DK51092D0 - Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf - Google Patents

Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Info

Publication number
DK51092D0
DK51092D0 DK92510A DK51092A DK51092D0 DK 51092 D0 DK51092 D0 DK 51092D0 DK 92510 A DK92510 A DK 92510A DK 51092 A DK51092 A DK 51092A DK 51092 D0 DK51092 D0 DK 51092D0
Authority
DK
Denmark
Prior art keywords
synthones
monomeric
pen
procedures
preparing
Prior art date
Application number
DK92510A
Other languages
Danish (da)
English (en)
Inventor
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Rolf Henrik Berg
Original Assignee
Ole Buchardt
Michael Egholm
Peter Eigil Nielsen
Berg Rolf H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220741&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK51092(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK98791A external-priority patent/DK98791D0/da
Priority claimed from DK98691A external-priority patent/DK98691D0/da
Application filed by Ole Buchardt, Michael Egholm, Peter Eigil Nielsen, Berg Rolf H filed Critical Ole Buchardt
Priority to DK92510A priority Critical patent/DK51092D0/da
Publication of DK51092D0 publication Critical patent/DK51092D0/da
Priority to PCT/EP1992/001219 priority patent/WO1992020702A1/en
Priority to AT92923579T priority patent/ATE155483T1/de
Priority to HU9303023A priority patent/HU221003B1/hu
Priority to EP92923579A priority patent/EP0586618B1/en
Priority to AU18806/92A priority patent/AU666480B2/en
Priority to DE69220946T priority patent/DE69220946T2/de
Priority to CA002109805A priority patent/CA2109805A1/en
Priority to DK92923579.4T priority patent/DK0586618T3/da
Priority to PCT/EP1992/001220 priority patent/WO1992020703A1/en
Priority to US08/108,591 priority patent/US6395474B1/en
Priority to ES92911165T priority patent/ES2164052T3/es
Priority to DE69232055T priority patent/DE69232055T2/de
Priority to AT92911165T priority patent/ATE205504T1/de
Priority to EP03077836A priority patent/EP1411063B1/en
Priority to EP01203303A priority patent/EP1162206A3/en
Priority to EP92911165A priority patent/EP0586474B1/en
Priority to JP4510434A priority patent/JP2758988B2/ja
Priority to BR9206049A priority patent/BR9206049A/pt
Priority to CA002109320A priority patent/CA2109320C/en
Priority to EP00203148A priority patent/EP1074559B1/en
Priority to AU18843/92A priority patent/AU1884392A/en
Priority to DK92911165T priority patent/DK0586474T3/da
Priority to AT00203148T priority patent/ATE515569T1/de
Priority to US08/150,156 priority patent/US6357163B1/en
Priority to JP51013992A priority patent/JP3982828B2/ja
Priority to ES92923579T priority patent/ES2107552T3/es
Priority to NO19934122A priority patent/NO312516B1/no
Priority to KR93703558A priority patent/KR0133131B1/ko
Priority to FI935208A priority patent/FI118424B/fi
Priority to NO19934235A priority patent/NO313201B1/no
Priority to US08/275,951 priority patent/US6451968B1/en
Priority to US08/319,411 priority patent/US7223833B1/en
Priority to US08/366,231 priority patent/US5977296A/en
Priority to US08/462,977 priority patent/US6713602B1/en
Priority to US08/468,719 priority patent/US6710163B1/en
Priority to US08/765,798 priority patent/US6441130B1/en
Priority to US08/595,387 priority patent/US5773571A/en
Priority to US08/686,113 priority patent/US5766855A/en
Priority to US08/686,116 priority patent/US5714331A/en
Priority to US08/686,114 priority patent/US6414112B1/en
Priority to US08/847,095 priority patent/US5786461A/en
Priority to US08/847,108 priority patent/US5736336A/en
Priority to GR970402663T priority patent/GR3025018T3/el
Priority to US09/209,149 priority patent/US6201103B1/en
Priority to US09/337,304 priority patent/US6613873B1/en
Priority to US09/955,410 priority patent/US20020146718A1/en
Priority to US09/983,210 priority patent/US20020160383A1/en
Priority to US10/154,890 priority patent/US7378485B2/en
Priority to US10/188,404 priority patent/US20030105286A1/en
Priority to JP2003015384A priority patent/JP2003235590A/ja
Priority to US10/657,600 priority patent/US20040059087A1/en
Priority to US10/691,012 priority patent/US20060160731A1/en
Priority to US10/755,118 priority patent/US20050009041A1/en
Priority to US11/029,005 priority patent/US20060046255A1/en
Priority to JP2007147536A priority patent/JP2007306926A/ja
Priority to JP2008060342A priority patent/JP2008253251A/ja
Priority to JP2008258890A priority patent/JP2009069158A/ja
Priority to US13/190,164 priority patent/US20120115136A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK92510A 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf DK51092D0 (da)

Priority Applications (59)

