DK1165791T3 - Humant cytokin som zalpha-receptor-ligand og anvendelse deraf - Google Patents

Humant cytokin som zalpha-receptor-ligand og anvendelse deraf

Info

Publication number
DK1165791T3
DK1165791T3 DK00916164T DK00916164T DK1165791T3 DK 1165791 T3 DK1165791 T3 DK 1165791T3 DK 00916164 T DK00916164 T DK 00916164T DK 00916164 T DK00916164 T DK 00916164T DK 1165791 T3 DK1165791 T3 DK 1165791T3
Authority
DK
Denmark
Prior art keywords
receptor ligand
human cytokine
polypeptide
zalpha
zalpha receptor
Prior art date
Application number
DK00916164T
Other languages
English (en)
Inventor
Scott R Presnell
Donald C Foster
Richard D Holly
Janet V Johnston
Julie E Novak
Cindy A Sprecher
Jane A Gross
Andrew J Nelson
Stacey R Dillon
Angela K Hammond
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27385745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1165791(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK1165791T3 publication Critical patent/DK1165791T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK00916164T 1999-03-09 2000-03-09 Humant cytokin som zalpha-receptor-ligand og anvendelse deraf DK1165791T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26490899A 1999-03-09 1999-03-09
US26599299A 1999-03-11 1999-03-11
US14201399P 1999-07-01 1999-07-01
PCT/US2000/006067 WO2000053761A2 (en) 1999-03-09 2000-03-09 Human cytokine as ligand of the zalpha receptor and uses thereof

Publications (1)

Publication Number Publication Date
DK1165791T3 true DK1165791T3 (da) 2008-02-11

Family

ID=27385745

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00916164T DK1165791T3 (da) 1999-03-09 2000-03-09 Humant cytokin som zalpha-receptor-ligand og anvendelse deraf

Country Status (23)

