DK51092D0 - Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf - Google Patents

Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Info

Publication number
DK51092D0
DK51092D0 DK92510A DK51092A DK51092D0 DK 51092 D0 DK51092 D0 DK 51092D0 DK 92510 A DK92510 A DK 92510A DK 51092 A DK51092 A DK 51092A DK 51092 D0 DK51092 D0 DK 51092D0
Authority
DK
Denmark
Prior art keywords
synthones
monomeric
pen
procedures
preparing
Prior art date
Application number
DK92510A
Other languages
Danish (da)
English (en)
Inventor
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Rolf Henrik Berg
Original Assignee
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Berg Rolf H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK51092(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK98791A external-priority patent/DK98791D0/da
Priority claimed from DK98691A external-priority patent/DK98691D0/da
Application filed by Ole Buchardt, Michael Egholm, Peter Eigil Nielsen, Berg Rolf H filed Critical Ole Buchardt
Priority to DK92510A priority Critical patent/DK51092D0/da
Publication of DK51092D0 publication Critical patent/DK51092D0/da
Priority to AU18843/92A priority patent/AU1884392A/en
Priority to EP92911165A priority patent/EP0586474B1/en
Priority to CA002109320A priority patent/CA2109320C/en
Priority to DE69220946T priority patent/DE69220946T2/de
Priority to CA002109805A priority patent/CA2109805A1/en
Priority to DK92923579.4T priority patent/DK0586618T3/da
Priority to DE69232055T priority patent/DE69232055T2/de
Priority to ES92923579T priority patent/ES2107552T3/es
Priority to EP01203303A priority patent/EP1162206A3/en
Priority to EP92923579A priority patent/EP0586618B1/en
Priority to US08/150,156 priority patent/US6357163B1/en
Priority to ES92911165T priority patent/ES2164052T3/es
Priority to AT92911165T priority patent/ATE205504T1/de
Priority to JP4510434A priority patent/JP2758988B2/ja
Priority to JP51013992A priority patent/JP3982828B2/ja
Priority to BR9206049A priority patent/BR9206049A/pt
Priority to HU9303023A priority patent/HU221003B1/hu
Priority to US08/108,591 priority patent/US6395474B1/en
Priority to AU18806/92A priority patent/AU666480B2/en
Priority to AT92923579T priority patent/ATE155483T1/de
Priority to PCT/EP1992/001219 priority patent/WO1992020702A1/en
Priority to EP00203148A priority patent/EP1074559B1/en
Priority to PCT/EP1992/001220 priority patent/WO1992020703A1/en
Priority to DK92911165T priority patent/DK0586474T3/da
Priority to EP03077836A priority patent/EP1411063B1/en
Priority to AT00203148T priority patent/ATE515569T1/de
Priority to NO19934122A priority patent/NO312516B1/no
Priority to KR93703558A priority patent/KR0133131B1/ko
Priority to NO19934235A priority patent/NO313201B1/no
Priority to FI935208A priority patent/FI118424B/fi
Priority to US08/275,951 priority patent/US6451968B1/en
Priority to US08/319,411 priority patent/US7223833B1/en
Priority to US08/366,231 priority patent/US5977296A/en
Priority to US08/462,977 priority patent/US6713602B1/en
Priority to US08/468,719 priority patent/US6710163B1/en
Priority to US08/765,798 priority patent/US6441130B1/en
Priority to US08/595,387 priority patent/US5773571A/en
Priority to US08/686,113 priority patent/US5766855A/en
Priority to US08/686,114 priority patent/US6414112B1/en
Priority to US08/686,116 priority patent/US5714331A/en
Priority to US08/847,108 priority patent/US5736336A/en
Priority to US08/847,095 priority patent/US5786461A/en
Priority to GR970402663T priority patent/GR3025018T3/el
Priority to US09/209,149 priority patent/US6201103B1/en
Priority to US09/337,304 priority patent/US6613873B1/en
Priority to US09/955,410 priority patent/US20020146718A1/en
Priority to US09/983,210 priority patent/US20020160383A1/en
Priority to US10/154,890 priority patent/US7378485B2/en
Priority to US10/188,404 priority patent/US20030105286A1/en
Priority to JP2003015384A priority patent/JP2003235590A/ja
Priority to US10/657,600 priority patent/US20040059087A1/en
Priority to US10/691,012 priority patent/US20060160731A1/en
Priority to US10/755,118 priority patent/US20050009041A1/en
Priority to US11/029,005 priority patent/US20060046255A1/en
Priority to JP2007147536A priority patent/JP2007306926A/ja
Priority to JP2008060342A priority patent/JP2008253251A/ja
Priority to JP2008258890A priority patent/JP2009069158A/ja
Priority to US13/190,164 priority patent/US20120115136A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003Peptide-nucleic acids (PNAs)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06017Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92510A 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf DK51092D0 (da)

Priority Applications (59)

