EA003998B1 - ДИМЕРНЫЕ ТРОМБОПОЭТИНОВЫЕ ПЕПТИДНЫЕ МИМЕТИКИ, СВЯЗЫВАЮЩИЕ Mpl РЕЦЕПТОР И ИМЕЮЩИЕ ТРОМБОПОЭТИЧЕСКУЮ АКТИВНОСТЬ - Google Patents

ДИМЕРНЫЕ ТРОМБОПОЭТИНОВЫЕ ПЕПТИДНЫЕ МИМЕТИКИ, СВЯЗЫВАЮЩИЕ Mpl РЕЦЕПТОР И ИМЕЮЩИЕ ТРОМБОПОЭТИЧЕСКУЮ АКТИВНОСТЬ Download PDF

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Publication number
EA003998B1
EA003998B1 EA200100465A EA200100465A EA003998B1 EA 003998 B1 EA003998 B1 EA 003998B1 EA 200100465 A EA200100465 A EA 200100465A EA 200100465 A EA200100465 A EA 200100465A EA 003998 B1 EA003998 B1 EA 003998B1
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EA
Eurasian Patent Office
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group
compound according
iegptlrqwlaara
seq
gly
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EA200100465A
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English (en)
Russian (ru)
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EA200100465A1 (ru
Inventor
Чуан-Фа Лиу
Улрих Фейдже
Дженет Читхэм
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Амген Инк.
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Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA200100465A1 publication Critical patent/EA200100465A1/ru
Publication of EA003998B1 publication Critical patent/EA003998B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EA200100465A 1998-10-23 1999-10-22 ДИМЕРНЫЕ ТРОМБОПОЭТИНОВЫЕ ПЕПТИДНЫЕ МИМЕТИКИ, СВЯЗЫВАЮЩИЕ Mpl РЕЦЕПТОР И ИМЕЮЩИЕ ТРОМБОПОЭТИЧЕСКУЮ АКТИВНОСТЬ EA003998B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
PCT/US1999/024834 WO2000024770A2 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity

Publications (2)

Publication Number Publication Date
EA200100465A1 EA200100465A1 (ru) 2001-10-22
EA003998B1 true EA003998B1 (ru) 2003-12-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100465A EA003998B1 (ru) 1998-10-23 1999-10-22 ДИМЕРНЫЕ ТРОМБОПОЭТИНОВЫЕ ПЕПТИДНЫЕ МИМЕТИКИ, СВЯЗЫВАЮЩИЕ Mpl РЕЦЕПТОР И ИМЕЮЩИЕ ТРОМБОПОЭТИЧЕСКУЮ АКТИВНОСТЬ

Country Status (36)

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US (8) US6835809B1 (OSRAM)
EP (3) EP1783222B1 (OSRAM)
JP (2) JP3820105B2 (OSRAM)
KR (1) KR100719202B1 (OSRAM)
CN (2) CN1250721C (OSRAM)
AR (1) AR020934A1 (OSRAM)
AT (1) ATE348163T1 (OSRAM)
AU (1) AU773891C (OSRAM)
BG (3) BG65663B1 (OSRAM)
BR (1) BRPI9914698B8 (OSRAM)
CA (1) CA2346996C (OSRAM)
CY (4) CY1107526T1 (OSRAM)
CZ (1) CZ302155B6 (OSRAM)
DE (2) DE69934425T2 (OSRAM)
DK (3) DK1124961T3 (OSRAM)
EA (1) EA003998B1 (OSRAM)
ES (3) ES2388341T3 (OSRAM)
FR (1) FR09C0030I2 (OSRAM)
HK (1) HK1042114B (OSRAM)
HU (1) HU228582B1 (OSRAM)
IL (1) IL142023A0 (OSRAM)
LT (1) LTC1124961I2 (OSRAM)
LU (1) LU91598I2 (OSRAM)
ME (2) ME00238B (OSRAM)
MY (1) MY126795A (OSRAM)
NL (1) NL300398I2 (OSRAM)
NO (2) NO331027B1 (OSRAM)
NZ (1) NZ510529A (OSRAM)
PL (1) PL219605B1 (OSRAM)
PT (3) PT1783222E (OSRAM)
RS (1) RS51237B (OSRAM)
SI (3) SI1783222T1 (OSRAM)
SK (1) SK287737B6 (OSRAM)
TW (2) TWI250988B (OSRAM)
WO (1) WO2000024770A2 (OSRAM)
ZA (1) ZA200102102B (OSRAM)

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