Country Link
EP (3) EP1165791B1 (da)
JP (1) JP4405686B2 (da)
KR (1) KR100743640B1 (da)
CN (5) CN100500846C (da)
AT (1) ATE377076T1 (da)
AU (2) AU777842B2 (da)
BR (1) BR0008772B1 (da)
CA (1) CA2366921C (da)
CZ (1) CZ302921B6 (da)
DE (1) DE60036930T2 (da)
DK (1) DK1165791T3 (da)
ES (1) ES2295019T3 (da)
HU (1) HU229148B1 (da)
IL (5) IL145288A0 (da)
MX (1) MXPA01009074A (da)
NO (2) NO331551B1 (da)
NZ (1) NZ514708A (da)
PL (1) PL207350B1 (da)
PT (1) PT1165791E (da)
RU (1) RU2346951C2 (da)
UA (1) UA84387C2 (da)
WO (1) WO2000053761A2 (da)
ZA (1) ZA017370B (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
UA84387C2 (ru) * 1999-03-09 2008-10-27 Займодженетикс, Инк. Человеческий цитокин как лиганд зальфа рецептора и его применение
NZ532021A (en) * 2001-10-04 2008-05-30 Genetics Inst Llc Methods and compositions for modulating interleukin-21 receptor activity
EP2130919A1 (en) * 2001-11-05 2009-12-09 ZymoGenetics, Inc. IL-21 antagonists
AU2003243415A1 (en) * 2002-06-07 2003-12-22 Zymogenetics, Inc. Use of il-21 in cancer and other therapeutic applications
CN1688340A (zh) 2002-07-15 2005-10-26 韦思公司 调节t辅助(th)细胞发育和功能的方法和组合物
EP1553970A1 (en) * 2002-10-11 2005-07-20 Novo Nordisk A/S Treatment of allergic conditions by use of il 21
EP1782823A3 (en) * 2002-10-11 2007-05-16 Novo Nordisk A/S IL-21 peptides and nucleic acids
PL209009B1 (pl) * 2002-12-13 2011-07-29 Zymogenetics Inc Wektor ekspresyjny do otrzymywania białka IL-21, komórka prokariotycznego gospodarza i sposób otrzymywania białek
ES2340280T3 (es) * 2003-03-14 2010-06-01 Wyeth Llc Anticuerpos dirigidos contra el receptor de il-21 humano y uso de los mismos.
EP1641422A4 (en) * 2003-06-19 2007-08-22 Centocor Inc ANALOGUES OF INTERLEUKINE-21
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
EP1925626A1 (en) 2003-07-21 2008-05-28 Transgene S.A. Novel multifunctional cytokines
EP1670501A2 (en) * 2003-09-25 2006-06-21 ZymoGenetics, Inc. Methods of treating autoimmune diseases using il-21
US20060228331A1 (en) * 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
ES2428358T3 (es) 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
WO2005067956A2 (en) * 2004-01-15 2005-07-28 Novo Nordisk A/S Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection
ATE550041T1 (de) 2004-01-21 2012-04-15 Novo Nordisk Healthcare Ag Transglutaminase-vermittelte konjugation von peptiden
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
JP2008538290A (ja) 2005-04-18 2008-10-23 ノボ ノルディスク アクティーゼルスカブ Ｉｌ−２１変異体
ES2409835T3 (es) 2005-11-28 2013-06-28 Zymogenetics, Inc. Antagonistas de IL-21
JP2010507382A (ja) 2006-10-26 2010-03-11 ノヴォ ノルディスク アクティーゼルスカブ Ｉｌ−２１変異体
AU2007336184A1 (en) 2006-12-21 2008-06-26 Novo Nordisk A/S Interleukin-21 variants with altered binding to the IL-21 receptor
CA2910933C (en) 2007-12-07 2017-04-11 Zymogenetics, Inc. Anti-human il-21 monoclonal antibodies
EP2296689A1 (en) 2008-05-23 2011-03-23 Wyeth LLC Methods of treatment utilizing binding proteins of the interleukin-21 receptor
AR071885A1 (es) 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
JP2012504939A (ja) 2008-09-23 2012-03-01 ワイス・エルエルシー 架橋結合タンパク質による活性化シグナルの産生を予測するための方法
CN102021196B (zh) * 2009-11-20 2013-06-26 上海杰隆生物工程股份有限公司 毕赤酵母生产重组人白细胞介素21的方法
EP3828278A1 (en) 2012-06-27 2021-06-02 Rutgers, the State University of New Jersey Rapid assays for t-cell activation by rna measurements using flow cytometry
WO2015110930A1 (en) 2014-01-24 2015-07-30 Pfizer Inc. Modified interleukin 21 receptor proteins
EP2982693A1 (en) * 2014-08-07 2016-02-10 Affimed Therapeutics AG CD3 binding domain
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK368882A (da) 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US4486533A (en) 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4977092A (en) 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US5139936A (en) 1983-02-28 1992-08-18 Collaborative Research, Inc. Use of the GAL1 yeast promoter
US4661454A (en) 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
DE3578435D1 (de) 1984-12-06 1990-08-02 Labofina Sa Promotoren fuer die expression von fremden genen in hefe, plasmide, die diese promotoren enthalten, sowie deren verwendung zur herstellung von polypeptiden.
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5063154A (en) 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
ES2092468T3 (es) 1988-01-22 1996-12-01 Zymogenetics Inc Metodos para producir analogos de receptores secretados.
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5162228A (en) 1988-12-28 1992-11-10 Takeda Chemical Industries, Ltd. Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5298418A (en) 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
WO1994006463A1 (en) 1992-09-14 1994-03-31 Pfizer Inc Immortalized cells and uses therefor
EP0711354A1 (en) 1993-07-30 1996-05-15 University Of Medicine & Dentistry Of New Jersey Efficient gene transfer into primary lymphocytes
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
WO1997017450A2 (en) 1995-11-09 1997-05-15 Zymogenetics, Inc. Compositions and methods for producing heterologous polypeptides in pichia methanolica
JP2002514049A (ja) 1996-07-17 2002-05-14 ザイモジェネティクス，インコーポレイティド ピヒア・メタノリカの栄養要求性突然変異体の製造
IL128073A0 (en) 1996-07-17 1999-11-30 Zymogenetics Inc Transformation of pichia methanolica
CA2273194C (en) 1996-12-03 2011-02-01 Abgenix, Inc. Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
US6057128A (en) * 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
UA84387C2 (ru) * 1999-03-09 2008-10-27 Займодженетикс, Инк. Человеческий цитокин как лиганд зальфа рецептора и его применение
US9418201B1 (en) 2015-11-19 2016-08-16 International Business Machines Corporation Integration of functional analysis and common path pessimism removal in static timing analysis