Application Number Priority Date Filing Date Title
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
AU18843/92A AU1884392A (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP92911165A EP0586474B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
CA002109320A CA2109320C (en) 1991-05-24 1992-05-22 Peptide nucleic acids
DE69220946T DE69220946T2 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
CA002109805A CA2109805A1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
DE69232055T DE69232055T2 (de) 1991-05-24 1992-05-22 Peptidnukleinsäuren
ES92923579T ES2107552T3 (es) 1991-05-24 1992-05-22 Uso de analogos de acido nucleico en diagnosticos y procedimientos analiticos.
EP01203303A EP1162206A3 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP92923579A EP0586618B1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
US08/150,156 US6357163B1 (en) 1991-05-24 1992-05-22 Use of nucleic acid analogues in diagnostics and analytical procedures
ES92911165T ES2164052T3 (es) 1991-05-24 1992-05-22 Acidos nucleicos de peptidos.
AT92911165T ATE205504T1 (de) 1991-05-24 1992-05-22 Peptidnukleinsäuren
JP4510434A JP2758988B2 (ja) 1991-05-24 1992-05-22 ペプチド核酸
JP51013992A JP3982828B2 (ja) 1991-05-24 1992-05-22 診断薬および分析方法における核酸類縁体の使用方法
BR9206049A BR9206049A (pt) 1991-05-24 1992-05-22 Composto, processos para preparar o composto, para o reconhecimento específico por sequência de um polinucleotídio de filamento duplo, para modular a expressão de um gene em um organismo, para tratar as condições associadas com produção de proteínas indesejada em um organismo, para induzir a degradação de DNA ou RNA em células de um organismo e para exterminar células ou vírus e composição farmacêutica
HU9303023A HU221003B1 (hu) 1991-05-24 1992-05-22 Peptid-nukleinsavak
US08/108,591 US6395474B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
AU18806/92A AU666480B2 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
AT92923579T ATE155483T1 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
PCT/EP1992/001219 WO1992020702A1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP00203148A EP1074559B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
PCT/EP1992/001220 WO1992020703A1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer
EP03077836A EP1411063B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
AT00203148T ATE515569T1 (de) 1991-05-24 1992-05-22 Peptidnucleinsäuren
NO19934122A NO312516B1 (no) 1991-05-24 1993-11-15 Peptid-nukleinsyrer
KR93703558A KR0133131B1 (en) 1991-05-24 1993-11-20 Peptide nucleic acids
NO19934235A NO313201B1 (no) 1991-05-24 1993-11-23 Nukleinsyreanalog, anvendelse derav, in vitro-fremgangsmåte og kit
FI935208A FI118424B (fi) 1991-05-24 1993-11-23 Nukleiinihappoanalogit ja niiden käyttö diagnostisissa ja analyyttisissä toimenpiteissä
US08/275,951 US6451968B1 (en) 1991-05-24 1994-07-15 Peptide nucleic acids
US08/319,411 US7223833B1 (en) 1991-05-24 1994-10-06 Peptide nucleic acid conjugates
US08/366,231 US5977296A (en) 1991-05-24 1994-12-28 Chiral peptide nucleic acid monomers and oligomers
US08/462,977 US6713602B1 (en) 1991-05-24 1995-06-05 Synthetic procedures for peptide nucleic acids
US08/468,719 US6710163B1 (en) 1991-05-24 1995-06-06 Peptide nucleic acid synthons
US08/765,798 US6441130B1 (en) 1991-05-24 1995-07-13 Linked peptide nucleic acids
US08/595,387 US5773571A (en) 1991-05-24 1996-02-01 Peptide nucleic acids
US08/686,113 US5766855A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity and sequence specificity
US08/686,114 US6414112B1 (en) 1991-05-24 1996-07-24 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US08/686,116 US5714331A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US08/847,108 US5736336A (en) 1991-05-24 1997-05-01 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US08/847,095 US5786461A (en) 1991-05-24 1997-05-01 Peptide nucleic acids having amino acid side chains
GR970402663T GR3025018T3 (en) 1991-05-24 1997-10-14 The use of nucleic acid analogues in diagnostics and analytical procedures
US09/209,149 US6201103B1 (en) 1991-05-24 1998-12-10 Peptide nucleic acid incorporating a chiral backbone
US09/337,304 US6613873B1 (en) 1991-05-24 1999-06-21 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US09/955,410 US20020146718A1 (en) 1991-05-24 2001-09-18 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US09/983,210 US20020160383A1 (en) 1991-05-24 2001-10-23 Use of nucleic acid analogues in diagnostics and analytical procedures
US10/154,890 US7378485B2 (en) 1991-05-24 2002-05-23 Peptide nucleic acids with polyamide-containing backbones
US10/188,404 US20030105286A1 (en) 1991-05-24 2002-07-01 Linked peptide nucleic acids
JP2003015384A JP2003235590A (ja) 1991-05-24 2003-01-23 核酸類縁体並びに診断薬および分析方法におけるその使用方法
US10/657,600 US20040059087A1 (en) 1991-05-24 2003-09-08 Peptide nucleic acids
US10/691,012 US20060160731A1 (en) 1991-05-24 2003-10-22 Peptide nucleic acids
US10/755,118 US20050009041A1 (en) 1991-05-24 2004-01-09 Peptide nucleic acids and synthetic procedures therefor
US11/029,005 US20060046255A1 (en) 1991-05-24 2005-01-05 Use of nucleic acid analogues in diagnostics and analytical procedures
JP2007147536A JP2007306926A (ja) 1991-05-24 2007-06-01 核酸類縁体並びに診断薬および分析方法におけるその使用方法
JP2008060342A JP2008253251A (ja) 1991-05-24 2008-03-10 核酸類縁体並びに診断薬および分析方法におけるその使用方法
JP2008258890A JP2009069158A (ja) 1991-05-24 2008-10-03 核酸類縁体並びに診断薬および分析方法におけるその使用方法
US13/190,164 US20120115136A1 (en) 1991-05-24 2011-07-25 Pna diagnostic use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK98791A DK98791D0 (da) 1991-05-24 1991-05-24 Fremgangsmaade til sekvensspecifik genkendelse af et dobbeltstrenget polynucleotid
DK98691A DK98691D0 (da) 1991-05-24 1991-05-24 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Publications (1)

Publication Number Publication Date
DK51092D0 true DK51092D0 (da) 1992-04-15

Family

ID=27220741

Family Applications (3)

