ATE224911T1 - Gmp-140 ligand - Google Patents
Gmp-140 ligandInfo
- Publication number
- ATE224911T1 ATE224911T1 AT95202380T AT95202380T ATE224911T1 AT E224911 T1 ATE224911 T1 AT E224911T1 AT 95202380 T AT95202380 T AT 95202380T AT 95202380 T AT95202380 T AT 95202380T AT E224911 T1 ATE224911 T1 AT E224911T1
- Authority
- AT
- Austria
- Prior art keywords
- gmp
- alpha
- sialyated
- carbohydrate
- structures
- Prior art date
Links
- 108010035766 P-Selectin Proteins 0.000 title abstract 4
- 102000008212 P-Selectin Human genes 0.000 title abstract 4
- 239000003446 ligand Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001720 carbohydrates Chemical group 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- PNIWLNAGKUGXDO-LNCRCTFVSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical group O[C@@H]1[C@@H](N)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 PNIWLNAGKUGXDO-LNCRCTFVSA-N 0.000 abstract 1
- 102100021333 Alpha-(1,3)-fucosyltransferase 7 Human genes 0.000 abstract 1
- 108010024212 E-Selectin Proteins 0.000 abstract 1
- 102000015689 E-Selectin Human genes 0.000 abstract 1
- 101000819503 Homo sapiens 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 Proteins 0.000 abstract 1
- 101001022183 Homo sapiens 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 Proteins 0.000 abstract 1
- 101001022175 Homo sapiens 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 Proteins 0.000 abstract 1
- 101000862183 Homo sapiens Alpha-(1,3)-fucosyltransferase 10 Proteins 0.000 abstract 1
- 101000862213 Homo sapiens Alpha-(1,3)-fucosyltransferase 11 Proteins 0.000 abstract 1
- 101000819497 Homo sapiens Alpha-(1,3)-fucosyltransferase 7 Proteins 0.000 abstract 1
- 108010092694 L-Selectin Proteins 0.000 abstract 1
- 108090001090 Lectins Proteins 0.000 abstract 1
- 102000004856 Lectins Human genes 0.000 abstract 1
- 102000010836 Lymphocyte Homing Receptors Human genes 0.000 abstract 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 abstract 1
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 108090000184 Selectins Proteins 0.000 abstract 1
- 102000003800 Selectins Human genes 0.000 abstract 1
- 239000000370 acceptor Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000002523 lectin Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000014508 negative regulation of coagulation Effects 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55419990A | 1990-07-17 | 1990-07-17 | |
| US65048491A | 1991-02-05 | 1991-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE224911T1 true ATE224911T1 (de) | 2002-10-15 |
Family
ID=27070521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95202380T ATE224911T1 (de) | 1990-07-17 | 1991-07-17 | Gmp-140 ligand |
Country Status (9)
| Country | Link |
|---|---|
| EP (2) | EP0714912B1 (de) |
| JP (5) | JP3096305B2 (de) |
| AT (1) | ATE224911T1 (de) |
| AU (2) | AU660627B2 (de) |
| CA (1) | CA2086323C (de) |
| DE (1) | DE69133120T2 (de) |
| DK (1) | DK0714912T3 (de) |
| ES (1) | ES2183851T3 (de) |
| WO (1) | WO1992001718A2 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5800815A (en) * | 1903-05-05 | 1998-09-01 | Cytel Corporation | Antibodies to P-selectin and their uses |
| US5464778A (en) * | 1989-03-08 | 1995-11-07 | Board Of Regents Of The University Of Oklahoma | Glycoprotein ligand for P-selectin and methods of use thereof |
| DK0496832T3 (da) * | 1989-10-20 | 1996-12-30 | New England Medical Center Inc | Inhibering af PADGEM-formidlet cellebinding |
| US6387884B1 (en) | 1990-06-18 | 2002-05-14 | Stanford University | Leukocyte homing modulation |
| US6391857B1 (en) | 1990-06-18 | 2002-05-21 | Stanford University | Methods and compositions for endothelial binding |
| NZ240316A (en) * | 1990-10-25 | 1996-12-20 | Univ Michigan | Compound for treating disease mediated by the elaboration of elam-1 on endothelial cells |