Application Number Priority Date Filing Date Title
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
PCT/EP1992/001219 WO1992020702A1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
AT92923579T ATE155483T1 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
HU9303023A HU221003B1 (hu) 1991-05-24 1992-05-22 Peptid-nukleinsavak
EP92923579A EP0586618B1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
AU18806/92A AU666480B2 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
DE69220946T DE69220946T2 (de) 1991-05-24 1992-05-22 Verwendung von nukleinsäureanaloga in diagnostischen und analytischen verfahren
CA002109805A CA2109805A1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
PCT/EP1992/001220 WO1992020703A1 (en) 1991-05-24 1992-05-22 The use of nucleic acid analogues in diagnostics and analytical procedures
US08/108,591 US6395474B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
ES92911165T ES2164052T3 (es) 1991-05-24 1992-05-22 Acidos nucleicos de peptidos.
DE69232055T DE69232055T2 (de) 1991-05-24 1992-05-22 Peptidnukleinsäuren
AT92911165T ATE205504T1 (de) 1991-05-24 1992-05-22 Peptidnukleinsäuren
EP03077836A EP1411063B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP01203303A EP1162206A3 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP92911165A EP0586474B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
JP4510434A JP2758988B2 (ja) 1991-05-24 1992-05-22 ペプチド核酸
BR9206049A BR9206049A (pt) 1991-05-24 1992-05-22 Composto, processos para preparar o composto, para o reconhecimento específico por sequência de um polinucleotídio de filamento duplo, para modular a expressão de um gene em um organismo, para tratar as condições associadas com produção de proteínas indesejada em um organismo, para induzir a degradação de DNA ou RNA em células de um organismo e para exterminar células ou vírus e composição farmacêutica
CA002109320A CA2109320C (en) 1991-05-24 1992-05-22 Peptide nucleic acids
EP00203148A EP1074559B1 (en) 1991-05-24 1992-05-22 Peptide nucleic acids
AU18843/92A AU1884392A (en) 1991-05-24 1992-05-22 Peptide nucleic acids
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer
AT00203148T ATE515569T1 (de) 1991-05-24 1992-05-22 Peptidnucleinsäuren
US08/150,156 US6357163B1 (en) 1991-05-24 1992-05-22 Use of nucleic acid analogues in diagnostics and analytical procedures
JP51013992A JP3982828B2 (ja) 1991-05-24 1992-05-22 診断薬および分析方法における核酸類縁体の使用方法
ES92923579T ES2107552T3 (es) 1991-05-24 1992-05-22 Uso de analogos de acido nucleico en diagnosticos y procedimientos analiticos.
NO19934122A NO312516B1 (no) 1991-05-24 1993-11-15 Peptid-nukleinsyrer
KR93703558A KR0133131B1 (en) 1991-05-24 1993-11-20 Peptide nucleic acids
FI935208A FI118424B (fi) 1991-05-24 1993-11-23 Nukleiinihappoanalogit ja niiden käyttö diagnostisissa ja analyyttisissä toimenpiteissä
NO19934235A NO313201B1 (no) 1991-05-24 1993-11-23 Nukleinsyreanalog, anvendelse derav, in vitro-fremgangsmåte og kit
US08/275,951 US6451968B1 (en) 1991-05-24 1994-07-15 Peptide nucleic acids
US08/319,411 US7223833B1 (en) 1991-05-24 1994-10-06 Peptide nucleic acid conjugates
US08/366,231 US5977296A (en) 1991-05-24 1994-12-28 Chiral peptide nucleic acid monomers and oligomers
US08/462,977 US6713602B1 (en) 1991-05-24 1995-06-05 Synthetic procedures for peptide nucleic acids
US08/468,719 US6710163B1 (en) 1991-05-24 1995-06-06 Peptide nucleic acid synthons
US08/765,798 US6441130B1 (en) 1991-05-24 1995-07-13 Linked peptide nucleic acids
US08/595,387 US5773571A (en) 1991-05-24 1996-02-01 Peptide nucleic acids
US08/686,113 US5766855A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity and sequence specificity
US08/686,116 US5714331A (en) 1991-05-24 1996-07-24 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US08/686,114 US6414112B1 (en) 1991-05-24 1996-07-24 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US08/847,095 US5786461A (en) 1991-05-24 1997-05-01 Peptide nucleic acids having amino acid side chains
US08/847,108 US5736336A (en) 1991-05-24 1997-05-01 Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GR970402663T GR3025018T3 (en) 1991-05-24 1997-10-14 The use of nucleic acid analogues in diagnostics and analytical procedures
US09/209,149 US6201103B1 (en) 1991-05-24 1998-12-10 Peptide nucleic acid incorporating a chiral backbone
US09/337,304 US6613873B1 (en) 1991-05-24 1999-06-21 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US09/955,410 US20020146718A1 (en) 1991-05-24 2001-09-18 Peptide nucleic acids having 2,6-diaminopurine nucleobases
US09/983,210 US20020160383A1 (en) 1991-05-24 2001-10-23 Use of nucleic acid analogues in diagnostics and analytical procedures
US10/154,890 US7378485B2 (en) 1991-05-24 2002-05-23 Peptide nucleic acids with polyamide-containing backbones
US10/188,404 US20030105286A1 (en) 1991-05-24 2002-07-01 Linked peptide nucleic acids
JP2003015384A JP2003235590A (ja) 1991-05-24 2003-01-23 核酸類縁体並びに診断薬および分析方法におけるその使用方法
US10/657,600 US20040059087A1 (en) 1991-05-24 2003-09-08 Peptide nucleic acids
US10/691,012 US20060160731A1 (en) 1991-05-24 2003-10-22 Peptide nucleic acids
US10/755,118 US20050009041A1 (en) 1991-05-24 2004-01-09 Peptide nucleic acids and synthetic procedures therefor
US11/029,005 US20060046255A1 (en) 1991-05-24 2005-01-05 Use of nucleic acid analogues in diagnostics and analytical procedures
JP2007147536A JP2007306926A (ja) 1991-05-24 2007-06-01 核酸類縁体並びに診断薬および分析方法におけるその使用方法
JP2008060342A JP2008253251A (ja) 1991-05-24 2008-03-10 核酸類縁体並びに診断薬および分析方法におけるその使用方法
JP2008258890A JP2009069158A (ja) 1991-05-24 2008-10-03 核酸類縁体並びに診断薬および分析方法におけるその使用方法
US13/190,164 US20120115136A1 (en) 1991-05-24 2011-07-25 Pna diagnostic use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK98791A DK98791D0 (da) 1991-05-24 1991-05-24 Fremgangsmaade til sekvensspecifik genkendelse af et dobbeltstrenget polynucleotid
DK98691A DK98691D0 (da) 1991-05-24 1991-05-24 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Publications (1)

Publication Number Publication Date
DK51092D0 true DK51092D0 (da) 1992-04-15

Family

ID=27220741

Family Applications (3)

Application Number Title Priority Date Filing Date
DK92510A DK51092D0 (da) 1991-05-24 1992-04-15 Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK92923579.4T DK0586618T3 (da) 1991-05-24 1992-05-22 Anvendelse af nuklainsyreanaloger i diagnostiske og analytiske fremgangsmåder
DK92911165T DK0586474T3 (da) 1991-05-24 1992-05-22 Peptionukleinsyrer

Country Status (16)

Country Link
US (11) US6395474B1 (ja)
EP (5) EP1162206A3 (ja)
JP (6) JP2758988B2 (ja)
KR (1) KR0133131B1 (ja)
AT (3) ATE155483T1 (ja)
AU (2) AU666480B2 (ja)
BR (1) BR9206049A (ja)
CA (2) CA2109805A1 (ja)
DE (2) DE69232055T2 (ja)
DK (3) DK51092D0 (ja)
ES (2) ES2107552T3 (ja)
FI (1) FI118424B (ja)
GR (1) GR3025018T3 (ja)
HU (1) HU221003B1 (ja)
NO (2) NO312516B1 (ja)
WO (2) WO1992020702A1 (ja)

