ATE377076T1 - Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen - Google Patents
Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungenInfo
- Publication number
- ATE377076T1 ATE377076T1 AT00916164T AT00916164T ATE377076T1 AT E377076 T1 ATE377076 T1 AT E377076T1 AT 00916164 T AT00916164 T AT 00916164T AT 00916164 T AT00916164 T AT 00916164T AT E377076 T1 ATE377076 T1 AT E377076T1
- Authority
- AT
- Austria
- Prior art keywords
- ligand
- polypeptide
- human cytokine
- zalpha
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26490899A | 1999-03-09 | 1999-03-09 | |
US26599299A | 1999-03-11 | 1999-03-11 | |
US14201399P | 1999-07-01 | 1999-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE377076T1 true ATE377076T1 (de) | 2007-11-15 |
Family
ID=27385745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00916164T ATE377076T1 (de) | 1999-03-09 | 2000-03-09 | Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen |
Country Status (23)
Country | Link |
---|---|
EP (3) | EP1881070B1 (de) |
JP (1) | JP4405686B2 (de) |
KR (1) | KR100743640B1 (de) |
CN (5) | CN102406937A (de) |
AT (1) | ATE377076T1 (de) |
AU (2) | AU777842B2 (de) |
BR (1) | BR0008772B1 (de) |
CA (1) | CA2366921C (de) |
CZ (1) | CZ302921B6 (de) |
DE (1) | DE60036930T2 (de) |
DK (1) | DK1165791T3 (de) |
ES (1) | ES2295019T3 (de) |
HU (1) | HU229148B1 (de) |
IL (5) | IL145288A0 (de) |
MX (1) | MXPA01009074A (de) |
NO (2) | NO331551B1 (de) |
NZ (1) | NZ514708A (de) |
PL (1) | PL207350B1 (de) |
PT (1) | PT1165791E (de) |
RU (1) | RU2346951C2 (de) |
UA (1) | UA84387C2 (de) |
WO (1) | WO2000053761A2 (de) |
ZA (1) | ZA017370B (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189400B2 (en) | 1998-03-17 | 2007-03-13 | Genetics Institute, Llc | Methods of treatment with antagonists of MU-1 |
US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
EP1881070B1 (de) * | 1999-03-09 | 2012-10-03 | Zymogenetics, Inc. | Menschliche Zytokine als Liganden des Z-Alpha-Rezeptors und Verwendungen davon |
ES2629395T3 (es) | 2001-10-04 | 2017-08-09 | Genetics Institute, Llc | Métodos y composiciones para modular la actividad de la interleucina-21 |
WO2003040313A2 (en) * | 2001-11-05 | 2003-05-15 | Zymogenetics, Inc | Il-21 antagonists |
EP1531850B1 (de) * | 2002-06-07 | 2012-02-22 | ZymoGenetics, Inc. | Verwendung von IL-21 und monoklonalem Antikörper zur Behandlung von fester Tumore |
CA2491320A1 (en) | 2002-07-15 | 2004-01-22 | Wyeth | Methods and compositions for modulating t helper (th) cell development and function |
RU2005113992A (ru) * | 2002-10-11 | 2005-10-27 | Ново Нордиск А/С (DK) | Лечение аллергических состояний с использованием il-21 |
AU2003273758A1 (en) * | 2002-10-11 | 2004-05-04 | Novo Nordisk A/S | Treatment of allergic conditions by use of il 21 |
CA2507817C (en) * | 2002-12-13 | 2014-04-22 | Zymogenetics, Inc. | Il-21 production in prokaryotic hosts |
EP2184298A1 (de) | 2003-03-14 | 2010-05-12 | Wyeth a Corporation of the State of Delaware | Antikörper gegen Il-21-Rezeptor und deren Verwendung |
EP1641422A4 (de) * | 2003-06-19 | 2007-08-22 | Centocor Inc | Interleukin-21 analoga |
DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
EP1648931B1 (de) | 2003-07-21 | 2011-02-09 | Transgene S.A. | Multifunktionelle cytokine |
JP2007506789A (ja) * | 2003-09-25 | 2007-03-22 | ザイモジェネティクス, インコーポレイテッド | Il−21を用いた自己免疫疾患の治療方法 |
CN102516386A (zh) | 2003-10-10 | 2012-06-27 | 诺沃挪第克公司 | Il-21衍生物 |
US20060228331A1 (en) | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