Application Number Title Priority Date Filing Date
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer

Country Status (16)

Country Link
US (11) US6395474B1 (ja)
EP (5) EP1411063B1 (ja)
JP (6) JP3982828B2 (ja)
KR (1) KR0133131B1 (ja)
AT (3) ATE205504T1 (ja)
AU (2) AU666480B2 (ja)
BR (1) BR9206049A (ja)
CA (2) CA2109805A1 (ja)
DE (2) DE69220946T2 (ja)
DK (3) DK51092D0 (ja)
ES (2) ES2107552T3 (ja)
FI (1) FI118424B (ja)
GR (1) GR3025018T3 (ja)
HU (1) HU221003B1 (ja)
NO (2) NO312516B1 (ja)
WO (2) WO1992020703A1 (ja)

Families Citing this family (361)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852182A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5783682A (en) * 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US7223833B1 (en) * 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US6713602B1 (en) * 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US6414112B1 (en) 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5766855A (en) * 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
AU3250093A (en) 1991-12-12 1993-07-19 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
AU669353B2 (en) * 1991-12-24 1996-06-06 Isis Pharmaceuticals, Inc. Gapped 2' modified oligonucleotides
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US6033884A (en) * 1992-03-20 2000-03-07 Baylor College Of Medicine Nucleic acid transporter systems and methods of use
US6770738B1 (en) 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
GB9211979D0 (en) * 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
US7825215B1 (en) * 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
GB9311386D0 (en) * 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
AU7206794A (en) * 1993-06-11 1995-01-03 Isis Pharmaceuticals, Inc. Oligomers for modulating ras oncogene
WO1995004748A1 (en) * 1993-08-09 1995-02-16 Isis Pharmaceuticals, Inc. Oligomers for modulating viral processes
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331011A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
US20020068275A1 (en) * 1993-09-21 2002-06-06 Michael A. Reeve Methods of using a chimeric nucleic acid/nucleic acid analogue molecule
WO1998003542A1 (en) * 1996-07-24 1998-01-29 Buchardt, Dorte Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6710164B1 (en) * 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
GB2285445A (en) * 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
JPH11503713A (ja) * 1993-12-22 1999-03-30 パーセプティブ・バイオシステムズ・インコーポレーテッド ペプチド核酸合成用のグアニンシントンと、その調製方法
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) * 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
DE4408533A1 (de) 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
AU2369895A (en) * 1994-04-29 1995-11-29 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules
EP0760008A1 (en) 1994-05-19 1997-03-05 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
DE4427980A1 (de) * 1994-08-08 1996-02-15 Bayer Ag Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
DE69527857T2 (de) * 1994-10-06 2003-05-28 Buchardt, Dorte Peptid-nukleinsäure-konjugate
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
UA48150C2 (uk) * 1994-11-02 2002-08-15 Ай-Сі-Ен Фармасьютикалз Похідні амінокислот або аміноспиртів, олігонуклеотид
AU4159396A (en) * 1994-11-14 1996-06-06 Chiron Corporation Synthesis of peptide nucleic acids (pnas) and analogues via submonomer approach
WO1996019587A2 (en) * 1994-12-22 1996-06-27 Abbott Laboratories Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides
DK0815259T3 (da) * 1995-03-04 2001-09-17 Pna Diagnostics As Modulation af nucleinsyre-bindingspartneres bindingsegenskaber
US6475721B2 (en) * 1995-03-04 2002-11-05 Boston Probes, Inc. Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
DE69632324T2 (de) * 1995-06-07 2005-06-16 PerSeptive Biosystems, Inc., Framingham Pna-dna-chimäre und pna-synthone zu deren herstellung
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
AU4327296A (en) * 1995-06-22 1996-05-15 Dako A/S Recombinant antibody capable of binding to pna/nucleic acid complexes
WO1996014341A1 (en) * 1995-06-22 1996-05-17 Dako A/S Monoclonal antibody capable of binding to pna/nucleic acid complexes
GB9519299D0 (en) * 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
EP1477572A3 (en) * 1995-10-06 2006-02-15 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
WO1997012995A1 (en) * 1995-10-06 1997-04-10 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
ATE362546T1 (de) 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US5874532A (en) * 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
AU7016096A (en) * 1995-10-20 1997-05-07 Trustees Of Boston University Nucleic acid clamps
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
DE69637194T2 (de) * 1995-11-16 2008-04-30 Dako Denmark A/S In situ-hybridisation zum nachweis von spezifischen nukleinsäuresequenzen in eukaryontischen proben
CA2190430A1 (en) * 1995-12-12 1997-06-13 Margret Barbara Basinski Method for measuring genetic messages
US6180767B1 (en) 1996-01-11 2001-01-30 Thomas Jefferson University Peptide nucleic acid conjugates
US20030069195A1 (en) * 1996-03-01 2003-04-10 Farrar Gwenyth Jane Suppression of polymorphic alleles
US6020126A (en) * 1996-03-21 2000-02-01 Hsc, Reasearch And Development Limited Partnership Rapid genetic screening method
CA2250923A1 (en) * 1996-03-26 1997-10-02 Gabriella Zupi Oligonucleotide treatments and compositions for human melanoma
US20040234999A1 (en) * 1996-04-02 2004-11-25 Farrar Gwenyth Jane Genetic suppression and replacement
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
US8551970B2 (en) * 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9608803D0 (en) * 1996-04-27 1996-07-03 Univ Newcastle Mitochondrial dna defects
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US20050042647A1 (en) * 1996-06-06 2005-02-24 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
US20050032068A1 (en) * 2002-11-05 2005-02-10 Prakash Thazha P. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
WO2005121370A2 (en) * 2004-06-03 2005-12-22 Isis Pharmaceuticals, Inc. Oligomeric compounds that facilitate risc loading
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US5858683A (en) 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6444202B1 (en) 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use
DE69826992T2 (de) * 1997-02-24 2005-10-20 Georgia Tech Research Corp. Verfahren zur bestimmung einer nukleinsäure
US6117973A (en) * 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US6692912B1 (en) * 1997-03-05 2004-02-17 Matrix Technologies Corporation Nucleic acid-containing polymerizable complex
US5932711A (en) * 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US6015887A (en) * 1997-04-11 2000-01-18 Isis Pharmaceuticals, Inc. Chiral peptide nucleic acids and methods for preparing same