Families Citing this family (361)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852182A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5783682A (en) * 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) * 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6441130B1 (en) 1991-05-24 2002-08-27 Isis Pharmaceuticals, Inc. Linked peptide nucleic acids
US6713602B1 (en) 1991-05-24 2004-03-30 Ole Buchardt Synthetic procedures for peptide nucleic acids
US6414112B1 (en) 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US5714331A (en) * 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
AU3250093A (en) 1991-12-12 1993-07-19 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US6277603B1 (en) 1991-12-24 2001-08-21 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
ATE515510T1 (de) * 1991-12-24 2011-07-15 Isis Pharmaceuticals Inc Durch dna-abschnitte unterbrochene modifizierte oligonukleotide
US6033884A (en) * 1992-03-20 2000-03-07 Baylor College Of Medicine Nucleic acid transporter systems and methods of use
US6770738B1 (en) 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
GB9211979D0 (en) * 1992-06-05 1992-07-15 Buchard Ole Uses of nucleic acid analogues
US7825215B1 (en) * 1993-04-26 2010-11-02 Peter E. Nielsen Substituted nucleic acid mimics
US6350853B1 (en) 1993-04-26 2002-02-26 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
GB9311386D0 (en) * 1993-06-02 1993-07-21 Pna Diagnostics As Nucleic acid analogue assay procedures
AU7206794A (en) * 1993-06-11 1995-01-03 Isis Pharmaceuticals, Inc. Oligomers for modulating ras oncogene
AU7523794A (en) * 1993-08-09 1995-02-28 Isis Pharmaceuticals, Inc. Oligomers for modulating viral processes
US5527675A (en) * 1993-08-20 1996-06-18 Millipore Corporation Method for degradation and sequencing of polymers which sequentially eliminate terminal residues
DE4331011A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit C-Verzweigung für Therapie und Diagnostik
DE4331012A1 (de) * 1993-09-13 1995-03-16 Bayer Ag Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik
EP0720615B1 (en) * 1993-09-21 2000-07-26 Amersham Pharmacia Biotech UK Limited Elongation, amplification and sequence determination using a chimeric oligonucleotide
WO1998003542A1 (en) * 1996-07-24 1998-01-29 Buchardt, Dorte Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US6710164B1 (en) * 1993-11-22 2004-03-23 Peter E. Nielsen Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
GB2284208A (en) * 1993-11-25 1995-05-31 Pna Diagnostics As Nucleic acid analogues with a chelating functionality for metal ions
GB2284209A (en) 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
GB2285445A (en) * 1993-12-06 1995-07-12 Pna Diagnostics As Protecting nucleic acids and methods of analysis
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
WO1995017403A1 (en) * 1993-12-22 1995-06-29 Perseptive Biosystems, Inc. Guanine synthons for peptide nucleic acid synthesis and method for production
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DK145493D0 (da) * 1993-12-23 1993-12-23 Dako As Antistof
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
DE4408533A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer basenlabilen Amino-Schutzgruppe
DE4408531A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag PNA-Synthese unter Verwendung einer gegen schwache Säuren labilen Amino-Schutzgruppe
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
AU2369895A (en) * 1994-04-29 1995-11-29 Perseptive Biosystems, Inc. Activated esters of 1-phenylpyrazolin-5-one for labelling amine-functionalized molecules
EP0760008A1 (en) * 1994-05-19 1997-03-05 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
US5629152A (en) * 1994-08-01 1997-05-13 Isis Pharmaceuticals, Inc. Trisubstituted β-lactams and oligo β-lactamamides
DE4427980A1 (de) * 1994-08-08 1996-02-15 Bayer Ag Nukleinsäuren-bindende Oligomere für Therapie und Diagnostik
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
EP0804456B1 (en) * 1994-10-06 2002-08-21 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
US5629178A (en) * 1994-10-28 1997-05-13 Genetics & Ivf Institute Method for enhancing amplification in the polymerase chain reaction employing peptide nucleic acid (PNA)
UA48150C2 (uk) * 1994-11-02 2002-08-15 Ай-Сі-Ен Фармасьютикалз Похідні амінокислот або аміноспиртів, олігонуклеотид
AU4159396A (en) * 1994-11-14 1996-06-06 Chiron Corporation Synthesis of peptide nucleic acids (pnas) and analogues via submonomer approach
WO1996019587A2 (en) * 1994-12-22 1996-06-27 Abbott Laboratories Methods of immobilizing oligonucleotides to solid support materials and methods of using support bound oligonucleotides
US6475721B2 (en) * 1995-03-04 2002-11-05 Boston Probes, Inc. Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes
US7682786B1 (en) * 1995-03-04 2010-03-23 Oerum Henrik Modulation of the binding properties of nucleic acid binding partners
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
WO1996040709A1 (en) 1995-06-07 1996-12-19 Perseptive Biosystems, Inc. Pna-dna chimeras and pna synthons for their preparation
EP0830368A1 (en) 1995-06-07 1998-03-25 Genta Incorporated Novel carbamate-based cationic lipids
WO1996014341A1 (en) * 1995-06-22 1996-05-17 Dako A/S Monoclonal antibody capable of binding to pna/nucleic acid complexes
JPH11511642A (ja) * 1995-06-22 1999-10-12 ダコ アクティーゼルスカブ Ｐｎａ／核酸複合体に結合し得る組換え抗体
GB9519299D0 (en) * 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
EP1477572A3 (en) * 1995-10-06 2006-02-15 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
EP0854937B9 (en) * 1995-10-06 2006-06-28 Perseptive Biosystems, Inc. Methods and kit for hybridization analysis using peptide nucleic acid probes
ATE362546T1 (de) 1995-10-12 2007-06-15 Lansdorp Peter M Verfahren zum nachweis von mehrfachkopien einer wiederholungssequenz in einem nukleinsäuremolekül
US6001966A (en) * 1995-10-19 1999-12-14 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
US5874532A (en) * 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
AU7016096A (en) * 1995-10-20 1997-05-07 Trustees Of Boston University Nucleic acid clamps
US5888733A (en) * 1995-11-16 1999-03-30 Dako A/S In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples
JP4494529B2 (ja) * 1995-11-16 2010-06-30 ダコ デンマーク アクティーゼルスカブ 真核系サンプル中の特異的核酸配列を検出するためのｉｎ ｓｉｔｕハイブリダイゼーション
CA2190430A1 (en) * 1995-12-12 1997-06-13 Margret Barbara Basinski Method for measuring genetic messages
US6180767B1 (en) 1996-01-11 2001-01-30 Thomas Jefferson University Peptide nucleic acid conjugates
US20030069195A1 (en) * 1996-03-01 2003-04-10 Farrar Gwenyth Jane Suppression of polymorphic alleles
US6020126A (en) * 1996-03-21 2000-02-01 Hsc, Reasearch And Development Limited Partnership Rapid genetic screening method
EP0932698A1 (en) * 1996-03-26 1999-08-04 Lynx Therapeutics, Inc. Oligonucleotide treatments and compositions for human melanoma
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
US20040234999A1 (en) * 1996-04-02 2004-11-25 Farrar Gwenyth Jane Genetic suppression and replacement
US8551970B2 (en) * 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9608803D0 (en) * 1996-04-27 1996-07-03 Univ Newcastle Mitochondrial dna defects
SE506700C2 (sv) * 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20050042647A1 (en) * 1996-06-06 2005-02-24 Baker Brenda F. Phosphorous-linked oligomeric compounds and their use in gene modulation
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US20050032068A1 (en) * 2002-11-05 2005-02-10 Prakash Thazha P. Sugar and backbone-surrogate-containing oligomeric compounds and compositions for use in gene modulation
US9096636B2 (en) * 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US5858683A (en) * 1996-08-30 1999-01-12 Matritech, Inc. Methods and compositions for the detection of cervical cancer
DE19637339A1 (de) * 1996-09-13 1998-03-19 Hoechst Ag Verfahren zur Amplifikation von Nukleinsäuren
US5919638A (en) * 1996-10-08 1999-07-06 Abbott Laboratories Reagents and methods useful for detecting prostate tumors
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US6444202B1 (en) 1996-11-25 2002-09-03 Bundesrepublic Deutschland, Vertreten Durch Den Bundesminister Fur Gesundheit Processed polypeptides with IL-16 activity, processes for their production and their use
DE69826992T2 (de) * 1997-02-24 2005-10-20 Georgia Tech Research Corp. Verfahren zur bestimmung einer nukleinsäure
US6117973A (en) 1997-02-24 2000-09-12 Georgia Tech Research Corp. PNA monomers with electron donor or acceptor
US6692912B1 (en) * 1997-03-05 2004-02-17 Matrix Technologies Corporation Nucleic acid-containing polymerizable complex
US5932711A (en) * 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex
US6015887A (en) * 1997-04-11 2000-01-18 Isis Pharmaceuticals, Inc. Chiral peptide nucleic acids and methods for preparing same
