | FI95572C (es) |
GR (2) | GR3019142T3 (es) |
HK (1) | HK216396A (es) |
HU (3) | HU214592B (es) |
LU (1) | LU90221I2 (es) |
NO (2) | NO177590C (es) |
NZ (1) | NZ224970A (es) |
PH (1) | PH26315A (es) |
PT (1) | PT87783B (es) |
RU (1) | RU2009128C1 (es) |
SG (1) | SG50439A1 (es) |
ZA (1) | ZA884338B (es) |
Families Citing this family (321)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2832979B2 (ja) * | 1988-02-15 | 1998-12-09 | 武田薬品工業株式会社 | 不飽和カルボン酸アミド誘導体 |
WO1990006303A1 (en) * | 1988-12-02 | 1990-06-14 | Pfizer Inc. | Arylpiperidine derivatives |
JP2777159B2 (ja) | 1988-12-22 | 1998-07-16 | エーザイ株式会社 | 環状アミン誘導体を含有する医薬 |
JP2969359B2 (ja) * | 1989-01-13 | 1999-11-02 | 武田薬品工業株式会社 | 環状アミン化合物 |
US5225402A (en) * | 1989-02-10 | 1993-07-06 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JP2931986B2 (ja) * | 1989-02-17 | 1999-08-09 | 武田薬品工業株式会社 | アラルキルアミン誘導体 |
US5250528A (en) * | 1989-08-02 | 1993-10-05 | Fujisawa Pharmaceutical Co., Ltd. | New aminopiperazine derivatives |
US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
US5356906A (en) * | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
KR927002347A (ko) * | 1989-10-27 | 1992-09-03 | 레이몬드 지. 아너 | (n-프탈이미도알킬) 피페리딘 |
JPH03151358A (ja) * | 1989-10-30 | 1991-06-27 | Syntex Usa Inc | ドーパミン・アゴニストとしてのベンジルピロリジン誘導体 |
US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
WO1991009594A1 (en) * | 1989-12-28 | 1991-07-11 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
US5428043A (en) * | 1990-02-08 | 1995-06-27 | Pfizer Inc. | Tricyclic-cyclic amines as novel cholinesterase inhibitors |
US5272157A (en) * | 1990-03-07 | 1993-12-21 | Synthelabo | Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application |
FR2659323B1 (fr) * | 1990-03-07 | 1992-06-12 | Synthelabo | Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique. |
US5116846A (en) * | 1990-03-28 | 1992-05-26 | Du Pont Merck Pharmaceutical Company | N-aralkyl piperidine derivatives as psychotropic drugs |
US5173209A (en) * | 1990-05-10 | 1992-12-22 | Cyprus Foote Mineral Company | Stable lithium cycloalkylimides |
US6004980A (en) * | 1990-06-01 | 1999-12-21 | Merrell Pharmaceuticals, Inc. | (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
AU652759B2 (en) * | 1990-06-01 | 1994-09-08 | Aventisub Ii Inc. | (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)- 4-piperidinemethanol |
JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
EP0465254B1 (en) * | 1990-07-06 | 1996-11-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused thiophene compounds and uses thereof |
FR2664592B1 (fr) * | 1990-07-10 | 1994-09-02 | Adir | Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
TW199153B (es) * | 1990-08-07 | 1993-02-01 | Dtsuka Seiyaku Kk | |
US5240934A (en) * | 1990-10-19 | 1993-08-31 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
US5190951A (en) * | 1990-10-19 | 1993-03-02 | Ss Pharmaceutical Co., Ltd. | Quinoline derivatives |
TW197435B (es) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
DE4104870A1 (de) * | 1991-02-17 | 1992-08-27 | Bayer Ag | Verwendung von 3,(4)-substituierten pyrrolidinen als katalysatoren fuer das polyisocyanatpolyadditionsverfahren, verfahren zu ihrer herstellung sowie verfahren zur herstellung von polyurethan(harnstoff)en |
US5162341A (en) * | 1991-02-22 | 1992-11-10 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists for treatment of amphetamine abuse |
ES2188584T3 (es) * | 1991-03-28 | 2003-07-01 | Eisai Co Ltd | Derivados heterociclicos de amina. |
US5750542A (en) * | 1993-09-28 | 1998-05-12 | Pfizer | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors |
FR2676225B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
FR2676226B1 (fr) * | 1991-05-03 | 1993-08-27 | Sanofi Elf | Nouveaux intermediaires pour la synthese de composes dialkylenepiperidino. |
CA2067475C (en) * | 1991-05-08 | 2000-10-10 | Yasuo Oshiro | Carbostyril derivatives and their use |
US5556857A (en) * | 1991-05-08 | 1996-09-17 | Otsuka Pharmaceutical Co., Ltd. | Disturbance-of-consciousness improving agent |
FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
US5106856A (en) * | 1991-06-07 | 1992-04-21 | Hoechst-Roussel Pharmaceuticals Inc. | [(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds |
EP0535496A1 (en) | 1991-09-25 | 1993-04-07 | Hoechst-Roussel Pharmaceuticals Incorporated | (1-Indanon-2yl)methylpiperidines, intermediates and a process for their preparation and their use as medicaments |
TW263504B (es) * | 1991-10-03 | 1995-11-21 | Pfizer | |
SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
US5462934A (en) * | 1992-03-09 | 1995-10-31 | Takeda Chemical Industries | Condensed heterocyclic ketone derivatives and their use |
ATE194982T1 (de) | 1992-04-24 | 2000-08-15 | Takeda Chemical Industries Ltd | Benzoxazepin-derivate als cholinesterase- inhibitoren |