SE522077C2 (sv) * 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
IL133087A0 (en) * 1997-05-28 2001-03-19 Nielsen Peter E Conjugated peptide nucleic acids having enhanced cellular uptake
DK0881228T3 (da) * 1997-05-30 2005-12-19 Pna Diagnostics As 2- eller 3-dimensionale geometriske strukturer af peptidnukleinsyrer
AU8147798A (en) * 1997-06-16 1999-01-04 University Of North Carolina At Chapel Hill, The Peptido oligonucleotides (pons) and their combinatorial libraries
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブpnaによるdnaの検出方法
DK0897991T3 (da) * 1997-08-22 2005-07-25 Pna Diagnostics Aps Små triplexdannende PNA-oligoer
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
DE19816550A1 (de) 1997-12-24 1999-06-24 Roche Diagnostics Gmbh Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung
US6030997A (en) * 1998-01-21 2000-02-29 Eilat; Eran Acid labile prodrugs
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
DE19824900B4 (de) 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
US6664045B1 (en) * 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
JP2002520008A (ja) 1998-07-09 2002-07-09 バイオセプト インコーポレイテッド Dna配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
DE60025172T2 (de) 1999-03-18 2006-09-21 Exiqon A/S Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
US20020049173A1 (en) * 1999-03-26 2002-04-25 Bennett C. Frank Alteration of cellular behavior by antisense modulation of mRNA processing
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
DE19927783A1 (de) 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
AU6629200A (en) * 1999-08-25 2001-03-19 Philip P Garner Alpha-helical peptide nucleic acid alpha-pna
ATE342271T1 (de) 1999-08-30 2006-11-15 Roche Diagnostics Gmbh 2-azapurine verbindungen und ihre verwendung
US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
US7125542B2 (en) 2000-02-10 2006-10-24 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
CA2402319A1 (en) 2000-03-14 2001-09-20 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
WO2001075174A2 (en) 2000-04-03 2001-10-11 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
DE10019136A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
ATE384731T1 (de) 2000-08-03 2008-02-15 Hoffmann La Roche Nukleinsäurebindende verbindungen mit pyrazolo 3, 4-d pyrimidinanalogen von purin-2,6-diamin und ihre verwendung
PT1315519E (pt) 2000-08-08 2011-03-17 Technion Res & Dev Foundation Composições farmacêuticas e métodos úteis para tratamento de cancro e fibrose hepática
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
US7183394B1 (en) * 2000-08-11 2007-02-27 Garner Philip P Helical nucleopeptides
ATE544473T1 (de) * 2000-11-09 2012-02-15 Cold Spring Harbor Lab Chimäre moleküle zur modulation der genexpression
JPWO2002051797A1 (ja) * 2000-12-26 2004-09-02 池田 壽文 新規な機能性ペプチド核酸モノマーとその製法
US7034131B2 (en) 2001-01-29 2006-04-25 Bio-Rad Laboratories Inc. Nucleic acid derivatives
GB0102388D0 (en) * 2001-01-31 2001-03-14 Secr Defence Polymers
EP1236804A1 (en) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
DK1412517T3 (da) 2001-03-09 2007-03-05 Boston Probes Inc Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer
EP2261241A1 (en) 2001-04-16 2010-12-15 Wyeth Holdings Corporation Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
US8026051B2 (en) 2001-05-18 2011-09-27 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of Candida
US20030207804A1 (en) * 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
JP2005524384A (ja) * 2001-09-24 2005-08-18 ボストン プローブス,インコーポレイテッド ゲノム核酸におけるランダム分布反復配列への検出可能なプローブ結合の抑制に関する方法、キットおよび組成物
EP1442137A4 (en) 2001-11-07 2005-08-31 Applera Corp UNIVERSAL NUCLEOTIDES FOR NUCLEIC ACID ANALYSIS
EP2196544A1 (en) 2001-11-21 2010-06-16 Applied Biosystems, LLC Kit for ligation detection assays using codeable labels
KR100464261B1 (ko) 2002-01-24 2005-01-03 주식회사 파나진 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
CA2474482A1 (en) 2002-01-25 2003-08-07 Applera Corporation Methods for placing, accepting, and filling orders for products and services
AU2003230717A1 (en) * 2002-03-21 2003-10-08 Boston Probes, Inc. Pna oligomers, oligomers sets, methods and kits pertaining to the detection of bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
US7052840B2 (en) 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
KR20030084444A (ko) 2002-04-26 2003-11-01 주식회사 파나진 Pna 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7015317B2 (en) 2002-05-02 2006-03-21 Abbott Laboratories Polynucleotides for the detection and quantification of hepatitis B virus nucleic acids
CA2484010A1 (en) * 2002-05-17 2003-12-04 Applera Corporation Pna probes, probe sets, methods and kits pertaining to the determination of listeria
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
CA2495895A1 (en) 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
CA2502610A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
EP1552025A4 (en) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc METHODS FOR IDENTIFYING TARGETED ANTIVIRAL MOLECULES TO QUADRUPLEX STRUCTURES
AU2003287502B2 (en) 2002-11-05 2010-12-09 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
AU2003291753B2 (en) * 2002-11-05 2010-07-08 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US9150606B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
EP1576188B1 (en) 2002-11-21 2008-10-15 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US20040219685A1 (en) * 2003-01-30 2004-11-04 Applera Corporation Methods and mixtures pertaining to analyte determination using electrophilic labeling reagents
US20040171149A1 (en) * 2003-02-11 2004-09-02 Wraight Christopher J. Modulation of insulin like growth factor I receptor expression
WO2004072284A1 (en) * 2003-02-11 2004-08-26 Antisense Therapeutics Ltd Modulation of insulin like growth factor i receptor expression
ATE552339T1 (de) 2003-02-21 2012-04-15 Eisai R&D Man Co Ltd Signalverstärkungsverfahren zum nachweis eines mutanten gens
MXPA05012482A (es) * 2003-05-20 2006-07-03 Investigen Inc Sistema para detectar polinucleotidos.
WO2005012546A2 (en) * 2003-07-25 2005-02-10 Andreas Braun Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences
WO2005010181A1 (ja) * 2003-07-25 2005-02-03 Credia Japan Co., Ltd. 核酸検出方法
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20050063932A1 (en) * 2003-08-14 2005-03-24 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
CN1910289B (zh) 2004-01-07 2012-05-23 日立化成研究中心公司 用于检测hiv的引物和探针
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
ATE399884T1 (de) 2004-03-24 2008-07-15 Applera Corp Codierungs- und decodierungsreaktionen zur bestimmung von target-polynukleotiden
ATE478158T1 (de) 2004-04-28 2010-09-15 Eisai R&D Man Co Ltd Hybridisierungsverfahren
EP1745156A2 (en) * 2004-05-04 2007-01-24 Dako Denmark A/S Methods for detecting chromosome aberrations