SE522077C2 (sv) * 1997-09-05 2004-01-13 Lightup Technologies Ab Förfarande att välja sekvens hos sond för nukleinsyrahybridisering
US6617422B1 (en) 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
CA2291839A1 (en) * 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
DK0881228T3 (da) * 1997-05-30 2005-12-19 Pna Diagnostics As 2- eller 3-dimensionale geometriske strukturer af peptidnukleinsyrer
US5962665A (en) 1997-06-16 1999-10-05 Abbott Laboratories Nucleic acid primers and probes for detecting HIV-1 and HIV-2
WO1998058256A1 (en) * 1997-06-16 1998-12-23 The University Of North Carolina At Chapel Hill PEPTIDO OLIGONUCLEOTIDES (PONs) AND THEIR COMBINATORIAL LIBRARIES
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
EP0897991B1 (en) * 1997-08-22 2004-12-08 PNA Diagnostics ApS Small Triplex Forming PNA Oligos
US6300318B1 (en) 1997-09-16 2001-10-09 Peter E. Nielsen Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor
DE19741739B4 (de) * 1997-09-22 2006-04-27 Nanogen Recognomics Gmbh Supramolekulares Paarungssystem, dessen Herstellung und Verwendung
US6723560B2 (en) 1998-10-08 2004-04-20 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6989270B1 (en) 1997-10-17 2006-01-24 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response
US6007992A (en) * 1997-11-10 1999-12-28 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6028183A (en) * 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
DE19816550A1 (de) 1997-12-24 1999-06-24 Roche Diagnostics Gmbh Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung
US6030997A (en) * 1998-01-21 2000-02-29 Eilat; Eran Acid labile prodrugs
US6326479B1 (en) * 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6361942B1 (en) * 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
US20040063618A1 (en) * 2002-09-30 2004-04-01 Muthiah Manoharan Peptide nucleic acids having improved uptake and tissue distribution
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
DE19824900B4 (de) 1998-06-04 2006-05-04 Roche Diagnostics Gmbh DNA-Nachweis über einen Strangreassoziationskomplex
US6664045B1 (en) * 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
DE69933770D1 (de) 1998-07-09 2006-12-07 Biocept Inc Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
ATE314488T1 (de) * 1999-03-18 2006-01-15 Exiqon As Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
US20020049173A1 (en) * 1999-03-26 2002-04-25 Bennett C. Frank Alteration of cellular behavior by antisense modulation of mRNA processing
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
DE19927783A1 (de) * 1999-06-18 2000-12-21 Roche Diagnostics Gmbh Element zur Bestimmung eines Analyts in einer Flüssigkeit, entsprechendes Bestimmungsverfahren unter Verwendung des Elementes sowie Kit zur Bestimmugn eines Analyts
AU6629200A (en) * 1999-08-25 2001-03-19 Philip P Garner Alpha-helical peptide nucleic acid alpha-pna
JP4202646B2 (ja) 1999-08-30 2008-12-24 ロッシュ ディアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング ２−アザプリン化合物及びその使用
US6348583B1 (en) * 1999-08-30 2002-02-19 Bio-Rad Laboratories, Inc. Poly(ether-thioether), poly(ether-sulfoxide) and poly(ether-sulfone) nucleic acids
CA2317179A1 (en) 1999-09-01 2001-03-01 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
US6660845B1 (en) * 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
JP2003530146A (ja) 2000-02-10 2003-10-14 マサチューセッツ・アイ・アンド・イア・インファーマリー 眼の状態を処置するための光力学的治療
US20040014644A1 (en) * 2000-03-14 2004-01-22 Vladimir Efimov Oligonucleotide analogues and methods of use for modulating gene expression
US6962906B2 (en) 2000-03-14 2005-11-08 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
CA2402319A1 (en) * 2000-03-14 2001-09-20 Active Motif Oligonucleotide analogues, methods of synthesis and methods of use
US6936443B2 (en) 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
EP1294939B1 (en) 2000-04-03 2010-01-27 Cytyc Corporation Detection and typing of human papillomavirus using pna probes
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
DE10019136A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
ES2300346T3 (es) 2000-08-03 2008-06-16 F. Hoffmann-La Roche Ag Compuestos de enlace de acidos nucleicos que contienen analogos de pirazolo-3,4-d pirimidina de purina 2,6-diamina y sus usos.
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
EP2359854B1 (en) 2000-08-08 2013-10-09 Technion Research and Development Foundation, Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis
US7183394B1 (en) * 2000-08-11 2007-02-27 Garner Philip P Helical nucleopeptides
EP1416972B1 (en) * 2000-11-09 2012-02-08 Cold Spring Harbor Laboratory Chimeric molecules to modulate gene expression
WO2002051797A1 (fr) * 2000-12-26 2002-07-04 Applied Biosystems Japan Ltd Nouveau monomere d'acide nucleique peptidique fonctionnel et procede de production correspondant
ATE465739T1 (de) 2001-01-29 2010-05-15 Bio Rad Laboratories Nukleinsäurederivative
GB0102388D0 (en) * 2001-01-31 2001-03-14 Secr Defence Polymers
EP1236804A1 (en) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh A method for determination of a nucleic acid using a control
WO2002072865A2 (en) 2001-03-09 2002-09-19 Boston Probes, Inc. Methods, kits and compositions of combination oligomers
CA2444133A1 (en) 2001-04-16 2002-10-24 Wyeth Holdings Corporation Novel streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof
EP1417333B1 (en) 2001-05-18 2011-10-05 Boston Probes, Inc. Pna probes, probe sets, methods and kits pertaining to the detection of candida
US20030207804A1 (en) * 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
EP1925672A1 (en) 2001-06-22 2008-05-28 Syngeta Participations AG Abiotic stress responsive polynucleotides and polypeptides
US6921812B1 (en) 2001-07-03 2005-07-26 Isis Pharmaceuticals, Inc. Methods of modulating pharmacokinetics of oligonucleotides
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030129626A1 (en) * 2001-09-24 2003-07-10 Nielsen Kirsten Vang Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid
WO2003040395A2 (en) 2001-11-07 2003-05-15 Applera Corporation Universal nucleotides for nucleic acid analysis
CN100360722C (zh) 2001-11-21 2008-01-09 艾普勒拉公司 数字化分析
KR100464261B1 (ko) 2002-01-24 2005-01-03 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US20040018506A1 (en) 2002-01-25 2004-01-29 Koehler Ryan T. Methods for placing, accepting, and filling orders for products and services
CA2479594A1 (en) * 2002-03-21 2003-10-02 Boston Probes, Inc. Pna oligomers, oligomer sets, methods and kits pertaining to the detection of bacillus anthracis
US20030211509A1 (en) * 2002-03-26 2003-11-13 Wiley Steven R. TNF-delta ligand and uses thereof
US7052840B2 (en) 2002-04-03 2006-05-30 Capitol Genomix, Inc. Reversible association of nucleic acid with a carboxylated substrate
US7026120B2 (en) 2002-04-15 2006-04-11 Abbott Laboratories Probes for detecting tumor cells
KR20030084444A (ko) 2002-04-26 2003-11-01 주식회사 파나진 Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법
US7015317B2 (en) 2002-05-02 2006-03-21 Abbott Laboratories Polynucleotides for the detection and quantification of hepatitis B virus nucleic acids
AU2003239432A1 (en) * 2002-05-17 2003-12-12 Applera Corporation Pna probes, probe sets, method and kits pertaining to the determination of listeria
US20030220844A1 (en) * 2002-05-24 2003-11-27 Marnellos Georgios E. Method and system for purchasing genetic data
JP4588451B2 (ja) 2002-09-08 2010-12-01 アプライド バイオシステムズ， エルエルシー Ｐｎａダイマーおよびｐｎａオリゴマー合成に関する方法、組成物およびライブラリー
CA2502610A1 (en) * 2002-10-16 2005-01-13 Board Of Regents Of The University Of Texas System Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries
US20060183106A1 (en) * 2002-10-18 2006-08-17 Adam Siddiqui-Jain Processes for identifying quadruplex-targeted antiviral molecules
US7696345B2 (en) * 2002-11-05 2010-04-13 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
AU2003291755A1 (en) 2002-11-05 2004-06-07 Isis Pharmaceuticals, Inc. Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US9150606B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
SI1576138T1 (sl) 2002-11-15 2017-07-31 Idenix Pharmaceuticals Llc 2'-metil nukleozidi v kombinaciji z interferon in flaviviridae mutacijo
WO2004048594A2 (en) * 2002-11-21 2004-06-10 Epicentre Technologies Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
US20040259132A1 (en) * 2002-11-22 2004-12-23 Henrik Stender Peptide nucleic acid probes for analysis of pseudomonas (sensu stricto)
EP2112229A3 (en) 2002-11-25 2009-12-02 Sequenom, Inc. Methods for identifying risk of breast cancer and treatments thereof
US7736909B2 (en) 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
WO2004070352A2 (en) * 2003-01-30 2004-08-19 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
AU2003900609A0 (en) * 2003-02-11 2003-02-27 Antisense Therapeutics Ltd Modulation of insulin like growth factor i receptor expression
