CY1107526T1 - Θρομβοποιητικες εnωσεις - Google Patents
Θρομβοποιητικες εnωσειςInfo
- Publication number
- CY1107526T1 CY1107526T1 CY20071100334T CY071100334T CY1107526T1 CY 1107526 T1 CY1107526 T1 CY 1107526T1 CY 20071100334 T CY20071100334 T CY 20071100334T CY 071100334 T CY071100334 T CY 071100334T CY 1107526 T1 CY1107526 T1 CY 1107526T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- thrombolic
- polypeptides
- peptides
- megakaryocytes
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000003593 megakaryocyte Anatomy 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000002885 thrombogenetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10534898P | 1998-10-23 | 1998-10-23 | |
| PCT/US1999/024834 WO2000024770A2 (en) | 1998-10-23 | 1999-10-22 | Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107526T1 true CY1107526T1 (el) | 2010-07-28 |
Family
ID=22305310
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100334T CY1107526T1 (el) | 1998-10-23 | 2007-03-12 | Θρομβοποιητικες εnωσεις |
| CY2009012C CY2009012I1 (el) | 1998-10-23 | 2009-08-03 | Θρομβοποιητικες εnωσεις |
| CY20121100797T CY1113107T1 (el) | 1998-10-23 | 2012-09-05 | Διμερη μιμητικα πεπτιδια θρομβοποιητινης που δεσμευονται με υποδοχεα mpl και που εχουν θρομβοποιητικη δραστικοτητα |
| CY20131100482T CY1114940T1 (el) | 1998-10-23 | 2013-06-14 | Διμερη μιμητικα πεπτιδια θρομβοποιητινης που δεσμευονται με υποδοχεα μρ1 και που εχουν θρομβοποιητικη δραστικοτητα |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2009012C CY2009012I1 (el) | 1998-10-23 | 2009-08-03 | Θρομβοποιητικες εnωσεις |
| CY20121100797T CY1113107T1 (el) | 1998-10-23 | 2012-09-05 | Διμερη μιμητικα πεπτιδια θρομβοποιητινης που δεσμευονται με υποδοχεα mpl και που εχουν θρομβοποιητικη δραστικοτητα |
| CY20131100482T CY1114940T1 (el) | 1998-10-23 | 2013-06-14 | Διμερη μιμητικα πεπτιδια θρομβοποιητινης που δεσμευονται με υποδοχεα μρ1 και που εχουν θρομβοποιητικη δραστικοτητα |
Country Status (36)
| Country | Link |
|---|---|
| US (8) | US6835809B1 (OSRAM) |
| EP (3) | EP1783222B1 (OSRAM) |
| JP (2) | JP3820105B2 (OSRAM) |
| KR (1) | KR100719202B1 (OSRAM) |
| CN (2) | CN1250721C (OSRAM) |
| AR (1) | AR020934A1 (OSRAM) |
| AT (1) | ATE348163T1 (OSRAM) |
| AU (1) | AU773891C (OSRAM) |
| BG (3) | BG110221A (OSRAM) |
| BR (1) | BRPI9914698B8 (OSRAM) |
| CA (1) | CA2346996C (OSRAM) |
| CY (4) | CY1107526T1 (OSRAM) |
| CZ (1) | CZ302155B6 (OSRAM) |
| DE (2) | DE69934425T2 (OSRAM) |
| DK (3) | DK1783222T3 (OSRAM) |
| EA (1) | EA003998B1 (OSRAM) |
| ES (3) | ES2279649T3 (OSRAM) |
| FR (1) | FR09C0030I2 (OSRAM) |
| HK (1) | HK1042114B (OSRAM) |
| HU (1) | HU228582B1 (OSRAM) |
| IL (1) | IL142023A0 (OSRAM) |
| LT (1) | LTC1124961I2 (OSRAM) |
| LU (1) | LU91598I2 (OSRAM) |
| ME (2) | MEP42108A (OSRAM) |
| MY (1) | MY126795A (OSRAM) |
| NL (1) | NL300398I2 (OSRAM) |
| NO (2) | NO331027B1 (OSRAM) |
| NZ (1) | NZ510529A (OSRAM) |
| PL (1) | PL219605B1 (OSRAM) |
| PT (3) | PT1783222E (OSRAM) |
| RS (1) | RS51237B (OSRAM) |
| SI (3) | SI1783222T1 (OSRAM) |
| SK (1) | SK287737B6 (OSRAM) |
| TW (2) | TWI250988B (OSRAM) |
| WO (1) | WO2000024770A2 (OSRAM) |
| ZA (1) | ZA200102102B (OSRAM) |
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| DK1783222T3 (da) * | 1998-10-23 | 2012-07-09 | Kirin Amgen Inc | Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| WO2001081377A2 (en) * | 2000-04-21 | 2001-11-01 | Amgen, Inc. | Integrin/adhesion antagonists |
| US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
| CA2411967A1 (en) * | 2000-06-09 | 2001-12-20 | The Government Of The United States Of America, As Represented By The Se Cretary Of The Departent Of Health And Human Services | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| DE60136656D1 (de) | 2000-12-05 | 2009-01-02 | Alexion Pharma Inc | Rationell entworfene Antikörper |
| US20040018203A1 (en) * | 2001-06-08 | 2004-01-29 | Ira Pastan | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| WO2003016351A2 (en) | 2001-08-17 | 2003-02-27 | Enkam Pharmaceuticals A/S | N - cam related compounds modulating cell groth |
| US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| MXPA05003057A (es) * | 2002-09-18 | 2006-04-18 | Johnson & Johnson | Metodos para aumentar la produccion de celulas madre hematopoyeticas y plaquetas. |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| UA88146C2 (ru) | 2003-05-12 | 2009-09-25 | Афимакс, Инк. | Новые пептиды, которые связываются с рецептором эритропоэтина |
| US7919118B2 (en) * | 2003-05-12 | 2011-04-05 | Affymax, Inc. | Spacer moiety for poly (ethylene glycol) modified peptide based compounds |
| EP1626983B8 (en) * | 2003-05-12 | 2010-12-22 | Affymax, Inc. | Novel poly (ethylene glycol) modified erythropoietin agonists and uses thereof |
| WO2004101611A2 (en) | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Peptides that bind to the erythropoietin receptor |
| ES2390082T5 (es) * | 2004-06-30 | 2018-01-19 | Nektar Therapeutics | Conjugados de resto de Factor IX y polímeros |
| EP1773400A2 (en) * | 2004-07-08 | 2007-04-18 | Amgen Inc. | Therapeutic peptides |
| MX2007003320A (es) | 2004-09-24 | 2007-05-18 | Amgen Inc | Moleculas fc modificadas. |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
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| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
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| US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
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| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
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| CA2658639C (en) * | 2006-07-24 | 2015-08-04 | The University Of Queensland | Method of producing a population of cells of the neutrophil lineage |
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| JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
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| KR102492792B1 (ko) | 2011-10-11 | 2023-01-30 | 제넨테크, 인크. | 이중특이적 항체의 개선된 어셈블리 |
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| CN102552184A (zh) * | 2012-02-16 | 2012-07-11 | 山东泉港药业有限公司 | 一种血小板生成素拟肽冻干制剂 |
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