WO1988007576A3 - Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation - Google Patents
Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation Download PDFInfo
- Publication number
- WO1988007576A3 WO1988007576A3 PCT/EP1988/000266 EP8800266W WO8807576A3 WO 1988007576 A3 WO1988007576 A3 WO 1988007576A3 EP 8800266 W EP8800266 W EP 8800266W WO 8807576 A3 WO8807576 A3 WO 8807576A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- code
- application
- dnas
- manufacture
- anticoagulant proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Protéines biologiquement actives, molécules d'ADN de codage de ces protéines, leur procédé de production et leur utilisation.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK198806622A DK175468B1 (da) | 1987-03-28 | 1988-11-25 | Vaskulære- antikoagulerende proteiner, DNA som koder for disse og fremgangsmåde til fremstilling deraf |
NO88885275A NO885275L (no) | 1987-03-28 | 1988-11-25 | Vaskulaere antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav. |
KR1019880701535A KR890700666A (ko) | 1987-03-28 | 1988-11-25 | 혈관 항응고 단백질, 이를 암호화하는 dna, 이의 제조방법 및 용도 |
FI885504A FI103892B (fi) | 1987-03-28 | 1988-11-28 | Rekombinantti-DNA-molekyyli, joka koodaa polypeptidiä/proteiinia, jolla on oleellisesti vaskulaaristen antikoaguloivien proteiinien biologiset ominaisuudet sekä niiden valmistus |
US08/376,050 US5837842A (en) | 1987-03-28 | 1995-01-23 | Vascular anticoagulant proteins DNA which codes them, processer for preparing them and their use |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873710364 DE3710364A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DEP3710364.4 | 1987-03-28 | ||
DEP3710309.1 | 1987-03-28 | ||
DEP3710430.6 | 1987-03-28 | ||
DE19873710309 DE3710309A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DE19873710430 DE3710430A1 (de) | 1987-03-28 | 1987-03-28 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
DEP3737367.6 | 1987-11-04 | ||
DE19873737367 DE3737367A1 (de) | 1987-11-04 | 1987-11-04 | Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1988007576A2 WO1988007576A2 (fr) | 1988-10-06 |
WO1988007576A3 true WO1988007576A3 (fr) | 1989-01-26 |
Family
ID=27433878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1988/000266 WO1988007576A2 (fr) | 1987-03-28 | 1988-03-26 | Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation |
Country Status (17)
Country | Link |
---|---|
US (1) | US5837842A (fr) |
EP (1) | EP0293567B1 (fr) |
JP (1) | JPH01503515A (fr) |
KR (1) | KR890700666A (fr) |
AT (1) | ATE133707T1 (fr) |
AU (1) | AU625214B2 (fr) |
DD (1) | DD273285A5 (fr) |
DE (1) | DE3854950D1 (fr) |
DK (1) | DK175468B1 (fr) |
FI (1) | FI103892B (fr) |
HU (1) | HUT52544A (fr) |
IE (2) | IE960853L (fr) |
IL (1) | IL85878A (fr) |
NO (1) | NO885275L (fr) |
NZ (1) | NZ224057A (fr) |
PT (1) | PT87083B (fr) |
WO (1) | WO1988007576A2 (fr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2660514B2 (ja) * | 1987-02-20 | 1997-10-08 | 興和株式会社 | 抗血液凝固作用を有するポリペプチド |
ES2096556T3 (es) * | 1988-02-26 | 1997-03-16 | Biogen Inc | Secuencias de adn, moleculas de adn recombinante y procedimientos para producir lipocortinas iii, iv, v y vi. |
EP0339285A3 (fr) * | 1988-03-31 | 1989-11-29 | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) | Endonéxine II recombinante |
DE3910240A1 (de) * | 1989-03-30 | 1990-10-04 | Behringwerke Ag | Pp4-delta, seine herstellung und verwendung |
ATE89169T1 (de) * | 1989-07-15 | 1993-05-15 | Boehringer Ingelheim Int | Antikoagulanz enthaltendes mittel. |