CA2515484C (en) * 2003-02-11 2011-09-20 Antisense Therapeutics Ltd Modulation of insulin like growth factor i receptor expression
JP4255472B2 (ja) 2003-02-21 2009-04-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 変異遺伝子検出のためのシグナル増幅方法
DE602004030114D1 (de) * 2003-05-20 2010-12-30 Investigen Inc System zum nachweis von polynukleotiden
WO2005012546A2 (en) * 2003-07-25 2005-02-10 Andreas Braun Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences
WO2005010181A1 (ja) * 2003-07-25 2005-02-03 Credia Japan Co., Ltd. 核酸検出方法
WO2005016364A1 (en) * 2003-08-14 2005-02-24 Guthy-Renker Corporation Skin care composition including hexapeptide complexes and methods of their manufacture
US20060198800A1 (en) * 2003-08-14 2006-09-07 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture
US20050095627A1 (en) * 2003-09-03 2005-05-05 The Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
DE602005027809D1 (de) 2004-01-07 2011-06-16 Hitachi Chemical Co Ltd Primer und sonden zum nachweis von hiv
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
EP2161346B1 (en) 2004-03-24 2013-06-19 Applied Biosystems, LLC Ligation and amplification reactions for determining target molecules
US7745124B2 (en) 2004-04-28 2010-06-29 Eisai R&D Management Co., Ltd. Hybridization method
WO2005111235A2 (en) * 2004-05-04 2005-11-24 Dak Denmark A/S Methods for detecting chromosome aberrations
CA2568735A1 (en) * 2004-06-03 2005-12-22 Isis Pharmaceuticals, Inc. Double strand compositions comprising differentially modified strands for use in gene modulation
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
EP1776482A2 (en) 2004-06-30 2007-04-25 Applera Corporation Log-linear amplification
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US7306785B2 (en) * 2004-09-23 2007-12-11 General Electric Company Multifunctional cross-bridged tetraaza macrocyclic compounds and methods of making and using
EP1836317A2 (en) * 2004-12-06 2007-09-26 BioVeris Corporation Methods and compositions for detecting bacillus anthracis
BRPI0515777A (pt) * 2004-12-11 2008-08-05 Cytogenix Inc biossìntese isenta de células de ácido nucléico de alta qualidade e usos dos mesmos
AU2006204006A1 (en) 2005-01-06 2006-07-13 Applera Corporation Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
US20060257902A1 (en) 2005-03-25 2006-11-16 Ambion, Inc. Methods and compositions for depleting abundant RNA transcripts
US7229769B2 (en) * 2005-03-25 2007-06-12 Illumina, Inc. Compositions and methods for detecting protease activity
US20090246758A1 (en) 2005-06-02 2009-10-01 Advandx, Inc. Peptide nucleic acid probes for analysis of microorganisms
CA3027954C (en) 2005-06-07 2021-11-02 Luminex Corporation Methods for detection and typing of nucleic acids
WO2007045998A2 (en) 2005-07-01 2007-04-26 Dako Denmark A/S New nucleic acid base pairs
US20070059713A1 (en) 2005-09-09 2007-03-15 Lee Jun E SSB-DNA polymerase fusion proteins
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
WO2007073149A1 (en) 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
US8021839B2 (en) * 2006-02-24 2011-09-20 Investigen, Inc. Methods and compositions for detecting polynucleotides
JPWO2007108378A1 (ja) 2006-03-15 2009-08-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 シグナルプローブポリマーの形成方法
WO2007133703A2 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
US20100196336A1 (en) 2006-05-23 2010-08-05 Dongsu Park Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
JP2009543058A (ja) 2006-06-30 2009-12-03 アプライド バイオシステムズ， エルエルシー 結合相互作用を分析する方法
CN101558167A (zh) 2006-08-01 2009-10-14 应用生物系统有限公司 分析物和核酸的检测
US20080096193A1 (en) * 2006-10-24 2008-04-24 Charles Robert Bupp Methods and compositions for detecting polynucleotides
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
US8324359B1 (en) 2006-12-04 2012-12-04 Luminex Corporation Oxocarbonamide peptide nucleic acids and methods of using same
EP2857526B1 (en) 2006-12-13 2016-08-17 Luminex Corporation Systems and methods for multiplex analysis of PCR in real time
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
JP2010514450A (ja) * 2006-12-29 2010-05-06 アプライド バイオシステムズ インコーポレイテッド 核酸検出方法及びシステム
EP2118310B1 (en) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systems and methods for detecting nucleic acids
US7803543B2 (en) 2007-01-19 2010-09-28 Chang Gung University Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both PCR clamp and sensor probe
US9260476B2 (en) 2007-02-23 2016-02-16 The Research Foundation For The State University Of New York RNA targeting compounds and methods for making and using same
DK2591795T3 (en) * 2007-02-23 2018-05-07 Univ New York State Res Found RNA TARGETING COMPOUNDS AND PROCEDURES FOR PREPARING AND USING THE SAME
WO2008103702A2 (en) * 2007-02-23 2008-08-28 Investigen, Inc. Methods and compositions for rapid light-activated isolation and detection of analytes
EP2514838B1 (en) 2007-04-13 2017-12-06 Abbott Molecular Inc. Primer and probe sequences for detecting chlamydia trachomatis
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
WO2009003493A2 (en) 2007-07-03 2009-01-08 Dako Denmark A/S Mhc multimers, methods for their generation, labeling and use
IL184627A0 (en) 2007-07-15 2008-12-29 Technion Res & Dev Foundation Agents for diagnosing and modulating metastasis and fibrosis as well as inflammation in a mammalian tissue
CN105622756B (zh) 2007-08-02 2020-07-28 吉利德生物制剂公司 Lox和loxl2抑制剂及其应用
KR20100085923A (ko) 2007-10-24 2010-07-29 에자이 알앤드디 매니지먼트 가부시키가이샤 핵산프로브 및 프로브폴리머의 형성방법
WO2009057702A1 (ja) 2007-10-31 2009-05-07 Eisai R & D Management Co., Ltd. 標的物質検出用ポリマー及び標的物質の検出方法
US8017338B2 (en) 2007-11-20 2011-09-13 Life Technologies Corporation Reversible di-nucleotide terminator sequencing
USRE47320E1 (en) 2007-11-20 2019-03-26 Ionis Pharmaceuticals, Inc. Modulation of CD40 expression
MX2010007530A (es) 2008-01-10 2010-11-10 Res Dev Foundation Vacunas y diagnosticos para ehrlichiosis.
WO2009091934A1 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes and compositions
KR101072899B1 (ko) * 2008-01-21 2011-10-17 주식회사 파나진 아미노산 스페이서가 결합된 펩티드 핵산의 합성 및 그의응용
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
JP5592357B2 (ja) * 2008-05-27 2014-09-17 ダコ・デンマーク・エー／エス 新規なハイブリダイゼーションバッファーを用いた染色体異常の検出のための組成物及び方法
CN102066561B (zh) 2008-06-13 2013-09-25 科德克希思公司 合成多核苷酸变体的方法
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
KR20110059743A (ko) 2008-09-03 2011-06-03 난양 테크놀러지컬 유니버시티 펩티드 핵산 단량체 및 올리고머
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP2340310B1 (en) 2008-09-22 2015-06-03 RXi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
EP2342334A4 (en) 2008-09-29 2012-03-14 Univ Pennsylvania TARGETED VACCINES ON A TUMOR VASCULAR MARKER
JP2012505644A (ja) 2008-10-15 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー オリゴヌクレオチド検出法
US20100135904A1 (en) 2008-11-07 2010-06-03 Research Development Foundation Compositions and methods for the inhibition of cripto / grp78 complex formation and signaling
US8715732B2 (en) * 2009-01-05 2014-05-06 Cornell University Nucleic acid hydrogel via rolling circle amplification
WO2010080769A2 (en) 2009-01-06 2010-07-15 Arresto Biosciences, Inc. Chemotherapeutic methods and compositions
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
US7964355B2 (en) 2009-02-17 2011-06-21 Investigen, Inc. Assays based on detection of photobleaching reaction products from dye catalytic complex
WO2010097655A1 (en) 2009-02-26 2010-09-02 Dako Denmark A/S Compositions and methods for rna hybridization applications
US8063193B2 (en) 2009-03-27 2011-11-22 Abbott Laboratories Nucleotide and amino acid sequences encoding an exported protein 1 derived from Plasmodium vivax and uses thereof
CA2757300C (en) 2009-04-01 2018-01-09 Dxterity Diagnostics Incorporated Chemical ligation dependent probe amplification (clpa)
US20100297127A1 (en) 2009-04-08 2010-11-25 Ghilardi Nico P Use of il-27 antagonists to treat lupus
JP5828837B2 (ja) 2009-06-02 2015-12-09 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 神経変性疾患を有する被験者において抗体により認識される小分子の同定
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
US8614081B2 (en) 2009-07-23 2013-12-24 Codexis, Inc. Nitrilase biocatalysts
WO2011017315A2 (en) * 2009-08-03 2011-02-10 Recombinetics, Inc. Methods and compositions for targeted gene modification
RU2012110585A (ru) 2009-08-21 2013-09-27 Джилид Байолоджикс, Инк. Каталичические домены лизилоксидазы и loxl2
TW201124726A (en) 2009-10-16 2011-07-16 Univ Texas Compositions and methods for producing coded peptoid libraries
CA2781907C (en) 2009-12-02 2019-07-16 Dako Denmark A/S Compositions and methods for performing hybridizations with no denaturation
WO2011087789A2 (en) 2009-12-22 2011-07-21 Becton, Dickinson And Company Methods for the detection of microorganisms
EP3660165B1 (en) 2009-12-22 2023-01-04 Sequenom, Inc. Processes and kits for identifying aneuploidy
WO2011119852A1 (en) 2010-03-24 2011-09-29 Rxi Pharmaceuticals Corporation Reduced size self-delivering rnai compounds