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US20060057611A1 (en) 2004-06-30 2006-03-16 Applera Corporation Log-linear amplification
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
JP2008522588A (ja) * 2004-12-06 2008-07-03 バイオヴェリス コーポレイション 炭疽菌(Bacillusanthracis)を検出するための方法及び組成物
AU2005314431B2 (en) * 2004-12-11 2011-02-17 Cytogenix, Inc. Cell free biosynthesis of high-quality nucleic acid and uses thereof
AU2006204006A1 (en) 2005-01-06 2006-07-13 Applera Corporation Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US20090264635A1 (en) 2005-03-25 2009-10-22 Applera Corporation Methods and compositions for depleting abundant rna transcripts
US20090246758A1 (en) 2005-06-02 2009-10-01 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
CA2610863C (en) 2005-06-07 2017-01-17 Eragen Biosciences, Inc. Methods for detection and typing of nucleic acids
US8481697B2 (en) * 2005-07-01 2013-07-09 Dako Denmark A/S Nucleic acid base pairs
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
WO2007100711A2 (en) * 2006-02-24 2007-09-07 Investigen, Inc. Methods and compositions for detecting polynucleotides
WO2007108378A1 (ja) 2006-03-15 2007-09-27 Eisai R & D Management Co., Ltd. シグナルプローブポリマーの形成方法
JP2009536525A (ja) 2006-05-10 2009-10-15 ディクステリティー ダイアグノーティクス 化学反応性オリゴヌクレオチドプローブを使用した核酸標的の検出
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
EP2035831B1 (en) 2006-06-30 2013-08-14 Applied Biosystems, LLC Methods of analyzing binding interactions
EP2484781B1 (en) 2006-08-01 2017-08-23 Applied Biosystems, LLC Detection of analytes and nucleic acids
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
WO2008070525A1 (en) 2006-12-04 2008-06-12 Luminex Corporation Oxocarbonamide peptide nucleic acids and methods of using same
US7955802B2 (en) 2006-12-13 2011-06-07 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
EP2118310B1 (en) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systems and methods for detecting nucleic acids
WO2008083259A1 (en) * 2006-12-29 2008-07-10 Applera Corporation Systems and methods for detecting nucleic acids
US7803543B2 (en) 2007-01-19 2010-09-28 Chang Gung University Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe
EP2591795B1 (en) * 2007-02-23 2018-02-28 The Research Foundation Of State University Of New York RNA targeting compounds and methods for making and using same
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
US9260476B2 (en) 2007-02-23 2016-02-16 The Research Foundation For The State University Of New York RNA targeting compounds and methods for making and using same
EP2035440B1 (en) 2007-04-13 2012-06-13 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
EP3023436A1 (en) 2007-07-03 2016-05-25 Dako Denmark A/S Improved methods for generation, labeling and use of mhc multimers
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
JP5659014B2 (ja) 2007-08-02 2015-01-28 ジリード バイオロジクス,インク. 線維症、腫瘍浸潤、血管新生及び転移の治療及び診断のための方法及び組成物
WO2009054320A1 (ja) 2007-10-24 2009-04-30 Eisai R & D Management Co., Ltd. 核酸プローブ及びプローブポリマーの形成方法
JPWO2009057702A1 (ja) 2007-10-31 2011-03-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 標的物質検出用ポリマー及び標的物質の検出方法
ES2641290T3 (es) 2007-11-20 2017-11-08 Ionis Pharmaceuticals, Inc Modulación de la expresión de CD40
US8017338B2 (en) 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
EP2944649A1 (en) 2008-01-10 2015-11-18 Research Development Foundation Vaccines and diagnostics for the ehrlichioses
EP2245191A1 (en) 2008-01-17 2010-11-03 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes and compositions
KR101072899B1 (ko) * 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
US8709726B2 (en) 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
KR20090098710A (ko) * 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
ES2610588T3 (es) 2008-05-27 2017-04-28 Dako Denmark A/S Composiciones y métodos para la detección de aberraciones cromosómicas con tampones de hibridación novedosos
DK3023494T3 (en) 2008-06-13 2019-02-25 Codexis Inc PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
KR20110059743A (ko) 2008-09-03 2011-06-03 난양 테크놀러지컬 유니버시티 펩티드 핵산 단량체 및 올리고머
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP2949752B1 (en) 2008-09-22 2017-12-20 RXi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
EP2568044B1 (en) 2008-09-29 2015-04-08 The Trustees of The University of Pennsylvania Tumor vascular marker-targeted vaccines
ES2794401T3 (es) 2008-10-15 2020-11-18 Axolabs Gmbh Método de detección de oligonucleótidos
JP5805538B2 (ja) 2008-11-07 2015-11-04 リサーチ ディベロップメント ファウンデーション Cripto/GSP78複合体形成およびシグナル伝達を阻害するための組成物および方法
US8715732B2 (en) * 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
WO2010087994A2 (en) 2009-01-30 2010-08-05 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US7964355B2 (en) 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
EP2765205B1 (en) 2009-04-01 2016-05-18 DxTerity Diagnostics Incorporated Chemical ligation dependent probe amplification (CLPA)
WO2010118243A2 (en) 2009-04-08 2010-10-14 Genentech, Inc. Use of il-27 antagonists to treat lupus
CN102439451B (zh) 2009-06-02 2014-12-03 德克萨斯大学系统董事会 患神经退行性疾病的对象中抗体所识别的小分子的鉴定
CN102686728B (zh) 2009-06-29 2018-09-18 卢米耐克斯公司 具有发夹构象的嵌合引物及其使用方法
WO2011011630A2 (en) 2009-07-23 2011-01-27 Codexis, Inc. Nitrilase biocatalysts
ES2550202T3 (es) * 2009-08-03 2015-11-05 Recombinetics, Inc. Métodos y composiciones para la modificación dirigida de genes
BR112012008054A2 (pt) 2009-08-21 2017-05-23 Gilead Biologics Inc domínios catalíticos de lisil oxidase e loxl2
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
ES2601237T3 (es) 2009-12-02 2017-02-14 Dako Denmark A/S Composiciones y métodos para realizar hibridaciones sin desnaturalización
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
US9404160B2 (en) 2009-12-22 2016-08-02 Becton, Dickinson And Company Methods for the detection of microorganisms
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
MX2017015093A (es) 2011-01-11 2023-03-10 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
WO2012134195A2 (en) 2011-03-29 2012-10-04 Seegene, Inc. Detection of target nucleic acid sequence by pto cleavage and extension-dependent cleavage
EP3913065A1 (en) 2011-04-08 2021-11-24 Carnegie Mellon University Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
MX342067B (es) 2011-05-04 2016-09-09 Seegene Inc Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
DK2710145T3 (en) 2011-05-17 2016-02-22 Dxterity Diagnostics Inc METHOD AND COMPOSITIONS FOR THE DETECTION OF TARGET NUCLEIC ACIDS
EP2761028A1 (en) 2011-09-30 2014-08-06 Dako Denmark A/S Hybridization compositions and methods using formamide
GB201117482D0 (en) 2011-10-11 2011-11-23 Univ Dundee Targetiing of miRNA precursors
EP2768974B1 (en) 2011-10-21 2017-07-19 Dako Denmark A/S Hybridization compositions and methods
