ES2092468T3 - Metodos para producir analogos de receptores secretados. - Google Patents
Metodos para producir analogos de receptores secretados.Info
- Publication number
- ES2092468T3 ES2092468T3 ES89100787T ES89100787T ES2092468T3 ES 2092468 T3 ES2092468 T3 ES 2092468T3 ES 89100787 T ES89100787 T ES 89100787T ES 89100787 T ES89100787 T ES 89100787T ES 2092468 T3 ES2092468 T3 ES 2092468T3
- Authority
- ES
- Spain
- Prior art keywords
- methods
- polypeptides
- disclosed
- human pdgf
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/49—Platelet-derived growth factor [PDGF]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
Abstract
SE PRESENTAN METODOS PARA LA PRODUCCION DE ANALOGOS DE RECEPTORES SECRETADOS Y DIMEROS DE PEPTIDOS BIOLOGICAMENTE ACTIVOS. ESTOS METODOS UTILIZAN SECUENCIAS DE DNA QUE CODIFICAN UN ANALOGO DEL RECEPTOR O UN PEPTIDO QUE REQUIERE DIMERIZACION PARA LA ACTIVIDAD BIOLOGICA VIENDOSE A UNA PROTEINA DE DIMERIZACION. EL ANALOGO DEL REC EPTOR INCLUYE UN DOMINIO DE UNION AL LIGANDO. TAMBIEN SE PRESENTAN LOS POLIPEPTIDOS QUE COMPRENDEN EL DOMINIO EXTRA CELULAR ESENCIALMENTE DE UN RECEPTOR HUMANO PDGF. SE FUNDEN CON PROTEINAS DE DIMERIZACION, LA PORCION ES CAPAZ DE UNIRSE AL PDGF HUMANO O UN ISOMERO DE EL. LOS POLIPEPTIDOS PUEDEN USARSE EN LOS METODOS PARA DETERMINAR LA PRESENCIA Y PURIFICACION DE PDGF HUMANO O SUS ISOMEROS. TAMBIEN SE PRESENTAN COMPUESTOS FARMACEUTICOS Y DIAGNOSTICOS QUE UTILIZAN LOS POLIPEPTIDOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14687788A | 1988-01-22 | 1988-01-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2092468T3 true ES2092468T3 (es) | 1996-12-01 |
Family
ID=22519371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89100787T Expired - Lifetime ES2092468T3 (es) | 1988-01-22 | 1989-01-18 | Metodos para producir analogos de receptores secretados. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5155027A (es) |
EP (3) | EP0325224B1 (es) |
JP (1) | JP3424823B2 (es) |
AT (1) | ATE140963T1 (es) |
AU (1) | AU628035B2 (es) |
CA (1) | CA1340908C (es) |
DE (2) | DE721983T1 (es) |
DK (1) | DK175949B1 (es) |
ES (1) | ES2092468T3 (es) |
GR (1) | GR3021102T3 (es) |
IE (1) | IE80960B1 (es) |
Families Citing this family (144)
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JPH02500329A (ja) * | 1987-05-21 | 1990-02-08 | クリエイテイブ・バイオマリキユールズ・インコーポレーテツド | ターゲット化多機能蛋白質 |
US5567584A (en) * | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
US5750375A (en) * | 1988-01-22 | 1998-05-12 | Zymogenetics, Inc. | Methods of producing secreted receptor analogs and biologically active dimerized polypeptide fusions |
US6018026A (en) * | 1988-01-22 | 2000-01-25 | Zymogenetics, Inc. | Biologically active dimerized and multimerized polypeptide fusions |
US6372438B1 (en) | 1988-02-02 | 2002-04-16 | The Regents Of The University Of California | Human platelet-derived growth factor receptors |
US6110737A (en) | 1988-02-02 | 2000-08-29 | The Regents Of The University Of California | Human platelet-derived growth factor receptor, type A |
WO1990000178A1 (en) * | 1988-06-30 | 1990-01-11 | Cor Therapeutics, Inc. | Platelet blocking peptides |
WO1990008160A1 (en) * | 1989-01-20 | 1990-07-26 | Imperial Cancer Research Technology Ltd. | Growth factor receptor-like peptides without tyrosine-kinase activity |
US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
US6406697B1 (en) | 1989-02-23 | 2002-06-18 | Genentech, Inc. | Hybrid immunoglobulins |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
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US6541610B1 (en) | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
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-
1989
- 1989-01-18 EP EP89100787A patent/EP0325224B1/en not_active Expired - Lifetime
- 1989-01-18 DE DE0721983T patent/DE721983T1/de active Pending
- 1989-01-18 EP EP06017915A patent/EP1762623A1/en not_active Withdrawn
- 1989-01-18 DE DE68926888T patent/DE68926888T2/de not_active Expired - Lifetime
- 1989-01-18 AT AT89100787T patent/ATE140963T1/de not_active IP Right Cessation
- 1989-01-18 EP EP95118567A patent/EP0721983A1/en not_active Withdrawn
- 1989-01-18 ES ES89100787T patent/ES2092468T3/es not_active Expired - Lifetime
- 1989-01-20 DK DK198900254A patent/DK175949B1/da not_active IP Right Cessation
- 1989-01-20 AU AU28668/89A patent/AU628035B2/en not_active Expired
- 1989-01-20 CA CA000588851A patent/CA1340908C/en not_active Expired - Fee Related
- 1989-01-20 IE IE17289A patent/IE80960B1/en not_active IP Right Cessation
- 1989-01-23 JP JP01204589A patent/JP3424823B2/ja not_active Expired - Lifetime
- 1989-05-02 US US07/347,291 patent/US5155027A/en not_active Expired - Lifetime
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1996
- 1996-09-19 GR GR960402462T patent/GR3021102T3/el unknown
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---|---|
EP0325224B1 (en) | 1996-07-31 |
ATE140963T1 (de) | 1996-08-15 |
IE80960B1 (en) | 1999-07-14 |
EP0325224A3 (en) | 1991-04-17 |
JP3424823B2 (ja) | 2003-07-07 |
GR3021102T3 (en) | 1996-12-31 |
EP0325224A2 (en) | 1989-07-26 |
AU628035B2 (en) | 1992-09-10 |
US5155027A (en) | 1992-10-13 |
DE68926888D1 (de) | 1996-09-05 |
AU2866889A (en) | 1989-07-27 |
IE890172L (en) | 1989-07-22 |
EP0721983A1 (en) | 1996-07-17 |
DK175949B1 (da) | 2005-08-15 |
CA1340908C (en) | 2000-02-22 |
DK25489A (da) | 1989-07-23 |
EP1762623A1 (en) | 2007-03-14 |
DK25489D0 (da) | 1989-01-20 |
JPH0231688A (ja) | 1990-02-01 |
DE721983T1 (de) | 2002-07-04 |
DE68926888T2 (de) | 1997-01-09 |
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