WO2011133931A1 (en) 2010-04-22 2011-10-27 Genentech, Inc. Use of il-27 antagonists for treating inflammatory bowel disease
WO2012096430A1 (en) 2011-01-11 2012-07-19 Seegene, Inc. Detection of target nucleic acid sequences by pto cleavage and extension assay
JP5852222B2 (ja) 2011-03-29 2016-02-03 シージーン アイエヌシー Ｐｔｏ切断及び延長−依存的切断によるターゲット核酸配列の検出
CA2832553A1 (en) 2011-04-08 2012-10-11 Srinivas RAPIREDDY Conformationally-preorganized, minipeg-containing gamma-peptide nucleic acids
EP3378954B1 (en) 2011-04-29 2021-02-17 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012150749A1 (en) 2011-05-04 2012-11-08 Seegene, Inc. Detection of target nucleic acid sequences by po cleavage and hybridization
JP2014513557A (ja) 2011-05-17 2014-06-05 ディクステリティー ダイアグノスティクス インコーポレイテッド 標的核酸を検出する方法及び組成物
EP2761028A1 (en) 2011-09-30 2014-08-06 Dako Denmark A/S Hybridization compositions and methods using formamide
GB201117482D0 (en) 2011-10-11 2011-11-23 Univ Dundee Targetiing of miRNA precursors
WO2013057310A2 (en) 2011-10-21 2013-04-25 Dako Denmark A/S Hybridization compositions and methods
EP2594942A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Long rigid spacers to enhance binding kinetics in immunoassays
JPWO2013085026A1 (ja) 2011-12-09 2015-04-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 塩基変異の検出方法及び検出用キット
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2013228226B2 (en) 2012-03-05 2016-06-02 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by PTO cleavage and extension assay
US20150299788A1 (en) 2012-05-15 2015-10-22 Eisai R&D Management Co., Ltd. Rna detection method and detection kit
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
WO2013177191A1 (en) 2012-05-21 2013-11-28 The Scripps Research Institute Ribosomal polynucleotides and related expression systems
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
CA2878979C (en) 2012-07-13 2021-09-14 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014033314A1 (en) 2012-09-03 2014-03-06 Uab Bioseka Antisense oligonucleotide targeting bacterial glucosyltransferases
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
WO2014093291A1 (en) 2012-12-10 2014-06-19 Advandx, Inc. Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
ES2662825T3 (es) 2013-02-25 2018-04-09 Seegene, Inc. Detección de variación de nucleótido en una secuencia de ácidos nucleicos diana
US9289502B2 (en) 2013-03-08 2016-03-22 Emerald Therapeutics, Inc. Preparation of oligo conjugates
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
KR101943623B1 (ko) 2013-03-13 2019-01-30 주식회사 씨젠 멜팅 피크 분석을 이용한 타겟 핵산서열의 정량
CN105026580A (zh) 2013-03-15 2015-11-04 雅培分子公司 重亚硫酸盐转化的核苷酸序列的检测
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
US10370415B2 (en) 2013-04-11 2019-08-06 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US10221216B2 (en) 2013-04-11 2019-03-05 Carnegie Mellon University Template-directed γPNA synthesis process and γPNA targeting compounds
SG11201508999UA (en) 2013-07-12 2015-11-27 Emd Millipore Corp A method of determining virus removal from a sample containing a target protein using activated carbon
KR101863943B1 (ko) 2013-07-15 2018-06-01 주식회사 씨젠 Ｐｔｏ 절단 및 연장-의존적 고정화 올리고뉴클레오타이드 혼성화를 이용한 타겟 핵산 서열의 검출
LT6214B (lt) 2013-10-07 2015-08-25 Uab "Bioseka" Priešprasminiai oligonukleotidai aterosklerozės ir kardiovaskulinių infekcijų prevencijai
JP2016537965A (ja) 2013-10-11 2016-12-08 ジェネンテック， インコーポレイテッド Ｎｓｐ４阻害剤及び使用方法
US10159652B2 (en) 2013-10-16 2018-12-25 The University Of British Columbia Device for formulating particles at small volumes
CN105705657B (zh) 2013-10-18 2020-07-28 Seegene株式会社 基于利用杂交-捕捉和模板化寡核苷酸的探测和标记寡核苷酸切割及延伸分析的在固相中的靶核酸序列检测
CA2929555A1 (en) 2013-11-08 2015-05-14 Baylor Research Institute Nuclear localization of glp-1 stimulates myocardial regeneration and reverses heart failure
CA2940526A1 (en) 2014-01-28 2015-08-06 Dice Molecules Sv, Llc Monoliths with attached recognition compounds, arrays thereof and uses thereof
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10851407B2 (en) 2014-05-08 2020-12-01 Carnegie Mellon University Left-handed gamma-peptide nucleic acids, methods of synthesis and uses therefor
EP3154696B1 (en) 2014-06-10 2020-04-08 DxTerity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
US9909187B2 (en) 2014-06-24 2018-03-06 Abbott Molecular Inc. Detection of single nucleotide polymorphisms in human KRAS
BR112017001500A2 (pt) 2014-07-24 2018-02-20 Abbott Molecular Inc composições e métodos para a detecção e análise de tuberculose por micobactéria
EP3633047B1 (en) 2014-08-19 2022-12-28 Pacific Biosciences of California, Inc. Method of sequencing nucleic acids based on an enrichment of nucleic acids
WO2016134293A1 (en) 2015-02-20 2016-08-25 Baylor College Of Medicine p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE
JP7497953B2 (ja) 2015-06-12 2024-06-11 アレクトル エルエルシー 抗ｃｄ３３抗体及びその使用方法
CN116063499A (zh) 2015-06-12 2023-05-05 艾利妥 抗cd33抗体及其使用方法
CA2992565A1 (en) 2015-07-14 2017-01-19 Abbott Molecular Inc. Compositions and methods for identifying drug resistant tuberculosis
CA2996059A1 (en) 2015-08-28 2017-03-09 Alector Llc Anti-siglec-7 antibodies and methods of use thereof
US11046999B2 (en) 2015-09-16 2021-06-29 PetaOmics, Inc. Methods and compositions for genomic target enrichment and selective DNA sequencing
EP3359573B1 (en) 2015-10-01 2023-01-04 The Whitehead Institute for Biomedical Research Labeling of antibodies
MX2018004637A (es) 2015-10-14 2019-05-06 Bio Path Holdings Inc Ácidos nucleicos p-etoxi para formulacion liposomal.
JP7011830B2 (ja) 2015-10-14 2022-01-27 エックス－サーマ インコーポレイテッド 氷晶形成を低減するための組成物および方法
KR20180084817A (ko) 2015-10-29 2018-07-25 알렉터 엘엘씨 항-siglec-9 항체 및 이의 이용 방법
WO2017117647A1 (en) 2016-01-06 2017-07-13 The University Of British Columbia Bifurcating mixers and methods of their use and manufacture
WO2017168348A1 (en) 2016-03-31 2017-10-05 Baylor Research Institute Angiopoietin-like protein 8 (angptl8)
US10400274B2 (en) 2016-06-18 2019-09-03 Jan Biotech, Inc. Fluorogenic probes and their use in quantitative detection of target RNA sequences
US10300145B2 (en) 2016-07-15 2019-05-28 Massachusetts Institute Of Technology Synthetic nanoparticles for delivery of immunomodulatory compounds
JP7132911B2 (ja) 2016-09-16 2022-09-07 バイオ－パス ホールディングス， インコーポレイテッド リポソームアンチセンスオリゴヌクレオチドとの併用療法
CA3076694A1 (en) 2016-09-26 2018-03-29 Carnegie Mellon University Divalent nucleobase compounds and uses therefor
US11147249B2 (en) 2016-12-08 2021-10-19 Alector Llc Siglec transgenic mice and methods of use thereof
WO2018213316A1 (en) 2017-05-16 2018-11-22 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
WO2018218250A2 (en) 2017-05-26 2018-11-29 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
KR20200033798A (ko) 2017-08-03 2020-03-30 알렉터 엘엘씨 항-cd33 항체 및 이의 이용 방법
KR102380264B1 (ko) 2017-08-31 2022-03-29 주식회사 씨젠 다이머-형성 프라이머 쌍을 이용한 구성요소의 성능 평가
WO2019066461A2 (en) 2017-09-29 2019-04-04 Seegene, Inc. DETECTION OF TARGET NUCLEIC ACID SEQUENCES BY CLEAVAGE ANALYSIS AND EXTENSION OF PTO
US11470827B2 (en) 2017-12-12 2022-10-18 Alector Llc Transgenic mice expressing human TREM proteins and methods of use thereof
WO2019126646A1 (en) * 2017-12-21 2019-06-27 Carnegie Mellon University Template-directed nucleic acid targeting compounds
AU2019310597A1 (en) 2018-07-27 2021-03-11 Alector Llc Anti-siglec-5 antibodies and methods of use thereof
WO2020061591A1 (en) 2018-09-21 2020-03-26 President And Fellows Of Harvard College Methods and compositions for treating diabetes, and methods for enriching mrna coding for secreted proteins
US20220251567A1 (en) 2019-07-10 2022-08-11 Inserm (Institut National De La Santè Et De La Recherche Médicale) Methods for the treatment of epilepsy
EP4061943A1 (en) 2019-11-19 2022-09-28 Institut National de la Santé et de la Recherche Médicale (INSERM) Antisense oligonucleotides and their use for the treatment of cancer
WO2021243271A2 (en) 2020-05-29 2021-12-02 Front Range Biosciences, Inc. Methods and compositions for pathogen detection in plants
US20230002779A1 (en) 2020-06-29 2023-01-05 Front Range Biosciences, Inc. Characterization of plant cultivars based on terpene synthase gene profiles
WO2022011262A1 (en) 2020-07-10 2022-01-13 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating epilepsy
CA3218220A1 (en) * 2021-05-11 2022-11-17 Russell Lewis Mccurdy Replaceable floating attractant accessories for fishing line
KR20240058112A (ko) 2021-09-17 2024-05-03 주식회사 씨젠 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
CN114409890A (zh) * 2022-02-28 2022-04-29 中国科学院长春应用化学研究所 一种氨基功能化的聚乙二醇衍生物及其制备方法
WO2024017990A1 (en) 2022-07-21 2024-01-25 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders
WO2024146935A1 (en) 2023-01-06 2024-07-11 Institut National de la Santé et de la Recherche Médicale Intravenous administration of antisense oligonucleotides for the treatment of pain