EP2594942A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Long rigid spacers to enhance binding kinetics in immunoassays
US20140349879A1 (en) 2011-12-09 2014-11-27 Eisai R & D Management Co., Ltd. Method for detecting nucleotide mutation, and detection kit
ES2930180T3 (es) 2012-03-02 2022-12-07 Sequenom Inc Métodos para enriquecer ácido nucleico canceroso a partir de una muestra biológica
KR101794981B1 (ko) 2012-03-05 2017-11-09 주식회사 씨젠 Pto 절단 및 연장 어세이에 의한 타겟 핵산서열에서의 뉴클레오타이드 변이 검출
US20150299788A1 (en) 2012-05-15 2015-10-22 Eisai R&D Management Co., Ltd. Rna detection method and detection kit
CN104540944A (zh) 2012-05-21 2015-04-22 斯克利普斯研究所 核糖体多核苷酸和相关表达系统
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014033314A1 (en) 2012-09-03 2014-03-06 Uab Bioseka Antisense oligonucleotide targeting bacterial glucosyltransferases
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
EP2929050A1 (en) 2012-12-10 2015-10-14 AdvanDx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
ES2662825T3 (es) 2013-02-25 2018-04-09 Seegene, Inc. Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana
US9289502B2 (en) 2013-03-08 2016-03-22 Emerald Therapeutics, Inc. Preparation of oligo conjugates
KR101943623B1 (ko) 2013-03-13 2019-01-30 주식회사 씨젠 멜팅 피크 분석을 이용한 타겟 핵산서열의 정량
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
EP2971160B1 (en) 2013-03-15 2018-05-30 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
WO2014149356A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Detection of bisulfite converted nucleotide sequences
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
CA2912765C (en) 2013-07-12 2018-05-01 Emd Millipore Corporation A method of determining virus removal from a sample containing a target protein using activated carbon
JP6050555B2 (ja) 2013-07-15 2016-12-21 シージーン アイエヌシー Ptoの切断及び延長−依存的固定化オリゴヌクレオチドハイブリダイゼーションを用いたターゲット核酸配列の検出
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
CA2926084A1 (en) 2013-10-11 2015-04-16 Genentech, Inc. Nsp4 inhibitors and methods of use
CN105813721B (zh) 2013-10-16 2019-11-05 不列颠哥伦比亚大学 用于以小体积配制颗粒的装置
WO2015057008A2 (en) 2013-10-18 2015-04-23 Seegene, Inc. Detection of target nucleic acid sequence on solid phase by pto cleavage and extension using hcto assay
WO2015070050A1 (en) 2013-11-08 2015-05-14 Baylor Research Institute Nuclear loclization of glp-1 stimulates myocardial regeneration and reverses heart failure
CA2940526A1 (en) 2014-01-28 2015-08-06 Dice Molecules Sv, Llc Monoliths with attached recognition compounds, arrays thereof and uses thereof
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015172058A1 (en) 2014-05-08 2015-11-12 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
AU2015274660B2 (en) 2014-06-10 2020-07-16 Dxterity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
US9909187B2 (en) 2014-06-24 2018-03-06 Abbott Molecular Inc. Detection of single nucleotide polymorphisms in human KRAS
ES2752761T3 (es) 2014-07-24 2020-04-06 Abbott Molecular Inc Composiciones para la detección y análisis de mycobacterium tuberculosis
WO2016028887A1 (en) 2014-08-19 2016-02-25 Pacific Biosciences Of California, Inc. Compositions and methods for enrichment of nucleic acids
EP3259346B1 (en) 2015-02-20 2024-08-07 Baylor College of Medicine P63 inactivation for the treatment of heart failure
JP7497953B2 (ja) 2015-06-12 2024-06-11 アレクトル エルエルシー 抗cd33抗体及びその使用方法
CN116063499A (zh) 2015-06-12 2023-05-05 艾利妥 抗cd33抗体及其使用方法
US10526664B2 (en) 2015-07-14 2020-01-07 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
CN108137702B (zh) 2015-08-28 2023-01-06 艾利妥 抗siglec-7抗体及其使用方法
DK3350343T3 (da) 2015-09-16 2020-07-20 Petaomics Inc Fremgangsmåder og sammensætninger til genommålberigelse og selektiv dna-sekventering
US12048753B2 (en) 2015-10-01 2024-07-30 Whitehead Institute For Biomedical Research Labeling of antibodies
SG10202104058XA (en) 2015-10-14 2021-05-28 Bio Path Holdings Inc P-ethoxy nucleic acids for liposomal formulation
SG11201802777XA (en) 2015-10-14 2018-05-30 X Therma Inc Compositions and methods for reducing ice crystal formation
JP7060502B2 (ja) 2015-10-29 2022-04-26 アレクトル エルエルシー 抗Siglec-9抗体及びその使用方法
EP3797860A1 (en) 2016-01-06 2021-03-31 The University of British Columbia Bifurcating mixers and methods of their use and manufacture
US20190177391A1 (en) 2016-03-31 2019-06-13 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
US10400274B2 (en) 2016-06-18 2019-09-03 Jan Biotech, Inc. Fluorogenic probes and their use in quantitative detection of target RNA sequences
US10300145B2 (en) 2016-07-15 2019-05-28 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
ES2928654T3 (es) 2016-09-16 2022-11-21 Bio Path Holdings Inc Terapia combinada con oligonucleótidos antisentido liposomales
WO2018058091A1 (en) 2016-09-26 2018-03-29 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
US11359014B2 (en) 2017-05-16 2022-06-14 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
WO2019028283A1 (en) 2017-08-03 2019-02-07 Alector Llc ANTI-CD33 ANTIBODIES AND METHODS OF USE
KR102380264B1 (ko) 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
CA3086479A1 (en) 2017-12-21 2019-06-27 Carnegie Mellon University Template-directed nucleic acid targeting compounds
MA53328A (fr) 2018-07-27 2021-06-09 Alector Llc Anticorps anti-siglec-5 et leurs procédés d'utilisation
CA3113676A1 (en) 2018-09-21 2020-03-26 President And Fellows Of Harvard College Methods and compositions for treating diabetes, and methods for enriching mrna coding for secreted proteins
WO2021005223A1 (en) 2019-07-10 2021-01-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of epilepsy
WO2021099394A1 (en) 2019-11-19 2021-05-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Antisense oligonucleotides and their use for the treatment of cancer
US20210381039A1 (en) 2020-05-29 2021-12-09 Front Range Biosciences, Inc. Methods and compositions for pathogen detection in plants
WO2022006019A1 (en) 2020-06-29 2022-01-06 Front Range Biosciences, Inc. Characterization of cannabis cultivars based on terpene synthase gene profiles
AU2021305665A1 (en) 2020-07-10 2023-02-23 Centre National De La Recherche Scientifique Methods and compositions for treating epilepsy
WO2022241007A1 (en) * 2021-05-11 2022-11-17 Mccurdy Russell Lewis Replaceable floating attractant accessories for fishing line
EP4403645A1 (en) 2021-09-17 2024-07-24 Seegene, Inc. Detection of target nucleic acid sequence by using synthetic non-natural base-bearing tag oligonucleotide
CN114409890A (zh) * 2022-02-28 2022-04-29 中国科学院长春应用化学研究所 一种氨基功能化的聚乙二醇衍生物及其制备方法
WO2024017990A1 (en) 2022-07-21 2024-01-25 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders
WO2024146935A1 (en) 2023-01-06 2024-07-11 Institut National de la Santé et de la Recherche Médicale Intravenous administration of antisense oligonucleotides for the treatment of pain

