NO885275D0 - VaskulŸre antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav. - Google Patents

VaskulŸre antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav.

Info

Publication number
NO885275D0
NO885275D0 NO885275A NO885275A NO885275D0 NO 885275 D0 NO885275 D0 NO 885275D0 NO 885275 A NO885275 A NO 885275A NO 885275 A NO885275 A NO 885275A NO 885275 D0 NO885275 D0 NO 885275D0
Authority
NO
Norway
Prior art keywords
dnas
encode
manufacture
anticoagulant proteins
vascular anticoagulant
Prior art date
Application number
NO885275A
Other languages
English (en)
Other versions
NO885275L (no
Inventor
Rudolf Hauptmann
Ingrid Maurer-Fogy
Gerhard Bodo
Peter Swetly
Christian Stratowa
Edgar Falkner
Guenther Adolf
Christian Mar Reutelingsperger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19873710309 external-priority patent/DE3710309A1/de
Priority claimed from DE19873710430 external-priority patent/DE3710430A1/de
Priority claimed from DE19873710364 external-priority patent/DE3710364A1/de
Priority claimed from DE19873737367 external-priority patent/DE3737367A1/de
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO885275D0 publication Critical patent/NO885275D0/no
Publication of NO885275L publication Critical patent/NO885275L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
NO88885275A 1987-03-28 1988-11-25 Vaskulaere antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav. NO885275L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19873710309 DE3710309A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873710430 DE3710430A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873710364 DE3710364A1 (de) 1987-03-28 1987-03-28 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
DE19873737367 DE3737367A1 (de) 1987-11-04 1987-11-04 Vascular-antikoagulierende proteine, dna die diese kodieren, verfahren zu deren herstellung sowie deren verwendung
PCT/EP1988/000266 WO1988007576A2 (fr) 1987-03-28 1988-03-26 Proteines vasculaires anticoagulantes, leurs adn de codage, production et utilisation

Publications (2)

Publication Number Publication Date
NO885275D0 true NO885275D0 (no) 1988-11-25
NO885275L NO885275L (no) 1989-01-25

Family

ID=27433878

Family Applications (1)

Application Number Title Priority Date Filing Date
NO88885275A NO885275L (no) 1987-03-28 1988-11-25 Vaskulaere antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav.

Country Status (17)

Country Link
US (1) US5837842A (no)
EP (1) EP0293567B1 (no)
JP (1) JPH01503515A (no)
KR (1) KR890700666A (no)
AT (1) ATE133707T1 (no)
AU (1) AU625214B2 (no)
DD (1) DD273285A5 (no)
DE (1) DE3854950D1 (no)
DK (1) DK175468B1 (no)
FI (1) FI103892B1 (no)
HU (1) HUT52544A (no)
IE (2) IE960853L (no)
IL (1) IL85878A (no)
NO (1) NO885275L (no)
NZ (1) NZ224057A (no)
PT (1) PT87083B (no)
WO (1) WO1988007576A2 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2660514B2 (ja) * 1987-02-20 1997-10-08 興和株式会社 抗血液凝固作用を有するポリペプチド
EP0330396B1 (en) * 1988-02-26 1995-06-21 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing lipocortins III, IV, V & VI
EP0339285A3 (en) * 1988-03-31 1989-11-29 RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) Recombinant endonexin ii
DE3910240A1 (de) * 1989-03-30 1990-10-04 Behringwerke Ag Pp4-delta, seine herstellung und verwendung
ATE89169T1 (de) * 1989-07-15 1993-05-15 Boehringer Ingelheim Int Antikoagulanz enthaltendes mittel.
DE3937607A1 (de) * 1989-11-11 1991-05-16 Boehringer Ingelheim Int Verwendung eines antikoagulanz zur behandlung von tumorerkrankungen
WO1991009628A1 (de) * 1989-12-27 1991-07-11 Boehringer Ingelheim International Gmbh Verwendung eines antikoagulant als diagnostikum
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5632986A (en) * 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
JPH05508664A (ja) * 1991-05-09 1993-12-02 ボード・オブ・リージェンツ・オブ・ザ・ユニヴァーシティ・オブ・ワシントン リン脂質標的血栓溶解剤
DK0672136T3 (da) * 1992-07-08 2000-08-21 Innogenetics Nv Polypeptider, der er afledt fra endonexin 2 og har hepatitis B virus-receptoraktivitet, og deres anvendelse i diagnostiske
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
EP0741144B1 (en) * 1994-11-11 2002-07-24 Noboru Kaneko Antiannexin-v monoclonal antibody, process for producing the same, and use therof
DE60219611T2 (de) * 2001-02-21 2007-12-27 Alavita Pharmaceuticals, Inc., Mountain View Modifizierte annexin-proteine und verhinderung und behandlung von thrombose
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US20090291086A1 (en) * 2001-02-21 2009-11-26 Alavita Pharmaceuticals, Inc. Compositions and Methods for Treating Cerebral Thrombosis and Global Cerebral Ischemia
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7635676B2 (en) * 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US20050222030A1 (en) * 2001-02-21 2005-10-06 Anthony Allison Modified annexin proteins and methods for preventing thrombosis
CA2373468A1 (en) * 2001-03-16 2002-09-16 Ortho-Clinical Diagnostics, Inc. Reg-like protein
DE60236951D1 (de) * 2001-05-21 2010-08-19 Fujifilm Corp Vorrichtung zur Durchführung biochemischer Analysen und Verfahren zu ihrer Herstellung
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
FR2841558B1 (fr) * 2002-07-01 2004-08-13 Commissariat Energie Atomique Peptides marques ayant une affinite pour un phospholipide et utilisations
FR2841557B1 (fr) * 2002-07-01 2005-12-09 Commissariat Energie Atomique Peptides ayant une affinite pour un phospholipide et utilisations
EP1533619B1 (en) * 2003-11-20 2009-04-29 F. Hoffmann-Roche AG Specific markers for metabolic syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (de) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt Neue polypeptide mit blutgerinnungshemmender wirkung, verfahren zu deren herstellung bzw. gewinnung, deren verwendung und diese enthaltende mittel
NZ213563A (en) * 1984-09-21 1991-08-27 Boehringer Ingelheim Int Anticoagulant proteins and pharmaceutical compositions
US5066788A (en) * 1984-09-21 1991-11-19 Boehringer Ingelheim International Gmbh Blood coagulation inhibiting proteins, processes for preparing them and their uses
EP0209568B1 (en) * 1985-01-10 1994-07-20 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human lipocortin-like polypeptides
JP2757987B2 (ja) * 1985-04-15 1998-05-25 バイオテクノロジー リサーチ パートナーズ，リミテッド ヒト抗‐炎症ホスホリパーゼ阻害蛋白
CA1265446A (en) * 1985-09-30 1990-02-06 Masahiro Maki Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component
EP0300030A1 (en) * 1987-02-06 1989-01-25 Zymogenetics, Inc. Human proteins having anticoagulant and anti-inflammatory activity
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity
US5179081A (en) * 1988-07-21 1993-01-12 Kowa Co., Ltd. Method of treatment using an anticoagulant polypeptide

Also Published As

Publication number Publication date
WO1988007576A2 (fr) 1988-10-06
IE74679B1 (en) 1997-07-30
ATE133707T1 (de) 1996-02-15
WO1988007576A3 (fr) 1989-01-26
FI103892B (fi) 1999-10-15
DK662288A (da) 1989-01-25
IL85878A0 (en) 1988-09-30
EP0293567B1 (de) 1996-01-31
JPH01503515A (ja) 1989-11-30
PT87083B (pt) 1992-07-31
DD273285A5 (de) 1989-11-08
KR890700666A (ko) 1989-11-26
IL85878A (en) 1993-07-08
PT87083A (pt) 1988-04-01
AU625214B2 (en) 1992-07-02
DK662288D0 (da) 1988-11-25
AU1402788A (en) 1988-09-29
DE3854950D1 (de) 1996-03-14
IE880928L (en) 1988-09-28
FI885504A0 (fi) 1988-11-28
DK175468B1 (da) 2004-11-01
IE960853L (en) 1988-09-28
EP0293567A1 (de) 1988-12-07
FI103892B1 (fi) 1999-10-15
NZ224057A (en) 1991-04-26
HUT52544A (en) 1990-07-28
NO885275L (no) 1989-01-25
US5837842A (en) 1998-11-17
FI885504A (fi) 1988-11-28

Similar Documents

Publication Publication Date Title
NO885275D0 (no) VaskulŸre antikoagulantproteiner, dna'er som koder for dem, fremstilling og anvendelse derav.
ES2142953T3 (es) Factor de crecimiento y diferenciacion de la familia del tgf-beta.
MX9203379A (es) Proteinas producidas por los linfocitos humanos, secuencia de adn que codifica para estas proteinas y composiciones farmaceuticas que las contienen.
DE69033040D1 (de) Verfahren zur Herstellung von biologisch aktivem Protein (z.B. TGF)
NO873753L (no) Periodisk biologisk luftbehandlingsprosess og system for denne.
ES8702431A1 (es) Procedimiento para preparar una proteina inhibidora de la coagulacion de la sangre
ES2168361T3 (es) Secuencias de adn para metaloproteasas de la matriz, su preparacion y empleo.
DE3882078D1 (de) Amperometrische methode zur titration von nadh (1,4-dihydronicotinamid-adenine-dinucleotide) in loesung.
IT8919735A0 (it) Procedimento per la riduzione del cod da reflui industriali o urbani.
ATE25969T1 (de) 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten.
DK0381984T3 (da) 3- eller 4-substituerede oxotremorinderivater
NO905496D0 (no) Biologisk forenelige, stoff-spesifikke reagenser til behandling av fysiologiske vaesker.
ES2067514T3 (es) Secuencia de adn de solanum tuberosum estimulada por vulneracion, y su empleo.
PT88913A (pt) Processo para a preparacao da proteina pp4-x anticoagulante
ZA897586B (en) Antidote
DE68919887D1 (de) Verfahren zur Herstellung von 1-alpha,25-dihydroxy-vitamin D2 und dessen 24-Epimer.
DE3777359D1 (de) Aminosaeuresequenz des menschlichen alpha 2-plasmininhibitors und cdns sowie diese aminosaeuresequenz codierende genomische dns.
ATE193324T1 (de) Rekombinante herstellung von laktoperoxidase
DE69023331D1 (de) Behandeltes hämoglobin und dessen herstellung.
DE3765250D1 (de) Verwendung von 24,25-dihydroxycholecalciferol zur behandlung von harnsteinen.
IT1237514B (it) Composti ad attivita' antitussiva, processo per la loro preparazione, loro composizioni farmaceutiche.
ES555466A0 (es) Mejoras introducidas en el objeto de la patente de invencion 516.212 por perfeccionamientos introducidos en atomizadores agricolas
ATE63692T1 (de) Ein gegenstand, geeignet zum blutkontakt, dessen herstellung und verwendungen.