| US6124267A (en) * | 1991-02-05 | 2000-09-26 | Southpac Trust Internationals, Inc. | O-glycan inhibitors of selectin mediated inflammation derived from PSGL-1 |
| US6309639B1 (en) | 1991-02-05 | 2001-10-30 | The Board Of Regents Of The University Of Oklahoma | Method for inhibiting an inflammatory response using antibodies to P-selectin glycoprotein ligand |
| US5807745A (en) * | 1991-03-11 | 1998-09-15 | New England Medical Center Hospitals, Inc. | Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte adhesion using an inhibitor comprising a Lex core component |
| AU1926692A (en) * | 1991-04-19 | 1992-11-17 | Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for endothelial binding |
| US6121233A (en) | 1991-04-19 | 2000-09-19 | John L. Magnani | Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules |
| US5817617A (en) * | 1991-05-03 | 1998-10-06 | The Rockefeller University | Selectin and pertussis toxin derived peptides and uses thereof |
| WO1992020708A1 (en) * | 1991-05-14 | 1992-11-26 | Board Of Regents For The University Of Oklahoma | Peptide inhibitors of inflammation |
| US5646123A (en) * | 1991-06-10 | 1997-07-08 | Alberta Research Council | Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen |
| JPH07507040A (ja) * | 1991-09-10 | 1995-08-03 | セントコー，インコーポレイテッド | セレクチンによって介在される炎症のペプチド阻害剤 |
| WO1993005803A1 (en) * | 1991-09-25 | 1993-04-01 | Genetics Institute, Inc. | Anti-inflammatory selectin inhibitors |
| EP0602194A1 (de) * | 1991-12-18 | 1994-06-22 | Centocor, Inc. | Peptid-inhibitoren von die durch selektine verursachten entzundungen |
| DE69328928T2 (de) * | 1992-04-30 | 2000-11-30 | Genentech, Inc. | Varianten in den leltin domäne von selektin |
| US6033667A (en) * | 1992-05-05 | 2000-03-07 | Cytel Corporation | Method for detecting the presence of P-selectin |
| DK0642356T3 (da) * | 1992-05-05 | 2003-08-04 | Aeres Biomedical Ltd | Antistoffer mod P-selectin og deres anvendelser |
| US5643873A (en) * | 1992-05-06 | 1997-07-01 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 |
| US5728802A (en) * | 1992-05-06 | 1998-03-17 | Affymax Technologies N.V. | Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) |
| US5648458A (en) * | 1992-05-06 | 1997-07-15 | Affymax Technologies N.V. | Peptides and compounds that bind to ELAM-1 |
| JPH08504171A (ja) * | 1992-05-28 | 1996-05-07 | セントコー・インコーポレーテッド | セレクチン結合のペプチド阻害剤 |
| CA2136844A1 (en) * | 1992-05-28 | 1993-12-09 | George A. Heavner | Peptide inhibitors of selectin binding |
| US5440015A (en) * | 1992-07-21 | 1995-08-08 | Glycomed Incorporated | Selectin peptide medicaments for treating disease |
| WO1994005310A1 (en) * | 1992-09-08 | 1994-03-17 | Centocor, Inc. | Peptide inhibitors of cellular adhesion |
| WO1994007517A1 (en) | 1992-10-02 | 1994-04-14 | Alberta Research Council | Anti-inflammatory tolerogenic and immunoinhibiting properties of carbohydrate binding-peptides |
| US6277975B1 (en) | 1992-10-23 | 2001-08-21 | Genetics Institute, Inc. | Fusions of P-selectin ligand protein and polynucleotides encoding same |
| US5843707A (en) * | 1992-10-23 | 1998-12-01 | Genetics Institute, Inc. | Nucleic acid encoding a novel P-selectin ligand protein |
| CA2497857C (en) * | 1992-10-23 | 2009-05-26 | Genetics Institute, Llc | Novel p-selectin ligand protein |
| AU681369B2 (en) * | 1992-11-16 | 1997-08-28 | Board Of Regents Of The University Of Oklahoma, The | Glycoprotein ligand for P-selectin and methods of use thereof |
| US5710123A (en) * | 1992-12-18 | 1998-01-20 | Centocor, Inc. | Peptide inhibitors of selectin binding |
| US5856300A (en) * | 1994-05-12 | 1999-01-05 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| SG52383A1 (en) | 1993-05-17 | 1998-09-28 | T Cell Sciences Inc | Compositions comprising complement related proteins and carbohydrates and methods for producing and using said compositions |