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2910130A1 (de) 1979-03-15 1980-09-25 Franz Rossmoeller Verbesserte befestigungsvorrichtung zum aufhaengen von paneelen und moebelelementen
DE2910129C2 (de) 1979-03-15 1986-01-23 Oskar 4354 Datteln Fleck Leiste zum Abdichten des Zwischenraums zwischen der Trauflatte eines Daches und den darüberliegenden traufseitigen Dacheindeckungsplatten
JPS5927900A (ja) 1982-08-09 1984-02-14 Wakunaga Seiyaku Kk 固定化オリゴヌクレオチド
ATE171185T1 (de) * 1985-03-15 1998-10-15 Antivirals Inc Immunotestmittel für polynukleotid und verfahren
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
DE3856406T2 (de) 1987-10-28 2000-10-19 Howard Florey Institute Of Experimental Physiology And Medicine, Parkville Oligonucleotid-polyamid konjugate
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
EP0433345B1 (en) 1988-09-01 1994-04-20 Forskningscenter Riso Peptide synthesis method and solid support for use in the method
JPH02156895A (ja) * 1988-12-08 1990-06-15 Sumitomo Heavy Ind Ltd 好塩菌による5’‐ヌクレオチド類の製造法
JPH0635469B2 (ja) * 1989-09-13 1994-05-11 信 高橋 ジエチレントリアミン三酢酸化合物及びその製造中間体並びにそれらの製造法
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US6414112B1 (en) * 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
MX9207334A (es) 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US6770738B1 (en) * 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
AU4525093A (en) * 1992-05-28 1993-12-30 Gilead Sciences, Inc. Conformationally restrained oligomers containing amide or carbamate linkages for sequence-specific binding
US5705333A (en) * 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6472209B1 (en) * 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