KR100262254B1 (ko) * | 1992-10-05 | 2000-07-15 | 나카히로 마오미 | 피리미딘 화합물 |
US5948793A (en) * | 1992-10-09 | 1999-09-07 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release |
US5914328A (en) * | 1992-10-09 | 1999-06-22 | Abbott Laboratories | Heterocyclic ether compounds useful in controlling neurotransmitter release |
TW248556B (es) * | 1993-01-18 | 1995-06-01 | Takeda Pharm Industry Co | |
US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
US5459151A (en) * | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
AU7177694A (en) * | 1993-06-23 | 1995-01-17 | Cambridge Neuroscience, Inc. | Sigma receptor ligands and the use thereof |
EP0637586B1 (en) * | 1993-08-05 | 1999-06-02 | HOECHST MARION ROUSSEL, Inc. | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)-benzofuran-7-carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors |
GB9319534D0 (en) * | 1993-09-22 | 1993-11-10 | Boots Co Plc | Therapeutic agents |
JP2686366B2 (ja) * | 1993-11-30 | 1997-12-08 | ファイザー・インコーポレーテッド | キラルテトラロンの製造方法 |
DE4439822A1 (de) | 1994-11-08 | 1996-08-29 | Bayer Ag | Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen |
US6214994B1 (en) | 1997-04-21 | 2001-04-10 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1′-yl propanones |
US5658909A (en) | 1994-11-17 | 1997-08-19 | Molecular Geriatrics Corporation | Certain substituted 1-aryl-3-piperazin-1'-yl propanones to treat Alzheimer's Disease |
US5859295A (en) * | 1994-12-05 | 1999-01-12 | University Of Kentucky Research Foundation | Canavanine analogs and their use as chemotherapeutic agents |
AU4483896A (en) * | 1995-01-18 | 1996-08-07 | Bayer Aktiengesellschaft | N-substituted 1-acylaminoalkyl piperidines for treatment of cerebral disorders and depressions |
IL117149A0 (en) * | 1995-02-23 | 1996-06-18 | Schering Corp | Muscarinic antagonists |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
US5703239A (en) * | 1995-06-02 | 1997-12-30 | Bristol-Myers Squibb Company | Indanylpiperidines as melatonergic agents |
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
WO1997022584A1 (en) * | 1995-12-15 | 1997-06-26 | Pfizer Inc. | Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine |
US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US5629325A (en) * | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
US6437138B1 (en) | 1996-06-06 | 2002-08-20 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
TW513409B (en) * | 1996-06-07 | 2002-12-11 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
CA2252806C (en) * | 1996-06-07 | 2005-11-22 | Eisai Co., Ltd. | Polymorphs of donepezil hydrochloride and process for production |
AU1153097A (en) * | 1996-06-07 | 1998-01-05 | Eisai Co. Ltd. | Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production |
US5935958A (en) * | 1996-07-01 | 1999-08-10 | Schering Corporation | Muscarinic antagonists |
FR2750991A1 (fr) * | 1996-07-12 | 1998-01-16 | Pf Medicament | Nouveaux benzodioxannes et 1-(2h)-benzopyrannes, leur preparation et leur utilisation comme medicament |
US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US5977138A (en) * | 1996-08-15 | 1999-11-02 | Schering Corporation | Ether muscarinic antagonists |
EP0934932A4 (en) * | 1996-08-22 | 2002-06-26 | Meiji Seika Kaisha | CHINOLINE DERIVATIVES AND PSYCHOTROPES MEDIUM |
FR2752732B1 (fr) | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
US6133253A (en) * | 1996-12-10 | 2000-10-17 | Abbott Laboratories | 3-Pyridyl enantiomers and their use as analgesics |
US5962535A (en) * | 1997-01-17 | 1999-10-05 | Takeda Chemical Industries, Ltd. | Composition for alzheimer's disease |
DE19707655A1 (de) * | 1997-02-26 | 1998-08-27 | Hoechst Ag | Kombinationspräparat zur Anwendung bei Demenz |
ATE241358T1 (de) * | 1997-03-03 | 2003-06-15 | Eisai Co Ltd | Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen |
WO1998056380A1 (en) * | 1997-06-11 | 1998-12-17 | Alcon Laboratories, Inc. | Method to reverse mydriasis |
US6028083A (en) * | 1997-07-25 | 2000-02-22 | Hoechst Marion Roussel, Inc. | Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol |
US5945421A (en) * | 1997-08-11 | 1999-08-31 | Warner-Lambert Company | Dopamine D4 receptor antagonists |
IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
AU9454098A (en) * | 1997-09-24 | 1999-04-12 | Nova Molecular, Inc. | Methods for increasing apoe levels for the treatment of neurodegenerative disease |
ATE260896T1 (de) | 1997-12-05 | 2004-03-15 | Eisai Co Ltd | Donepezil polykristalle und verfharen zu ihrer herstellung |
DE69924467T2 (de) | 1998-01-16 | 2006-02-16 | Eisai Co., Ltd. | Verfahren zur herstellung von donepezilderivaten |
US6713627B2 (en) | 1998-03-13 | 2004-03-30 | Aventis Pharmaceuticals Inc. | Processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol |
US6066636A (en) * | 1998-06-30 | 2000-05-23 | Schering Corporation | Muscarinic antagonists |