EP2641611A3 (de) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Kombinationstherapie |
CA2551879A1 (en) * | 2004-01-15 | 2005-07-28 | Novo Nordisk A/S | Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection |
EP1708755B1 (de) | 2004-01-21 | 2012-03-21 | Novo Nordisk Health Care AG | Transglutaminase-vermittelte konjugation von peptiden |
GT200600148A (es) | 2005-04-14 | 2006-11-22 | Metodos para el tratamiento y la prevencion de fibrosis | |
RU2412199C2 (ru) | 2005-04-18 | 2011-02-20 | Ново Нордиск А/С | Варианты ил-21 |
EP2805971A1 (de) * | 2005-11-28 | 2014-11-26 | ZymoGenetics, Inc. | IL-21-Antagonisten |
CN101553501A (zh) | 2006-10-26 | 2009-10-07 | 诺沃-诺迪斯克有限公司 | Il-21变种 |
EP2109620B1 (de) | 2006-12-21 | 2012-08-22 | Novo Nordisk A/S | Interleukin-21-varianten mit geänderter bindung an den il-21-rezeptor |
US7883700B2 (en) | 2007-12-07 | 2011-02-08 | Zymogenetics, Inc. | Anti-human IL-21 monoclonal antibodies |
PE20100141A1 (es) | 2008-05-23 | 2010-02-22 | Wyeth Corp | Proteina de union al receptor de interleuquina 21 |
CA2725154A1 (en) | 2008-05-23 | 2009-11-26 | Wyeth Llc | Methods of treatment utilizing binding proteins of the interleukin-21 receptor |
CA2739357A1 (en) | 2008-09-23 | 2010-04-08 | Wyeth Llc | Methods for predicting production of activating signals by cross-linked binding proteins |
CN102021196B (zh) * | 2009-11-20 | 2013-06-26 | 上海杰隆生物工程股份有限公司 | 毕赤酵母生产重组人白细胞介素21的方法 |
EP3828278A1 (de) | 2012-06-27 | 2021-06-02 | Rutgers, the State University of New Jersey | Schnelle assays zur aktivierung von t-zellen durch rns messungen mittels durchflusszytometrie |
WO2015110930A1 (en) | 2014-01-24 | 2015-07-30 | Pfizer Inc. | Modified interleukin 21 receptor proteins |
EP2982693A1 (de) * | 2014-08-07 | 2016-02-10 | Affimed Therapeutics AG | CD3 Bindungsdomäne |
CN112662694A (zh) * | 2020-12-25 | 2021-04-16 | 康九生物科技(长春)有限公司 | 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用 |
Family Cites Families (45)
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DK368882A (da) | 1981-08-25 | 1983-02-26 | Alan John Kingsman | Expessions vektorer |
US4579821A (en) | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
US4486533A (en) | 1982-09-02 | 1984-12-04 | St. Louis University | Filamentous fungi functional replicating extrachromosomal element |
US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
US4977092A (en) | 1985-06-26 | 1990-12-11 | Amgen | Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
US4661454A (en) | 1983-02-28 | 1987-04-28 | Collaborative Research, Inc. | GAL1 yeast promoter linked to non galactokinase gene |
US5139936A (en) | 1983-02-28 | 1992-08-18 | Collaborative Research, Inc. | Use of the GAL1 yeast promoter |
US4650764A (en) | 1983-04-12 | 1987-03-17 | Wisconsin Alumni Research Foundation | Helper cell |
US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4990446A (en) | 1984-12-06 | 1991-02-05 | Labofina, S.A. | Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
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GB8611832D0 (en) | 1986-05-15 | 1986-06-25 | Holland I B | Polypeptide |
US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
US5063154A (en) | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
US5567584A (en) | 1988-01-22 | 1996-10-22 | Zymogenetics, Inc. | Methods of using biologically active dimerized polypeptide fusions to detect PDGF |
ES2092468T3 (es) | 1988-01-22 | 1996-12-01 | Zymogenetics Inc | Metodos para producir analogos de receptores secretados. |