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2910130A1 (de) 1979-03-15 1980-09-25 Franz Rossmoeller Verbesserte befestigungsvorrichtung zum aufhaengen von paneelen und moebelelementen
DE2910129C2 (de) 1979-03-15 1986-01-23 Oskar 4354 Datteln Fleck Leiste zum Abdichten des Zwischenraums zwischen der Trauflatte eines Daches und den darüberliegenden traufseitigen Dacheindeckungsplatten
JPS5927900A (ja) 1982-08-09 1984-02-14 Wakunaga Seiyaku Kk 固定化オリゴヌクレオチド
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
DE3650349T2 (de) * 1985-03-15 1995-12-14 Antivirals Inc Immunotestmittel für polynukleotid und verfahren.
ATE192465T1 (de) 1987-10-28 2000-05-15 Florey Howard Inst Oligonucleotid-polyamid konjugate
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
DE68914843T2 (de) 1988-09-01 1994-11-10 Risoe Forskningscenter Peptid-synthese und fester träger zur verwendung dabei.
JPH02156895A (ja) * 1988-12-08 1990-06-15 Sumitomo Heavy Ind Ltd 好塩菌による５’‐ヌクレオチド類の製造法
JPH0635469B2 (ja) * 1989-09-13 1994-05-11 信 高橋 ジエチレントリアミン三酢酸化合物及びその製造中間体並びにそれらの製造法
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5539082A (en) * 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US6414112B1 (en) * 1991-05-24 2002-07-02 Ole Buchardt Peptide nucleic acids having 2,6-diaminopurine nucleobases
US6451968B1 (en) * 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
DK51092D0 (da) 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
US6228982B1 (en) * 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
MX9207334A (es) 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
US6770738B1 (en) * 1992-05-22 2004-08-03 Isis Pharmaceuticals, Inc. Higher order structure and binding of peptide nucleic acids
WO1993024507A1 (en) * 1992-05-28 1993-12-09 Gilead Sciences, Inc. Conformationally restrained oligomers containing amide or carbamate linkages for sequence-specific binding
US5705333A (en) * 1994-08-05 1998-01-06 The Regents Of The University Of California Peptide-based nucleic acid mimics(PENAMS)
US6472209B1 (en) * 1997-10-17 2002-10-29 Mayo Foundation For Medical Education And Research Using polyamide nucleic acid oligomers to engender a biological response