US6262081B1 (en) | 1998-07-10 | 2001-07-17 | Dupont Pharmaceuticals Company | Composition for and method of treating neurological disorders |
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
IL125809A (en) * | 1998-08-17 | 2005-08-31 | Finetech Lab Ltd | Process and intermediates for production of donepezil and related compounds |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
WO2000018391A1 (fr) * | 1998-09-30 | 2000-04-06 | Takeda Chemical Industries, Ltd. | Medicaments qui ameliorent le pouvoir de vidange de la vessie |
US20020177593A1 (en) | 1998-09-30 | 2002-11-28 | Yuji Ishihara | Agents and crystals for improving excretory potency of urinary bladder |
BR9915735A (pt) | 1998-11-20 | 2001-09-04 | Hoffmann La Roche | Antagonistas receptores de ccr-3 de piperidina |
TR200101398T2 (tr) * | 1998-11-20 | 2001-09-21 | F.Hoffmann-La Roche Ag | Pirolidin türevleri-CCR-3 reseptörü antagonistleri. |
AU2160900A (en) * | 1998-12-11 | 2000-06-26 | American Biogenetic Sciences, Inc. | Substituted nitrogen heterocyclic compounds and therapeutic uses thereof |
US6277866B1 (en) * | 1999-03-03 | 2001-08-21 | Eisai Co., Ltd. | 1-benzyl-4[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine |
KR100694682B1 (ko) * | 1999-03-03 | 2007-03-13 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 4-치환 피페리딘 유도체 불화물 |
US6833370B1 (en) | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
US7091218B1 (en) | 1999-09-01 | 2006-08-15 | Eisai Co., Ltd. | 4-substituted piperidine compound |
GB0002100D0 (en) | 2000-01-28 | 2000-03-22 | Novartis Ag | Organic compounds |
US20060183776A9 (en) * | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
PT1311272E (pt) * | 2000-03-03 | 2007-02-28 | Eisai R&D Man Co Ltd | Novos métodos utilizando inibidores de colinesterase |
US20030153598A1 (en) * | 2000-07-25 | 2003-08-14 | Raymond Pratt | Methods for treating Parkinson's disease with cholinesterase inhibitors |
EP1764101A1 (en) * | 2000-03-03 | 2007-03-21 | Eisai R&D Management Co., Ltd. | Use of a cholinesterase inhibitor for the treatment of dementia and cognitive impairments |
WO2001078728A1 (fr) * | 2000-04-13 | 2001-10-25 | Eisai Co., Ltd. | Inhibiteurs d'acetylcholinesterases contenant des sels de 1-benzyl-pyridinium |
AU5702201A (en) * | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
EP1300395B1 (en) | 2000-06-21 | 2009-09-02 | Eisai R&D Management Co., Ltd. | 4-substituted piperidine compound |
WO2002002526A1 (fr) * | 2000-07-03 | 2002-01-10 | Eisai Co., Ltd. | Compositions pharmaceutiques servant a stabiliser la tension intraoculaire |
CN1317276C (zh) * | 2000-09-29 | 2007-05-23 | 中国科学院上海药物研究所 | 一类吲哚基哌啶类化合物及其制备方法和用途 |
AU2002224046A1 (en) * | 2000-12-07 | 2002-06-18 | Fujisawa Pharmaceutical Co. Ltd. | Nootropic effect enhancer |
AU2002338334B8 (en) * | 2001-04-03 | 2008-09-18 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists |
US20030013699A1 (en) * | 2001-05-25 | 2003-01-16 | Davis Harry R. | Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject |
WO2003020289A1 (en) * | 2001-08-30 | 2003-03-13 | Ortho-Mcneil Pharmaceutical, Inc. | Treatment of dementia and memory disorders with anticonvulsants and acetylcholinesterase inhibitors |
WO2003024450A1 (en) * | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
US20050227911A1 (en) * | 2001-09-28 | 2005-10-13 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules |
US20050249786A1 (en) * | 2001-09-28 | 2005-11-10 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
US20050226934A1 (en) * | 2001-09-28 | 2005-10-13 | Solubest Ltd. | Inclusion complexes of active compounds in acrylate (co)polymers and methods for their production |
US20050233003A1 (en) * | 2001-09-28 | 2005-10-20 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of salicylic acid |
US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
WO2003032914A2 (en) * | 2001-10-17 | 2003-04-24 | Eisai Co., Ltd. | Methods for treating substance abuse with cholinesterase inhibitors |
GB0126378D0 (en) * | 2001-11-02 | 2002-01-02 | Oxford Biomedica Ltd | Antigen |
JPWO2003061658A1 (ja) * | 2002-01-22 | 2005-05-19 | エーザイ株式会社 | インダノン誘導体を含有するシグマ受容体結合剤 |
US20050142088A1 (en) * | 2002-02-07 | 2005-06-30 | Mitsuru Mizuno | Hair growth stimulants, percutaneous preparations and method of stimulating hair growth |
AU2003218180B2 (en) * | 2002-03-15 | 2008-03-20 | Georgetown University | Neuroprotective spirostenol pharmaceutical compositions |
ES2297141T3 (es) * | 2002-03-29 | 2008-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Derivados de (1-indanona)-(1,2,3,6-tetrahidropiridina). |
US20040033986A1 (en) | 2002-05-17 | 2004-02-19 | Protopopova Marina Nikolaevna | Anti tubercular drug: compositions and methods |
CN101404986B (zh) | 2002-05-17 | 2011-09-28 | 赛奎拉公司 | 用于诊断和治疗感染性疾病的组合物和制药方法 |