| US5976540A (en) * | 1993-05-17 | 1999-11-02 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| US5750508A (en) * | 1993-06-16 | 1998-05-12 | Glycomed Incorporated | Sialic acid/fucose based medicaments |
| WO1995014787A1 (en) * | 1993-11-22 | 1995-06-01 | Centocor, Inc. | Peptide inhibitors of selecting binding |
| US5663151A (en) * | 1994-03-04 | 1997-09-02 | Bristol-Myers Squibb Company | Sulfated α-glycolipid derivatives as cell adhesion inhibitors |
| CA2142153A1 (en) * | 1994-03-04 | 1995-09-05 | Jacques Banville | Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors |
| WO1995030001A2 (en) * | 1994-04-28 | 1995-11-09 | Genetics Institute, Inc. | Novel p-selectin ligand protein |
| US5686426A (en) * | 1994-11-17 | 1997-11-11 | Bristol-Myers Squibb Company | Dicarboxymethylated glycolipid derivatives as cell adhesion inhibitors |
| JPH11508131A (ja) * | 1995-06-14 | 1999-07-21 | ザ ジェネラル ホスピタル コーポレーション | Ｐ−セレクチンリガンドおよび関連分子並びに方法 |
| US5747463A (en) * | 1995-11-13 | 1998-05-05 | Bristol-Myers Squibb Company | Malonate derivatives of glycolipids as cell adhesion inhibitors |
| DE69737323T2 (de) | 1996-06-10 | 2007-11-08 | Thomas Boren | Adhesin aus Helicobacter pylori, welches an Blutgruppenantigene bindet |
| HK1042114B (zh) | 1998-10-23 | 2006-09-29 | Amgen K-A, Inc. | 与mp1受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽 |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| AU2003249641B2 (en) | 2002-05-16 | 2009-08-20 | Glycomimetics, Inc. | Compounds and methods for inhibiting selectin-mediated function |
| US7361644B2 (en) | 2003-11-19 | 2008-04-22 | Glycomimetics, Inc. | Specific antagonist for both E- and P-selectins |
| CA2572765C (en) | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
| US7442778B2 (en) | 2004-09-24 | 2008-10-28 | Amgen Inc. | Modified Fc molecules |
| JP5175190B2 (ja) | 2005-08-09 | 2013-04-03 | グリコミメティクス， インコーポレイテッド | シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤 |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US7728117B2 (en) | 2005-09-02 | 2010-06-01 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| WO2009126556A1 (en) | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| SI2794626T1 (en) | 2011-12-22 | 2018-02-28 | Glycomimetics, Inc. | E-SELECTINE ANTAGONIST COMPOUNDS |
| LT2928476T (lt) | 2012-12-07 | 2018-05-25 | Glycomimetics, Inc. | Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai |
| HUE045542T2 (hu) | 2014-12-03 | 2019-12-30 | Glycomimetics Inc | E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai |
| WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| EP3497131B1 (de) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Kombination von t-zell-checkpoint-inhibitoren mit e-selectin- oder cxcr4-inhibitoren oder mit heterobifunktionellen e-selectin- wie auch cxcr4-inhibitoren |
| CA3037850A1 (en) | 2016-10-07 | 2018-04-12 | Glycomimetics, Inc. | Highly potent multimeric e-selectin antagonists |
| KR102630011B1 (ko) | 2017-01-11 | 2024-01-26 | 브리스톨-마이어스 스큅 컴퍼니 | Psgl-1 길항제 및 그의 용도 |
| EP3595720A4 (de) | 2017-03-14 | 2021-05-26 | Five Prime Therapeutics, Inc. | An vista bei saurem ph-wert bindende antikörper |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (de) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Verfahren zur mobilisierung von knochenmarkinfiltrierenden lymphozyten und deren verwendung |
| EP3732186A1 (de) | 2017-12-29 | 2020-11-04 | GlycoMimetics, Inc. | Heterobifunktionale inhibitoren von e-selektin und galectin-3 |
| US11707474B2 (en) | 2018-03-05 | 2023-07-25 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| MX2020009786A (es) | 2018-03-21 | 2020-10-12 | Five Prime Therapeutics Inc | Anticuerpos de union a supresor de la activacion de celulas t que contiene el dominio variable de inmunoglobulina (vista) a ph acido. |
| WO2020014327A2 (en) | 2018-07-11 | 2020-01-16 | Five Prime Therapeutics, Inc. | Antibodies binding to vista at acidic ph |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| CA3181285A1 (en) * | 2020-07-20 | 2022-01-27 | Jessica BASSO | Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3625214A (en) | 1970-05-18 | 1971-12-07 | Alza Corp | Drug-delivery device |
| US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4305872A (en) | 1979-10-19 | 1981-12-15 | Kenneth Wingrove | Polypeptide derivatives |
| US4316891A (en) | 1980-06-14 | 1982-02-23 | The Salk Institute For Biological Studies | Extended N-terminal somatostatin |
| US4792525A (en) | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4906474A (en) | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
| US4629784A (en) | 1983-08-16 | 1986-12-16 | The University Of Georgia Research Foundation, Inc. | Synthesis of cyclopropane amino acids |
| US4752569A (en) * | 1984-06-21 | 1988-06-21 | The Regents Of The University Of California | Sialylated Lewisx epitope, antibodies and diagnosis |
| US4783330A (en) * | 1984-11-15 | 1988-11-08 | New England Medical Center Hospitals, Inc. | Monoclonal antibodies to activated platelets |
| US4789734A (en) | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
| US4904596A (en) * | 1985-08-07 | 1990-02-27 | Fred Hutchinson Cancer Research Center | Hybridoma antibody (FH6) defining a human cancer-associated difucoganglioside |
| WO1988001213A1 (en) | 1986-08-18 | 1988-02-25 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents |
| US5030723A (en) * | 1988-05-31 | 1991-07-09 | The Biomembrane Institute | Long-chain glycolipid structure |
| DK0496832T3 (da) * | 1989-10-20 | 1996-12-30 | New England Medical Center Inc | Inhibering af PADGEM-formidlet cellebinding |
-
1991
- 1991-07-17 AT AT95202380T patent/ATE224911T1/de not_active IP Right Cessation
- 1991-07-17 DE DE69133120T patent/DE69133120T2/de not_active Expired - Fee Related
- 1991-07-17 CA CA002086323A patent/CA2086323C/en not_active Expired - Fee Related
- 1991-07-17 DK DK95202380T patent/DK0714912T3/da active
- 1991-07-17 JP JP03517240A patent/JP3096305B2/ja not_active Expired - Fee Related
- 1991-07-17 WO PCT/US1991/005059 patent/WO1992001718A2/en not_active Ceased
- 1991-07-17 AU AU86207/91A patent/AU660627B2/en not_active Ceased
- 1991-07-17 EP EP95202380A patent/EP0714912B1/de not_active Expired - Lifetime
- 1991-07-17 EP EP19910916882 patent/EP0544815A1/de not_active Withdrawn
- 1991-07-17 ES ES95202380T patent/ES2183851T3/es not_active Expired - Lifetime
-
1995
- 1995-04-28 AU AU17731/95A patent/AU697488B2/en not_active Ceased
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1998
- 1998-08-03 JP JP10219500A patent/JPH11147900A/ja not_active Withdrawn
-
2000
- 2000-11-22 JP JP2000356784A patent/JP2001197899A/ja not_active Withdrawn
-
2003
- 2003-06-23 JP JP2003178744A patent/JP2004002444A/ja not_active Withdrawn
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2005
- 2005-05-26 JP JP2005154747A patent/JP2005255691A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0714912A2 (de) | 1996-06-05 |
| JPH05509330A (ja) | 1993-12-22 |
| DE69133120T2 (de) | 2003-05-15 |
| DK0714912T3 (da) | 2003-02-03 |
| JP2005255691A (ja) | 2005-09-22 |
| EP0714912A3 (de) | 1996-06-26 |
| JPH11147900A (ja) | 1999-06-02 |
| DE69133120D1 (de) | 2002-10-31 |
| WO1992001718A2 (en) | 1992-02-06 |
| JP3096305B2 (ja) | 2000-10-10 |
| CA2086323A1 (en) | 1992-01-18 |
| ES2183851T3 (es) | 2003-04-01 |
| JP2004002444A (ja) | 2004-01-08 |
| AU1773195A (en) | 1995-07-06 |
| JP2001197899A (ja) | 2001-07-24 |
| AU8620791A (en) | 1992-02-18 |
| EP0714912B1 (de) | 2002-09-25 |
| EP0544815A1 (de) | 1993-06-09 |
| WO1992001718A3 (en) | 1992-05-14 |
| CA2086323C (en) | 2002-05-14 |
| AU660627B2 (en) | 1995-07-06 |
| AU697488B2 (en) | 1998-10-08 |
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