Also Published As

Publication number Publication date
HUP0200418A3 (en) 2003-12-29
EP2295577A2 (en) 2011-03-16
PL207350B1 (pl) 2010-12-31
NO20014364D0 (no) 2001-09-07
ATE377076T1 (de) 2007-11-15
IL207424A (en) 2013-04-30
NO331551B1 (no) 2012-01-23
EP1881070A2 (en) 2008-01-23
IL207403A (en) 2012-03-29
CN101575377B (zh) 2012-12-26
CN100500846C (zh) 2009-06-17
AU3731200A (en) 2000-09-28
WO2000053761A2 (en) 2000-09-14
ES2295019T3 (es) 2008-04-16
IL195713A (en) 2010-11-30
CA2366921A1 (en) 2000-09-14
WO2000053761A3 (en) 2000-12-21
EP1165791B1 (en) 2007-10-31
BR0008772A (pt) 2002-05-07
EP2295577A3 (en) 2012-08-08
CN1927883B (zh) 2011-09-21
DE60036930D1 (de) 2007-12-13
CN101575377A (zh) 2009-11-11
JP4405686B2 (ja) 2010-01-27
CN102406937A (zh) 2012-04-11
PL351160A1 (en) 2003-03-24
AU2005200240A1 (en) 2005-02-17
BR0008772B1 (pt) 2011-11-01
HU229148B1 (en) 2013-09-30
CZ20013184A3 (cs) 2002-04-17
JP2002537839A (ja) 2002-11-12
ZA017370B (en) 2002-06-26
MXPA01009074A (es) 2002-03-27
IL145288A (en) 2010-11-30
PT1165791E (pt) 2008-01-16
AU777842B2 (en) 2004-11-04
DE60036930T2 (de) 2008-10-09
IL145288A0 (en) 2002-06-30
EP1881070B1 (en) 2012-10-03
EP1165791A2 (en) 2002-01-02
KR20010103794A (ko) 2001-11-23
NZ514708A (en) 2005-01-28
NO20111085L (no) 2001-11-09
EP1881070A3 (en) 2008-03-05
CA2366921C (en) 2013-12-17
NO20014364L (no) 2001-11-09
CN1827639A (zh) 2006-09-06
CN1378595A (zh) 2002-11-06
RU2004126135A (ru) 2006-02-10
KR100743640B1 (ko) 2007-07-27
CN1927883A (zh) 2007-03-14
RU2346951C2 (ru) 2009-02-20
HUP0200418A2 (hu) 2002-05-29
UA84387C2 (ru) 2008-10-27
CZ302921B6 (cs) 2012-01-18

Similar Documents

Publication Publication Date Title
DK1165791T3 (da) Humant cytokin som zalpha-receptor-ligand og anvendelse deraf
DE69428214D1 (de) Transformierender wachstumsfaktor alpha h1
NO20043419L (no) Nytt cytokin, zcytor17-ligand
DK0751992T3 (da) Karendotelvækstfaktor 2
DK0839196T3 (da) Humant CTLA-8 og anvendelser af CTLA-8-relaterede proteiner
MXPA02004666A (es) Gelatinas recombinantes.
AU2003244855A1 (en) Method to enhance an immune response of nucleic acid vaccination
EP0712926A3 (da)
EP0967283A4 (en) GENES CODING FOR PROTEINS WITH TRANSGLYCOLYSTING ACTIVITY.
MX9803634A (es) Difenileteroxazolinas y su empleo como agentes pesticidas.
DK0939769T3 (da) Vertebrat-Smoothened-proteiner
KR950700988A (ko) 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
ATE487735T1 (de) Säugetier milchwachstumsfaktor
FI944907A (fi) Uusi antineoplastinen sytokiini
WO2001044490A3 (en) A NOVEL METHOD TO PRODUCE HUMAN NATURAL INTERFERON-$g(a)
GB2361923A (en) Novel protein
EP1295943A4 (en) POLYPEPTIDES CAPABLE THE POWER TO STIMULATE NEUTROPHILES
DK133086A (da) 5h-pyrido(3',4'.4,5)pyrrolo(3,2-c)pyridoner, fremgangsmaade til fremstilling deraf og deres anvendelse som syntesemellemprodukter
DK0382268T3 (da) Aminocarboxylsyrederivater
ITRM940091A0 (it) Procedimento per la preparazione di colture cellulari di eisenia foetida (anellidi, oligocheti).
DE60033562D1 (de) Künstliche promotoren zür protein expression in pflanzen
UA29770A (uk) Спосіб пригнічення репродукції вірусу імунодефіциту людини
WO2000070015A3 (fr) Cultures de cellules d'insecte se multipliant a 37°c, leur p rocede d'obtention, et leurs utilisations
MX9802486A (es) Proteina de helicobacter pylori.