ES2379948T3 (es) | 2002-06-14 | 2012-05-07 | Toyama Chemical Co., Ltd. | Composición medicinal que comprende Tacrine o Donepezil para mejorar la función cerebral |
IL150509A (en) * | 2002-07-01 | 2007-07-04 | Joseph Kaspi | Pharmaceutical preparations containing donafazil hydrochloride |
CN1678608A (zh) * | 2002-07-02 | 2005-10-05 | 先灵公司 | 新的神经肽yy5受体拮抗剂 |
US7148354B2 (en) * | 2002-07-24 | 2006-12-12 | Dr. Reddy's Laboratories Limited | Process for preparation of donepezil |
IL150982A (en) * | 2002-07-30 | 2007-02-11 | Ori Lerman | Process for making Donafzil |
GB0218326D0 (en) * | 2002-08-07 | 2002-09-11 | Glaxo Group Ltd | Compounds |
MXPA04006900A (es) * | 2002-10-24 | 2004-10-15 | Merz Pharma Gmbh & Co Kgaa | Politerapia que utiliza derivados de 1-aminociclohexano e inhibidores de acetilcolinesterasa. |
US20060014801A1 (en) * | 2002-11-22 | 2006-01-19 | The Johns Hopkins University | Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs |
JP2004189706A (ja) * | 2002-12-13 | 2004-07-08 | Eisai Co Ltd | 高度アルツハイマー型痴呆治療剤 |
WO2004071431A2 (en) * | 2003-02-05 | 2004-08-26 | Myriad Genetics, Inc. | Method and composition for treating neurodegenerative disorders |
US20080057491A1 (en) * | 2003-02-07 | 2008-03-06 | Mckee Patrick A | Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use |
US7186842B2 (en) * | 2003-02-12 | 2007-03-06 | Usv, Ltd. | Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof |
US7439365B2 (en) * | 2003-11-17 | 2008-10-21 | Usv, Ltd. | Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil) |
US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
US6953856B2 (en) * | 2003-02-12 | 2005-10-11 | Usv, Limited | Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI) |
US6649765B1 (en) | 2003-02-12 | 2003-11-18 | Usv Limited, Bsd Marg. | Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL) |
CA2516618A1 (en) * | 2003-02-27 | 2004-09-10 | Shirankai Kyoto University Faculty Of Medicine Alumni Association Inc. | Pharmaceutical composition for treatment of drug dependence |
CN100422148C (zh) * | 2003-02-27 | 2008-10-01 | 天津药物研究院 | 工业化生产盐酸多奈哌齐的工艺方法 |
US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
US20060009433A1 (en) * | 2003-03-14 | 2006-01-12 | Zhi-Xing Yao | Neuroprotective spirostenol pharmaceutical compositions |
WO2004082685A1 (en) * | 2003-03-21 | 2004-09-30 | Ranbaxy Laboratories Limited | Process for the preparation of donepezil and derivatives thereof |
US20040229914A1 (en) * | 2003-04-02 | 2004-11-18 | Dr. Reddy's Laboratories Limited | Novel crystalline form-VI of donepezil hydrochloride and process for the preparation thereof |
US7772399B2 (en) * | 2003-04-02 | 2010-08-10 | Hetero Drugs Limited | Process for amorphous form of donepezil hydrochloride |
WO2004092137A1 (en) | 2003-04-16 | 2004-10-28 | Hetero Drugs Limited | Novel crystalline forms of donepezil hydrochloride |
AU2003247158A1 (en) * | 2003-07-01 | 2005-01-21 | Hetero Drugs Limited | Preparation of intermediates for acetyl cholinesterase inhibitors |
JP2007528857A (ja) * | 2003-07-11 | 2007-10-18 | ミリアド ジェネティクス, インコーポレイテッド | アルツハイマー病の処置のための薬学的方法、投与レジメンおよび投薬形態 |
GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
ATE374030T1 (de) * | 2003-07-25 | 2007-10-15 | Hoffmann La Roche | Kombination eines mglur2 antagonists und eines ache inhibitors zur behandlung von akuten und/oder chronischen neurologischen krankheiten |
CN1280273C (zh) | 2003-11-05 | 2006-10-18 | 天津和美生物技术有限公司 | 合成多奈哌齐及其衍生物的方法 |
ATE473967T1 (de) * | 2003-11-26 | 2010-07-15 | Pfizer Prod Inc | Aminopyrazolderivate als gsk-3-inhibitoren |
US20050232990A1 (en) * | 2003-12-31 | 2005-10-20 | Garth Boehm | Donepezil formulations |
CN1300112C (zh) * | 2004-01-06 | 2007-02-14 | 浙江大学 | N-苄基-4-哌啶基甲醛的合成方法 |
US20050222123A1 (en) | 2004-01-27 | 2005-10-06 | North Shore-Long Island Jewish Research Institute | Cholinesterase inhibitors for treating inflammation |
MY142362A (en) * | 2004-01-29 | 2010-11-30 | Otsuka Pharma Co Ltd | Pharmaceutical composition for promoting angiogenesis |
EP1729761A4 (en) * | 2004-03-05 | 2008-09-03 | Eisai Co Ltd | TREATMENT OF CADASIL WITH CHOLINESTERASE INHIBITORS |
US20070293538A1 (en) * | 2004-04-13 | 2007-12-20 | Myriad Genetics, Incorporated | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders |
CN100534982C (zh) * | 2004-04-28 | 2009-09-02 | 卫材R&D管理有限公司 | 生产1-苄基-4-[(5,6-二甲氧基-2,3-二氢-1-茚酮)-2-基]甲基哌啶及其盐酸盐的方法 |
MXPA06012165A (es) * | 2004-04-29 | 2007-01-17 | Keystone Retaining Wall System | Chapas para muros, muros de contencion y similares. |
US20050267076A1 (en) * | 2004-05-14 | 2005-12-01 | Johns Hopkins University | Method for improving cognitive function |
US20080045500A1 (en) * | 2004-07-01 | 2008-02-21 | Eisai R&D Management Co., Ltd. | Nerve Regeneration Stimulator |
WO2006015338A2 (en) * | 2004-07-30 | 2006-02-09 | Dr. Reddy's Laboratories Ltd. | Crystalline form of donepezil hydrochloride |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020853A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