DE3937607A1 (de) * | 1989-11-11 | 1991-05-16 | Boehringer Ingelheim Int | Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen |
US5627036A (en) * | 1989-12-27 | 1997-05-06 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
EP0806670B1 (fr) * | 1989-12-27 | 2009-04-22 | Boehringer Ingelheim International GmbH | Utilisation d'un anticoagulant comme moyen de diagnostic |
JPH05508664A (ja) * | 1991-05-09 | 1993-12-02 | ボード・オブ・リージェンツ・オブ・ザ・ユニヴァーシティ・オブ・ワシントン | リン脂質標的血栓溶解剤 |
US5632986A (en) * | 1991-05-09 | 1997-05-27 | The University Of Washington | Phospholipid-targeted thrombolytic agents |
DE69328035T2 (de) * | 1992-07-08 | 2000-11-02 | Innogenetics Nv | Polypeptide, von endonexin 2 stammend, mit hepatitis b virus rezeptor aktivität und deren verwendungen in diagnotischen und pharmazeutischen zusammensetzungen |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
WO1996015152A1 (fr) * | 1994-11-11 | 1996-05-23 | International Reagents Corporation | Anticorps monoclonal antiannexine-v, procede pour produire cet anticorps, et utilisation de cet anticorps |
US7645739B2 (en) | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
US20050222030A1 (en) * | 2001-02-21 | 2005-10-06 | Anthony Allison | Modified annexin proteins and methods for preventing thrombosis |
US7635676B2 (en) * | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
US20090291086A1 (en) * | 2001-02-21 | 2009-11-26 | Alavita Pharmaceuticals, Inc. | Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia |
JP2004528025A (ja) * | 2001-02-21 | 2004-09-16 | サーロメッド・インコーポレーテッド | 修飾されたアネキシン蛋白質及び血栓症を防ぐための方法 |
CA2373468A1 (fr) * | 2001-03-16 | 2002-09-16 | Ortho-Clinical Diagnostics, Inc. | Proteine de type reg |
DE60202240T2 (de) * | 2001-05-21 | 2005-12-15 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Vorrichtung zur Durchführung biochemischer Analysen und Verfahren zu ihrer Herstellung |
US7622260B2 (en) | 2001-09-05 | 2009-11-24 | The Brigham And Women's Hospital, Inc. | Diagnostic and prognostic tests |
FR2841557B1 (fr) | 2002-07-01 | 2005-12-09 | Commissariat Energie Atomique | Peptides ayant une affinite pour un phospholipide et utilisations |
FR2841558B1 (fr) * | 2002-07-01 | 2004-08-13 | Commissariat Energie Atomique | Peptides marques ayant une affinite pour un phospholipide et utilisations |
EP1533619B1 (fr) * | 2003-11-20 | 2009-04-29 | F. Hoffmann-Roche AG | Marqueurs spécifiques du syndrome métabolique. |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0181465A1 (fr) * | 1984-09-21 | 1986-05-21 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protéines inhibant la coagulation du sang, leur application |
WO1986004094A1 (fr) * | 1985-01-10 | 1986-07-17 | Biogen .N.V. | Sequences d'adn, molecules d'adn recombinant et procedes de production de polypeptides similaires a la lipocortine humaine |
WO1986006100A1 (fr) * | 1985-04-15 | 1986-10-23 | Biotechnology Research Partners, Limited | Proteine anti-inflammatoire d'inhibition de la phospholipase humaine |
WO1988005659A1 (fr) * | 1987-02-06 | 1988-08-11 | Zymogenetics, Inc. | Proteines humaines possedant une activite anticoagulante et anti-inflammatoire |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3438296A1 (de) * | 1984-04-18 | 1985-11-07 | Hoechst Ag, 6230 Frankfurt | Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel |
US5066788A (en) * | 1984-09-21 | 1991-11-19 | Boehringer Ingelheim International Gmbh | Blood coagulation inhibiting proteins, processes for preparing them and their uses |
CA1265446A (fr) * | 1985-09-30 | 1990-02-06 | Masahiro Maki | Substance anticoagulante, procede de preparation et anticoagulant comprenant ces substances actives |
US4937324A (en) * | 1987-02-06 | 1990-06-26 | Zymogenetics, Inc. | Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity |
US5179081A (en) * | 1988-07-21 | 1993-01-12 | Kowa Co., Ltd. | Method of treatment using an anticoagulant polypeptide |
-
1988
- 1988-03-25 PT PT87083A patent/PT87083B/pt not_active IP Right Cessation
- 1988-03-26 EP EP88104916A patent/EP0293567B1/fr not_active Expired - Lifetime
- 1988-03-26 WO PCT/EP1988/000266 patent/WO1988007576A2/fr active IP Right Grant
- 1988-03-26 AT AT88104916T patent/ATE133707T1/de not_active IP Right Cessation
- 1988-03-26 JP JP63503314A patent/JPH01503515A/ja active Pending
- 1988-03-26 HU HU882496A patent/HUT52544A/hu unknown
- 1988-03-26 DE DE3854950T patent/DE3854950D1/de not_active Expired - Lifetime
- 1988-03-27 IL IL8885878A patent/IL85878A/xx not_active IP Right Cessation
- 1988-03-28 DD DD31410688A patent/DD273285A5/de not_active IP Right Cessation
- 1988-03-28 AU AU14027/88A patent/AU625214B2/en not_active Expired
- 1988-03-28 IE IE960853A patent/IE960853L/xx unknown
- 1988-03-28 NZ NZ224057A patent/NZ224057A/xx unknown
- 1988-03-28 IE IE92888A patent/IE74679B1/en not_active IP Right Cessation
- 1988-11-25 KR KR1019880701535A patent/KR890700666A/ko not_active Application Discontinuation
- 1988-11-25 DK DK198806622A patent/DK175468B1/da not_active IP Right Cessation
- 1988-11-25 NO NO88885275A patent/NO885275L/no unknown
- 1988-11-28 FI FI885504A patent/FI103892B/fi not_active IP Right Cessation
-
1995
- 1995-01-23 US US08/376,050 patent/US5837842A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0181465A1 (fr) * | 1984-09-21 | 1986-05-21 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Protéines inhibant la coagulation du sang, leur application |
WO1986004094A1 (fr) * | 1985-01-10 | 1986-07-17 | Biogen .N.V. | Sequences d'adn, molecules d'adn recombinant et procedes de production de polypeptides similaires a la lipocortine humaine |
WO1986006100A1 (fr) * | 1985-04-15 | 1986-10-23 | Biotechnology Research Partners, Limited | Proteine anti-inflammatoire d'inhibition de la phospholipase humaine |
WO1988005659A1 (fr) * | 1987-02-06 | 1988-08-11 | Zymogenetics, Inc. | Proteines humaines possedant une activite anticoagulante et anti-inflammatoire |
Also Published As
Publication number | Publication date |
---|---|
US5837842A (en) | 1998-11-17 |
DE3854950D1 (de) | 1996-03-14 |
AU1402788A (en) | 1988-09-29 |
IE74679B1 (en) | 1997-07-30 |
DK662288A (da) | 1989-01-25 |
KR890700666A (ko) | 1989-11-26 |
DK175468B1 (da) | 2004-11-01 |
FI885504A (fi) | 1988-11-28 |
WO1988007576A2 (fr) | 1988-10-06 |
IE960853L (en) | 1988-09-28 |
DK662288D0 (da) | 1988-11-25 |
NO885275L (no) | 1989-01-25 |
ATE133707T1 (de) | 1996-02-15 |
FI103892B1 (fi) | 1999-10-15 |
FI885504A0 (fi) | 1988-11-28 |
PT87083A (pt) | 1988-04-01 |
HUT52544A (en) | 1990-07-28 |
NO885275D0 (no) | 1988-11-25 |
JPH01503515A (ja) | 1989-11-30 |
NZ224057A (en) | 1991-04-26 |
AU625214B2 (en) | 1992-07-02 |
IL85878A0 (en) | 1988-09-30 |
EP0293567A1 (fr) | 1988-12-07 |
IE880928L (en) | 1988-09-28 |
EP0293567B1 (fr) | 1996-01-31 |
FI103892B (fi) | 1999-10-15 |
IL85878A (en) | 1993-07-08 |
PT87083B (pt) | 1992-07-31 |
DD273285A5 (de) | 1989-11-08 |
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