Also Published As

Publication number Publication date
US20020160383A1 (en) 2002-10-31
CA2109320C (en) 2003-07-22
JP2008253251A (ja) 2008-10-23
KR0133131B1 (en) 1998-04-14
EP1074559B1 (en) 2011-07-06
NO934122L (no) 1994-01-11
US20120115136A1 (en) 2012-05-10
JPH06509063A (ja) 1994-10-13
US6201103B1 (en) 2001-03-13
ES2164052T3 (es) 2002-02-16
US5977296A (en) 1999-11-02
ATE155483T1 (de) 1997-08-15
WO1992020703A1 (en) 1992-11-26
US6395474B1 (en) 2002-05-28
AU1880692A (en) 1992-12-30
HUT66597A (en) 1994-12-28
JP3982828B2 (ja) 2007-09-26
EP1411063A1 (en) 2004-04-21
US6357163B1 (en) 2002-03-19
EP1162206A2 (en) 2001-12-12
DE69220946D1 (de) 1997-08-21
DE69232055T2 (de) 2002-06-06
US7378485B2 (en) 2008-05-27
NO934122D0 (no) 1993-11-15
HU221003B1 (hu) 2002-07-29
JP2758988B2 (ja) 1998-05-28
EP1074559A1 (en) 2001-02-07
GR3025018T3 (en) 1998-01-30
JP2007306926A (ja) 2007-11-29
FI935208A0 (fi) 1993-11-23
EP1411063B1 (en) 2006-07-19
FI935208A (fi) 1993-11-23
ATE515569T1 (de) 2011-07-15
JP2003235590A (ja) 2003-08-26
NO312516B1 (no) 2002-05-21
WO1992020702A1 (en) 1992-11-26
EP1162206A3 (en) 2004-04-14
US20060160731A1 (en) 2006-07-20
DE69220946T2 (de) 1998-01-15
US20060046255A1 (en) 2006-03-02
NO934235L (no) 1994-01-20
CA2109805A1 (en) 1992-11-26
BR9206049A (pt) 1994-12-27
EP0586618B1 (en) 1997-07-16
JPH06506945A (ja) 1994-08-04
NO313201B1 (no) 2002-08-26
JP2009069158A (ja) 2009-04-02
NO934235D0 (no) 1993-11-23
ES2107552T3 (es) 1997-12-01
US6710163B1 (en) 2004-03-23
ATE205504T1 (de) 2001-09-15
EP0586618A1 (en) 1994-03-16
US20030180734A1 (en) 2003-09-25
US20040059087A1 (en) 2004-03-25
DK0586474T3 (da) 2001-12-31
FI118424B (fi) 2007-11-15
HU9303023D0 (en) 1994-01-28
AU666480B2 (en) 1996-02-15
CA2109320A1 (en) 1992-11-25
DE69232055D1 (de) 2001-10-18
EP0586474A1 (en) 1994-03-16
AU1884392A (en) 1992-12-30
EP0586474B1 (en) 2001-09-12
DK0586618T3 (da) 1998-02-09

Similar Documents

Publication Publication Date Title
DK51092D0 (da) Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
WO1994025477A3 (en) Novel peptide nucleic acids
DE69431485D1 (de) Doppelsträngige peptidenukleinsäuren
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
PT92640A (pt) Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules by forming a colinear triplex the synthetic oligonucleotides and methods of use
DE69527857D1 (de) Peptid-nukleinsäure-konjugate
DE69432419D1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
NO972868L (no) Oligonukleotid-dendrimer konjugater
DK0840802T3 (da) Fremgangsmåde til sekvensering gennem oligomerhybridisering
DE69613971D1 (de) Oligonukelotide mit transversalkovalenter bindung, verfahren zu ihrer herstellung und darin benutztes synthon
DE69232351D1 (de) Ribozymstruktur die von den genomischen rns des hepatitis delta virus abgeleitet ist
WO2001031025A3 (de) Formylglycinamidinribotid-synthase aus pflanzen
DK98691D0 (da) Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment