DK0381984T3 - 3- eller 4-substituerede oxotremorinderivater - Google Patents

3- eller 4-substituerede oxotremorinderivater

Info

Publication number
DK0381984T3
DK0381984T3 DK90101248.4T DK90101248T DK0381984T3 DK 0381984 T3 DK0381984 T3 DK 0381984T3 DK 90101248 T DK90101248 T DK 90101248T DK 0381984 T3 DK0381984 T3 DK 0381984T3
Authority
DK
Denmark
Prior art keywords
compounds
substituted
oxotremorine
derivatives
oxotremorine derivatives
Prior art date
Application number
DK90101248.4T
Other languages
English (en)
Inventor
Eugene John Trybulski
Richard Hermann Kramss
Herbert Joseph Brabander
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DK0381984T3 publication Critical patent/DK0381984T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
DK90101248.4T 1989-01-23 1990-01-22 3- eller 4-substituerede oxotremorinderivater DK0381984T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/300,447 US4937235A (en) 1989-01-23 1989-01-23 3- or 4-substituted oxotremorine derivatives

Publications (1)

Publication Number Publication Date
DK0381984T3 true DK0381984T3 (da) 1995-05-08

Family

ID=23159138

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90101248.4T DK0381984T3 (da) 1989-01-23 1990-01-22 3- eller 4-substituerede oxotremorinderivater

Country Status (9)

Country Link
US (2) US4937235A (da)
EP (1) EP0381984B1 (da)
JP (1) JP2894358B2 (da)
AT (1) ATE121388T1 (da)
AU (1) AU622517B2 (da)
CA (1) CA2008107C (da)
DE (1) DE69018659T2 (da)
DK (1) DK0381984T3 (da)
ES (1) ES2070934T3 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089518A (en) * 1989-01-23 1992-02-18 American Cyanamid Company 3- or 4-substituted oxotremorine derivatives and a method of treating cholinergic dysfunction therewith
JP2834501B2 (ja) * 1989-11-25 1998-12-09 鐘淵化学工業株式会社 3,4―エポキシ酪酸エステルの製法および中間体
US5356885A (en) * 1991-04-24 1994-10-18 American Cyanamid Company Substituted oxotremorine derivatives and pharmaceutical use thereof
US5550257A (en) * 1991-04-24 1996-08-27 American Cyanamid Company Substituted oxotremorine derivatives
US5346910A (en) * 1992-06-03 1994-09-13 American Cyanamid Company Maleimide derivatives of oxotremorine
US5932745A (en) * 1997-07-30 1999-08-03 American Home Products Corporation Process for converting propargylic amine-N-oxides to enaminones
KR100295740B1 (ko) 1998-09-17 2001-11-05 박영구 N-치환된-하이드록시고리화알킬아민유도체의제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1245743A (en) * 1967-11-09 1971-09-08 Astra Ab Alkynyl lactams
US3856790A (en) 1970-01-06 1974-12-24 American Home Prod Cyclic amides of 1,4-diaminobut-2-yne
EP0009326A3 (en) * 1978-08-30 1980-04-16 Pfizer Limited Pyrrolyl keto and amino acids and derivatives thereof, processes for their preparation and pharmaceutical compositions containing them
GR78370B (da) * 1981-12-24 1984-09-26 Delalande Sa
US4847284A (en) * 1988-03-23 1989-07-11 Merck & Co., Inc. Antifungal fermentation product and derivatives and compositions thereof
DE3835291A1 (de) * 1988-04-19 1989-11-02 Bayer Ag 1,3-disubstituierte pyrrolidine

Also Published As

Publication number Publication date
EP0381984B1 (en) 1995-04-19
ATE121388T1 (de) 1995-05-15
ES2070934T3 (es) 1995-06-16
EP0381984A1 (en) 1990-08-16
AU622517B2 (en) 1992-04-09
CA2008107C (en) 1996-08-13
US4952600A (en) 1990-08-28
DE69018659D1 (de) 1995-05-24
AU4868490A (en) 1990-07-26
CA2008107A1 (en) 1990-07-23
JPH02229155A (ja) 1990-09-11
JP2894358B2 (ja) 1999-05-24
US4937235A (en) 1990-06-26
DE69018659T2 (de) 1996-01-18

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