Also Published As

Publication number Publication date
DK0586474T3 (da) 2001-12-31
NO934122L (no) 1994-01-11
JP2758988B2 (ja) 1998-05-28
HUT66597A (en) 1994-12-28
JPH06509063A (ja) 1994-10-13
FI118424B (fi) 2007-11-15
NO312516B1 (no) 2002-05-21
US20030180734A1 (en) 2003-09-25
EP0586474B1 (en) 2001-09-12
JP2007306926A (ja) 2007-11-29
JP3982828B2 (ja) 2007-09-26
GR3025018T3 (en) 1998-01-30
EP0586618A1 (en) 1994-03-16
NO313201B1 (no) 2002-08-26
EP0586474A1 (en) 1994-03-16
BR9206049A (pt) 1994-12-27
CA2109805A1 (en) 1992-11-26
ATE205504T1 (de) 2001-09-15
EP1411063B1 (en) 2006-07-19
AU1884392A (en) 1992-12-30
US20060160731A1 (en) 2006-07-20
AU1880692A (en) 1992-12-30
US6357163B1 (en) 2002-03-19
JPH06506945A (ja) 1994-08-04
AU666480B2 (en) 1996-02-15
ES2107552T3 (es) 1997-12-01
FI935208A (fi) 1993-11-23
US20120115136A1 (en) 2012-05-10
US20020160383A1 (en) 2002-10-31
JP2009069158A (ja) 2009-04-02
US6710163B1 (en) 2004-03-23
CA2109320A1 (en) 1992-11-25
US20060046255A1 (en) 2006-03-02
EP1411063A1 (en) 2004-04-21
JP2003235590A (ja) 2003-08-26
NO934235D0 (no) 1993-11-23
FI935208A0 (fi) 1993-11-23
US7378485B2 (en) 2008-05-27
WO1992020703A1 (en) 1992-11-26
DE69232055D1 (de) 2001-10-18
EP1074559B1 (en) 2011-07-06
NO934235L (no) 1994-01-20
NO934122D0 (no) 1993-11-15
EP1162206A2 (en) 2001-12-12
KR0133131B1 (en) 1998-04-14
DE69220946T2 (de) 1998-01-15
ATE515569T1 (de) 2011-07-15
ES2164052T3 (es) 2002-02-16
EP0586618B1 (en) 1997-07-16
DK0586618T3 (da) 1998-02-09
US6395474B1 (en) 2002-05-28
DE69232055T2 (de) 2002-06-06
EP1074559A1 (en) 2001-02-07
CA2109320C (en) 2003-07-22
HU9303023D0 (en) 1994-01-28
ATE155483T1 (de) 1997-08-15
US5977296A (en) 1999-11-02
WO1992020702A1 (en) 1992-11-26
US20040059087A1 (en) 2004-03-25
EP1162206A3 (en) 2004-04-14
DE69220946D1 (de) 1997-08-21
JP2008253251A (ja) 2008-10-23
HU221003B1 (hu) 2002-07-29
US6201103B1 (en) 2001-03-13

Similar Documents

Publication Publication Date Title
DK51092D0 (da) Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
EP1310507A3 (en) Novel peptide nucleic acids
DE69431485D1 (de) Doppelsträngige peptidenukleinsäuren
ATE239090T1 (de) Methode zum generieren von einzelsträngigen dna molekülen
PT92640A (pt) Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules by forming a colinear triplex the synthetic oligonucleotides and methods of use
ATE222589T1 (de) Peptid-nukleinsäure-konjugate
ATE236269T1 (de) Ein elektrochemiluminescenter nachweis von nukleinsäuren auf basis der selbsttragenden sequenzreplikation
NO972868L (no) Oligonukleotid-dendrimer konjugater
EP0002322A3 (en) Improved triester process for the synthesis of oligonucleotides
FR2744455B1 (fr) Nouvelles sequences d'acides nucleiques de la famille des facteurs suppresseurs de tumeurs, produits d'expression correspondants et leurs applications
DK0840802T3 (da) Fremgangsmåde til sekvensering gennem oligomerhybridisering
ATE212057T1 (de) Ribozymstruktur die von den genomischen rns des hepatitis delta virus abgeleitet ist
WO2001031025A3 (de) Formylglycinamidinribotid-synthase aus pflanzen
DK98691D0 (da) Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment