DK2319928T3 - Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet - Google Patents

Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet

Info

Publication number
DK2319928T3
DK2319928T3 DK10011689T DK10011689T DK2319928T3 DK 2319928 T3 DK2319928 T3 DK 2319928T3 DK 10011689 T DK10011689 T DK 10011689T DK 10011689 T DK10011689 T DK 10011689T DK 2319928 T3 DK2319928 T3 DK 2319928T3
Authority
DK
Denmark
Prior art keywords
thrombopoietic
peptidomimetics
dimeric
bind
activity
Prior art date
Application number
DK10011689T
Other languages
Danish (da)
English (en)
Inventor
Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Application granted granted Critical
Publication of DK2319928T3 publication Critical patent/DK2319928T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK10011689T 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet DK2319928T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
EP20060022333 EP1783222B1 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to MPL receptor and having thrombopoietic activity.

Publications (1)

Publication Number Publication Date
DK2319928T3 true DK2319928T3 (da) 2013-06-24

Family

ID=22305310

Family Applications (3)

Application Number Title Priority Date Filing Date
DK06022333T DK1783222T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
DK99970998T DK1124961T3 (da) 1998-10-23 1999-10-22 Trombopoietiske forbindelser
DK10011689T DK2319928T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK06022333T DK1783222T3 (da) 1998-10-23 1999-10-22 Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
DK99970998T DK1124961T3 (da) 1998-10-23 1999-10-22 Trombopoietiske forbindelser

Country Status (36)

Country Link
US (8) US6835809B1 (OSRAM)
EP (3) EP1124961B9 (OSRAM)
JP (2) JP3820105B2 (OSRAM)
KR (1) KR100719202B1 (OSRAM)
CN (2) CN1810832B (OSRAM)
AR (1) AR020934A1 (OSRAM)
AT (1) ATE348163T1 (OSRAM)
AU (1) AU773891C (OSRAM)
BG (3) BG65663B1 (OSRAM)
BR (1) BRPI9914698B8 (OSRAM)
CA (1) CA2346996C (OSRAM)
CY (4) CY1107526T1 (OSRAM)
CZ (1) CZ302155B6 (OSRAM)
DE (2) DE69934425T2 (OSRAM)
DK (3) DK1783222T3 (OSRAM)
EA (1) EA003998B1 (OSRAM)
ES (3) ES2279649T3 (OSRAM)
FR (1) FR09C0030I2 (OSRAM)
HK (1) HK1042114B (OSRAM)
HU (1) HU228582B1 (OSRAM)
IL (1) IL142023A0 (OSRAM)
LT (1) LTC1124961I2 (OSRAM)
LU (1) LU91598I2 (OSRAM)
ME (2) MEP42108A (OSRAM)
MY (1) MY126795A (OSRAM)
NL (1) NL300398I2 (OSRAM)
NO (2) NO331027B1 (OSRAM)
NZ (1) NZ510529A (OSRAM)
PL (1) PL219605B1 (OSRAM)
PT (3) PT1124961E (OSRAM)
RS (1) RS51237B (OSRAM)
SI (3) SI1783222T1 (OSRAM)
SK (1) SK287737B6 (OSRAM)
TW (2) TWI250988B (OSRAM)
WO (1) WO2000024770A2 (OSRAM)
ZA (1) ZA200102102B (OSRAM)

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