FI103892B1 - Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus - Google Patents

Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus

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Publication number
FI103892B1
FI103892B1 FI885504A FI885504A FI103892B1 FI 103892 B1 FI103892 B1 FI 103892B1 FI 885504 A FI885504 A FI 885504A FI 885504 A FI885504 A FI 885504A FI 103892 B1 FI103892 B1 FI 103892B1
Authority
FI
Finland
Prior art keywords
essentially
preparation
recombinant dna
dna molecule
molecule encoding
Prior art date
Application number
FI885504A
Other languages
English (en)
Swedish (sv)
Other versions
FI103892B (fi
FI885504A0 (fi
FI885504A (fi
Inventor
Rudolfy Hauptmann
Ingrid Maurer-Fogy
Gerhard Bodo
Peter Swetly
Christian Stratowa
Egard Falkner
Guenther Adolf
Christian Mar Reutelingsperger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873710430 external-priority patent/DE3710430A1/de
Priority claimed from DE19873710364 external-priority patent/DE3710364A1/de
Priority claimed from DE19873710309 external-priority patent/DE3710309A1/de
Priority claimed from DE19873737367 external-priority patent/DE3737367A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of FI885504A0 publication Critical patent/FI885504A0/fi
Publication of FI885504A publication Critical patent/FI885504A/fi
Application granted granted Critical
Publication of FI103892B publication Critical patent/FI103892B/fi
Publication of FI103892B1 publication Critical patent/FI103892B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
FI885504A 1987-03-28 1988-11-28 Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus FI103892B1 (fi)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DE19873710430 DE3710430A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3710364 1987-03-28
DE19873710364 DE3710364A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3710309 1987-03-28
DE3710430 1987-03-28
DE19873710309 DE3710309A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE3737367 1987-11-04
DE19873737367 DE3737367A1 (de) 1987-11-04 1987-11-04 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
PCT/EP1988/000266 WO1988007576A2 (fr) 1987-03-28 1988-03-26 Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation
EP8800266 1988-03-26

Publications (4)

Publication Number Publication Date
FI885504A0 FI885504A0 (fi) 1988-11-28
FI885504A FI885504A (fi) 1988-11-28
FI103892B FI103892B (fi) 1999-10-15
FI103892B1 true FI103892B1 (fi) 1999-10-15

Family

ID=27433878

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885504A FI103892B1 (fi) 1987-03-28 1988-11-28 Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus

Country Status (17)

Country Link
US (1) US5837842A (fi)
EP (1) EP0293567B1 (fi)
JP (1) JPH01503515A (fi)
KR (1) KR890700666A (fi)
AT (1) ATE133707T1 (fi)
AU (1) AU625214B2 (fi)
DD (1) DD273285A5 (fi)
DE (1) DE3854950D1 (fi)
DK (1) DK175468B1 (fi)
FI (1) FI103892B1 (fi)
HU (1) HUT52544A (fi)
IE (2) IE960853L (fi)
IL (1) IL85878A (fi)
NO (1) NO885275L (fi)
NZ (1) NZ224057A (fi)
PT (1) PT87083B (fi)
WO (1) WO1988007576A2 (fi)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660514B2 (ja) * 1987-02-20 1997-10-08 興和株式会社 抗血液凝固作用を有するポリペプチド
EP0330396B1 (en) * 1988-02-26 1995-06-21 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lipocortins III, IV, V & VI
AU3231189A (en) * 1988-03-31 1989-10-05 Rorer International (Overseas) Inc. Recombinant endonexin ii
DE3910240A1 (de) * 1989-03-30 1990-10-04 Behringwerke Ag Pp4-delta, seine herstellung und verwendung
ATE89169T1 (de) * 1989-07-15 1993-05-15 Boehringer Ingelheim Int Antikoagulanz enthaltendes mittel.
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
JP3135261B2 (ja) * 1989-12-27 2001-02-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗凝血剤の診断薬としての使用
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
CA2086437A1 (en) * 1991-05-09 1992-11-10 Jonathan Tait Phospholipid-targeted thrombolytic agents
AU676483B2 (en) * 1992-07-08 1997-03-13 N.V. Innogenetics S.A. Polypeptides, derived from endonexin 2, having hepatitis B virus receptor activity and their use in diagnostic and pharmaceutical compositions
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
DE69527505D1 (de) * 1994-11-11 2002-08-29 Noboru Kaneko Monoklonaler antikörper gegen antiannexin-v, verfahren zu seiner herstellung und seiner verwendung
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
ATE359807T1 (de) * 2001-02-21 2007-05-15 Surromed Inc Modifizierte annexin-proteine und verhinderung und behandlung von thrombose
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
AU784548B2 (en) * 2001-03-16 2006-04-27 Ortho-Clinical Diagnostics, Inc. Reg-like protein
EP1267169B1 (en) * 2001-05-21 2004-12-15 Fuji Photo Film Co., Ltd. Biochemical analysis unit and method for its production
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
FR2841558B1 (fr) 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations
FR2841557B1 (fr) 2002-07-01 2005-12-09 Commissariat Energie Atomique Peptides ayant une affinite pour un phospholipide et utilisations
DE602004020855D1 (de) * 2003-11-20 2009-06-10 Hoffmann La Roche Spezifische Marker für Stoffwechselssyndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
DK166587B1 (da) * 1984-09-21 1993-06-14 Boehringer Ingelheim Int Blodkoagulationshaemmende proteiner, fremgangsmaade til deres fremstilling samt deres anvendelse
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
JPH0787789B2 (ja) * 1985-01-10 1995-09-27 バイオジェン インコーポレイテッド リポコルチンをコードするｄｎａ分子および形質転換宿主
EP0218696A4 (en) * 1985-04-15 1989-08-16 Biotech Res Partners Ltd ANTI-INFLAMMATORY PROTEIN FOR INHIBITION OF HUMAN PHOSPHOLIPASE.
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
JPH01502667A (ja) * 1987-02-06 1989-09-14 ザイモジェネティクス，インコーポレイティド 抗凝固活性及び抗炎症活性を有するヒト蛋白質
US5179081A (en) * 1988-07-21 1993-01-12 Kowa Co., Ltd. Method of treatment using an anticoagulant polypeptide

Also Published As

Publication number Publication date
NO885275L (no) 1989-01-25
FI103892B (fi) 1999-10-15
IE74679B1 (en) 1997-07-30
KR890700666A (ko) 1989-11-26
AU625214B2 (en) 1992-07-02
FI885504A0 (fi) 1988-11-28
PT87083A (pt) 1988-04-01
ATE133707T1 (de) 1996-02-15
DD273285A5 (de) 1989-11-08
DK662288A (da) 1989-01-25
EP0293567A1 (de) 1988-12-07
HUT52544A (en) 1990-07-28
PT87083B (pt) 1992-07-31
DE3854950D1 (de) 1996-03-14
IE880928L (en) 1988-09-28
DK662288D0 (da) 1988-11-25
WO1988007576A2 (fr) 1988-10-06
JPH01503515A (ja) 1989-11-30
IL85878A0 (en) 1988-09-30
DK175468B1 (da) 2004-11-01
IE960853L (en) 1988-09-28
IL85878A (en) 1993-07-08
US5837842A (en) 1998-11-17
NZ224057A (en) 1991-04-26
FI885504A (fi) 1988-11-28
AU1402788A (en) 1988-09-29
WO1988007576A3 (fr) 1989-01-26
NO885275D0 (no) 1988-11-25
EP0293567B1 (de) 1996-01-31

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Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH

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