HUP0401850A3 (en) * | 2004-09-15 | 2008-03-28 | Egis Gyogyszergyar Nyilvanosan | Donepezil salts for producing pharmaceutical composition |
WO2006036936A2 (en) | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
KR20070083679A (ko) * | 2004-09-29 | 2007-08-24 | 케마지스 리미티드 | 약학적으로 순수한 비정질 도네페닐 염산염의 제조를 위한정제된 도네페질 말레산염의 용도 |
WO2006040688A2 (en) * | 2004-10-12 | 2006-04-20 | Ernir Snorrason | Inhibitors of acetylcholinesterase for treating skin diseases |
GB2419093A (en) * | 2004-10-12 | 2006-04-19 | Ernir Snorrason | Acetylcholinesterase inhibitors for the treatment of skin |
WO2006050359A2 (en) * | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
CA2590533C (en) * | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
US20060122226A1 (en) | 2004-12-08 | 2006-06-08 | Itai Adin | Crystalline forms of Donepezil base |
JP4980242B2 (ja) * | 2004-12-30 | 2012-07-18 | ジュビラント・オルガノシス・リミテッド | 新規の中間体を介する1−ベンジル−4−[(5,6−ジメトキシ−1−インダノン−2−イル)メチル]ピペリジンまたはその塩の製造方法 |
JP5731094B2 (ja) | 2005-02-11 | 2015-06-10 | スティーブン・ウィルスStephen WILLS | アセチルコリンエステラーゼ阻害剤による微小血管系疾患の治療 |
WO2006097341A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Process for making crystalline donepezil hydrochloride monohydrate |
RS51822B (en) * | 2005-04-04 | 2012-02-29 | Eisai R. &D. Management Co. Ltd. | DIHYDROPYRIDINE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND Dementia |
JP5666087B2 (ja) | 2005-04-06 | 2015-02-12 | アダマス・ファーマシューティカルズ・インコーポレーテッド | Cns関連疾患の治療のための方法及び組成物 |
US20080188510A1 (en) * | 2005-05-23 | 2008-08-07 | Eisai R & D Management Co., Ltd. | Novel methods using zonisamide |
US20070015832A1 (en) * | 2005-07-14 | 2007-01-18 | Myriad Genetics, Incorporated | Methods of treating overactive bladder and urinary incontinence |
WO2007010910A1 (en) * | 2005-07-15 | 2007-01-25 | Eisai R & D Management Co., Ltd. | 1-benzyl-4-[(5, 6-dimethoxy-1-indanon)-2-yl]-methyl piperidine p-toluenesulfonate or crystal thereof |
KR20080039876A (ko) * | 2005-07-22 | 2008-05-07 | 미리어드 제네틱스, 인크. | 높은 약물 충진 제형 및 투여형 |
EP1911745A4 (en) * | 2005-07-25 | 2010-10-27 | Eisai R&D Man Co Ltd | PROCESS FOR PRODUCING 1-BENZYL-4 - [(5,6-DIMETHOXY-1-INDANONE) -2-YLIDENE] METHYLPIPERIDINE |
WO2007018801A1 (en) * | 2005-07-28 | 2007-02-15 | Teikoku Pharma Usa, Inc. | Gelled donepezil compositions and methods for making and using the same |
CN100436416C (zh) * | 2005-07-29 | 2008-11-26 | 西南合成制药股份有限公司 | 盐酸多奈哌齐合成工艺 |
GB0515803D0 (en) | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
KR20080046708A (ko) * | 2005-10-14 | 2008-05-27 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 1-벤질-4-[(5,6-디메톡시-1-인다논)-2-일]메틸피페리딘또는 그 염산염의 제조 방법 |
JPWO2007043440A1 (ja) * | 2005-10-14 | 2009-04-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 1−ベンジル−4−[(5,6−ジメトキシ−1−インダノン)−2−イル]メチルピペリジンまたはその塩酸塩の製造法 |
ES2537898T3 (es) | 2005-10-25 | 2015-06-15 | Shionogi & Co., Ltd. | Derivados de aminotiazolidina y aminotetrahidrotiazepina como inhibidores de BACE 1 |
JP2008280248A (ja) * | 2005-11-02 | 2008-11-20 | Eisai R & D Management Co Ltd | アルツハイマー型痴呆症治療薬塩酸ドネペジルのプロドラッグ |
AR057910A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar donepezilo |
HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
AU2007203969B2 (en) * | 2006-01-04 | 2012-04-05 | Cipla Limited | Process and intermediate for preparation of donepezil |
US7994328B2 (en) | 2006-02-16 | 2011-08-09 | Aurobindo Pharma Ltd. | Process for the preparation of donepezil hydrochloride |
EP1988077A4 (en) | 2006-02-23 | 2009-09-02 | Shionogi & Co | NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS |
WO2007108011A2 (en) * | 2006-03-20 | 2007-09-27 | Ind-Swift Laboratories Limited | Process for the preparation of highly pure donepezil |
EP2015750A2 (en) * | 2006-04-28 | 2009-01-21 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
EP2026766A1 (en) | 2006-05-17 | 2009-02-25 | Synthon B.V. | Tablet composition with a prolonged release of tamsulosin |
US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
US20080033045A1 (en) * | 2006-07-07 | 2008-02-07 | Myriad Genetics, Incorporated | Treatment of psychiatric disorders |
AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
WO2008010235A2 (en) * | 2006-07-19 | 2008-01-24 | Torrent Pharmaceuticals Limited | An improved process for the preparation of donepezil |
CA2655809C (en) | 2006-07-21 | 2013-10-01 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
US20080161324A1 (en) * | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
WO2008051599A2 (en) | 2006-10-27 | 2008-05-02 | Medivation Neurology, Inc. | Combination therapies for treating alzheimer's disease using i. a. dimebon and dolepezil |
US8247563B2 (en) * | 2006-12-11 | 2012-08-21 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