US4956288A (en) | 1988-04-22 | 1990-09-11 | Biogen, Inc. | Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA |
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US5124263A (en) | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
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US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
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IL122818A0 (en) * | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
US6057128A (en) * | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
EP1881070B1 (de) * | 1999-03-09 | 2012-10-03 | Zymogenetics, Inc. | Menschliche Zytokine als Liganden des Z-Alpha-Rezeptors und Verwendungen davon |
US9418201B1 (en) | 2015-11-19 | 2016-08-16 | International Business Machines Corporation | Integration of functional analysis and common path pessimism removal in static timing analysis |
-
2000
- 2000-03-09 EP EP07017344A patent/EP1881070B1/de not_active Expired - Lifetime
- 2000-03-09 ES ES00916164T patent/ES2295019T3/es not_active Expired - Lifetime
- 2000-03-09 CN CN2011103037822A patent/CN102406937A/zh active Pending
- 2000-03-09 AU AU37312/00A patent/AU777842B2/en not_active Ceased
- 2000-03-09 CN CN2009101354816A patent/CN101575377B/zh not_active Expired - Fee Related
- 2000-03-09 KR KR1020017011499A patent/KR100743640B1/ko not_active IP Right Cessation
- 2000-03-09 CA CA2366921A patent/CA2366921C/en not_active Expired - Fee Related
- 2000-03-09 NZ NZ514708A patent/NZ514708A/en not_active IP Right Cessation
- 2000-03-09 UA UA2001106769A patent/UA84387C2/ru unknown
- 2000-03-09 BR BRPI0008772-6A patent/BR0008772B1/pt not_active IP Right Cessation
- 2000-03-09 PL PL351160A patent/PL207350B1/pl unknown
- 2000-03-09 RU RU2004126135/13A patent/RU2346951C2/ru not_active IP Right Cessation
- 2000-03-09 DK DK00916164T patent/DK1165791T3/da active
- 2000-03-09 EP EP00916164A patent/EP1165791B1/de not_active Expired - Lifetime
- 2000-03-09 CZ CZ20013184A patent/CZ302921B6/cs not_active IP Right Cessation
- 2000-03-09 HU HU0200418A patent/HU229148B1/hu not_active IP Right Cessation
- 2000-03-09 WO PCT/US2000/006067 patent/WO2000053761A2/en active Application Filing
- 2000-03-09 CN CNB008068747A patent/CN100500846C/zh not_active Expired - Fee Related
- 2000-03-09 PT PT00916164T patent/PT1165791E/pt unknown
- 2000-03-09 AT AT00916164T patent/ATE377076T1/de active
- 2000-03-09 JP JP2000603382A patent/JP4405686B2/ja not_active Expired - Fee Related
- 2000-03-09 IL IL14528800A patent/IL145288A0/xx unknown
- 2000-03-09 CN CNA2005101141968A patent/CN1827639A/zh active Pending
- 2000-03-09 MX MXPA01009074A patent/MXPA01009074A/es active IP Right Grant
- 2000-03-09 EP EP20100185147 patent/EP2295577A3/de not_active Withdrawn
- 2000-03-09 DE DE60036930T patent/DE60036930T2/de not_active Expired - Lifetime
- 2000-03-09 CN CN2006101031515A patent/CN1927883B/zh not_active Expired - Fee Related
-
2001
- 2001-09-05 IL IL145288A patent/IL145288A/en not_active IP Right Cessation
- 2001-09-06 ZA ZA2001/07370A patent/ZA017370B/en unknown
- 2001-09-07 NO NO20014364A patent/NO331551B1/no not_active IP Right Cessation
-
2005
- 2005-01-20 AU AU2005200240A patent/AU2005200240A1/en not_active Abandoned
-
2008
- 2008-12-04 IL IL195713A patent/IL195713A/en not_active IP Right Cessation
-
2010
- 2010-08-04 IL IL207403A patent/IL207403A/en not_active IP Right Cessation
- 2010-08-05 IL IL207424A patent/IL207424A/en not_active IP Right Cessation
-
2011
- 2011-07-29 NO NO20111085A patent/NO20111085L/no unknown
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