EP2131828A2 (en) * | 2007-03-05 | 2009-12-16 | Eisai R&D Management Co., Ltd. | Ampa and nmda receptor antagonists for neurodegenerative diseases |
KR20080092515A (ko) * | 2007-04-12 | 2008-10-16 | 동화약품공업주식회사 | 도네페질 중간체의 제조방법 |
JP5383484B2 (ja) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | 環式基で置換されたアミノジヒドロチアジン誘導体 |
JP5383483B2 (ja) * | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
JP2010524844A (ja) * | 2007-04-26 | 2010-07-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 認知症のためのシンナミド化合物 |
WO2008139288A2 (en) * | 2007-05-09 | 2008-11-20 | Pfizer Inc. | Substituted heterocyclic derivatives and compositions and their pharmaceutical use as antibacterials |
EP2937085B1 (en) * | 2007-05-22 | 2019-07-10 | Otsuka Pharmaceutical Co., Ltd. | A medicament comprising a carbostyril derivative and donezepil for treating alzheimer's disease |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
MX2009013505A (es) * | 2007-06-12 | 2010-01-27 | Ac Immune Sa | Anticuerpos humanizados para amiloide beta. |
US20100168174A1 (en) * | 2007-07-13 | 2010-07-01 | Eisai R&D Management Co., Ltd. | Combination of AMPA Receptor Antagonists and Acetylcholinesterase Inhibitors for the Treatment of Neuropathic Pain |
DE102007037932A1 (de) | 2007-08-11 | 2009-02-12 | Alfred E. Tiefenbacher Gmbh & Co.Kg | Donepezilhydrochlorid in amorpher Form enthaltende Tablette |
US8304435B2 (en) | 2007-09-12 | 2012-11-06 | Deuteria Pharmaceuticals Inc. | Deuterium-enriched donepezil |
CN102603612A (zh) | 2007-09-28 | 2012-07-25 | 天津和美生物技术有限公司 | 多奈哌齐盐的多晶型物及其制备和应用 |
TWI432195B (zh) | 2007-10-03 | 2014-04-01 | Kowa Co | 神經細胞死亡抑制劑 |
US20100297012A1 (en) * | 2007-10-05 | 2010-11-25 | Andrea Pfeifer | Humanized antibody |
CN101883790B (zh) * | 2007-10-05 | 2015-09-09 | 基因技术公司 | 抗淀粉样蛋白β抗体在眼病中的用途 |
JP5566004B2 (ja) | 2007-11-14 | 2014-08-06 | 株式会社Dnpファインケミカル宇都宮 | アルコキシインダノン誘導体の製造方法 |
NZ588252A (en) * | 2008-03-25 | 2012-08-31 | Cipla Ltd | Process for the preparation of donepezil hydrochloride |
US20110034565A1 (en) | 2008-04-18 | 2011-02-10 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
US8461389B2 (en) | 2008-04-18 | 2013-06-11 | University College Dublin, National University Of Ireland, Dublin | Psycho-pharmaceuticals |
US20090291127A1 (en) * | 2008-05-21 | 2009-11-26 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
WO2010019560A1 (en) * | 2008-08-12 | 2010-02-18 | Concert Pharmaceuticals Inc. | Deuterated derivatives of donepezil |
BRPI0917862A2 (pt) * | 2008-09-30 | 2015-11-24 | Teikoku Pharma Usa Inc | composições transdérmicas de donepezil com distribuição prolongada e métodos para usar as mesmas |
JPWO2010047372A1 (ja) * | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
US20100105916A1 (en) * | 2008-10-29 | 2010-04-29 | Sterling Biotech Limited | Processes for Preparing Donepezil |
US20110230497A1 (en) * | 2008-11-07 | 2011-09-22 | H. Lundbeck A/S | Biologically active amides |
WO2010077730A2 (en) * | 2008-12-09 | 2010-07-08 | Auspex Pharmaceutical, Inc | Indanone inhibitors of acetylcholinesterase |
US8247405B2 (en) | 2008-12-10 | 2012-08-21 | Conopco, Inc. | Skin lightening compositions with acetylcholinesterase inhibitors |
JP5562337B2 (ja) | 2008-12-17 | 2014-07-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ドネペジルの多形結晶及びその製造方法 |
US8465770B2 (en) * | 2008-12-24 | 2013-06-18 | Synthon Bv | Low dose controlled release tablet |
EP2674150A1 (de) | 2009-01-28 | 2013-12-18 | Labtec GmbH | Pharmazeutische Zubereitung mit verbesserter Stabilität des Wirkstoffs |
JP4666093B2 (ja) * | 2009-03-13 | 2011-04-06 | ユニマテック株式会社 | ポリフルオロアルキルホスホン酸エステルの製造法 |
CA2766277C (en) * | 2009-07-10 | 2014-02-18 | Unimatec Co., Ltd. | Polyfluoroalkylphosphonic acid ester and process for producing the same |
WO2011055609A1 (ja) * | 2009-11-04 | 2011-05-12 | ユニマテック株式会社 | ポリフルオロアルキルホスホン酸塩乳化剤およびこれを有効成分とする離型剤 |
WO2011061591A1 (en) | 2009-11-18 | 2011-05-26 | Jubilant Life Sciences Limited | Improved process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanone)-2-yl)methyl piperidine hydrochloride form-iii |
PL2513085T3 (pl) | 2009-11-18 | 2017-09-29 | Suven Life Sciences Limited | Związki dwupierścieniowe jako ligandy receptora nikotynowego alfa4beta2 acetylocholiny |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
AU2010337837B2 (en) | 2009-12-29 | 2013-09-05 | Suven Life Sciences Limited | Alpha4beta2 neuronal nicotinic acetylcholine receptor ligands |
US20100178307A1 (en) * | 2010-01-13 | 2010-07-15 | Jianye Wen | Transdermal anti-dementia active agent formulations and methods for using the same |
CA2789014C (en) | 2010-02-09 | 2019-01-15 | Michela Gallagher | Methods and compositions for improving cognitive function |
WO2011127235A1 (en) | 2010-04-07 | 2011-10-13 | Eisai Inc. | Combination therapy for the treatment of dementia |
GR1007368B (el) | 2010-05-27 | 2011-08-02 | Alapis Α.Β.Ε.Ε., | Ποσιμα φαρμακευτικα διαλυματα για τη θεραπεια των συμπτωματων της ανοιας |
WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
FR2962335B1 (fr) | 2010-07-12 | 2013-01-18 | Cll Pharma | Utilisation du nonapeptide pat dans le traitement et la prevention des maladies neurodegeneratives |
RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
TR201007109A2 (tr) | 2010-08-25 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Tek birim dozaj formları. |
TR201007110A2 (tr) | 2010-08-25 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Sinerjik etki gösteren kombinasyonlar |
WO2012038966A1 (en) | 2010-09-22 | 2012-03-29 | Tyche Industries Ltd. | Process for the preparation of donepezil intermediate |
WO2012057247A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
WO2012068161A1 (en) | 2010-11-15 | 2012-05-24 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
US8980924B2 (en) | 2010-11-24 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease |
WO2012147763A1 (ja) | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | オキサジン誘導体およびそれを含有するbace1阻害剤 |
EP2710203B1 (de) | 2011-05-16 | 2018-12-19 | Weitzer Holding GmbH | Boden- oder wandbelagsystem mit modular kombinierbaren verlegeeinheiten |
EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
WO2013155504A1 (en) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Novel methods |
CN103524515B (zh) | 2012-07-03 | 2016-07-06 | 浙江海正药业股份有限公司 | 具有乙酰胆碱酯酶抑制活性的苯并间二氧杂环戊烯衍生物及其制备方法和用途 |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
CN103787954B (zh) * | 2012-10-26 | 2016-01-20 | 中国科学院上海药物研究所 | 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途 |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
WO2014076965A1 (ja) * | 2012-11-16 | 2014-05-22 | 学校法人北里研究所 | 抗原虫活性を示す1-インダン誘導体 |
EP2759536A1 (en) | 2013-01-25 | 2014-07-30 | INSA (Institut National des Sciences Appliquees) de Rouen | Oxidisable pyridine derivatives, their preparation and use as anti-Alzheimer agents |
CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
JP6319912B2 (ja) | 2013-04-19 | 2018-05-09 | 国立大学法人 岡山大学 | アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法 |
AU2014307803A1 (en) | 2013-08-16 | 2016-03-10 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
US9359315B2 (en) * | 2013-09-10 | 2016-06-07 | Arrien Pharmaceuticals Llc | Substituted 2,3-dihydro-1H-inden-1-one retinoic acid-related orphan nuclear receptor antagonists for treating multiple sclerosis |
EP3083569B1 (en) | 2013-12-20 | 2022-01-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
FR3018689B1 (fr) * | 2014-03-20 | 2017-04-28 | Centre Hospitalier Univ De Clermont Ferrand | Inhibiteurs de l'acetylcholinesterase d'action centrale pour la prevention et/ou le traitement des neuropathies chimio-induites et leurs symptomes, compositions, utilisations, methodes et trousse correspondantes. |
CN105753768B (zh) * | 2014-12-15 | 2020-11-27 | 北京恒瑞新霖科技有限公司 | 一种含单个氮杂环化合物的生产方法 |
TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
EP3253759A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
US9932351B2 (en) | 2015-02-05 | 2018-04-03 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
WO2016126926A1 (en) | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
WO2016191288A1 (en) | 2015-05-22 | 2016-12-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
CN108026107B (zh) | 2015-06-19 | 2021-07-30 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法 |
CN115252586A (zh) | 2015-06-22 | 2022-11-01 | 考里安公司 | 包含难溶性治疗剂的透皮粘合剂组合物 |
CN105367483B (zh) * | 2015-11-20 | 2017-12-26 | 山东淄博新达制药有限公司 | 盐酸多奈哌齐的制备方法 |
CN109563034A (zh) | 2016-06-08 | 2019-04-02 | 葛兰素史密斯克莱知识产权发展有限公司 | 化学化合物 |
EP3474831A1 (en) | 2016-06-23 | 2019-05-01 | Corium International, Inc. | Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent |
KR101829631B1 (ko) * | 2016-07-20 | 2018-02-19 | 주식회사 엔솔바이오사이언스 | 신규 펩타이드 및 그 용도 |
MX2019001104A (es) | 2016-07-27 | 2019-10-02 | Corium Int Inc | Sistemas de suministro transdermico de memantina. |
KR20230109782A (ko) | 2016-07-27 | 2023-07-20 | 코리움, 엘엘씨 | 아민 약물의 나트륨 바이카보네이트 제자리 전환 구동된경피성 전달 |
WO2018022814A1 (en) | 2016-07-27 | 2018-02-01 | Corium International, Inc. | Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
BR112019012821A2 (pt) | 2016-12-19 | 2019-11-26 | Agenebio Inc | derivados de benzodiazepina, composições e métodos para o tratamento do comprometimento cognitivo |
US10369187B2 (en) | 2017-02-09 | 2019-08-06 | Vanderbilt University | Peptide regulators of JNK family kinases |
EP3723738A1 (en) | 2017-12-13 | 2020-10-21 | Corium, Inc. | Method for depot creation during transdermal drug delivery |
US11173132B2 (en) | 2017-12-20 | 2021-11-16 | Corium, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
CA3104478A1 (en) | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
PT3843702T (pt) | 2019-05-31 | 2023-10-13 | Tecnimede Soc Tecnico Medicinal Lda | Combinação de dose fixa de libertação imediata de memantina e donepezilo |
JP7452810B2 (ja) * | 2019-06-17 | 2024-03-19 | 東和薬品株式会社 | 固定化触媒を用いたフロー反応によるドネペジルの製造方法 |
KR20220059300A (ko) * | 2020-11-02 | 2022-05-10 | 주식회사 종근당 | 인덴 유도체 프로드럭의 산부가염 및 이의 제조방법 |
KR102451185B1 (ko) | 2021-08-05 | 2022-10-07 | 환인제약 주식회사 | 도네페질 함유 지속방출형 미립구 |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3171838A (en) * | 1961-10-10 | 1965-03-02 | Res Lab Dr C Janssen N V | Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds |
US3454565A (en) * | 1966-10-05 | 1969-07-08 | American Cyanamid Co | Novel indanones |
US3452030A (en) * | 1966-12-12 | 1969-06-24 | Aldrich Chem Co Inc The | 4-(n-isobutyrylanilino)-1-benzylpiperidine |
US3476759A (en) * | 1967-05-02 | 1969-11-04 | Mcneilab Inc | 2- and 3-(4-piperidyl) indanes and indanols |
DE2021262A1 (de) * | 1970-04-30 | 1971-11-11 | Cassella Farbwerke Mainkur Ag | Piperazinderivate |
DE2148959C3 (de) * | 1971-09-30 | 1978-05-18 | Ordena Trudovogo Krasnogo Znameni Institut Organitscheskogo Sintesa Akademii Nauk Latvijskoj Ssr, Riga (Sowjetunion) | Verfahren zur Herstellung N-substituierter 4-Anilinopiperidine |
GB1323508A (en) * | 1971-10-06 | 1973-07-18 | Inst Organicheskogo Sinteza Ak | Method for preparation of n-substituted 4-aniline piperidines |
GB1416872A (en) | 1972-03-10 | 1975-12-10 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
DE2513136C3 (de) * | 1974-03-21 | 1981-04-30 | Anphar S.A., Madrid | N-(1-Benzylpiperid-4-yl)-benzamide, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate |
DK141752B (da) * | 1974-07-31 | 1980-06-09 | Ciba Geigy Ag | Aalogifremgangsmåde til fremstilling af piperidiner eller salte deraf. |
JPS5152176A (es) * | 1974-10-12 | 1976-05-08 | Yoshitomi Pharmaceutical | |
US4130646A (en) * | 1975-07-25 | 1978-12-19 | E. R. Squibb & Sons, Inc. | 1,2,3,4-Tetrahydro-2-((4-(phenyl)-1-piperazinyl)methyl)-1-naphthalenols and derivatives and analogs thereof |
GB1583753A (en) * | 1976-07-14 | 1981-02-04 | Science Union & Cie | Piperidine derivatives processes for their preparation and pharmaceutical compositions containing them |
GB1586468A (en) * | 1976-10-29 | 1981-03-18 | Anphar Sa | Piperidine derivatives |
GB1575310A (en) * | 1976-11-16 | 1980-09-17 | Anphar Sa | Piperidine derivatives |
BE864269A (fr) | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
ZA786426B (en) | 1977-11-25 | 1979-10-31 | Scras | New indulo(2,3-a)quinolizidines,preparation and therapeutic use |
SE7907121L (sv) * | 1979-08-27 | 1981-02-28 | Astra Laekemedel Ab | Ftalimidinderivat |
EP0029707B1 (en) * | 1979-11-21 | 1984-02-01 | Kyowa Hakko Kogyo Co., Ltd | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
US4254127A (en) * | 1980-04-03 | 1981-03-03 | Janssen Pharmaceutica, N.V. | 1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives |
FR2484415A1 (fr) * | 1980-06-13 | 1981-12-18 | Pharmindustrie | Nouveaux derives de l'indene, procedes pour leur preparation, et leur utilisation comme medicaments |
JPS58180481A (ja) * | 1982-04-15 | 1983-10-21 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
JPS5976082A (ja) * | 1982-10-23 | 1984-04-28 | Kyowa Hakko Kogyo Co Ltd | 新規なピペリジン誘導体 |
JPS59112984A (ja) * | 1982-12-21 | 1984-06-29 | Shionogi & Co Ltd | 1,4−ベンゾジアゼピン誘導体 |
FR2538388B1 (fr) * | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
US4734275A (en) | 1983-08-19 | 1988-03-29 | Research Corporation | Anti-curare agents |
SE8503054D0 (sv) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | Catecholcarboxamides |
DE3541811A1 (de) * | 1985-11-27 | 1987-06-04 | Thomae Gmbh Dr K | Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
GB8601160D0 (en) | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
PH23078A (en) * | 1986-01-30 | 1989-04-10 | Ciba Geigy Ag | Substituted pyrrolidinones |
JPH0721821B2 (ja) * | 1986-07-07 | 1995-03-08 | ソニー株式会社 | 動き物体の集計装置 |
KR910006138B1 (ko) | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
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1988
- 1988-06-08 FI FI882716A patent/FI95572C/fi active IP Right Grant
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- 1988-06-22 DE DE1997175093 patent/DE19775093I1/de active Pending
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- 1988-06-22 DE DE3856487T patent/DE3856487T2/de not_active Expired - Lifetime
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1989
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1992
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1994
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1995
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- 1995-06-09 FI FI952850A patent/FI102534B1/fi active
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1996
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1998
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2001
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